Nowadays,there is considerable research interest in proposing modern permanent magnet(PM)electric machine structures for applications such as electric vehicles.Several radial and axial topologies with different arrang...Nowadays,there is considerable research interest in proposing modern permanent magnet(PM)electric machine structures for applications such as electric vehicles.Several radial and axial topologies with different arrangements of PM in the stator and rotor have been introduced for PM Vernier motors(PMVM)with the aim of increasing the performance characteristics such as power factor,efficiency,rotational torque torque density and wider constant torque-speed region.Meanwhile,the spoke PM arrangement has provided higher torque density than the surface and V-shaped arrangement.But in contrast,the V-shaped arrangement has a more sinusoidal flux and less cogging torque.In this paper,a 620 W,12-slot 16-pole Vernier PM motor with a fractional slot arrangement.Consequent K-shaped pole is introduced,which has the advantages of spoke and V-shaped magnetic arrangements.After presenting and confirming the concept of the proposed structure based on functional comparison with conventional structures,an analytical modeling based on the harmonic analysis method is introduced to accurately predict the performance of the machine,and finally the proposed structure is prototyped and the experimental results are simulated and modeling are compared.展开更多
Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique fea...Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique features,stator active HEFSMs are preferred for EV/HEV applications.In this paper a new Segmented PM Consequent Pole HE-FSM(SPMCPHEFSM)with flux bridge is proposed for EV/HEV.The developed SPMCPHEFSM exhibits improved flux modulation and flux regulation capability at reduced PM usage(suppressed PM volume by 46.52%and PM cost by 46.48%)and eliminating stator leakage flux.First,SPMCPHEFSM is geometric optimized(GO)for investigating influence of leading design with key performance indicators such as flux linkage(Ф_(pp)),average torque(T_(avg)),cogging torque(T_(cog)),T_(den),average power(P_(avg))and power density(P_(den))and then proceeded optimized model to structure modification for optimal stator design and position of field excitation coils(FEC).Comprehensive performance analysis reveals that the developed SPMCPHEFSM show improvedФ_(pp)maximum up to 9.11%,improved T_(avg)maximum up to 23.63%,truncate T_(cog)up to 18.9%whereas T_(den)and P_(den)are boost up to 23.55%and 89.72%respectively.展开更多
Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless...Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation.展开更多
Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power densi...Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power density(Pden)are the utmost requisite.However conventional PM-FSMs utilizes excessive rare earth PM volume VPM,higher cogging torque Tcog,high torque ripples(Trip)and comparatively lower(Tden)and Pden due to flux leakage.To overcome the aforesaid demerits,a new high(Tden)Segmented PM Consequent Pole(CP)FSM(SPMCPFSM)with flux bridge and barrier is proposed which successfully reduces VPM by 46.52%and PM cost by 46.48%.Moreover,Multi-Objective Optimization(MOO)examines electromagnetic performance due to variation in geometric parameters for global optimum parameters with key metric such as flux linkage(Φpp),flux harmonics(ΦTHD)average torque(Tavg),Tcog,Trip,Tden,average power(Pavg)and Pden.Analysis reveals that MOO improveΦpp by 22.68%,boost Tavg by 11.41%,enhanced Pavg by 4.55%and increased Tden and Pden by 11.41%.Detailed electromagnetic performance comparison with existing state of the art shows that proposed SPMCPFSM offer Tavg maximum up to 88.8%,truncate Trip up to 24.8%,suppress Tcog up to 22.74%,and results 2.45 times Tden and Pden.展开更多
Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet ...Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet linear machine(CP-TFPMLM)is proposed and investigated.The origination of the proposed machine is from an existing transverse-flux flux-reversal linear machine(TF-FRLM),by partially replacing permanent magnet poles with soft magnetic iron for further reducing the cost of magnets.The fundamental structure and operating principle are introduced at first.The electromagnetic performance,including back EMF,detent force,and thrust force,are investigated with the finite element method.The proposed machine can achieve similar performance as compared to the TF-FRLM but with half of the magnets are used.展开更多
The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depr...The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of"hard-linkage"faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of"hard-linkage",while the antithetic fault traps are formed at the beginning of the fault active period.展开更多
Silica-coated carbonyl iron particles （CIPs） are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and mic...Silica-coated carbonyl iron particles （CIPs） are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and microwave absorption of raw-CIPs and silica-coated CIPs are investigated using a scanning electron microscope, an energy dispersive spectrometer, a thermal-gravimetric analyzer, and a network analyzer. The results show that the heat-resistance of silica-coated CIPs is better than that of raw CIFs. The reflection losses exceeding -lOdB of silica-coated CIPs are obtained in the frequency range 9.5-12.4 GHz for the absorber thickness of 2.3 mm, and the same reflection losses of uncoated CIPs reach the data in the lower frequency range for the same thickness. The enhanced microwave absorption of silica-coated CIPs can be ascribed to the combination of proper electromagnetic impedance match and the decrease of dielectric permittivity.展开更多
Let d and n are positive integers, n≥2,1≤d≤ 2.In this paper we obtain that the set of the 2 - common consequent of primitive digraphs of order n with exact d vertices having loop is{1,2,…, n-[]}.
Let V = {a1,a2 ,...,an} be a finite set with n ≥ 2 and Pn（V） the set of all primitive binary relations on V. For Q E Pn（V）, denote by G（Q） the directed graph corresponding to Q. For positive integer d ≤ n, let...Let V = {a1,a2 ,...,an} be a finite set with n ≥ 2 and Pn（V） the set of all primitive binary relations on V. For Q E Pn（V）, denote by G（Q） the directed graph corresponding to Q. For positive integer d ≤ n, let Pn（V, d） = {Q ： Q ∈ Pn（V） and G（Q） contains exactly d loops}. In this paper, it is proved that the set of common consequent indices of binary relations in Pn （V, d） is {1, 2,..., n -[d/2] }. Furthermore, the minimal extremal binary relations are described.展开更多
Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses...Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses excessive rare earth PM volumes which ultimately increases machine the machine weight and PM cost.Moreover,the PMs extended at the stator yoke results in stator leakage flux which degrades the performance.To suppress the leakage flux and diminish the PM volume,the consequent pole PMFSM(CPPMFSM)with flux bridges and barriers encompassing partitioned circumferential and radial magnetized PMs is proposed,thereby ensuring an alternate magnetic path for the working harmonics which improves the modulation effect and flux distribution.Moreover,the influence of the rotor pole number on seven different rotor structures namely,curved rotor,trapezoidal rotor,wide rotor tooth tip,wide rotor base width,rectangular segmented and eccentric rotors are investigated based on the electromagnetic performance and stress distribution.Finite element analysis(FEA)reveals that the 12S-13P CPPMFSM with a wider rotor base offers comparatively better electromagnetic performance.Compare to the conventional PMFSM,the proposed CPPMFSM reduces the PM volume which minimizes the overall machine cost and weight,suppresses the torque ripples by 16.49%,diminishes total harmonic distortion(THD)by 35.24%and decreases cogging torque by 32.88%.Furthermore,the torque and power density are enhanced by 7.028%and 7.025%respectively.展开更多
Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(...Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).展开更多
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).展开更多
To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary cancers.IRE has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues...To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary cancers.IRE has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues[2].For lesions in complex areas,bile duct[3],and large blood vessels[4],IRE has been developed as an alternative to thermal ablation such as radiofrequency and microwave.The IRE tumor ablative technique combines cell biology and pulsed high-voltage engineering.Repeated high-voltage,high-frequency and transient pulses can create irreversible electroporation in the phospholipid bilayer of the cell membrane and nuclear envelope,resulting in cell apoptosis.Compared with radiofrequency ablation and microwave ablation[5],IRE does not cause damage to important vessels and ducts.IRE has some unique shortcomings in delivering high currents,which has limited its clinical applications in the past.In animal and clinical studies,side effects including muscle contraction,procedural hypertension,and arrhythmia are frequently reported[6].However,during the ablation process,if the pulse is synchronized with the heart rhythm,the risk of arrhythmia is reduced.Sufficient muscle relaxant eliminates muscle contraction.Still,arrhythmia[7],hypertension[8],and myocardial infarction[9]are potential risks requiring proper precautions.These adverse events are mostly moderate and self-limiting,but they may have serious consequences for patients with coronary artery disease.Due to the potential risks,patients with a history of cardiovascular disease are not recommended for IRE treatment.展开更多
Compact stator structure of flux switching machines(FSMs)encompassing both permanent magnets(PMs)and armature winding slots(AWS)attract research interest whenever high power and density are the basic requirements.Howe...Compact stator structure of flux switching machines(FSMs)encompassing both permanent magnets(PMs)and armature winding slots(AWS)attract research interest whenever high power and density are the basic requirements.However,it also results in temperature rises owing to heat generation by electromagnetic power losses degrading the electromagnetic performance and affecting machine performance.In this study,a segmented permanent magnet(SPM)consequent pole FSM(SPM-CPFSM)is developed,which provides a stator cooling channel(duct)for improved heat dissipation to avoid demagnetization of PM as well as overheating.Furthermore,this study investigates detailed electromagnetic performance analysis and prediction of temperature variation in various machine parts owing to the heat generated by iron,copper,and magnet eddy current losses utilizing coupled electromagnetic-thermal analysis accounting for magnetic flux density variation.In comparison with the 2D analysis,the developed 3D coupled-field analysis more accurately predicts electromagnetic performance and temperature distribution.Analysis reveals that a cooling duct at the stator significantly assists in stator heat dissipation in the axial direction ensuring a safe operating condition of the PMs as well as machine parts to avoid overheating.展开更多
We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism
Substance use disorders(SUDs)impact an estimated 300 million people worldwide,significantly impairing both health and social functioning.These disorders are marked by an inability to regulate substance use,despite the...Substance use disorders(SUDs)impact an estimated 300 million people worldwide,significantly impairing both health and social functioning.These disorders are marked by an inability to regulate substance use,despite the harmful consequences.Addiction affects various neurotransmitter systems,including dopamine,serotonin,γ-aminobutyric acid(GABA),and glutamate,each of which plays a role in the reward,stress,and self-control pathways of the brain(Koob&Volkow,2016).While significant advances have been made in neuroscience,our understanding of how these neurotransmitter systems interact and contribute to addiction is still evolving.This knowledge gap represents a significant challenge in the formulation of effective treatments for SUDs.At present,the US Food and Drug Administration(FDA)has approved pharmacological treatments for alcohol,nicotine,and opioid use disorders(Vasiliu,2022);however,no such treatments have been authorized for SUDs in general,or specifically for stimulant use disorders,such as cocaine and methamphetamine addiction.Notably,the FDA has not approved any new drugs for SUD treatment in the past 40 years.展开更多
The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are...The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are revolutionizing mining through robotic and data-driven innovations[4]-[7].While AI offers mining industry advantages,it is crucial to acknowledge the potential risks associated with its widespread use.Over-reliance on AI may lead to a loss of human control over mining operations in the future,resulting in unpredictable consequences.展开更多
Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor...Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural instability.It usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic dysfunction.The gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.2.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).展开更多
The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as obse...The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and death.Ischemic stroke is thus a vascular disorder with a dramatic neurological impact.There is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical success.Since accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be indispensable.Encouragingly,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.展开更多
The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and rev...The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and reviews written by faculty members,researchers and postgraduates in universities,colleges and research institutes all over China and overseas.It reports the latest and the most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across sub-disciplines.This journal is sponsored by Jilin University and mandated by the Ministry of Education of P.R.China.展开更多
文摘Nowadays,there is considerable research interest in proposing modern permanent magnet(PM)electric machine structures for applications such as electric vehicles.Several radial and axial topologies with different arrangements of PM in the stator and rotor have been introduced for PM Vernier motors(PMVM)with the aim of increasing the performance characteristics such as power factor,efficiency,rotational torque torque density and wider constant torque-speed region.Meanwhile,the spoke PM arrangement has provided higher torque density than the surface and V-shaped arrangement.But in contrast,the V-shaped arrangement has a more sinusoidal flux and less cogging torque.In this paper,a 620 W,12-slot 16-pole Vernier PM motor with a fractional slot arrangement.Consequent K-shaped pole is introduced,which has the advantages of spoke and V-shaped magnetic arrangements.After presenting and confirming the concept of the proposed structure based on functional comparison with conventional structures,an analytical modeling based on the harmonic analysis method is introduced to accurately predict the performance of the machine,and finally the proposed structure is prototyped and the experimental results are simulated and modeling are compared.
文摘Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique features,stator active HEFSMs are preferred for EV/HEV applications.In this paper a new Segmented PM Consequent Pole HE-FSM(SPMCPHEFSM)with flux bridge is proposed for EV/HEV.The developed SPMCPHEFSM exhibits improved flux modulation and flux regulation capability at reduced PM usage(suppressed PM volume by 46.52%and PM cost by 46.48%)and eliminating stator leakage flux.First,SPMCPHEFSM is geometric optimized(GO)for investigating influence of leading design with key performance indicators such as flux linkage(Ф_(pp)),average torque(T_(avg)),cogging torque(T_(cog)),T_(den),average power(P_(avg))and power density(P_(den))and then proceeded optimized model to structure modification for optimal stator design and position of field excitation coils(FEC).Comprehensive performance analysis reveals that the developed SPMCPHEFSM show improvedФ_(pp)maximum up to 9.11%,improved T_(avg)maximum up to 23.63%,truncate T_(cog)up to 18.9%whereas T_(den)and P_(den)are boost up to 23.55%and 89.72%respectively.
文摘Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation.
文摘Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power density(Pden)are the utmost requisite.However conventional PM-FSMs utilizes excessive rare earth PM volume VPM,higher cogging torque Tcog,high torque ripples(Trip)and comparatively lower(Tden)and Pden due to flux leakage.To overcome the aforesaid demerits,a new high(Tden)Segmented PM Consequent Pole(CP)FSM(SPMCPFSM)with flux bridge and barrier is proposed which successfully reduces VPM by 46.52%and PM cost by 46.48%.Moreover,Multi-Objective Optimization(MOO)examines electromagnetic performance due to variation in geometric parameters for global optimum parameters with key metric such as flux linkage(Φpp),flux harmonics(ΦTHD)average torque(Tavg),Tcog,Trip,Tden,average power(Pavg)and Pden.Analysis reveals that MOO improveΦpp by 22.68%,boost Tavg by 11.41%,enhanced Pavg by 4.55%and increased Tden and Pden by 11.41%.Detailed electromagnetic performance comparison with existing state of the art shows that proposed SPMCPFSM offer Tavg maximum up to 88.8%,truncate Trip up to 24.8%,suppress Tcog up to 22.74%,and results 2.45 times Tden and Pden.
基金This work was supported by the National Natural Science Foundation of China under Grant 51520105010。
文摘Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet linear machine(CP-TFPMLM)is proposed and investigated.The origination of the proposed machine is from an existing transverse-flux flux-reversal linear machine(TF-FRLM),by partially replacing permanent magnet poles with soft magnetic iron for further reducing the cost of magnets.The fundamental structure and operating principle are introduced at first.The electromagnetic performance,including back EMF,detent force,and thrust force,are investigated with the finite element method.The proposed machine can achieve similar performance as compared to the TF-FRLM but with half of the magnets are used.
基金Supported by the National Natural Science Foundation of China(41602129,41602164)China National Science and Technology Major Project(2016ZX05007003,2016ZX05006-005)
文摘The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of"hard-linkage"faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of"hard-linkage",while the antithetic fault traps are formed at the beginning of the fault active period.
文摘Silica-coated carbonyl iron particles （CIPs） are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and microwave absorption of raw-CIPs and silica-coated CIPs are investigated using a scanning electron microscope, an energy dispersive spectrometer, a thermal-gravimetric analyzer, and a network analyzer. The results show that the heat-resistance of silica-coated CIPs is better than that of raw CIFs. The reflection losses exceeding -lOdB of silica-coated CIPs are obtained in the frequency range 9.5-12.4 GHz for the absorber thickness of 2.3 mm, and the same reflection losses of uncoated CIPs reach the data in the lower frequency range for the same thickness. The enhanced microwave absorption of silica-coated CIPs can be ascribed to the combination of proper electromagnetic impedance match and the decrease of dielectric permittivity.
文摘Let d and n are positive integers, n≥2,1≤d≤ 2.In this paper we obtain that the set of the 2 - common consequent of primitive digraphs of order n with exact d vertices having loop is{1,2,…, n-[]}.
基金Foundation item： the Natural Science Foundation of Jiangsu Province （No. BK2007030） the Natural Science Foundation of Education Committee of Jiangsu Province （No. 07KJD110207）.
文摘Let V = {a1,a2 ,...,an} be a finite set with n ≥ 2 and Pn（V） the set of all primitive binary relations on V. For Q E Pn（V）, denote by G（Q） the directed graph corresponding to Q. For positive integer d ≤ n, let Pn（V, d） = {Q ： Q ∈ Pn（V） and G（Q） contains exactly d loops}. In this paper, it is proved that the set of common consequent indices of binary relations in Pn （V, d） is {1, 2,..., n -[d/2] }. Furthermore, the minimal extremal binary relations are described.
文摘Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses excessive rare earth PM volumes which ultimately increases machine the machine weight and PM cost.Moreover,the PMs extended at the stator yoke results in stator leakage flux which degrades the performance.To suppress the leakage flux and diminish the PM volume,the consequent pole PMFSM(CPPMFSM)with flux bridges and barriers encompassing partitioned circumferential and radial magnetized PMs is proposed,thereby ensuring an alternate magnetic path for the working harmonics which improves the modulation effect and flux distribution.Moreover,the influence of the rotor pole number on seven different rotor structures namely,curved rotor,trapezoidal rotor,wide rotor tooth tip,wide rotor base width,rectangular segmented and eccentric rotors are investigated based on the electromagnetic performance and stress distribution.Finite element analysis(FEA)reveals that the 12S-13P CPPMFSM with a wider rotor base offers comparatively better electromagnetic performance.Compare to the conventional PMFSM,the proposed CPPMFSM reduces the PM volume which minimizes the overall machine cost and weight,suppresses the torque ripples by 16.49%,diminishes total harmonic distortion(THD)by 35.24%and decreases cogging torque by 32.88%.Furthermore,the torque and power density are enhanced by 7.028%and 7.025%respectively.
基金funded by the FWO(1S34321N)the Fondation Charcot Stichting(to TV and RS)。
文摘Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).
文摘The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).
基金supported by grants from the National S&T Ma-jor Project of China (2018ZX10301201)National Natural Sci-ence Foundation of China (82027803)。
文摘To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary cancers.IRE has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues[2].For lesions in complex areas,bile duct[3],and large blood vessels[4],IRE has been developed as an alternative to thermal ablation such as radiofrequency and microwave.The IRE tumor ablative technique combines cell biology and pulsed high-voltage engineering.Repeated high-voltage,high-frequency and transient pulses can create irreversible electroporation in the phospholipid bilayer of the cell membrane and nuclear envelope,resulting in cell apoptosis.Compared with radiofrequency ablation and microwave ablation[5],IRE does not cause damage to important vessels and ducts.IRE has some unique shortcomings in delivering high currents,which has limited its clinical applications in the past.In animal and clinical studies,side effects including muscle contraction,procedural hypertension,and arrhythmia are frequently reported[6].However,during the ablation process,if the pulse is synchronized with the heart rhythm,the risk of arrhythmia is reduced.Sufficient muscle relaxant eliminates muscle contraction.Still,arrhythmia[7],hypertension[8],and myocardial infarction[9]are potential risks requiring proper precautions.These adverse events are mostly moderate and self-limiting,but they may have serious consequences for patients with coronary artery disease.Due to the potential risks,patients with a history of cardiovascular disease are not recommended for IRE treatment.
文摘Compact stator structure of flux switching machines(FSMs)encompassing both permanent magnets(PMs)and armature winding slots(AWS)attract research interest whenever high power and density are the basic requirements.However,it also results in temperature rises owing to heat generation by electromagnetic power losses degrading the electromagnetic performance and affecting machine performance.In this study,a segmented permanent magnet(SPM)consequent pole FSM(SPM-CPFSM)is developed,which provides a stator cooling channel(duct)for improved heat dissipation to avoid demagnetization of PM as well as overheating.Furthermore,this study investigates detailed electromagnetic performance analysis and prediction of temperature variation in various machine parts owing to the heat generated by iron,copper,and magnet eddy current losses utilizing coupled electromagnetic-thermal analysis accounting for magnetic flux density variation.In comparison with the 2D analysis,the developed 3D coupled-field analysis more accurately predicts electromagnetic performance and temperature distribution.Analysis reveals that a cooling duct at the stator significantly assists in stator heat dissipation in the axial direction ensuring a safe operating condition of the PMs as well as machine parts to avoid overheating.
文摘We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism
基金supported by the National Science Foundation of China(T2350008,T2341003,22207103)STI2030-Major Projects(2021ZD0203000(2021ZD0203003))。
文摘Substance use disorders(SUDs)impact an estimated 300 million people worldwide,significantly impairing both health and social functioning.These disorders are marked by an inability to regulate substance use,despite the harmful consequences.Addiction affects various neurotransmitter systems,including dopamine,serotonin,γ-aminobutyric acid(GABA),and glutamate,each of which plays a role in the reward,stress,and self-control pathways of the brain(Koob&Volkow,2016).While significant advances have been made in neuroscience,our understanding of how these neurotransmitter systems interact and contribute to addiction is still evolving.This knowledge gap represents a significant challenge in the formulation of effective treatments for SUDs.At present,the US Food and Drug Administration(FDA)has approved pharmacological treatments for alcohol,nicotine,and opioid use disorders(Vasiliu,2022);however,no such treatments have been authorized for SUDs in general,or specifically for stimulant use disorders,such as cocaine and methamphetamine addiction.Notably,the FDA has not approved any new drugs for SUD treatment in the past 40 years.
文摘The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are revolutionizing mining through robotic and data-driven innovations[4]-[7].While AI offers mining industry advantages,it is crucial to acknowledge the potential risks associated with its widespread use.Over-reliance on AI may lead to a loss of human control over mining operations in the future,resulting in unpredictable consequences.
基金supported by Department of Clinical and Movement Neurosciences,UCL Queen Square Institute of Neurology,London,United Kingdom,WC1N 3BGAligning Science Across Parkinson’s(ASAP)Collaborative Research Network,Chevy Chase,MD,United States(to AHVS)。
文摘Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural instability.It usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic dysfunction.The gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.2.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).
基金supported by Swiss National Science Foundation grant 31003A_150062(to OOO).
文摘The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and death.Ischemic stroke is thus a vascular disorder with a dramatic neurological impact.There is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical success.Since accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be indispensable.Encouragingly,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.
文摘The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and reviews written by faculty members,researchers and postgraduates in universities,colleges and research institutes all over China and overseas.It reports the latest and the most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across sub-disciplines.This journal is sponsored by Jilin University and mandated by the Ministry of Education of P.R.China.
