Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we descr...Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we describe CytoExam,an automatic liquid biopsy instrument designed based on inertial microfluidics and impedance cytometry,which uses a deep learning algorithm for the analysis of circulating tumor cells(CTCs).In silico and in vitro experiments demonstrated that CytoExam could achieve label-free detection of CTCs in the peripheral blood of cancer patients within 15 min.The clinical applicability of CytoExam was also verified using peripheral blood samples from 10 healthy donors and>50 patients with breast,colorectal,or lung cancer.Significant differences in the number of collected cells and predicted CTCs were observed between the 2 groups,with variations in the dielectric properties of the collected cells from cancer patients also being observed.The ultra-fast and minimally invasive features of CytoExam may pave the way for new paths for cancer diagnosis and scientific research.展开更多
The health problems of children differ greatly from those of adults. A child＇s response to illness and stress varies with increasing age. Pediatrics is a discipline that examines all aspects of the well-being of fetu...The health problems of children differ greatly from those of adults. A child＇s response to illness and stress varies with increasing age. Pediatrics is a discipline that examines all aspects of the well-being of fetuses, infants, children, and adolescents, including their physical, mental, and psychologic growth and development. The development of pediatrics relies on innovation. Innovation is defined as the combination of new ideas, including new concepts, science, technology, and theories, which advance the development of various disciplines of pediatrics. Innovation has a strong influence on pediatrics, especially in promoting the quality of life of children, preventing diseases, and protecting children from health threats. Indeed, innovation is a driving force of the development of pediatric studies, providing the latest knowledge, theories, and technologies in pediatrics.展开更多
基金supported by the National Natural Science Foundation of China(52375562,51875103,and 81727801)the Natural Science Foundation of Jiangsu Province(BK20190064)the“333”Project of Jiangsu Province.
文摘Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we describe CytoExam,an automatic liquid biopsy instrument designed based on inertial microfluidics and impedance cytometry,which uses a deep learning algorithm for the analysis of circulating tumor cells(CTCs).In silico and in vitro experiments demonstrated that CytoExam could achieve label-free detection of CTCs in the peripheral blood of cancer patients within 15 min.The clinical applicability of CytoExam was also verified using peripheral blood samples from 10 healthy donors and>50 patients with breast,colorectal,or lung cancer.Significant differences in the number of collected cells and predicted CTCs were observed between the 2 groups,with variations in the dielectric properties of the collected cells from cancer patients also being observed.The ultra-fast and minimally invasive features of CytoExam may pave the way for new paths for cancer diagnosis and scientific research.
文摘The health problems of children differ greatly from those of adults. A child＇s response to illness and stress varies with increasing age. Pediatrics is a discipline that examines all aspects of the well-being of fetuses, infants, children, and adolescents, including their physical, mental, and psychologic growth and development. The development of pediatrics relies on innovation. Innovation is defined as the combination of new ideas, including new concepts, science, technology, and theories, which advance the development of various disciplines of pediatrics. Innovation has a strong influence on pediatrics, especially in promoting the quality of life of children, preventing diseases, and protecting children from health threats. Indeed, innovation is a driving force of the development of pediatric studies, providing the latest knowledge, theories, and technologies in pediatrics.
