Mesoporous aluminosilica hollow nanospheres were prepared easily,which possess very strong acid site.The heterogeneous catalyst can be utilized in both intramolecular aza-Michael addition cyclization and intermolecula...Mesoporous aluminosilica hollow nanospheres were prepared easily,which possess very strong acid site.The heterogeneous catalyst can be utilized in both intramolecular aza-Michael addition cyclization and intermolecular Diels-Alder reaction.The catalyst could be easily recovered and reused.Furthermore,the catalyst could be used in continuous flow chemistry for the uninterrupted synthesis of 2,3-dihydroquinolin-4(1H)-ones,which disclosed the potential application of the present solid catalyst in both academic and industrial syntheses.In addition,the catalyst could be recovered and reused at least 7 times without obvious loss of activity.展开更多
An unprecedented enzyme-catalyzed asymmetric domino aza-Michael/aldol reaction of 2-aminobenzaldehyde and a,b-unsaturated aldehydes is achieved. Pepsin from porcine gastric mucosa provided mild and efficient access to...An unprecedented enzyme-catalyzed asymmetric domino aza-Michael/aldol reaction of 2-aminobenzaldehyde and a,b-unsaturated aldehydes is achieved. Pepsin from porcine gastric mucosa provided mild and efficient access to diverse substituted 1,2-dihydroquinolines in yields of 38%–97% with 6%–24%enantiomeric excess（ee）. This work not only provides a novel method for the synthesis of dihydroquinoline derivatives, but also promotes the development of enzyme catalytic promiscuity.展开更多
MCM-41 supported heteropoly acids （HPAs） catalysts were synthesized, characterized and their catalytic activity was evaluated in an aza-Michael addition reaction between nitroolefins and benzotriazole in water at ro...MCM-41 supported heteropoly acids （HPAs） catalysts were synthesized, characterized and their catalytic activity was evaluated in an aza-Michael addition reaction between nitroolefins and benzotriazole in water at room temperature. 50 wt% PW/MCM-41 showed the highest activity （up to 96% yield）. The catalyst was used in six consecutive experiments without obvious loss of activity, confirming the success of the anchoring process and the catalyst stability.展开更多
Phthalimide derivatives as nitrogen nucleophiles with α,β-unsaturated aldehydes for asymmetric aza-Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in goo...Phthalimide derivatives as nitrogen nucleophiles with α,β-unsaturated aldehydes for asymmetric aza-Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields （up to 98%） and enantioselectivities （up to 95% ee）.展开更多
An intramolecular organocatalytic enantioselective aza-Michael reaction of carbamates, sulfonamides and acetamides to a,b-unsaturated ketones was developed. This process is promoted by 9-amino-9-deoxy-epi-quinine and ...An intramolecular organocatalytic enantioselective aza-Michael reaction of carbamates, sulfonamides and acetamides to a,b-unsaturated ketones was developed. This process is promoted by 9-amino-9-deoxy-epi-quinine and diphenyl hydrogen phosphate to afford a straightforward and expeditious synthesis of several synthetically useful five-and six-membered heterocycles with excellent enantioselectivity（92%–97.5% ee） and very good yields（up to 99%）.展开更多
基金supported by the National Natural Science Foundation of China(No.21872095)the“111”Innovation and Talent Recruitment Base on Photochemical and Energy Materials,China(No.D18020)the Project of Shanghai Engineering Research Center of Green Energy Chemical Engineering,China(No.18DZ2254200).
文摘Mesoporous aluminosilica hollow nanospheres were prepared easily,which possess very strong acid site.The heterogeneous catalyst can be utilized in both intramolecular aza-Michael addition cyclization and intermolecular Diels-Alder reaction.The catalyst could be easily recovered and reused.Furthermore,the catalyst could be used in continuous flow chemistry for the uninterrupted synthesis of 2,3-dihydroquinolin-4(1H)-ones,which disclosed the potential application of the present solid catalyst in both academic and industrial syntheses.In addition,the catalyst could be recovered and reused at least 7 times without obvious loss of activity.
基金supported by the National Natural Science Foundation of China (Nos. 21276211 and 21472152)
文摘An unprecedented enzyme-catalyzed asymmetric domino aza-Michael/aldol reaction of 2-aminobenzaldehyde and a,b-unsaturated aldehydes is achieved. Pepsin from porcine gastric mucosa provided mild and efficient access to diverse substituted 1,2-dihydroquinolines in yields of 38%–97% with 6%–24%enantiomeric excess（ee）. This work not only provides a novel method for the synthesis of dihydroquinoline derivatives, but also promotes the development of enzyme catalytic promiscuity.
基金the financial support from the National Natural Science Foundation of China(Nos.21162026 and 20962018)Xinjiang Autonomous Region Youth Science Foundation(No. 2011211B05)Doctoral Fund of Xinjiang University(No. BS100109)
文摘MCM-41 supported heteropoly acids （HPAs） catalysts were synthesized, characterized and their catalytic activity was evaluated in an aza-Michael addition reaction between nitroolefins and benzotriazole in water at room temperature. 50 wt% PW/MCM-41 showed the highest activity （up to 96% yield）. The catalyst was used in six consecutive experiments without obvious loss of activity, confirming the success of the anchoring process and the catalyst stability.
文摘Phthalimide derivatives as nitrogen nucleophiles with α,β-unsaturated aldehydes for asymmetric aza-Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields （up to 98%） and enantioselectivities （up to 95% ee）.
基金financial support from the National Natural Science Foundation of China (No. 21262022)
文摘An intramolecular organocatalytic enantioselective aza-Michael reaction of carbamates, sulfonamides and acetamides to a,b-unsaturated ketones was developed. This process is promoted by 9-amino-9-deoxy-epi-quinine and diphenyl hydrogen phosphate to afford a straightforward and expeditious synthesis of several synthetically useful five-and six-membered heterocycles with excellent enantioselectivity（92%–97.5% ee） and very good yields（up to 99%）.
