BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue...BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.展开更多
The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zen...The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zener model with periodic modulation.We obtain adiabatic phase diagrams in the(ω,δ)parameter space,where the adiabatic region is bounded by the modulating frequencyωgreater than a critical valueω_(c) and the non-reciprocal parameterδless than one.The results show that the adiabaticity of the system is not sensitive to the modulating amplitude.We find that the critical modulating frequency can be expressed as a power function of the modulating period number or the sweeping rate.Our findings suggest that one can change the adiabatic region or improve the adiabaticity by adjusting the parameters of both the modulating and the sweeping fields,which provides an effective means to flexibly control the adiabatic dynamics of non-reciprocal systems.展开更多
The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits ...The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.展开更多
The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA...The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA,poor ability to avoid local optimum,and slow convergence speed,this paper proposes a multi-strategy improved HBA based on periodical mutation and t-distribution perturbation,called MHBA.Firstly,a good point set population initialization is introduced to get a uniform initial population.Secondly,periodic mutation and t-distribution perturbation are successively used to improve the algorithm’s ability to avoid local optimum.Finally,the density factor is improved for balancing exploration and exploitation.By comparing MHBA with HBA and 7 other SIs on 6 benchmark functions,it is evident that the performance of MHBA is far superior to HBA.In addition,by applying MHBA to robot path planning,MHBA can identify the shortest path more quickly and consistently compared with competitors.展开更多
Our study area covered the Eastern Himalayan Syntaxis (EHS) and its southern extension (Hengduan Mountain or western Sichuan and Yunnan (WSY)) which is located at the orthogonal and oblique collisional front between I...Our study area covered the Eastern Himalayan Syntaxis (EHS) and its southern extension (Hengduan Mountain or western Sichuan and Yunnan (WSY)) which is located at the orthogonal and oblique collisional front between Indian and Asian continents during Cenozoic.Based on geometric and kinematic mapping of the major boundary or regional faults (Dongjug—Mainling(1), Anigiao(2) and Jali(3), Guyu(4) faults in EHS, Ailaoshan—Red River(5), Lancangjiang(6), Gaoligong(7), Binlangjiang(8) and Magok(9) faults in WSY) (see Fig.1), especially on abundant geochronological dating of the mylonitic rocks along these faults, and coupled with magmato\|metamorphic sequences of this region, we try to deal with the temporal and spatial relationships of collisional process to answer questions such as: (1) when did collision start ? (2) is thrusting as a initial and dominant deformation mode to absorb the crustal shortening after suturing, or earlier thrusting usually followed by large\|scale strike\|slip faults? (3) are the two structural patterns coeval at times, or do they occur alternatively during deformation history? (4) are the collisional and associate uplift processes a continuous one or periodic? Insight into such questions is crucial for better understanding of the continental deformation and testing the models available or constraining a new one.展开更多
The Zhaxikang Pb-Zn-Ag-Sb deposit, the largest polymetallic deposit known in the Himalayan Orogen of southern Tibet, is characterized by vein-type mineralization that hosts multiple mineral assemblages and complicated...The Zhaxikang Pb-Zn-Ag-Sb deposit, the largest polymetallic deposit known in the Himalayan Orogen of southern Tibet, is characterized by vein-type mineralization that hosts multiple mineral assemblages and complicated metal associations. The deposit consists of at least six steeply dipping vein- type orebodies that are hosted by Early Jurassic black carbonaceous slates and are controlled by a Cenozoic N-S-striking normal fault system. This deposit records multiple stages of mineralization that include an early period （A） of massive coarse-grained galena-sphalerite deposition and a later period （B） of Sb-bearing vein-type mineralization. Period A is only associated with galena-sphalerite mineralization, whereas period B can be subdivided into ferrous rhodochrosite-sphalerite-pyrite, quartz -sulfosalt-sphalerite, calcite-pyrite, quartz-stibnite, and quartz-only stages of mineralization. The formation of brecciated galena and sphalerite ores during period A implies reworking of pre-existing Pb -Zn sulfides by Cenozoic tectonic deformation, whereas period B mineralization records extensive open- space filling during ore formation. Fluid inclusion microthermometric data indicate that both periods A and B were associated with low-medium temperature （187-267℃） and low salinity （4.00-10.18% wt. NaCl equivalent） ore-forming fluids, although variations in the physical-chemical nature of the period B fluids suggest that this phase of mineralization was characterized by variable water/rock ratios. Microprobe analyses indicate that Fe concentrations in sphalerite decrease from period A to period B, and can be divided into three groups with FeS concentrations of 8.999-9.577, 7.125-9.109, 5.438-1.460 mol.%. The concentrations of Zn, Sb, Pb, and Ag within orebodies in the study area are normally distributed in both lateral and vertical directions, and Pb, Sb, and/or Ag concentrations are positive correlation within the central part of these orebodies, but negatively correlate in the margins. Sulfide S isotope compositions are highly variable （4‰-13‰）, varying from 4‰ to 11‰ in period A and 10‰ to 1‰ in period B. The Pb isotope within these samples is highly radiogenic and defines linear trends in 206pb/204pb vs. 207pb/204pb and 206pb/204pb vs. 208pb/204pb diagrams, respectively. The S and Pb isotopic characteristics indicate that the period B orebodies formed by mixing of Pb-Zn sulfides and regional Sb- bearing fluids. These features are indicative of overprinting and remobilization of pre-existing Pb-Zn sulfides by Sb-bearing ore-forming fluids during a post-collisional period of the Himalayan Orogeny. The presence of similar ore types in the north Rhenish Massif that formed after the Variscan Orogeny suggests that Zhaxikang-style mineralization may be present in other orogenic belts, suggesting that this deposit may guide Pb-Zn exploration in these areas.展开更多
Through observing the phenology of two kinds of fruit trees,apple and peach trees,during their flowering periods in the past seven years,the meteorological conditions in the flowering stages were analyzed and summariz...Through observing the phenology of two kinds of fruit trees,apple and peach trees,during their flowering periods in the past seven years,the meteorological conditions in the flowering stages were analyzed and summarized in this paper.The late frost weather situation occurred in late April in Haiyang City also was elaborated in the paper.According to the data analysis,the terrain effect had induced a large temperature differences between north and south in April in Haiyang.Early flowering of fruit trees is as early as 5 to 8 days in the northern region than that in the southern region;accumulated temperature which was greater than or equal to 0 ℃ and the date of the temperature stably through a boundary,were the important meteorological indicators of the fruit trees' early flowering.The late frost in mid-late April is meteorological disasters of the fruit trees flowering period.The weather background of the occurred late frost,the disaster reasons and the measures for the prevention of late frost were proposed.展开更多
Rice grain yield and quality declines are due to unsuitable temperatures from wide regions and various sowing dates.This study aimed to evaluate the effects of temperature on rice yield and quality at different phenol...Rice grain yield and quality declines are due to unsuitable temperatures from wide regions and various sowing dates.This study aimed to evaluate the effects of temperature on rice yield and quality at different phenological periods and obtain suitable temperatures for phenological periods in the Yangtze River Basin,China.This study conducted experiments on different sowing dates under different areas in the Yangtze River Basin to observe and compare the differences in rice growth,yield,and quality,controlling for regional varieties.The results showed significant differences in rice growth,yield,and quality among sowing dates and areas,which were related to the average daily temperature during the vegetative period(VT)and the first 20 days of the grain-filling period(GT20).In addition,there was a smaller variation in the average daily temperature in the reproductive period(RT)than in the two phenological periods.Therefore,according to the VT and GT20 thresholds of different yields and qualities,the experimental results were divided into four scenarios(Ⅰ,Ⅱ,Ⅲ,andⅣ)in this study.In Scenario I,high head rice production(rice grain yield multiplied by head rice rate)and rice quality could be obtained.The head rice production of ScenariosⅢandⅣwas lower than that of ScenarioⅠ,by 30.1 and 27.6%,respectively.In Scenario II,the head rice production increased insignificantly while the chalky grain rate and chalkiness were 50.6 and 56.3%higher than those of Scenario I.In conclusion,the Scenario I combination with VT ranges of 22.8-23.9℃and GT20 ranges of 24.2-27.0℃or the combination with VT ranges of 23.9-25.3℃and GT20 ranges of 24.2-24.9℃,which can be obtained by adjusting sowing date and selecting rice varieties with suitable growth periods,is recommended to achieve high levels of rice grain yield and quality in the Yangtze River Basin.展开更多
NCEP/NCAR reanalysis data and a 30-year precipitation dataset of observed daily rainfall from 109 gauge stations are utilized in this paper.Using the REOF we analyzed the spatial distribution of precipitation in the 1...NCEP/NCAR reanalysis data and a 30-year precipitation dataset of observed daily rainfall from 109 gauge stations are utilized in this paper.Using the REOF we analyzed the spatial distribution of precipitation in the 109 stations in the Yangtze River Basin in Meiyu periods from 1978 to 2007.The result showed that the spatial distribution of precipitation in the Yangtze River Basin can be divided into the south and north part.As a result,relationships between an atmospheric heating source(hereafter called <Q_1>) over the Asian region and the precipitation on the south and north side of Yangtze River in Meiyu periods were separately studied in this paper.The results are shown as follows.The flood/drought to the north of Yangtze River(NYR) was mainly related to the <Q_1> over the East Asia summer monsoon region:when the <Q_1> over the Philippines through Western Pacific and the south China was weakened(strengthened),it would probably result in the flood(drought) in NYR;and the precipitation on the south side of Yangtze River(SYR)was related to the <Q_1> over the east Asia and Indian summer monsoon region:when the <Q_1> over the areas from south China to the northern East China Sea and Yellow Sea and south-eastern Japan was strengthened(weakened),and the <Q_1> over the areas from the Bay of Bengal to south-eastern Tibetan Plateau was weakened(strengthened),it will lead to flood(drought) in SYR.展开更多
Laiyang formation of Jiaolai Basin is the target stratum for oil and gas exploration. By measuring several field sections, the authors find that Laiyang formation reveals the whole processes from development to death ...Laiyang formation of Jiaolai Basin is the target stratum for oil and gas exploration. By measuring several field sections, the authors find that Laiyang formation reveals the whole processes from development to death of the lake basin and its sedimentary facies differ in different structural locations. Analyses about sedimentary facies and paleocurrent orientations in association with researches about the positive tectonic units such as Dayetou horseback and Chaigou horst indicate that Laiyang sag is a relatively independent sedimentary unit that shows great water depth typical of deep lake or semideep lake and was controlled by Wulongcun fault during the deposition period of Laiyang formation. Its sediments mainly originated from Jiaobei uplift area and Dayetou horseback. Gaomi-Zhucheng sag was a fast-filled basin controlled by Wurong fault and Yishu fault zone, being high in the northeast and low in the northwest and characterized by the development of pluvial facies and fluvial facies in most areas, and with the development of lake facies being limited to local low-lying regions. Selection of advantageous hydrocarbon reservoir areas for exploration purpose mainly relies on the sedimentation pattern of prototype basin and conservation conditions. The central-west area of Laiyang sag covered by overlying Laiyang formation is the most advantageous exploration area.展开更多
From October 1935 when the Central Red Army arrived in northern Shaanxi to March 1948 when the Central Committee of the Communist Party of China crossed the Yellow River,the Communist Party of China inspired ordinary ...From October 1935 when the Central Red Army arrived in northern Shaanxi to March 1948 when the Central Committee of the Communist Party of China crossed the Yellow River,the Communist Party of China inspired ordinary party members' political participation consciousness through rectification and seeking the opinions of non-party individuals,and stimulated the political participation enthusiasm of democracy activists through the special election to improve farmers' political participation awareness,in order to form a unique " Yan'an democratic model",which greatly accelerated the victory of the resistance war and accumulated rich experience for democratic construction.展开更多
Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fer...Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this effect.Moreover,no significant differences were observed in rumen fermentation parameters and serum indices between the two groups.Conclusions The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.展开更多
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction b...The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.展开更多
Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than t...Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than the diffraction limit,making it a useful method for efficient nanomanufacturing.However,compared with the low-spatial-frequency LIPSS(LSFL),the structure size of the HSFL is smaller,and it is more easily submerged.Therefore,the formation mechanism of HSFL is complex and has always been a research hotspot in this field.In this study,regular LSFL with a period of 760 nm was fabricated in advance on a silicon surface with two-beam interference using an 800 nm,50 fs femtosecond laser.The ultrafast dynamics of HSFL formation on the silicon surface of prefabricated LSFL under single femtosecond laser pulse irradiation were observed and analyzed for the first time using collinear pump-probe imaging method.In general,the evolution of the surface structure undergoes five sequential stages:the LSFL begins to split,becomes uniform HSFL,degenerates into an irregular LSFL,undergoes secondary splitting into a weakly uniform HSFL,and evolves into an irregular LSFL or is submerged.The results indicate that the local enhancement of the submerged nanocavity,or the nanoplasma,in the prefabricated LSFL ridge led to the splitting of the LSFL,and the thermodynamic effect drove the homogenization of the splitting LSFL,which evolved into HSFL.展开更多
Singular spectrum analysis is widely used in geodetic time series analysis.However,when extracting time-varying periodic signals from a large number of Global Navigation Satellite System(GNSS)time series,the selection...Singular spectrum analysis is widely used in geodetic time series analysis.However,when extracting time-varying periodic signals from a large number of Global Navigation Satellite System(GNSS)time series,the selection of appropriate embedding window size and principal components makes this method cumbersome and inefficient.To improve the efficiency and accuracy of singular spectrum analysis,this paper proposes an adaptive singular spectrum analysis method by combining spectrum analysis with a new trace matrix.The running time and correlation analysis indicate that the proposed method can adaptively set the embedding window size to extract the time-varying periodic signals from GNSS time series,and the extraction efficiency of a single time series is six times that of singular spectrum analysis.The method is also accurate and more suitable for time-varying periodic signal analysis of global GNSS sites.展开更多
Against the background of global warming,research on the spatial distribution of high-temperature risk is of great significance to effectively prevent the adverse effects of high temperatures.By using air temperature ...Against the background of global warming,research on the spatial distribution of high-temperature risk is of great significance to effectively prevent the adverse effects of high temperatures.By using air temperature data from 1951 to 2018 measured by meteorological stations located in the Yangtze River Delta urban agglomeration,the daily maximum air temperature distribution is interpolated at a resolution of 1 km based on the local thin disk smooth spline function;the high-temperature threshold for return periods of 5,10,20 and 30 yr are then calculated by using the generalized extreme value method.The yearly average high-temperature intensity and high-temperature days are finally calculated as high-temperature danger factors.Socioeconomic statistical data and remotely sensed image data in 2018 are used as the background data to calculate the spatial distribution of high-temperature vulnerability factors and prevention capacity factors,which are then used to compute the high-temperature risk index during different recurrence periods in the Yangtze River Delta urban agglomerations.The results show that the spatial distribution features of high-temperature risk in different return periods are similar.The high-temperature risk index gradually increases from northeast to southwest and from east coast to inland,which has obvious latitude variation characteristics and a relationship with the comprehensive influence of the underlying surface and urban scale.In terms of time variation,the high-temperature risk index and its spatial distribution difference gradually decreases with increasing return period.In different cities,the high-temperature risk in the central area of the city is generally higher than that in the surrounding suburban areas.Jinhua,Hangzhou of Zhejiang Province and Xuancheng of Anhui Province are the top three cities with high-temperature risk in the study area.展开更多
In this paper,we address the stability of periodic solutions of piecewise smooth periodic differential equations.By studying the Poincarémap,we give a sufficient condition to judge the stability of a periodic sol...In this paper,we address the stability of periodic solutions of piecewise smooth periodic differential equations.By studying the Poincarémap,we give a sufficient condition to judge the stability of a periodic solution.We also present examples of some applications.展开更多
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in...Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption.CD301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone regeneration.However,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain elusive.In this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)macrophages.We first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA sequencing.Moreover,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)macrophages.The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages.The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis progressed.Furthermore,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in periodontitis.Additionally,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages phenotype.In a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.展开更多
文摘BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12375019 and 11974273)。
文摘The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zener model with periodic modulation.We obtain adiabatic phase diagrams in the(ω,δ)parameter space,where the adiabatic region is bounded by the modulating frequencyωgreater than a critical valueω_(c) and the non-reciprocal parameterδless than one.The results show that the adiabaticity of the system is not sensitive to the modulating amplitude.We find that the critical modulating frequency can be expressed as a power function of the modulating period number or the sweeping rate.Our findings suggest that one can change the adiabatic region or improve the adiabaticity by adjusting the parameters of both the modulating and the sweeping fields,which provides an effective means to flexibly control the adiabatic dynamics of non-reciprocal systems.
基金supported bythe National Natural Science Foundation of China(Nos.U23A20523,82272504,and 82072456)the Department of Science and Technology of Jilin Province,China(Nos.20210101439JC,20210101321JC,20220204119YY,202201ZYTS131,202201ZYTS129,20230204114YY,YDZJ202201ZYTS505,and YDZJ202301ZYTS076)+4 种基金the Special Program for Science and Technology Personnel of Changchun(No.ZKICKJJ2023015)the Key Training Plan for Outstanding Youth of Jilin University(No.419070623036)the Research Fund of the First Hospital of Jilin University(No.2021-zl-01)the Graduate Innovation Fund of Jilin University(No.2024CX125)the Foun-dation of National Center for Translational Medicine(Shanghai)SHU Branch,China(No.SUITM-202405).
文摘The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.
基金Supported by the National Key Research and Development Program of China(No.2022ZD0119001)。
文摘The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA,poor ability to avoid local optimum,and slow convergence speed,this paper proposes a multi-strategy improved HBA based on periodical mutation and t-distribution perturbation,called MHBA.Firstly,a good point set population initialization is introduced to get a uniform initial population.Secondly,periodic mutation and t-distribution perturbation are successively used to improve the algorithm’s ability to avoid local optimum.Finally,the density factor is improved for balancing exploration and exploitation.By comparing MHBA with HBA and 7 other SIs on 6 benchmark functions,it is evident that the performance of MHBA is far superior to HBA.In addition,by applying MHBA to robot path planning,MHBA can identify the shortest path more quickly and consistently compared with competitors.
文摘Our study area covered the Eastern Himalayan Syntaxis (EHS) and its southern extension (Hengduan Mountain or western Sichuan and Yunnan (WSY)) which is located at the orthogonal and oblique collisional front between Indian and Asian continents during Cenozoic.Based on geometric and kinematic mapping of the major boundary or regional faults (Dongjug—Mainling(1), Anigiao(2) and Jali(3), Guyu(4) faults in EHS, Ailaoshan—Red River(5), Lancangjiang(6), Gaoligong(7), Binlangjiang(8) and Magok(9) faults in WSY) (see Fig.1), especially on abundant geochronological dating of the mylonitic rocks along these faults, and coupled with magmato\|metamorphic sequences of this region, we try to deal with the temporal and spatial relationships of collisional process to answer questions such as: (1) when did collision start ? (2) is thrusting as a initial and dominant deformation mode to absorb the crustal shortening after suturing, or earlier thrusting usually followed by large\|scale strike\|slip faults? (3) are the two structural patterns coeval at times, or do they occur alternatively during deformation history? (4) are the collisional and associate uplift processes a continuous one or periodic? Insight into such questions is crucial for better understanding of the continental deformation and testing the models available or constraining a new one.
基金supported by grants from the Ministry of Science and Technology of China(National Key Research and Development Project of China:2016YFC0600308)a Program of the China Geological Survey(DD20160015)NSFC(41702086&41503040)
文摘The Zhaxikang Pb-Zn-Ag-Sb deposit, the largest polymetallic deposit known in the Himalayan Orogen of southern Tibet, is characterized by vein-type mineralization that hosts multiple mineral assemblages and complicated metal associations. The deposit consists of at least six steeply dipping vein- type orebodies that are hosted by Early Jurassic black carbonaceous slates and are controlled by a Cenozoic N-S-striking normal fault system. This deposit records multiple stages of mineralization that include an early period （A） of massive coarse-grained galena-sphalerite deposition and a later period （B） of Sb-bearing vein-type mineralization. Period A is only associated with galena-sphalerite mineralization, whereas period B can be subdivided into ferrous rhodochrosite-sphalerite-pyrite, quartz -sulfosalt-sphalerite, calcite-pyrite, quartz-stibnite, and quartz-only stages of mineralization. The formation of brecciated galena and sphalerite ores during period A implies reworking of pre-existing Pb -Zn sulfides by Cenozoic tectonic deformation, whereas period B mineralization records extensive open- space filling during ore formation. Fluid inclusion microthermometric data indicate that both periods A and B were associated with low-medium temperature （187-267℃） and low salinity （4.00-10.18% wt. NaCl equivalent） ore-forming fluids, although variations in the physical-chemical nature of the period B fluids suggest that this phase of mineralization was characterized by variable water/rock ratios. Microprobe analyses indicate that Fe concentrations in sphalerite decrease from period A to period B, and can be divided into three groups with FeS concentrations of 8.999-9.577, 7.125-9.109, 5.438-1.460 mol.%. The concentrations of Zn, Sb, Pb, and Ag within orebodies in the study area are normally distributed in both lateral and vertical directions, and Pb, Sb, and/or Ag concentrations are positive correlation within the central part of these orebodies, but negatively correlate in the margins. Sulfide S isotope compositions are highly variable （4‰-13‰）, varying from 4‰ to 11‰ in period A and 10‰ to 1‰ in period B. The Pb isotope within these samples is highly radiogenic and defines linear trends in 206pb/204pb vs. 207pb/204pb and 206pb/204pb vs. 208pb/204pb diagrams, respectively. The S and Pb isotopic characteristics indicate that the period B orebodies formed by mixing of Pb-Zn sulfides and regional Sb- bearing fluids. These features are indicative of overprinting and remobilization of pre-existing Pb-Zn sulfides by Sb-bearing ore-forming fluids during a post-collisional period of the Himalayan Orogeny. The presence of similar ore types in the north Rhenish Massif that formed after the Variscan Orogeny suggests that Zhaxikang-style mineralization may be present in other orogenic belts, suggesting that this deposit may guide Pb-Zn exploration in these areas.
文摘Through observing the phenology of two kinds of fruit trees,apple and peach trees,during their flowering periods in the past seven years,the meteorological conditions in the flowering stages were analyzed and summarized in this paper.The late frost weather situation occurred in late April in Haiyang City also was elaborated in the paper.According to the data analysis,the terrain effect had induced a large temperature differences between north and south in April in Haiyang.Early flowering of fruit trees is as early as 5 to 8 days in the northern region than that in the southern region;accumulated temperature which was greater than or equal to 0 ℃ and the date of the temperature stably through a boundary,were the important meteorological indicators of the fruit trees' early flowering.The late frost in mid-late April is meteorological disasters of the fruit trees flowering period.The weather background of the occurred late frost,the disaster reasons and the measures for the prevention of late frost were proposed.
基金supported by the Science and Technology Plan Project of Hubei Province,China(2012BLB228)the National Key Research and Development Program of China(2017YFD0301402)+2 种基金the National Natural Science Foundation of China(31701359)the Fundamental Research Funds for the Central Universities,China(2662017JC007)the China Postdoctoral Science Foundation(2017M612477)。
文摘Rice grain yield and quality declines are due to unsuitable temperatures from wide regions and various sowing dates.This study aimed to evaluate the effects of temperature on rice yield and quality at different phenological periods and obtain suitable temperatures for phenological periods in the Yangtze River Basin,China.This study conducted experiments on different sowing dates under different areas in the Yangtze River Basin to observe and compare the differences in rice growth,yield,and quality,controlling for regional varieties.The results showed significant differences in rice growth,yield,and quality among sowing dates and areas,which were related to the average daily temperature during the vegetative period(VT)and the first 20 days of the grain-filling period(GT20).In addition,there was a smaller variation in the average daily temperature in the reproductive period(RT)than in the two phenological periods.Therefore,according to the VT and GT20 thresholds of different yields and qualities,the experimental results were divided into four scenarios(Ⅰ,Ⅱ,Ⅲ,andⅣ)in this study.In Scenario I,high head rice production(rice grain yield multiplied by head rice rate)and rice quality could be obtained.The head rice production of ScenariosⅢandⅣwas lower than that of ScenarioⅠ,by 30.1 and 27.6%,respectively.In Scenario II,the head rice production increased insignificantly while the chalky grain rate and chalkiness were 50.6 and 56.3%higher than those of Scenario I.In conclusion,the Scenario I combination with VT ranges of 22.8-23.9℃and GT20 ranges of 24.2-27.0℃or the combination with VT ranges of 23.9-25.3℃and GT20 ranges of 24.2-24.9℃,which can be obtained by adjusting sowing date and selecting rice varieties with suitable growth periods,is recommended to achieve high levels of rice grain yield and quality in the Yangtze River Basin.
基金National Natural Science Foundation of China(41275080)China Meteorological Administration Special Public Welfare Research Fund(GYHY201306022)Open Research Fund Program of Plateau Atmosphere and Environment Key Laboratory of Sichuan Province(PAEKL-2010-C3)
文摘NCEP/NCAR reanalysis data and a 30-year precipitation dataset of observed daily rainfall from 109 gauge stations are utilized in this paper.Using the REOF we analyzed the spatial distribution of precipitation in the 109 stations in the Yangtze River Basin in Meiyu periods from 1978 to 2007.The result showed that the spatial distribution of precipitation in the Yangtze River Basin can be divided into the south and north part.As a result,relationships between an atmospheric heating source(hereafter called <Q_1>) over the Asian region and the precipitation on the south and north side of Yangtze River in Meiyu periods were separately studied in this paper.The results are shown as follows.The flood/drought to the north of Yangtze River(NYR) was mainly related to the <Q_1> over the East Asia summer monsoon region:when the <Q_1> over the Philippines through Western Pacific and the south China was weakened(strengthened),it would probably result in the flood(drought) in NYR;and the precipitation on the south side of Yangtze River(SYR)was related to the <Q_1> over the east Asia and Indian summer monsoon region:when the <Q_1> over the areas from south China to the northern East China Sea and Yellow Sea and south-eastern Japan was strengthened(weakened),and the <Q_1> over the areas from the Bay of Bengal to south-eastern Tibetan Plateau was weakened(strengthened),it will lead to flood(drought) in SYR.
文摘Laiyang formation of Jiaolai Basin is the target stratum for oil and gas exploration. By measuring several field sections, the authors find that Laiyang formation reveals the whole processes from development to death of the lake basin and its sedimentary facies differ in different structural locations. Analyses about sedimentary facies and paleocurrent orientations in association with researches about the positive tectonic units such as Dayetou horseback and Chaigou horst indicate that Laiyang sag is a relatively independent sedimentary unit that shows great water depth typical of deep lake or semideep lake and was controlled by Wulongcun fault during the deposition period of Laiyang formation. Its sediments mainly originated from Jiaobei uplift area and Dayetou horseback. Gaomi-Zhucheng sag was a fast-filled basin controlled by Wurong fault and Yishu fault zone, being high in the northeast and low in the northwest and characterized by the development of pluvial facies and fluvial facies in most areas, and with the development of lake facies being limited to local low-lying regions. Selection of advantageous hydrocarbon reservoir areas for exploration purpose mainly relies on the sedimentation pattern of prototype basin and conservation conditions. The central-west area of Laiyang sag covered by overlying Laiyang formation is the most advantageous exploration area.
文摘From October 1935 when the Central Red Army arrived in northern Shaanxi to March 1948 when the Central Committee of the Communist Party of China crossed the Yellow River,the Communist Party of China inspired ordinary party members' political participation consciousness through rectification and seeking the opinions of non-party individuals,and stimulated the political participation enthusiasm of democracy activists through the special election to improve farmers' political participation awareness,in order to form a unique " Yan'an democratic model",which greatly accelerated the victory of the resistance war and accumulated rich experience for democratic construction.
基金funded by National Key R&D Program of China(2022YFA1304204)Agricultural Science and Technology Innovation Program(CAAS-ASTIP-2017-FRI-04)Beijing Innovation Consortium of livestock Research System(BAIC05-2023)。
文摘Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this effect.Moreover,no significant differences were observed in rumen fermentation parameters and serum indices between the two groups.Conclusions The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.
基金supported in part by the Japan Agency for Medical Research and Development (AMED) under grant number JP20ek0410073, JP23ek0410108, JP22ek0410100, AMEDCREST under grant number JP19gm1210008 and AMED-PRIME under grant number JP21gm6310029, the AMED Japan Initiative for World leading Vaccine Research and Development Centers (JP223fa627001)Japan Society for the Promotion of Science (JSPS): Scientific Research S (21H05046), Scientific Research B (21H03104, 22H03195, and 22H02844) and Challenging Research (20K21515 and 21K18254)+3 种基金the JST FOREST Program (JPMJFR2261, JPMJFR205Z)Y.A. was supported by a JSPS Research Fellowship for Young Scientists (23KJ1949)Japanese Society for Immunology (JSI)Kibou Scholarship for Doctoral Students in Immunology。
文摘The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.
基金supports from the National Natural Science Foundation of China(12074123,12174108)the Foundation of‘Manufacturing beyond limits’of Shanghai‘Talent Program'of Henan Academy of Sciences.
文摘Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than the diffraction limit,making it a useful method for efficient nanomanufacturing.However,compared with the low-spatial-frequency LIPSS(LSFL),the structure size of the HSFL is smaller,and it is more easily submerged.Therefore,the formation mechanism of HSFL is complex and has always been a research hotspot in this field.In this study,regular LSFL with a period of 760 nm was fabricated in advance on a silicon surface with two-beam interference using an 800 nm,50 fs femtosecond laser.The ultrafast dynamics of HSFL formation on the silicon surface of prefabricated LSFL under single femtosecond laser pulse irradiation were observed and analyzed for the first time using collinear pump-probe imaging method.In general,the evolution of the surface structure undergoes five sequential stages:the LSFL begins to split,becomes uniform HSFL,degenerates into an irregular LSFL,undergoes secondary splitting into a weakly uniform HSFL,and evolves into an irregular LSFL or is submerged.The results indicate that the local enhancement of the submerged nanocavity,or the nanoplasma,in the prefabricated LSFL ridge led to the splitting of the LSFL,and the thermodynamic effect drove the homogenization of the splitting LSFL,which evolved into HSFL.
基金supported by the National Natural Science Foundation of China(Grants:42204006,42274053,42030105,and 41504031)the Open Research Fund Program of the Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,China(Grants:20-01-03 and 21-01-04)。
文摘Singular spectrum analysis is widely used in geodetic time series analysis.However,when extracting time-varying periodic signals from a large number of Global Navigation Satellite System(GNSS)time series,the selection of appropriate embedding window size and principal components makes this method cumbersome and inefficient.To improve the efficiency and accuracy of singular spectrum analysis,this paper proposes an adaptive singular spectrum analysis method by combining spectrum analysis with a new trace matrix.The running time and correlation analysis indicate that the proposed method can adaptively set the embedding window size to extract the time-varying periodic signals from GNSS time series,and the extraction efficiency of a single time series is six times that of singular spectrum analysis.The method is also accurate and more suitable for time-varying periodic signal analysis of global GNSS sites.
基金Under the auspices of National Key R&D Program of China(No.2019YFC1510203)National Natural Science Foundation of China(No.42171101,41871028)。
文摘Against the background of global warming,research on the spatial distribution of high-temperature risk is of great significance to effectively prevent the adverse effects of high temperatures.By using air temperature data from 1951 to 2018 measured by meteorological stations located in the Yangtze River Delta urban agglomeration,the daily maximum air temperature distribution is interpolated at a resolution of 1 km based on the local thin disk smooth spline function;the high-temperature threshold for return periods of 5,10,20 and 30 yr are then calculated by using the generalized extreme value method.The yearly average high-temperature intensity and high-temperature days are finally calculated as high-temperature danger factors.Socioeconomic statistical data and remotely sensed image data in 2018 are used as the background data to calculate the spatial distribution of high-temperature vulnerability factors and prevention capacity factors,which are then used to compute the high-temperature risk index during different recurrence periods in the Yangtze River Delta urban agglomerations.The results show that the spatial distribution features of high-temperature risk in different return periods are similar.The high-temperature risk index gradually increases from northeast to southwest and from east coast to inland,which has obvious latitude variation characteristics and a relationship with the comprehensive influence of the underlying surface and urban scale.In terms of time variation,the high-temperature risk index and its spatial distribution difference gradually decreases with increasing return period.In different cities,the high-temperature risk in the central area of the city is generally higher than that in the surrounding suburban areas.Jinhua,Hangzhou of Zhejiang Province and Xuancheng of Anhui Province are the top three cities with high-temperature risk in the study area.
文摘In this paper,we address the stability of periodic solutions of piecewise smooth periodic differential equations.By studying the Poincarémap,we give a sufficient condition to judge the stability of a periodic solution.We also present examples of some applications.
基金supported by the National Natural Science Foundation of China(82025011,82220108018,82270981,82100975,82201078)the National Key R&D Program of China(2021YFC2400405)+1 种基金the Fundamental Research Funds for the Central Universities(2042023kfyq022042022dx0003).
文摘Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss.With the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption.CD301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone regeneration.However,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain elusive.In this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)macrophages.We first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA sequencing.Moreover,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)macrophages.The single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in macrophages.The following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis progressed.Furthermore,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in periodontitis.Additionally,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages phenotype.In a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.
