Selection of test cases plays a key role in improving testing efficiency. Black-box testing is an important way of testing, and its validity lies on the selection of test cases in some sense. A reasonable and effectiv...Selection of test cases plays a key role in improving testing efficiency. Black-box testing is an important way of testing, and its validity lies on the selection of test cases in some sense. A reasonable and effective method about the selection and generation of test cases is urgently needed. This letter first introduces some usualmethods on black-box test case generation,then proposes a new algorithm based on interface parameters and discusses its properties, finally shows the effectiveness of the algorithm.展开更多
Software testing is an important means to assure the software quality. This paper presents a practicable method to generate test cases of software testing, which is operational and high efficient. We discuss the ident...Software testing is an important means to assure the software quality. This paper presents a practicable method to generate test cases of software testing, which is operational and high efficient. We discuss the identification of software specification categories and choices and make a classification tree. Based on the orthogonal array, it is easy to generate test cases. The number of this method is less than that of all combination of the choices.展开更多
Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant...Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.展开更多
NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a nec...NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.展开更多
To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concret...To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.展开更多
Objective: Hereditary breast and ovarian cancer syndrome (HBOC) increases the risk of developing breast, ovarian, prostate, and pancreatic cancers. With the insurance coverage for BRCA genetic testing, the number of i...Objective: Hereditary breast and ovarian cancer syndrome (HBOC) increases the risk of developing breast, ovarian, prostate, and pancreatic cancers. With the insurance coverage for BRCA genetic testing, the number of individuals diagnosed with HBOC has increased. To use these test results effectively, cascade genetic testing (CGT) is recommended for at-risk relatives;however, it is not yet widely available. The purpose of this study was to investigate the willingness of the general population to share genetic test results and undergo CGT, as well as to analyze the factors influencing these decisions. Based on these findings, the study aimed to identify the types of support needed to support the sharing of genetic test results and promote the use of CGT. Methods: An online survey was conducted with 500 participants (50 men and women from each of the five generations, ranging from 20 to 69 years). Results: Among the HBOC blood relatives, 51.2% wanted to share the genetic results and 71.9% expressed a willingness to undergo CGT. “Matters to be shared with relatives” and “Helpful for my cancer prevention” were identified as key factors promoting the willingness to share the BRCA genetic test results and undergo CGT. The motivation for “Helpful for my cancer prevention” had a particularly strong influence on the decision to undergo CGT. Conclusion: In the general population, there is an emerging understanding that the genetic information impacts not only the individuals but also their entire families and can be valuable for cancer prevention. To promote the sharing of BRCA genetic test results and CGT uptake, the healthcare providers should offer support tailored to each family’s circumstances and establish cancer prevention measures recommended for HBOC.展开更多
The uniaxial compressive strength(UCS)of rocks is a vital geomechanical parameter widely used for rock mass classification,stability analysis,and engineering design in rock engineering.Various UCS testing methods and ...The uniaxial compressive strength(UCS)of rocks is a vital geomechanical parameter widely used for rock mass classification,stability analysis,and engineering design in rock engineering.Various UCS testing methods and apparatuses have been proposed over the past few decades.The objective of the present study is to summarize the status and development in theories,test apparatuses,data processing of the existing testing methods for UCS measurement.It starts with elaborating the theories of these test methods.Then the test apparatus and development trends for UCS measurement are summarized,followed by a discussion on rock specimens for test apparatus,and data processing methods.Next,the method selection for UCS measurement is recommended.It reveals that the rock failure mechanism in the UCS testing methods can be divided into compression-shear,compression-tension,composite failure mode,and no obvious failure mode.The trends of these apparatuses are towards automation,digitization,precision,and multi-modal test.Two size correction methods are commonly used.One is to develop empirical correlation between the measured indices and the specimen size.The other is to use a standard specimen to calculate the size correction factor.Three to five input parameters are commonly utilized in soft computation models to predict the UCS of rocks.The selection of the test methods for the UCS measurement can be carried out according to the testing scenario and the specimen size.The engineers can gain a comprehensive understanding of the UCS testing methods and its potential developments in various rock engineering endeavors.展开更多
Objective: To analyze the effectiveness of blood test indicators in the differential diagnosis of anemia. Methods: Sixty patients diagnosed with anemia (disease group) from June 2021 to June 2024 were selected. Based ...Objective: To analyze the effectiveness of blood test indicators in the differential diagnosis of anemia. Methods: Sixty patients diagnosed with anemia (disease group) from June 2021 to June 2024 were selected. Based on the type of disease, the group was subdivided into iron deficiency anemia (IDA) with 31 cases, hemolytic anemia (HA) with 11 cases, and aplastic anemia (AA) with 18 cases. Based on the severity of the disease, the group was divided into mild anemia (30 cases), moderate anemia (19 cases), and severe anemia (11 cases). Sixty healthy individuals (control group) were also included, and all underwent blood tests. Comparisons were made between the red blood cell (RBC) indicators of the disease group and the control group, the blood test indicators of different types of anemia, and the serum iron levels of varying severity of anemia. Results: Except for red cell distribution width (RDW), the RBC indicators in the disease group were lower than those in the control group (P < 0.05). Comparisons of RBC indicators among different types of anemia showed significant differences (P < 0.05). Serum iron levels varied significantly among different degrees of anemia severity (P < 0.05). Conclusion: Blood tests can detect anemia, distinguish types of anemia, and assess anemia severity, offering high diagnostic value.展开更多
Background:It has been reported that factors such as age and vestibular pathology (i.e. vestibular migraine) could impact self-motion perception during vestibular stimulation. However, to our knowledge, no objective t...Background:It has been reported that factors such as age and vestibular pathology (i.e. vestibular migraine) could impact self-motion perception during vestibular stimulation. However, to our knowledge, no objective test has been developed to quantify self-motion perception during clinical vestibular evaluation.ObjectiveThe main objective of the present study was to quantify vestibular perception during caloric vestibular stimulation using a tachometer.MethodsTwenty-two participants were divided into three groups: 1) younger healthy adults, 2) older healthy adults and 3) vestibular impaired adults. All participants performed bithermal water caloric irrigation during which slow-phase eye velocity (SPV) was measured using videonystagmography and self-motion velocity perception was assessed using a handheld tachometer (RPM).ResultsThe results revealed a significant difference in SPV between vestibular impaired ears and both healthy groups, and a significant difference in self-motion velocity perception between healthy young and vestibular impaired participants.ConclusionsThis study suggest that the SPV similarly to self-motion perception (RPM) can differentiate between vestibular impaired and young healthy participants. Future work is required to assess the influence of self-motion perception in aging.展开更多
AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge st...AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.展开更多
Triaxial testing serves as a fundamental method for evaluating the elastic and strength properties of rocks,crucial for developing accurate 3D geomechanical models.This paper presents a novel method for determining st...Triaxial testing serves as a fundamental method for evaluating the elastic and strength properties of rocks,crucial for developing accurate 3D geomechanical models.This paper presents a novel method for determining strength parameters by incorporating the dependence of uniaxial compressive strength(UCS)on P-wave velocity into the Hoek-Brown criterion.Additionally,a new approach is introduced to process triaxial test data efficiently using Python libraries such as SciPy,NumPy,Matplotlib,and Pandas.Furthermore,the paper addresses challenges in determining elastic parameters through triaxial testing.A Python script is developed to automate the calculation of elastic modulus and Poisson's ratio,over-coming subjectivity in selecting the linear portion of stress-strain curves.The script optimally identifies the linear region by minimizing the fit error with appropriate constraints,ensuring a more objective and standardized approach.The proposed methodologies are demonstrated using limestone specimens from Central Asian gas fields.These innovations offer faster,more reliable results,reducing error and enhancing the comparability of analyses in geomechanics,with potential applications across various geological settings.展开更多
Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model test...Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model tests is proposed.The fundamental principle and design of the sensor are demonstrated.The sensor comprises three earth pressure gages and one gyroscope,with the utilization of three-dimensional(3D)printing technology.The difficulties of installation location during model preparation and sensor rotation during testing can be effectively overcome using this sensor.Two different arrangements of the sensors are tested in verification tests.Additionally,the application of the sensor in an excavated-induced slope model is tested.The results demonstrate that the sensor exhibits commendable performance and achieves a desirable level of accuracy,with a principal stress angle error of±5°in the verification tests.The stress transformation of the slope model,generated by excavation,is demonstrated in the application test by monitoring the two miniature principal stress(MPS)sensors.The sensor has a significant potential for measuring primary stress in landslide model tests and other geotechnical model experiments.展开更多
The water conductivity of karst collapsed column is affected by multiple factors such as the characteristics of its own column filling,structure and mining disturbance.As a structural water-conducting channel,fault us...The water conductivity of karst collapsed column is affected by multiple factors such as the characteristics of its own column filling,structure and mining disturbance.As a structural water-conducting channel,fault usually plays a controlling role in hydrogeological structure.During the process of mine water hazard prevention and control,it was discovered that the lithology composition,compaction and cementation degree and water physical properties of karst collapsed column fillings were all non-conducting water,but due to the influence of combined development faults,some exploration drill holes showed concentrated water outflow.Based on this,the scientific hypothesis was proposed that fault cutting leads to water conduction in karst collapsed columns.The study comprehensively used methods like chronology,exploration data analysis,and hydrochemical testing to analyze the chronological relationship between faults and karst collapsed columns,their spatial relationship,outlet point distribution and water chemical properties,and the impact of faults on the water-conductivity of karst collapsed columns,which proved the effect of fault cutting on changing water conductivity of karst collapsed column.The research showed that later fault cutting through karst collapsed columns turned the originally non-conductive karst collapsed columns into water-conductive collapsed columns at the fault plane,creating a longitudinally connected water-conducting channel.A new model of fault cutting karst collapsed column to change the original water conductivity of karst collapsed column was proposed.The research results can provide a theoretical basis for the prediction of the water conductivity of the karst collapsed column.According to whether the karst collapsed column was cut by the fault,it was predicted theoretically,so as to determine the key areas of water conductivity detection and prevention and control,and has broad application prospects under the background of source control of mine water disaster.展开更多
Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial...Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial pneumonia as the observation group and 50 patients with non-bacterial pneumonia as the control group,recruited from May 2022 to October 2023.Fasting venous blood samples were collected in the morning from all 100 participants.CRP levels were measured using a fully automated biochemical analyzer,while PCT levels were detected using the immunoturbidimetric luminescence method.Results:CRP and PCT levels were significantly higher in bacterial pneumonia patients[(98.25±11.59)mg/L and(3.57±1.35)μg/L,respectively]compared to the control group[(5.55±2.78)mg/L and(0.25±0.12)μg/L,respectively],with significant intergroup differences(P<0.05).Patients with severe bacterial pneumonia exhibited higher serum CRP and PCT levels compared to those with moderate or mild disease(P<0.05).The combined testing of CRP and PCT showed higher sensitivity and specificity than individual tests.In the observation group,CRP and PCT levels significantly decreased after treatment compared to pre-treatment levels.Conclusion:The combination of CRP and PCT testing provides high diagnostic accuracy for bacterial pneumonia in elderly patients.It effectively differentiates bacterial from non-bacterial infections,offering valuable data to guide clinical treatment.展开更多
The advent of point-of-care testing(POCT)has revolutionized the approach to patient management,especially for pediatric care.POCT provides rapid,on-the-spot biochemical and microbiological evaluations,bypassing delays...The advent of point-of-care testing(POCT)has revolutionized the approach to patient management,especially for pediatric care.POCT provides rapid,on-the-spot biochemical and microbiological evaluations,bypassing delays typically associated with central laboratory testing,enabling swift clinical decision-making.Additionally,POCT has proven to be a valuable prognostic tool for monitoring electrolyte,lactate,creatinine levels,often a marker of severe illness and poor outcomes.POCT enables its faster identification,allowing for prompt inter-ventions.This capability is essential in managing conditions like sepsis,where timely treatment can significantly impact survival rates.However,the implementation of POCT is not without its challenges.Variability in sample handling,particularly with heparinized syringes,can affect the accuracy of certain measurements,such as potassium levels.The absence of comprehensive follow-up data and cost-effectiveness analyses in some studies indicate the need for continued research to optimize the use of POCT.In conclusion,POCT is a trans-formative tool in critical care,offering prompt and reliable assessments that significantly enhance patient management.As technology advances,the inte-gration of POCT into emergency departments and intensive critical care units holds great promise for improving the quality of healthcare and patient survival rates.展开更多
Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the...Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the solidification time of conventional cement paste is long when shotcrete is used to treat cohesionless soil landslide.The idea of reinforcing slope with polyurethane solidified soil(i.e.,mixture of polyurethane and sand)was proposed.Model tests and finite element analysis were carried out to study the effectiveness of the proposed new method on the emergency treatment of cohesionless soil landslide.Surcharge loading on the crest of the slope was applied step by step until landslide was triggered so as to test and compare the stability and bearing capacity of slope models with different conditions.The simulated slope displacements were relatively close to the measured results,and the simulated slope deformation characteristics were in good agreement with the observed phenomena,which verifies the accuracy of the numerical method.Under the condition of surcharge loading on the crest of the slope,the unreinforced slope slid when the surcharge loading exceeded 30 k Pa,which presented a failure mode of local instability and collapse at the shallow layer of slope top.The reinforced slope remained stable even when the surcharge loading reached 48 k Pa.The displacement of the reinforced slope was reduced by more than 95%.Overall,this study verifies the effectiveness of polyurethane in the emergency treatment of cohesionless soil landslide and should have broad application prospects in the field of geological disasters concerning the safety of people's live.展开更多
BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated wit...BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated with false-positive and false-negative FIT results.METHODS This retrospective study was based on the database of the Tianjin Colorectal Cancer Screening Program from 2012 to 2020.A total of 4129947 residents aged 40-74 years completed at least one FIT.Of these,24890 asymptomatic participants who underwent colonoscopy examinations and completed lifestyle questionnaires were included in the analysis.Multivariable logistic regression was performed to identify the factors associated with false FIT results.RESULTS Among the overall screening population,88687(2.15%)participants tested positive for FIT.The sensitivity,specificity,positive predictive value,and negative predictive value of FIT for advanced neoplasms were 58.2%,44.8%,9.7%,and 91.3%,respectively.Older age,female sex,smoking,alcohol consumption,higher body mass index,and hemorrhoids were significantly associated with increased odds of false-positive and lower odds of falsenegative FIT results.Moreover,features of high-grade dysplasia or villous for advanced adenoma and the presence of cancer were also associated with lower odds of false-negative results,while irregular exercise and diverticulum were associated with higher odds of false-positive results.CONCLUSION FIT results may be inaccurate in certain subgroups.Our results provide important evidence for further individualization of screening strategies.展开更多
Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by...Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.展开更多
Utilizing the ballast layer with more durable and stable characteristics can help avoid significant expenses due to decreased maintenance efforts.Strengthening the ballast layer with different types of reinforcements ...Utilizing the ballast layer with more durable and stable characteristics can help avoid significant expenses due to decreased maintenance efforts.Strengthening the ballast layer with different types of reinforcements or substituting the stone aggregates with the appropriate granular materials could potentially help to achieve this goal by reducing the ballast deterioration.One of the exquisite and most effective solutions to eliminate these challenges is to use waste materials such as steel slag aggregates and useless tires.Utilizing these waste materials in the ballasted railway track will contribute to sustainable development,an eco-friendly system,and green infrastructure.So in a state-of-the-art insightful,the ballast aggregates,including a mixture of steel slag and stone aggregates,are reinforced with a novel kind of geo-grid made of waste tire strips known as geo-scraps.This laboratory research tried to explain the shear strength behavior of the introduced mixing slag-stone ballast reinforced with tire geo-scrap.To achieve this goal,a series of large-scale direct shear tests were performed on the ballast which is reinforced by tire geo-scrap and included various combinations of slag and stone aggregates.The concluded results indicate that the optimal mixing ratio is attained by a combination of 75%slag and 25%stone aggregates which is reinforced by tire geo-scrap at a placing level of 120 mm.In this case,the shear strength,internal friction angle,vertical displacement,and dilatancy angle of stone–slag ballast reinforced with geo-scraps exhibited average changes of+28%,+9%,-28%,and-15%,respectively.展开更多
基金Supported in part by the National Natural Science Foundation of China (NSFC)(60073012),Natural Science Foundation of Jiangsu(BK2001004)
文摘Selection of test cases plays a key role in improving testing efficiency. Black-box testing is an important way of testing, and its validity lies on the selection of test cases in some sense. A reasonable and effective method about the selection and generation of test cases is urgently needed. This letter first introduces some usualmethods on black-box test case generation,then proposes a new algorithm based on interface parameters and discusses its properties, finally shows the effectiveness of the algorithm.
基金the Aviation Science Foundation of China( Grant No.02F15001)the National Natural Science Foundation of China( Grant No.60674100)
文摘Software testing is an important means to assure the software quality. This paper presents a practicable method to generate test cases of software testing, which is operational and high efficient. We discuss the identification of software specification categories and choices and make a classification tree. Based on the orthogonal array, it is easy to generate test cases. The number of this method is less than that of all combination of the choices.
文摘Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.
文摘NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.
文摘To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.
文摘Objective: Hereditary breast and ovarian cancer syndrome (HBOC) increases the risk of developing breast, ovarian, prostate, and pancreatic cancers. With the insurance coverage for BRCA genetic testing, the number of individuals diagnosed with HBOC has increased. To use these test results effectively, cascade genetic testing (CGT) is recommended for at-risk relatives;however, it is not yet widely available. The purpose of this study was to investigate the willingness of the general population to share genetic test results and undergo CGT, as well as to analyze the factors influencing these decisions. Based on these findings, the study aimed to identify the types of support needed to support the sharing of genetic test results and promote the use of CGT. Methods: An online survey was conducted with 500 participants (50 men and women from each of the five generations, ranging from 20 to 69 years). Results: Among the HBOC blood relatives, 51.2% wanted to share the genetic results and 71.9% expressed a willingness to undergo CGT. “Matters to be shared with relatives” and “Helpful for my cancer prevention” were identified as key factors promoting the willingness to share the BRCA genetic test results and undergo CGT. The motivation for “Helpful for my cancer prevention” had a particularly strong influence on the decision to undergo CGT. Conclusion: In the general population, there is an emerging understanding that the genetic information impacts not only the individuals but also their entire families and can be valuable for cancer prevention. To promote the sharing of BRCA genetic test results and CGT uptake, the healthcare providers should offer support tailored to each family’s circumstances and establish cancer prevention measures recommended for HBOC.
基金the National Natural Science Foundation of China(Grant Nos.52308403 and 52079068)the Yunlong Lake Laboratory of Deep Underground Science and Engineering(No.104023005)the China Postdoctoral Science Foundation(Grant No.2023M731998)for funding provided to this work.
文摘The uniaxial compressive strength(UCS)of rocks is a vital geomechanical parameter widely used for rock mass classification,stability analysis,and engineering design in rock engineering.Various UCS testing methods and apparatuses have been proposed over the past few decades.The objective of the present study is to summarize the status and development in theories,test apparatuses,data processing of the existing testing methods for UCS measurement.It starts with elaborating the theories of these test methods.Then the test apparatus and development trends for UCS measurement are summarized,followed by a discussion on rock specimens for test apparatus,and data processing methods.Next,the method selection for UCS measurement is recommended.It reveals that the rock failure mechanism in the UCS testing methods can be divided into compression-shear,compression-tension,composite failure mode,and no obvious failure mode.The trends of these apparatuses are towards automation,digitization,precision,and multi-modal test.Two size correction methods are commonly used.One is to develop empirical correlation between the measured indices and the specimen size.The other is to use a standard specimen to calculate the size correction factor.Three to five input parameters are commonly utilized in soft computation models to predict the UCS of rocks.The selection of the test methods for the UCS measurement can be carried out according to the testing scenario and the specimen size.The engineers can gain a comprehensive understanding of the UCS testing methods and its potential developments in various rock engineering endeavors.
文摘Objective: To analyze the effectiveness of blood test indicators in the differential diagnosis of anemia. Methods: Sixty patients diagnosed with anemia (disease group) from June 2021 to June 2024 were selected. Based on the type of disease, the group was subdivided into iron deficiency anemia (IDA) with 31 cases, hemolytic anemia (HA) with 11 cases, and aplastic anemia (AA) with 18 cases. Based on the severity of the disease, the group was divided into mild anemia (30 cases), moderate anemia (19 cases), and severe anemia (11 cases). Sixty healthy individuals (control group) were also included, and all underwent blood tests. Comparisons were made between the red blood cell (RBC) indicators of the disease group and the control group, the blood test indicators of different types of anemia, and the serum iron levels of varying severity of anemia. Results: Except for red cell distribution width (RDW), the RBC indicators in the disease group were lower than those in the control group (P < 0.05). Comparisons of RBC indicators among different types of anemia showed significant differences (P < 0.05). Serum iron levels varied significantly among different degrees of anemia severity (P < 0.05). Conclusion: Blood tests can detect anemia, distinguish types of anemia, and assess anemia severity, offering high diagnostic value.
基金supported bsy NSERC(RGPIN-2022-04402)and by the Fonds de Recherche en Santédu Quebec(FRQS-329974)both awarded to Dr Maheu。
文摘Background:It has been reported that factors such as age and vestibular pathology (i.e. vestibular migraine) could impact self-motion perception during vestibular stimulation. However, to our knowledge, no objective test has been developed to quantify self-motion perception during clinical vestibular evaluation.ObjectiveThe main objective of the present study was to quantify vestibular perception during caloric vestibular stimulation using a tachometer.MethodsTwenty-two participants were divided into three groups: 1) younger healthy adults, 2) older healthy adults and 3) vestibular impaired adults. All participants performed bithermal water caloric irrigation during which slow-phase eye velocity (SPV) was measured using videonystagmography and self-motion velocity perception was assessed using a handheld tachometer (RPM).ResultsThe results revealed a significant difference in SPV between vestibular impaired ears and both healthy groups, and a significant difference in self-motion velocity perception between healthy young and vestibular impaired participants.ConclusionsThis study suggest that the SPV similarly to self-motion perception (RPM) can differentiate between vestibular impaired and young healthy participants. Future work is required to assess the influence of self-motion perception in aging.
文摘AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.
文摘Triaxial testing serves as a fundamental method for evaluating the elastic and strength properties of rocks,crucial for developing accurate 3D geomechanical models.This paper presents a novel method for determining strength parameters by incorporating the dependence of uniaxial compressive strength(UCS)on P-wave velocity into the Hoek-Brown criterion.Additionally,a new approach is introduced to process triaxial test data efficiently using Python libraries such as SciPy,NumPy,Matplotlib,and Pandas.Furthermore,the paper addresses challenges in determining elastic parameters through triaxial testing.A Python script is developed to automate the calculation of elastic modulus and Poisson's ratio,over-coming subjectivity in selecting the linear portion of stress-strain curves.The script optimally identifies the linear region by minimizing the fit error with appropriate constraints,ensuring a more objective and standardized approach.The proposed methodologies are demonstrated using limestone specimens from Central Asian gas fields.These innovations offer faster,more reliable results,reducing error and enhancing the comparability of analyses in geomechanics,with potential applications across various geological settings.
基金supported by the National Nature Science Foundation of China(Grant No.42207216)the Major Program of the National Natural Science Foundation of China(Grant No.42090055)the National Nature Science Foundation of China(Grant No.42377182).
文摘Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model tests is proposed.The fundamental principle and design of the sensor are demonstrated.The sensor comprises three earth pressure gages and one gyroscope,with the utilization of three-dimensional(3D)printing technology.The difficulties of installation location during model preparation and sensor rotation during testing can be effectively overcome using this sensor.Two different arrangements of the sensors are tested in verification tests.Additionally,the application of the sensor in an excavated-induced slope model is tested.The results demonstrate that the sensor exhibits commendable performance and achieves a desirable level of accuracy,with a principal stress angle error of±5°in the verification tests.The stress transformation of the slope model,generated by excavation,is demonstrated in the application test by monitoring the two miniature principal stress(MPS)sensors.The sensor has a significant potential for measuring primary stress in landslide model tests and other geotechnical model experiments.
基金supported by the Postdoctoral Fellowship Program of CPSF(No.GZC20233005)the Fundamental Research Funds for the Central Universities(No.2024QN11025)+1 种基金the General Program of National Natural Science Foundation of China(No.52274243)the Hebei Province Natural Science Foundation Ecological Wisdom Mine Joint Fund Project(Nos.D2020402013 and D2022402040)。
文摘The water conductivity of karst collapsed column is affected by multiple factors such as the characteristics of its own column filling,structure and mining disturbance.As a structural water-conducting channel,fault usually plays a controlling role in hydrogeological structure.During the process of mine water hazard prevention and control,it was discovered that the lithology composition,compaction and cementation degree and water physical properties of karst collapsed column fillings were all non-conducting water,but due to the influence of combined development faults,some exploration drill holes showed concentrated water outflow.Based on this,the scientific hypothesis was proposed that fault cutting leads to water conduction in karst collapsed columns.The study comprehensively used methods like chronology,exploration data analysis,and hydrochemical testing to analyze the chronological relationship between faults and karst collapsed columns,their spatial relationship,outlet point distribution and water chemical properties,and the impact of faults on the water-conductivity of karst collapsed columns,which proved the effect of fault cutting on changing water conductivity of karst collapsed column.The research showed that later fault cutting through karst collapsed columns turned the originally non-conductive karst collapsed columns into water-conductive collapsed columns at the fault plane,creating a longitudinally connected water-conducting channel.A new model of fault cutting karst collapsed column to change the original water conductivity of karst collapsed column was proposed.The research results can provide a theoretical basis for the prediction of the water conductivity of the karst collapsed column.According to whether the karst collapsed column was cut by the fault,it was predicted theoretically,so as to determine the key areas of water conductivity detection and prevention and control,and has broad application prospects under the background of source control of mine water disaster.
文摘Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial pneumonia as the observation group and 50 patients with non-bacterial pneumonia as the control group,recruited from May 2022 to October 2023.Fasting venous blood samples were collected in the morning from all 100 participants.CRP levels were measured using a fully automated biochemical analyzer,while PCT levels were detected using the immunoturbidimetric luminescence method.Results:CRP and PCT levels were significantly higher in bacterial pneumonia patients[(98.25±11.59)mg/L and(3.57±1.35)μg/L,respectively]compared to the control group[(5.55±2.78)mg/L and(0.25±0.12)μg/L,respectively],with significant intergroup differences(P<0.05).Patients with severe bacterial pneumonia exhibited higher serum CRP and PCT levels compared to those with moderate or mild disease(P<0.05).The combined testing of CRP and PCT showed higher sensitivity and specificity than individual tests.In the observation group,CRP and PCT levels significantly decreased after treatment compared to pre-treatment levels.Conclusion:The combination of CRP and PCT testing provides high diagnostic accuracy for bacterial pneumonia in elderly patients.It effectively differentiates bacterial from non-bacterial infections,offering valuable data to guide clinical treatment.
文摘The advent of point-of-care testing(POCT)has revolutionized the approach to patient management,especially for pediatric care.POCT provides rapid,on-the-spot biochemical and microbiological evaluations,bypassing delays typically associated with central laboratory testing,enabling swift clinical decision-making.Additionally,POCT has proven to be a valuable prognostic tool for monitoring electrolyte,lactate,creatinine levels,often a marker of severe illness and poor outcomes.POCT enables its faster identification,allowing for prompt inter-ventions.This capability is essential in managing conditions like sepsis,where timely treatment can significantly impact survival rates.However,the implementation of POCT is not without its challenges.Variability in sample handling,particularly with heparinized syringes,can affect the accuracy of certain measurements,such as potassium levels.The absence of comprehensive follow-up data and cost-effectiveness analyses in some studies indicate the need for continued research to optimize the use of POCT.In conclusion,POCT is a trans-formative tool in critical care,offering prompt and reliable assessments that significantly enhance patient management.As technology advances,the inte-gration of POCT into emergency departments and intensive critical care units holds great promise for improving the quality of healthcare and patient survival rates.
基金the financial support from the Fujian Science Foundation for Outstanding Youth(2023J06039)the National Natural Science Foundation of China(Grant No.41977259,U2005205,41972268)the Independent Research Project of Technology Innovation Center for Monitoring and Restoration Engineering of Ecological Fragile Zone in Southeast China(KY-090000-04-2022-019)。
文摘Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the solidification time of conventional cement paste is long when shotcrete is used to treat cohesionless soil landslide.The idea of reinforcing slope with polyurethane solidified soil(i.e.,mixture of polyurethane and sand)was proposed.Model tests and finite element analysis were carried out to study the effectiveness of the proposed new method on the emergency treatment of cohesionless soil landslide.Surcharge loading on the crest of the slope was applied step by step until landslide was triggered so as to test and compare the stability and bearing capacity of slope models with different conditions.The simulated slope displacements were relatively close to the measured results,and the simulated slope deformation characteristics were in good agreement with the observed phenomena,which verifies the accuracy of the numerical method.Under the condition of surcharge loading on the crest of the slope,the unreinforced slope slid when the surcharge loading exceeded 30 k Pa,which presented a failure mode of local instability and collapse at the shallow layer of slope top.The reinforced slope remained stable even when the surcharge loading reached 48 k Pa.The displacement of the reinforced slope was reduced by more than 95%.Overall,this study verifies the effectiveness of polyurethane in the emergency treatment of cohesionless soil landslide and should have broad application prospects in the field of geological disasters concerning the safety of people's live.
基金Supported by Natural Science Foundation of Tianjin,No.21JCZDJC00060 and No.21JCYBJC00180Tianjin Health and Medical Science and Technology Project,No.TJWJ2023QN040National Key Research and Development Program,No.2017YFC1700606 and No.2017YFC1700604.
文摘BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated with false-positive and false-negative FIT results.METHODS This retrospective study was based on the database of the Tianjin Colorectal Cancer Screening Program from 2012 to 2020.A total of 4129947 residents aged 40-74 years completed at least one FIT.Of these,24890 asymptomatic participants who underwent colonoscopy examinations and completed lifestyle questionnaires were included in the analysis.Multivariable logistic regression was performed to identify the factors associated with false FIT results.RESULTS Among the overall screening population,88687(2.15%)participants tested positive for FIT.The sensitivity,specificity,positive predictive value,and negative predictive value of FIT for advanced neoplasms were 58.2%,44.8%,9.7%,and 91.3%,respectively.Older age,female sex,smoking,alcohol consumption,higher body mass index,and hemorrhoids were significantly associated with increased odds of false-positive and lower odds of falsenegative FIT results.Moreover,features of high-grade dysplasia or villous for advanced adenoma and the presence of cancer were also associated with lower odds of false-negative results,while irregular exercise and diverticulum were associated with higher odds of false-positive results.CONCLUSION FIT results may be inaccurate in certain subgroups.Our results provide important evidence for further individualization of screening strategies.
文摘Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.
文摘Utilizing the ballast layer with more durable and stable characteristics can help avoid significant expenses due to decreased maintenance efforts.Strengthening the ballast layer with different types of reinforcements or substituting the stone aggregates with the appropriate granular materials could potentially help to achieve this goal by reducing the ballast deterioration.One of the exquisite and most effective solutions to eliminate these challenges is to use waste materials such as steel slag aggregates and useless tires.Utilizing these waste materials in the ballasted railway track will contribute to sustainable development,an eco-friendly system,and green infrastructure.So in a state-of-the-art insightful,the ballast aggregates,including a mixture of steel slag and stone aggregates,are reinforced with a novel kind of geo-grid made of waste tire strips known as geo-scraps.This laboratory research tried to explain the shear strength behavior of the introduced mixing slag-stone ballast reinforced with tire geo-scrap.To achieve this goal,a series of large-scale direct shear tests were performed on the ballast which is reinforced by tire geo-scrap and included various combinations of slag and stone aggregates.The concluded results indicate that the optimal mixing ratio is attained by a combination of 75%slag and 25%stone aggregates which is reinforced by tire geo-scrap at a placing level of 120 mm.In this case,the shear strength,internal friction angle,vertical displacement,and dilatancy angle of stone–slag ballast reinforced with geo-scraps exhibited average changes of+28%,+9%,-28%,and-15%,respectively.
