The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimen...The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimental results showed that the pure culture of G. umbellata was unable to form sclerotia, whereas sclerotia produced easily in flasks or on trunks when the companion fungus was inoculated together with strain of G. umbellata. The companion fungus is critical for sclerotium formation from hyphae of G. umbellata. Morphological differences were found in cultures of the two fungi. The companion fungus possesses thin-walled narrow hyphae, while G. umbellata is of wider hyphae which are either thick- or thin-walled.展开更多
We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>...We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.展开更多
Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric ...Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer.展开更多
Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study,...Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study, seven different plant species were selected as companion plants for testing their effects on cucumber productivity. The effects of different companion plants on changes in soil chemical properties such as electrical conductivity （EC） and contents of essential nutrients as well as the structure and abundance of the soil Pseudomonas community were evaluated. The results showed a higher cucumber yield in the wheat/cucumber companion system than that in the cucumber monocultured and other companion cropping systems. The lowest phosphorus （P） and potassium （K） contents in the soil were found in the cucumber monocultured system, and the highest NO3＋-N and NH4＊-N contents were observed in the rye/cucumber companion system. PCR-denaturing gradient gel electrophoresis （DGGE） and real-time PCR analysis showed that the trifolium/cucumber companion system increased the diversity of the soil Pseudomonas community, while the chrysanthemum/cucumber companion system increased its abundance. Interestingly, plant-soil feedback trials revealed that inoculating the soil of the wheat/cucumber companion system increased the growth of cucumber seedlings. In conclusion, the effects of different companion plants on cucumber productivity, soil chemical characteristics and the soil Pseudomonas community were different, and wheat was a more suitable companion plant for increasing cucumber productivity. In addition, the altered microbial community caused by companion cropping with wheat contributed to increased cucumber productivity.展开更多
Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, ...Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, the representation of the Moore-Penrose inverse of M=[0 A C B]is given under the condition of EBF - 0, where E - I - CCT and F - I -AfA. This result generalizes the representation of the Moore-Penrose inverse of the companion matrix M =[0 a In b]due to Pedro Patricio. As for applications, some examples are given to illustrate the obtained results.展开更多
The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and elemen...The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and element free Galerkin method(EFGM), and is a truly meshless method possessing wide prospects in engineering applications. The companion solution and all the other formulas required in the meshless local boundary integral equation for a thin plate were presented, in order to make this method apply to solve the thin plate problem.展开更多
A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qua...A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qualitative data collection and analysis method on a sample of 20 primiparous women. The women were recruited from the postnatal ward of Bwaila hospital and were interviewed regarding their experiences on the support they received from their birth companions during labour and delivery using an open ended interview guide. Data was manually analyzed using content analysis. Primiparous women described the support they received from their birth companions as useful and beneficial. Birth companions provided advice, physical, emotional and spiritual support to the women during their labour and delivery. In addition, the birth companions were viewed as guardians of the women during labour and delivery. Results however, show that some women were not properly assisted by their companions because both the mothers and companions lacked knowledge on birth companionship. The results further show that birth companions play important roles during the birth and delivery of primiparous women and thereby improving birth outcomes. Therefore, there is a need to train the companions regarding support to a woman during labour and delivery. Primiparous women also need to be trained during antenatal care education so that they properly understand the roles of a birth companion as opposed to those of the midwives.展开更多
SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪（前身为EME公司产品）内部结构主要有三大部分组成。电源部分：主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑...SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪（前身为EME公司产品）内部结构主要有三大部分组成。电源部分：主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑部分：主要采用INTEL公司的迅驰移动式Inter Pen IV CPU,低功耗工业计算机专用主板,展开更多
A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provi...A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provide great convenience to the computation and analysis of the solutions to this class of equations, and can perform important functions in many analysis and design problems in descriptor system theory. The results proposed here are parallel to and more general than our early work about the linear matrix equation AX-XF = BY .展开更多
Electromagnetic forces generated by the inter-action of component satellites can be used to release companion satellites. Optimal release trajectories for companion satellite system using inter-electromagnetic forces ...Electromagnetic forces generated by the inter-action of component satellites can be used to release companion satellites. Optimal release trajectories for companion satellite system using inter-electromagnetic forces were investigated. Firstly,nonlinear relative motion dynamic equations of a two-craft electromagnetic companion satellite system were derived in spatial polar coordinates. Then principles of electromagnetic satellite formation flying were introduced. Secondly,the characteristics of the electromagnetic companion satellites release were analyzed and optimal release trajectories of companion satellites using electromagnetic forces were obtained using Gauss pseudospectral method. Three performance criteria were chosen as minimum time,minimum acceleration of the separation distance and minimum control acceleration. Finally,three release examples including expansion along separation distance, rotation in orbital plane and stable formation reconfiguration were given to demonstrate the feasibility of this method. Results indicated that the release trajectories can converge to optimal solutions effectively and the concept of release companion satellites using electromagnetic forces is practicable.展开更多
This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma(canine and equine), mastocytoma(canine), mammary adenocar...This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma(canine and equine), mastocytoma(canine), mammary adenocarcinoma(canine) and fibrosarcoma(feline) were treated by using diverse strategies. Non-viral vectors were usually employed to transfer genes of cytokines, suicide enzymes and/or tumor associated antigens. In general terms, minor or no adverse collateral effects were related to these procedures, and treated patients frequently improved their conditions(better quality of life, delayed or suppressed recurrence or metastatic spread, increased survival). Some of these new methodologies have a promising future if applied as adjuvant treatments of standard approaches. The auspicious results, derived from immunogene therapy studies carried out in companion animals, warrant their imperative usage in veterinary clinical oncology. Besides, they provide a strong preclinical basis(safety assays and proofs of concept) for analogous human clinical trials.展开更多
The objective of this paper is to present the result of a research of images and messages addressed to pet owners, posted in news and advertising websites in Brazilian cyberspace in the period between 2005 and 2012. T...The objective of this paper is to present the result of a research of images and messages addressed to pet owners, posted in news and advertising websites in Brazilian cyberspace in the period between 2005 and 2012. There are a wide variety of pet products and services, similar to those available to the human being and note that pet care industry address the posts to pet owners and the messages intend to motivate the emotions and feelings for the animals, in a sentimental anthropomorphism process. The marketing messages are similar to those of products shaped to induce a person to buy luxury products. Market social interaction is driven by both the human-animal bond and the pet care market campaigns advertisement. In many situations, people interact with pet as a person or a member of the family, as a unique and special living being. The authors conclude that in families which people and animal interacts, new meanings emerge from this contact.展开更多
Paula Hagen-Peterson an American reader, asked us in a recent letter, ’’Pats are treated as family members in many countries. Can you tell me how dogs, cats, birds and horses are treated in China" Many readers ...Paula Hagen-Peterson an American reader, asked us in a recent letter, ’’Pats are treated as family members in many countries. Can you tell me how dogs, cats, birds and horses are treated in China" Many readers have asked us this very question and so to satisfy their curiosity, China Today has asked several Chinese pet owners to talk about their relationships with their pets. Nowadays, Chinese not only like to raise traditional pets such as cats and dogs, but they also enjoy raising lizards end snaker.展开更多
To develop efficient sensitizers for dye-sensitized solar cells(DSSCs),we recently reported doubly concerted companion(DCC)dye XW83 with a wrapped porphyrin sub-dye unit linked to an organic sub-dye unit through a fle...To develop efficient sensitizers for dye-sensitized solar cells(DSSCs),we recently reported doubly concerted companion(DCC)dye XW83 with a wrapped porphyrin sub-dye unit linked to an organic sub-dye unit through a flexible chain,which exhibits panchromatic absorption and excellent anti-aggregation ability.To further improve the absorption,we herein report XW87 and XW88 by inserting an ethynyl group into the organic sub-dye unit of XW83 near the donor and acceptor,respectively.For the corresponding organic dyes Z3 and Z4,the introduced ethynyl group improves their absorption,but induces aggravated charge recombination,leading to lowered power conversion efficiencies(PCEs).Similar to the organic dyes,the introduced ethynyl group improves the absorption of DCC dyes XW87 and XW88 as well.In addition,the ethynyl group near the acceptor of the organic sub-dye unit can be well protected by the long wrapping chains from the porphyrin unit.As a result,XW88 affords the highest JSC(21.84 mA/cm^(2)),V_(OC)(782 mV)and PCE(12.2%)among the DCC dyes.These results provide an effective method for developing efficient DSSC dyes by inserting an ethynyl group at a suitable position of a DCC dye.展开更多
Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to...Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients,is becoming more and more important.However,most current US Food and Drug Administration(FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo.Consequently,new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables.They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments.This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx.We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.展开更多
文摘The companion fungus ( Grifola sp.) related to sclerotial formation from hyphae of Grifola umbellata (Pers.) Pilat was isolated from the cavity associated with sclerotia of G. umbellata in natural condition. Experimental results showed that the pure culture of G. umbellata was unable to form sclerotia, whereas sclerotia produced easily in flasks or on trunks when the companion fungus was inoculated together with strain of G. umbellata. The companion fungus is critical for sclerotium formation from hyphae of G. umbellata. Morphological differences were found in cultures of the two fungi. The companion fungus possesses thin-walled narrow hyphae, while G. umbellata is of wider hyphae which are either thick- or thin-walled.
文摘We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.
文摘Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer.
基金supported by the earmarked fund for the China Agriculture Research System (CARS-25)the National Natural Science Foundation of China (31471917)
文摘Companion cropping can influence cucumber productivity by altering soil chemical characteristics and microbial communities. However, how these alterations affect the growth of cucumber is still unknown. In this study, seven different plant species were selected as companion plants for testing their effects on cucumber productivity. The effects of different companion plants on changes in soil chemical properties such as electrical conductivity （EC） and contents of essential nutrients as well as the structure and abundance of the soil Pseudomonas community were evaluated. The results showed a higher cucumber yield in the wheat/cucumber companion system than that in the cucumber monocultured and other companion cropping systems. The lowest phosphorus （P） and potassium （K） contents in the soil were found in the cucumber monocultured system, and the highest NO3＋-N and NH4＊-N contents were observed in the rye/cucumber companion system. PCR-denaturing gradient gel electrophoresis （DGGE） and real-time PCR analysis showed that the trifolium/cucumber companion system increased the diversity of the soil Pseudomonas community, while the chrysanthemum/cucumber companion system increased its abundance. Interestingly, plant-soil feedback trials revealed that inoculating the soil of the wheat/cucumber companion system increased the growth of cucumber seedlings. In conclusion, the effects of different companion plants on cucumber productivity, soil chemical characteristics and the soil Pseudomonas community were different, and wheat was a more suitable companion plant for increasing cucumber productivity. In addition, the altered microbial community caused by companion cropping with wheat contributed to increased cucumber productivity.
基金The National Natural Science Foundation of China(No.11371089)the Natural Science Foundation of Jiangsu Province(No.BK20141327)+1 种基金Specialized Research Fund for the Doctoral Program of Higher Education(No.20120092110020)the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.15KJB110021)
文摘Let R be an associative ring with unity 1. The existence of the Moore-Penrose inverses of block matrices overR is investigated and the sufficient ad necessary conditions for such existence are obtained. Furthermore, the representation of the Moore-Penrose inverse of M=[0 A C B]is given under the condition of EBF - 0, where E - I - CCT and F - I -AfA. This result generalizes the representation of the Moore-Penrose inverse of the companion matrix M =[0 a In b]due to Pedro Patricio. As for applications, some examples are given to illustrate the obtained results.
文摘The meshless local boundary integral equation method is a currently developed numerical method, which combines the advantageous features of Galerkin finite element method(GFEM), boundary element method(BEM) and element free Galerkin method(EFGM), and is a truly meshless method possessing wide prospects in engineering applications. The companion solution and all the other formulas required in the meshless local boundary integral equation for a thin plate were presented, in order to make this method apply to solve the thin plate problem.
文摘A study was conducted to describe the experiences of primiparous women with the support they received from their birth companions during labour and delivery in Malawi. The study design was descriptive and utilized qualitative data collection and analysis method on a sample of 20 primiparous women. The women were recruited from the postnatal ward of Bwaila hospital and were interviewed regarding their experiences on the support they received from their birth companions during labour and delivery using an open ended interview guide. Data was manually analyzed using content analysis. Primiparous women described the support they received from their birth companions as useful and beneficial. Birth companions provided advice, physical, emotional and spiritual support to the women during their labour and delivery. In addition, the birth companions were viewed as guardians of the women during labour and delivery. Results however, show that some women were not properly assisted by their companions because both the mothers and companions lacked knowledge on birth companionship. The results further show that birth companions play important roles during the birth and delivery of primiparous women and thereby improving birth outcomes. Therefore, there is a need to train the companions regarding support to a woman during labour and delivery. Primiparous women also need to be trained during antenatal care education so that they properly understand the roles of a birth companion as opposed to those of the midwives.
文摘SciM ed Ltd Companion III二通道八深度颈颅多普勒检测仪（前身为EME公司产品）内部结构主要有三大部分组成。电源部分：主机电源部分,采用单相AC 220V输入,提供DC12V和DC5V直流电源输出;二次供电部分,主要为数据采集板提供电源。电脑部分：主要采用INTEL公司的迅驰移动式Inter Pen IV CPU,低功耗工业计算机专用主板,
基金supported by the Major Program of National Nat-ural Science Foundation of China (No. 60710002) Program for Changjiang Scholars and Innovative Research Team in University
文摘A closed-form solution to the linear matrix equation AX-EXF = BY with X and Y unknown and matrix F being in a companion form is proposed, and two equivalent forms of this solution are also presented. The results provide great convenience to the computation and analysis of the solutions to this class of equations, and can perform important functions in many analysis and design problems in descriptor system theory. The results proposed here are parallel to and more general than our early work about the linear matrix equation AX-XF = BY .
基金Sponsored by the National Natural Science Foundation of China(Grant No.11102007)
文摘Electromagnetic forces generated by the inter-action of component satellites can be used to release companion satellites. Optimal release trajectories for companion satellite system using inter-electromagnetic forces were investigated. Firstly,nonlinear relative motion dynamic equations of a two-craft electromagnetic companion satellite system were derived in spatial polar coordinates. Then principles of electromagnetic satellite formation flying were introduced. Secondly,the characteristics of the electromagnetic companion satellites release were analyzed and optimal release trajectories of companion satellites using electromagnetic forces were obtained using Gauss pseudospectral method. Three performance criteria were chosen as minimum time,minimum acceleration of the separation distance and minimum control acceleration. Finally,three release examples including expansion along separation distance, rotation in orbital plane and stable formation reconfiguration were given to demonstrate the feasibility of this method. Results indicated that the release trajectories can converge to optimal solutions effectively and the concept of release companion satellites using electromagnetic forces is practicable.
文摘This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma(canine and equine), mastocytoma(canine), mammary adenocarcinoma(canine) and fibrosarcoma(feline) were treated by using diverse strategies. Non-viral vectors were usually employed to transfer genes of cytokines, suicide enzymes and/or tumor associated antigens. In general terms, minor or no adverse collateral effects were related to these procedures, and treated patients frequently improved their conditions(better quality of life, delayed or suppressed recurrence or metastatic spread, increased survival). Some of these new methodologies have a promising future if applied as adjuvant treatments of standard approaches. The auspicious results, derived from immunogene therapy studies carried out in companion animals, warrant their imperative usage in veterinary clinical oncology. Besides, they provide a strong preclinical basis(safety assays and proofs of concept) for analogous human clinical trials.
文摘The objective of this paper is to present the result of a research of images and messages addressed to pet owners, posted in news and advertising websites in Brazilian cyberspace in the period between 2005 and 2012. There are a wide variety of pet products and services, similar to those available to the human being and note that pet care industry address the posts to pet owners and the messages intend to motivate the emotions and feelings for the animals, in a sentimental anthropomorphism process. The marketing messages are similar to those of products shaped to induce a person to buy luxury products. Market social interaction is driven by both the human-animal bond and the pet care market campaigns advertisement. In many situations, people interact with pet as a person or a member of the family, as a unique and special living being. The authors conclude that in families which people and animal interacts, new meanings emerge from this contact.
文摘Paula Hagen-Peterson an American reader, asked us in a recent letter, ’’Pats are treated as family members in many countries. Can you tell me how dogs, cats, birds and horses are treated in China" Many readers have asked us this very question and so to satisfy their curiosity, China Today has asked several Chinese pet owners to talk about their relationships with their pets. Nowadays, Chinese not only like to raise traditional pets such as cats and dogs, but they also enjoy raising lizards end snaker.
基金financially supported by the National Natural Science Foundation of China(Nos.22131005,22201074,22075077 and 21971063)the Fundamental Research Funds for the Central Universities,Program of Shanghai Academic Research Leader(No.20XD1401400)+1 种基金Shanghai Rising-Star Program(No.23QA1402100)Natural Science Foundation of Shanghai(Nos.23ZR1415600,22ZR1416100).
文摘To develop efficient sensitizers for dye-sensitized solar cells(DSSCs),we recently reported doubly concerted companion(DCC)dye XW83 with a wrapped porphyrin sub-dye unit linked to an organic sub-dye unit through a flexible chain,which exhibits panchromatic absorption and excellent anti-aggregation ability.To further improve the absorption,we herein report XW87 and XW88 by inserting an ethynyl group into the organic sub-dye unit of XW83 near the donor and acceptor,respectively.For the corresponding organic dyes Z3 and Z4,the introduced ethynyl group improves their absorption,but induces aggravated charge recombination,leading to lowered power conversion efficiencies(PCEs).Similar to the organic dyes,the introduced ethynyl group improves the absorption of DCC dyes XW87 and XW88 as well.In addition,the ethynyl group near the acceptor of the organic sub-dye unit can be well protected by the long wrapping chains from the porphyrin unit.As a result,XW88 affords the highest JSC(21.84 mA/cm^(2)),V_(OC)(782 mV)and PCE(12.2%)among the DCC dyes.These results provide an effective method for developing efficient DSSC dyes by inserting an ethynyl group at a suitable position of a DCC dye.
基金supported by the National Natural Science Foundation of China[grant number U21A20287]the Shenzhen Science and Technology Program[grant number JCYJ20210324140205013].
文摘Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses.Companion diagnostics(CDx),a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients,is becoming more and more important.However,most current US Food and Drug Administration(FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo.Consequently,new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables.They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments.This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx.We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.
