Novel heptamethine 3H-indocyanine dyes are synthesized and embedded into a matrix of silica gel derived from tetraethoxysilicane. The photophysical properties of these near infrared dyes in various solvents and in S...Novel heptamethine 3H-indocyanine dyes are synthesized and embedded into a matrix of silica gel derived from tetraethoxysilicane. The photophysical properties of these near infrared dyes in various solvents and in SiO2 sol gel were investigated. The results show that the dyes containing cyclohexenylene bridge and N-(p-carboxy)benzyl groups have better photostability and longer absorption wavelength than those containing linear heptamethine bridge and/or N-(5- carboxy)pentanyl groups. The absorption maxima of these dyes are in reverse proportion to the polarity of the solvents. The microenvironment of the dyes in SiO2 sol-gel characters medium polarity (between methanol and DMF) according to the absorption maxima.展开更多
Two Crown ether benzotellurastyryl cyanines and three crown ether benzotelluramerocyanines are synthesized via the key intermediate 3 methyl 5,6(15 crown 5) 2(β acetanilide)vinyl benzotellurazolium iodide.The ...Two Crown ether benzotellurastyryl cyanines and three crown ether benzotelluramerocyanines are synthesized via the key intermediate 3 methyl 5,6(15 crown 5) 2(β acetanilide)vinyl benzotellurazolium iodide.The reactive conditions are discussed.The influence of alkali( earth)metal ions on the visible absorption spectra of these two types of crown ether cyanines are also studied.展开更多
Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,...Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference.Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years.The NIR fluorescent labeling technique involving cyanine has attracted widespread attention.This review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,etc.We expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.展开更多
In the past decades,porphyrins,phthalocyanines and related materials have attracted significant attention due to their diverse and brilliant structures[1,2],as well as their unique electronic structures and photophysi...In the past decades,porphyrins,phthalocyanines and related materials have attracted significant attention due to their diverse and brilliant structures[1,2],as well as their unique electronic structures and photophysical properties which could be applicable in a wide range of areas[3–5].展开更多
Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the...Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the dye ion J-stacks in 'stoichiometric' relation. Concerning the fact that polyeletrolytes could promote the formation of J-aggregate of cyanine dye ions, the authors suggested that the J-aggregates of an ionic cyanine might more easily induce the J-aggregation of other cyanine ions with opposite charges. The two展开更多
Lonicera caerulea L.fruit is an excellent source of bioactive compounds.An efficient separation method of cyanins is important for the development of many value-added products and functional food ingredients.High-spee...Lonicera caerulea L.fruit is an excellent source of bioactive compounds.An efficient separation method of cyanins is important for the development of many value-added products and functional food ingredients.High-speed counter-current chromatography(HSCCC) was applied to isolate cyanins from Lonicera caerulea fruits with a biphasic solvent system composed of methyl tert-butyl ether/n-butanol/acetonitrile/water/trifluoroacetic acid(2:2:1:5:0.01,volume ratio).1.41 mg of cyanidin 3,5-O-diglucoside,1.08 mg of cyanidin 3-O-rutinoside and 6.38 mg of cyanidin 3-O-glucoside were obtained from 40 mg of crude extract.The purities of these compounds were 95.8%,92.4% and 97.6%,respectively,as identified by high-performance liquid chromatography–diode array detection(HPLC-DAD) and high-performance liquid chromatography-electrospray ionization mass spectrometryn(HPLC-ESI/MSn).In addition,the dominant anthocyanin,cyanidin 3-O-glucoside was demonstrated cytotoxic response of human hepatocarcinoma SMMC-7721 cells,inducing live cancer cell apoptotic by flow cytometric analysis.展开更多
A low cost cyanine dye, 1,1-dimethyl-3-ethyl-2-[3-(1,3-dihydro-3,3-dimethyl-1-ethyl- 5-carboxyl-2H-indol-2-ylidene)-1-propenyl]-1H-benz[e] indolium iodide (1) was synthesized and applied to sensitize mesoporous TiO2 e...A low cost cyanine dye, 1,1-dimethyl-3-ethyl-2-[3-(1,3-dihydro-3,3-dimethyl-1-ethyl- 5-carboxyl-2H-indol-2-ylidene)-1-propenyl]-1H-benz[e] indolium iodide (1) was synthesized and applied to sensitize mesoporous TiO2 electrode. Photoresponse of the electrode was extended to the visible and remarkably high incident photon-to-current conversion efficiency (IPCE) over 70% was achieved from 500 nm to 600 nm.展开更多
A squarylium dye is dissolved in 4-cyano-4＇-pentylbiphenyl （SCB） and oriented by sandwiching mixtures between two pieces of rubbed glass plates. The optical absorption spectra of the oriented squarylium dye-5CB lay...A squarylium dye is dissolved in 4-cyano-4＇-pentylbiphenyl （SCB） and oriented by sandwiching mixtures between two pieces of rubbed glass plates. The optical absorption spectra of the oriented squarylium dye-5CB layers exhibit high anisotropy. The third-order nonlinear optical responses and susceptibilities X^（3）e of squarylium dye in 5CB are measured with light polarizations parallel and perpendicular to the orientational direction by the resonant femtosecond degenerate four-wave mixing （DFWM） technique. Temporal profiles of the DFWM signal of the oriented squarylium dye-5CB layers with light polarizations parallel and perpendicular to the orientational direction are measured with a time resolution of 0.3ps （FWHM）, and are found to consist of two components, i.e., the coherent instantaneous nonlinear response and slow response due to the formation of excited molecules. A high anisotropic ratio of x^（3）e, 10.8 ：k 1.2, is observed for the oriented layers.展开更多
Individual titanyl phthalocyanine(TiOPc)molecules on ultrathin sodium chloride striped films grown on Cu(110)exhibit two different topographies with 8-lobes and 6-lobes when imaged by scanning tunneling microscopy(STM...Individual titanyl phthalocyanine(TiOPc)molecules on ultrathin sodium chloride striped films grown on Cu(110)exhibit two different topographies with 8-lobes and 6-lobes when imaged by scanning tunneling microscopy(STM).Direct images of the molecular orbitals of the molecules with 8-lobes are obtained,indicating that the electronic structure of the TiOPc molecule are decoupled from the metallic substrate.For the TiOPc molecule with 6-lobes,the STM images at negative and positive bias polarities show the same structures as 2-fold symmetry except for the 90°rotation with respect to each other.This phenomenon may be attributed to the splitting of the two former degenerate lowest unoccupied molecular orbitals due to the negative charging of the molecule.The identification of the molecular orbital splitting on the ultrathin insulating layer could deepen the understanding of the intrinsic properties of semi-conducting molecules.展开更多
The colour reactions of quaternary complexes of rare earths with eriochrome cyanine R, 1, 10-phenanthroline and cetyltrimethyl ammonium bromide (CTAB) have been reported by the present author.In this paper we are repo...The colour reactions of quaternary complexes of rare earths with eriochrome cyanine R, 1, 10-phenanthroline and cetyltrimethyl ammonium bromide (CTAB) have been reported by the present author.In this paper we are reporting results of studies on the colour reactions of the quaternary complexes of rare earths with eriochrome cyanine R(ECR)-2, 2-dipyridine (dipy) and CTAB, recommending a simple, selective spectrophotometric method for praseodymium in the presence of lanthanum, and for neodymium and samarium in their presence of each other.展开更多
This paper puts forward a biochemical analysis of the anthocyanins in the petals of Helichrysum bracteatum flower which takes a deep purple color. A pure antho-cyanin chloride crystal is obtained and identified as a c...This paper puts forward a biochemical analysis of the anthocyanins in the petals of Helichrysum bracteatum flower which takes a deep purple color. A pure antho-cyanin chloride crystal is obtained and identified as a cyanin glucoside by IR, UV and MS techniques. This paper also presents a study on the preservation mechanism of the flower color and flower shape according to the histochemical and anatomical characteristics of the petals.展开更多
The trans-cis photoisomerization of pentamethine cyanine dye （Cy5） has been theoretically investigated by the analysis on an analogical molecule model. All possible isomers have been searched by rotating the differe...The trans-cis photoisomerization of pentamethine cyanine dye （Cy5） has been theoretically investigated by the analysis on an analogical molecule model. All possible isomers have been searched by rotating the different bridge C-C bonds of the model. The relative stability of the isomers for the ground and first excited states as well as the corresponding excitation mechanism has been envisaged by DFT and time-dependent DFT method. The results show different conjugation degree of the isomers resulting in different absorption energy upon the different C-C bridge bond rotation. From the analyses of electronic density distribution of the frontier orbitals, it is predicted that there is charge transfer besides the π-π^＊ excitation for the cyanine dye model, which makes the mechanism and photo-properties different form those of other conjugated molecules.展开更多
The geometric and electronic structures at the interface between iron phthalocyanine(FePc)and Si(110)surface are studied by ultraviolet photoelectron spectroscopy and density functional theory(DFT)calculation.After Fe...The geometric and electronic structures at the interface between iron phthalocyanine(FePc)and Si(110)surface are studied by ultraviolet photoelectron spectroscopy and density functional theory(DFT)calculation.After FePc is deposited on Si(110),the emission features are located at 2.56,4.90,7.90,10.88 eV below the Fermi level for monolayer and 2.73,4.90,7.74,10.52 eV below the Fermi level for multilayer.At the coverage of 1 ML,FePc molecules are adsorbed on the bridge site in a flat-lying geometry with a 2.17?separation between the molecule and the substrate.The molecular plane is bent due to the interaction between the adsorbate and the substrate.展开更多
Multilayers consisting of bilayer alternation of hemicyanine dye and cadmium stearate have been prepared by the Langmuir-Blodgett technique.x-ray diffraction and optical absorption spectra are used to characterixe thl...Multilayers consisting of bilayer alternation of hemicyanine dye and cadmium stearate have been prepared by the Langmuir-Blodgett technique.x-ray diffraction and optical absorption spectra are used to characterixe thleir periodic structures and optical properties.The results show that a well ordered superlattice is produced and the hemicyanine dye is in non-aggregated formation in the alternating multilayers.展开更多
The indocyanine green(ICG)clearance test is an objective measurement of functional liver reserve(FLR)[1].The liver can preserve normal functions with a 70%−80%functional liver volume resection[2]and the remnant is cap...The indocyanine green(ICG)clearance test is an objective measurement of functional liver reserve(FLR)[1].The liver can preserve normal functions with a 70%−80%functional liver volume resection[2]and the remnant is capable of regeneration.However,liver regenerative properties are affected by hepatitis,fatty liver,cirrhosis and damage caused by chemotherapy[3].ICG combined with the Child-Pugh score are main criteria for evaluating FLR.A safe hepatectomy procedure requires the remnant liver to be 25%−30%of the normal volume.For patients with an indocyanine green retention rate at 15 min(ICG-R15)>20%,segment liver resection,limited hepatectomy or tumor enucleation is recommended,but there has been no clear clarification of the essential remnant liver volume[4].In China,the experts’consensus of preoperative evaluation of liver reserve function incorporates ICGR15 tests.展开更多
Three methods for synthesis of benzotellurazole crown ether(6)are described.The cyanine dye(8)can be easily obtained by treating(6) with CH_3I and CH(OEt)_3.
Surface enhanced resonance Raman scattering(SERRS)is a physical phenomenon that occurs when the energy of incident light is dose to that of electronic excitation of reporter molecules(RMs)attached on substrates.SERRS ...Surface enhanced resonance Raman scattering(SERRS)is a physical phenomenon that occurs when the energy of incident light is dose to that of electronic excitation of reporter molecules(RMs)attached on substrates.SERRS has showed great promise in healthcare applications such as tumor diagnosis,image guided tumor surgery and real-time evaluation of therapeutic response due to its ultra-sensitivity,manipulating convenience and easy acessibility.As the most widely used organic near-infrared(NIR)fuorophore,heptamethine cyanines possess the electronic ex-citation energy that is close to the plasmon absorption energy of the gold nano scafolds,which results in the extraordinary enhancement of the SERRS signal.However,the effect of hepta-methine cyanine structure and the gold nanoparticle morphology to the SERRS intensity are barely investigated.This work developed a series of SERRS nanoprobes in which two hepta-methine cyanine derivatives(IR783 and IR780)were used as the RM and three gold nanoparticles(nanorod,nanosphere and nanostar)were used as the substrates.Interestingly,even though IR780 and IR783 possess very similar chemical structure,SERRS signal produced by IR780 was determined as 14 times higher than that of IR783 when the RM concentration was6.5 × 10^(-6) M.In contrast,less than 4.0 fold SERRS signal intensity increase was measured by changing the substrate morphologies.Above experimental results indicate that finely tuning the chemical structure of the heptamethine cyanine could be a feasible way to develop robust SERRS probes to visualize tumor or guide tumor resection with high sensitivity and target to background ratio.展开更多
文摘Novel heptamethine 3H-indocyanine dyes are synthesized and embedded into a matrix of silica gel derived from tetraethoxysilicane. The photophysical properties of these near infrared dyes in various solvents and in SiO2 sol gel were investigated. The results show that the dyes containing cyclohexenylene bridge and N-(p-carboxy)benzyl groups have better photostability and longer absorption wavelength than those containing linear heptamethine bridge and/or N-(5- carboxy)pentanyl groups. The absorption maxima of these dyes are in reverse proportion to the polarity of the solvents. The microenvironment of the dyes in SiO2 sol-gel characters medium polarity (between methanol and DMF) according to the absorption maxima.
文摘Two Crown ether benzotellurastyryl cyanines and three crown ether benzotelluramerocyanines are synthesized via the key intermediate 3 methyl 5,6(15 crown 5) 2(β acetanilide)vinyl benzotellurazolium iodide.The reactive conditions are discussed.The influence of alkali( earth)metal ions on the visible absorption spectra of these two types of crown ether cyanines are also studied.
基金supported by the National Key R&D Program of China(No.2022YFA1207400)National Natural Science Foundation of China(No.22274061)+1 种基金the 111 Project(No.B17019)Fundamental Research Funds for the Central Universities(No.CCNU22QN007).
文摘Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference.Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years.The NIR fluorescent labeling technique involving cyanine has attracted widespread attention.This review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,etc.We expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.
文摘In the past decades,porphyrins,phthalocyanines and related materials have attracted significant attention due to their diverse and brilliant structures[1,2],as well as their unique electronic structures and photophysical properties which could be applicable in a wide range of areas[3–5].
文摘Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the dye ion J-stacks in 'stoichiometric' relation. Concerning the fact that polyeletrolytes could promote the formation of J-aggregate of cyanine dye ions, the authors suggested that the J-aggregates of an ionic cyanine might more easily induce the J-aggregation of other cyanine ions with opposite charges. The two
基金Project(KSCX2-YW-N-043)supported by the Knowledge Innovation Program of the Chinese Academy of Sciences,China
文摘Lonicera caerulea L.fruit is an excellent source of bioactive compounds.An efficient separation method of cyanins is important for the development of many value-added products and functional food ingredients.High-speed counter-current chromatography(HSCCC) was applied to isolate cyanins from Lonicera caerulea fruits with a biphasic solvent system composed of methyl tert-butyl ether/n-butanol/acetonitrile/water/trifluoroacetic acid(2:2:1:5:0.01,volume ratio).1.41 mg of cyanidin 3,5-O-diglucoside,1.08 mg of cyanidin 3-O-rutinoside and 6.38 mg of cyanidin 3-O-glucoside were obtained from 40 mg of crude extract.The purities of these compounds were 95.8%,92.4% and 97.6%,respectively,as identified by high-performance liquid chromatography–diode array detection(HPLC-DAD) and high-performance liquid chromatography-electrospray ionization mass spectrometryn(HPLC-ESI/MSn).In addition,the dominant anthocyanin,cyanidin 3-O-glucoside was demonstrated cytotoxic response of human hepatocarcinoma SMMC-7721 cells,inducing live cancer cell apoptotic by flow cytometric analysis.
文摘A low cost cyanine dye, 1,1-dimethyl-3-ethyl-2-[3-(1,3-dihydro-3,3-dimethyl-1-ethyl- 5-carboxyl-2H-indol-2-ylidene)-1-propenyl]-1H-benz[e] indolium iodide (1) was synthesized and applied to sensitize mesoporous TiO2 electrode. Photoresponse of the electrode was extended to the visible and remarkably high incident photon-to-current conversion efficiency (IPCE) over 70% was achieved from 500 nm to 600 nm.
文摘A squarylium dye is dissolved in 4-cyano-4＇-pentylbiphenyl （SCB） and oriented by sandwiching mixtures between two pieces of rubbed glass plates. The optical absorption spectra of the oriented squarylium dye-5CB layers exhibit high anisotropy. The third-order nonlinear optical responses and susceptibilities X^（3）e of squarylium dye in 5CB are measured with light polarizations parallel and perpendicular to the orientational direction by the resonant femtosecond degenerate four-wave mixing （DFWM） technique. Temporal profiles of the DFWM signal of the oriented squarylium dye-5CB layers with light polarizations parallel and perpendicular to the orientational direction are measured with a time resolution of 0.3ps （FWHM）, and are found to consist of two components, i.e., the coherent instantaneous nonlinear response and slow response due to the formation of excited molecules. A high anisotropic ratio of x^（3）e, 10.8 ：k 1.2, is observed for the oriented layers.
基金Supported by the National Basic Research Program of China(2012CB933001)the National Natural Science Foundation of China(21173058,21203038).
文摘Individual titanyl phthalocyanine(TiOPc)molecules on ultrathin sodium chloride striped films grown on Cu(110)exhibit two different topographies with 8-lobes and 6-lobes when imaged by scanning tunneling microscopy(STM).Direct images of the molecular orbitals of the molecules with 8-lobes are obtained,indicating that the electronic structure of the TiOPc molecule are decoupled from the metallic substrate.For the TiOPc molecule with 6-lobes,the STM images at negative and positive bias polarities show the same structures as 2-fold symmetry except for the 90°rotation with respect to each other.This phenomenon may be attributed to the splitting of the two former degenerate lowest unoccupied molecular orbitals due to the negative charging of the molecule.The identification of the molecular orbital splitting on the ultrathin insulating layer could deepen the understanding of the intrinsic properties of semi-conducting molecules.
文摘The colour reactions of quaternary complexes of rare earths with eriochrome cyanine R, 1, 10-phenanthroline and cetyltrimethyl ammonium bromide (CTAB) have been reported by the present author.In this paper we are reporting results of studies on the colour reactions of the quaternary complexes of rare earths with eriochrome cyanine R(ECR)-2, 2-dipyridine (dipy) and CTAB, recommending a simple, selective spectrophotometric method for praseodymium in the presence of lanthanum, and for neodymium and samarium in their presence of each other.
文摘This paper puts forward a biochemical analysis of the anthocyanins in the petals of Helichrysum bracteatum flower which takes a deep purple color. A pure antho-cyanin chloride crystal is obtained and identified as a cyanin glucoside by IR, UV and MS techniques. This paper also presents a study on the preservation mechanism of the flower color and flower shape according to the histochemical and anatomical characteristics of the petals.
基金supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2008-890)The Key Project of Educational Committee of Anhui Province (KJ2010A143)+1 种基金Special Project (xzx200812)Doctor’s Project Grant of Anhui Normal University
文摘The trans-cis photoisomerization of pentamethine cyanine dye （Cy5） has been theoretically investigated by the analysis on an analogical molecule model. All possible isomers have been searched by rotating the different bridge C-C bonds of the model. The relative stability of the isomers for the ground and first excited states as well as the corresponding excitation mechanism has been envisaged by DFT and time-dependent DFT method. The results show different conjugation degree of the isomers resulting in different absorption energy upon the different C-C bridge bond rotation. From the analyses of electronic density distribution of the frontier orbitals, it is predicted that there is charge transfer besides the π-π^＊ excitation for the cyanine dye model, which makes the mechanism and photo-properties different form those of other conjugated molecules.
基金by the National Natural Science Foundation of China under Grant No 10974172the Fundamental Research Funds for the Central Universities。
文摘The geometric and electronic structures at the interface between iron phthalocyanine(FePc)and Si(110)surface are studied by ultraviolet photoelectron spectroscopy and density functional theory(DFT)calculation.After FePc is deposited on Si(110),the emission features are located at 2.56,4.90,7.90,10.88 eV below the Fermi level for monolayer and 2.73,4.90,7.74,10.52 eV below the Fermi level for multilayer.At the coverage of 1 ML,FePc molecules are adsorbed on the bridge site in a flat-lying geometry with a 2.17?separation between the molecule and the substrate.The molecular plane is bent due to the interaction between the adsorbate and the substrate.
基金Supported by the National Natural Science Foundation of China。
文摘Multilayers consisting of bilayer alternation of hemicyanine dye and cadmium stearate have been prepared by the Langmuir-Blodgett technique.x-ray diffraction and optical absorption spectra are used to characterixe thleir periodic structures and optical properties.The results show that a well ordered superlattice is produced and the hemicyanine dye is in non-aggregated formation in the alternating multilayers.
基金This study was supported by a grant from the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201712).
文摘The indocyanine green(ICG)clearance test is an objective measurement of functional liver reserve(FLR)[1].The liver can preserve normal functions with a 70%−80%functional liver volume resection[2]and the remnant is capable of regeneration.However,liver regenerative properties are affected by hepatitis,fatty liver,cirrhosis and damage caused by chemotherapy[3].ICG combined with the Child-Pugh score are main criteria for evaluating FLR.A safe hepatectomy procedure requires the remnant liver to be 25%−30%of the normal volume.For patients with an indocyanine green retention rate at 15 min(ICG-R15)>20%,segment liver resection,limited hepatectomy or tumor enucleation is recommended,but there has been no clear clarification of the essential remnant liver volume[4].In China,the experts’consensus of preoperative evaluation of liver reserve function incorporates ICGR15 tests.
文摘Three methods for synthesis of benzotellurazole crown ether(6)are described.The cyanine dye(8)can be easily obtained by treating(6) with CH_3I and CH(OEt)_3.
基金supported by the National Basic Research Program of China(973 Program,2013CB932500)the National Natural Science Foundation of China(Nos 81371624,81571741)+1 种基金the Nanotechnology Program of Shanghai Science and Technology Committee(13NM1400400,15140901300)The innovation and entrepreneurship training program for college students in Huazhong University of Science&Technology(14A215).Yunfei Zhang and Danqi Li contributed equivalently to this work.
文摘Surface enhanced resonance Raman scattering(SERRS)is a physical phenomenon that occurs when the energy of incident light is dose to that of electronic excitation of reporter molecules(RMs)attached on substrates.SERRS has showed great promise in healthcare applications such as tumor diagnosis,image guided tumor surgery and real-time evaluation of therapeutic response due to its ultra-sensitivity,manipulating convenience and easy acessibility.As the most widely used organic near-infrared(NIR)fuorophore,heptamethine cyanines possess the electronic ex-citation energy that is close to the plasmon absorption energy of the gold nano scafolds,which results in the extraordinary enhancement of the SERRS signal.However,the effect of hepta-methine cyanine structure and the gold nanoparticle morphology to the SERRS intensity are barely investigated.This work developed a series of SERRS nanoprobes in which two hepta-methine cyanine derivatives(IR783 and IR780)were used as the RM and three gold nanoparticles(nanorod,nanosphere and nanostar)were used as the substrates.Interestingly,even though IR780 and IR783 possess very similar chemical structure,SERRS signal produced by IR780 was determined as 14 times higher than that of IR783 when the RM concentration was6.5 × 10^(-6) M.In contrast,less than 4.0 fold SERRS signal intensity increase was measured by changing the substrate morphologies.Above experimental results indicate that finely tuning the chemical structure of the heptamethine cyanine could be a feasible way to develop robust SERRS probes to visualize tumor or guide tumor resection with high sensitivity and target to background ratio.
