AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career...AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career plans.METHODS:This is a cross-sectional study.A questionnaire on the perception of the ophthalmic exam was sent via SurveyMonkey to ophthalmology residents throughout Israel.Eighty of them(one-half of all ophthalmology residents in 2019)completed it.The first part related to how they perceived each component of the ophthalmic evaluation.The second part related to their future fellowship plans.The Chi-squared test was used to compare categorical variables and Student’s t-test and One-way ANOVA were used to compare continuous variables.Multivariate logistic regression analysis was applied as needed to detect interactions between variables and to exclude confounder effects.RESULTS:Slit-lamp examination of the anterior and posterior segments ranked as the most likeable aspects,whereas gonioscopy,ocular motility examination and visual acuity assessment were least likeable.Anterior segment and retina subspecialties were the ones most sought after.Forty-nine respondents(61.3%)noted a direct correlation between their preferred parts of comprehensive ophthalmic evaluations and their choice of subspecialty.Perceptions of selected components of those evaluations were significantly associated with responders’intentions to pursue anterior segment,retina,or oculoplastic fellowships(P<0.05).CONCLUSION:Perspectives of residents toward the ophthalmic examination,and most specifically its individual components,play an important role in their choice of subspecialty training.展开更多
This paper analyzes the current status,technological developments,academic exchange platforms,and future challenges and solutions in the field of intelligent ophthalmology(IO)in China.In terms of technology,significan...This paper analyzes the current status,technological developments,academic exchange platforms,and future challenges and solutions in the field of intelligent ophthalmology(IO)in China.In terms of technology,significant progress has been made in various areas,including diabetic retinopathy,fundus image analysis,quality assessment of medical artificial intelligence products,clinical research methods,technical evaluation,and industry standards.Researchers continually enhance the safety and standardization of IO technology by formulating a series of clinical application guidelines and standards.The establishment of domestic and international academic exchange platforms provides extensive collaboration opportunities for professionals in various fields,and various academic journals serve as publication platforms for IO research.However,challenges such as technological innovation,data privacy and security,lagging regulations,and talent shortages still pose obstacles to future development.To address these issues,future efforts should focus on strengthening technological research and development,regulatory framework construction,talent cultivation,and increasing patient awareness and acceptance of new technologies.By comprehensively addressing these challenges,IO in China is poised to further lead the industry’s development on a global scale,bringing more innovation and convenience to the field of ophthalmic healthcare.展开更多
Our goal as medical educators is for our students to learn what they need to know and competently perform ophthalmic procedures.In addition,the students need to have good communication skills and behave professionally...Our goal as medical educators is for our students to learn what they need to know and competently perform ophthalmic procedures.In addition,the students need to have good communication skills and behave professionally and ethically(1,2).Most medical educators are not taught how to teach but rather learn by role-modeling their mentors.This can be good or bad depending on the mentor!In addition,the amount of knowledge and numbers of surgical procedures is ever increasing and yet,in most countries,the amount of time to train and become competent is not changing.Thus,our goal of creating competent ophthalmologists is ever more challenging.展开更多
Objective:To analyze the status of ophthalmology drug clinical trial institutions in China following the implementation of the registration system and provide a reference for their development.Methods:An analysis was ...Objective:To analyze the status of ophthalmology drug clinical trial institutions in China following the implementation of the registration system and provide a reference for their development.Methods:An analysis was conducted using data from the Drug Clinical Trial Institution Registration Management Information Platform and the Drug Clinical Trial Registration and Information Publicity Platform of the National Medical Products Administration.The search period was up to April 19,2024.Results:As of April 19,2024,314 ophthalmology-specific institutions were registered nationwide,comprising 274 comprehensive medical institutions and 40 specialized ophthalmology institutions,representing a 245%increase compared to the qualification certification phase.There were 965 major researchers in ophthalmology,accounting for 6.3%of the total number of researchers across all registered ophthalmology institutions.These institutions were predominantly located in economically developed areas such as Guangdong,Zhejiang,and Jiangsu Provinces,with the top five provinces and cities comprising 39.8%of the total registered institutions.Beijing had the highest number of major researchers(126),with their distribution positively correlated with the geographic spread of registered institutions.Furthermore,as of April 19,2024,there were 216 clinical drugs related to eye diseases,with the top three provinces conducting 77.8%of national clinical trial projects.The number of institutions was directly proportional to the volume of clinical trials conducted.Conclusion:The implementation of the registration system has facilitated the release of ophthalmic medical resources.However,regional disparities remain in the number of ophthalmology-specific institutions,the availability of major investigators,and the distribution of clinical trial projects.展开更多
目的:探索全球关于外泌体在眼科中研究、热点及趋势,以期为今后该领域的相关研究提供理论依据和建设性的参考,促进该研究领域的深入发展。方法:检索中国知网(CNKI)数据库、Web of Science(WOS)核心合集数据库以及PubMed数据库自建库至20...目的:探索全球关于外泌体在眼科中研究、热点及趋势,以期为今后该领域的相关研究提供理论依据和建设性的参考,促进该研究领域的深入发展。方法:检索中国知网(CNKI)数据库、Web of Science(WOS)核心合集数据库以及PubMed数据库自建库至2024-05-20已发表的关于外泌体在眼科中的研究相关文献,并通过CiteSpace 6.3.R1和VOSviewer等软件对发文国家、发文机构、研究作者、高频关键词、爆点关键词及时间线等内容进行可视化分析。结果:纳入中文文献37篇,英文文献548篇。全球发文量位于前5位的国家分别为美国(130)、中国(80)、韩国(24)、英国(20篇)和日本(19篇),国外前3位发文机构分别为University of California System、Duke University(杜克大学)、Harvard University,国内前3位发文机构分别为青岛大学、暨南大学附属第一医院眼科、北京师范大学体育与运动学院。中英文高频关键词和爆点关键词的分析结果显示,全球外泌体在眼科的研究热点中文高频词主要集中在干眼、细胞外囊泡、间充质干细胞、间充质干细胞来源外泌体、眼表疾病、眼表炎症、生物标志物、视网膜保护、免疫性眼病、葡萄膜炎、退行性眼病、黄斑变性、糖尿病视网膜病变、新生血管、甲状腺相关眼病、青光眼等方面;英文高频词主要集中在dry eye、dry eye disease、delivery、regenerative medicine、uveal melanoma、protein及transplantation等方面,外泌体在眼科的研究从最初的基础生物学研究,逐步向眼部疾病发病机制的探索以及作为新兴的诊断和治疗手段方向过渡。结论:近5 a来外泌体在眼科领域的研究迅速开展,外泌体作为新的生物标志物或潜在治疗靶点,在眼科疾病中的发病机制和临床应用前景成为主流研究热点,其在眼科疾病的诊断、治疗和预防将是外泌体未来新的研究方向。展开更多
The rapid development of artificial intelligence (AI) technology is profoundly reshaping all walks of life, especially in the medical field. AI provides innovative tools for medical diagnosis, treatment, and managemen...The rapid development of artificial intelligence (AI) technology is profoundly reshaping all walks of life, especially in the medical field. AI provides innovative tools for medical diagnosis, treatment, and management and lays a solid foundation for personalized medicine and precision medicine. This paper reviews the latest progress in the application of AI technologies such as machine learning (ML) and deep learning (DL) in ophthalmic diseases.展开更多
BACKGROUND Luscan-Lumish syndrome(LLS)is a rare genetic congenital anomaly syndrome characterised by neurodevelopmental disorders,including delayed psychomotor development,behavioral difficulties,relative or true macr...BACKGROUND Luscan-Lumish syndrome(LLS)is a rare genetic congenital anomaly syndrome characterised by neurodevelopmental disorders,including delayed psychomotor development,behavioral difficulties,relative or true macrocephaly and,in individual cases,ocular abnormalities.This paper aims to present the case of a child with ocular abnormalities associated with LLS.CASE SUMMARY A 10-year-old girl born at 40 weeks gestation with features of dysmorphia,neurodevelopmental disorders,genetically confirmed LLS,convergent strabismus and suspected congenital glaucoma.Eye examination,ultrasound,optical coherence tomography(OCT),perimetry and electrophysiological study[pattern visually evoked potentials(VEP)]were performed.Best-corrected distance visual acuity was 0.5 in the right eye(correction-1.0 Dsph,-1.0 Dcyl,axis 180°)and 0.62 in the left eye(correction-2.0 Dsph).Near visual acuity(Snellen Chart)with the above correction was-0.5 D.A cycloplegic refraction test yielded-1.25 Dsph,-1.25 Dcyl,axis 165°in the right eye,and-2.0 Dsph,-0.25 Dcyl,axis 154°in the left eye.Intraocular pressure was 15 mmHg in both eyes.OCT of the maculae showed no abnormalities.In both eyes,the average ganglion cell layer and inner plexiform layer thickness was 73μm.OCT of the optic nerve disc showed an average retinal nerve fibre layer thickness of 89μm in the right eye and 81μm in the left eye,with symmetry of 90%.The rim area was 1.59 mm^(2) and 1.74 mm^(2) in the right and left eye,respectively.The disc area was 2.77 mm^(2) in the right eye and 2.89 mm^(2) in the left.The average cup-to-disc ratio was 0.64 in the right eye and 0.62 in the left eye.Ocular ultrasound depicted single extra echoes inside the vitreous chamber;otherwise,there were no abnormalities.Right and left eyeball lengths were 24.59 mm and 24.51 mm,respectively.Kinetic perimetry revealed no visual field defects,while static testing showed single relative scotomas.The mean defect was 4.7 dB in the right and 2.6 dB in the left eye.The loss variance values were 4.8 and 3.8 dB for the right and left eye,respectively.Pattern VEP test revealed normal values of P100 Latency.Wave amplitude in the right eye was 50%at a visual angle of 1.0°and 30%at 15’.Due to the rarity of LLS,it seems interesting to present the child ophthalmological examination with changes in the electrophysiological examination.CONCLUSION Although eye abnormalities are infrequently described in children with LLS,the patients should undergo eye examinations,especially as they may have central nervous system anomalies that may give rise to visual impairments.Generally,children with genetically determined congenital syndromes should receive regular ophthalmic check-ups for a thorough evaluation of the eyes and prognosis of the development of visual function.展开更多
文摘AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career plans.METHODS:This is a cross-sectional study.A questionnaire on the perception of the ophthalmic exam was sent via SurveyMonkey to ophthalmology residents throughout Israel.Eighty of them(one-half of all ophthalmology residents in 2019)completed it.The first part related to how they perceived each component of the ophthalmic evaluation.The second part related to their future fellowship plans.The Chi-squared test was used to compare categorical variables and Student’s t-test and One-way ANOVA were used to compare continuous variables.Multivariate logistic regression analysis was applied as needed to detect interactions between variables and to exclude confounder effects.RESULTS:Slit-lamp examination of the anterior and posterior segments ranked as the most likeable aspects,whereas gonioscopy,ocular motility examination and visual acuity assessment were least likeable.Anterior segment and retina subspecialties were the ones most sought after.Forty-nine respondents(61.3%)noted a direct correlation between their preferred parts of comprehensive ophthalmic evaluations and their choice of subspecialty.Perceptions of selected components of those evaluations were significantly associated with responders’intentions to pursue anterior segment,retina,or oculoplastic fellowships(P<0.05).CONCLUSION:Perspectives of residents toward the ophthalmic examination,and most specifically its individual components,play an important role in their choice of subspecialty training.
基金Supported by National Nature Science Foundation of China(No.62306254)SanMing Project of Medicine in Shenzhen(No.SZSM202311012)+1 种基金Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZGSP014)Shenzhen Science and Technology Program(No.KCXFZ20211020163813019).
文摘This paper analyzes the current status,technological developments,academic exchange platforms,and future challenges and solutions in the field of intelligent ophthalmology(IO)in China.In terms of technology,significant progress has been made in various areas,including diabetic retinopathy,fundus image analysis,quality assessment of medical artificial intelligence products,clinical research methods,technical evaluation,and industry standards.Researchers continually enhance the safety and standardization of IO technology by formulating a series of clinical application guidelines and standards.The establishment of domestic and international academic exchange platforms provides extensive collaboration opportunities for professionals in various fields,and various academic journals serve as publication platforms for IO research.However,challenges such as technological innovation,data privacy and security,lagging regulations,and talent shortages still pose obstacles to future development.To address these issues,future efforts should focus on strengthening technological research and development,regulatory framework construction,talent cultivation,and increasing patient awareness and acceptance of new technologies.By comprehensively addressing these challenges,IO in China is poised to further lead the industry’s development on a global scale,bringing more innovation and convenience to the field of ophthalmic healthcare.
文摘Our goal as medical educators is for our students to learn what they need to know and competently perform ophthalmic procedures.In addition,the students need to have good communication skills and behave professionally and ethically(1,2).Most medical educators are not taught how to teach but rather learn by role-modeling their mentors.This can be good or bad depending on the mentor!In addition,the amount of knowledge and numbers of surgical procedures is ever increasing and yet,in most countries,the amount of time to train and become competent is not changing.Thus,our goal of creating competent ophthalmologists is ever more challenging.
文摘Objective:To analyze the status of ophthalmology drug clinical trial institutions in China following the implementation of the registration system and provide a reference for their development.Methods:An analysis was conducted using data from the Drug Clinical Trial Institution Registration Management Information Platform and the Drug Clinical Trial Registration and Information Publicity Platform of the National Medical Products Administration.The search period was up to April 19,2024.Results:As of April 19,2024,314 ophthalmology-specific institutions were registered nationwide,comprising 274 comprehensive medical institutions and 40 specialized ophthalmology institutions,representing a 245%increase compared to the qualification certification phase.There were 965 major researchers in ophthalmology,accounting for 6.3%of the total number of researchers across all registered ophthalmology institutions.These institutions were predominantly located in economically developed areas such as Guangdong,Zhejiang,and Jiangsu Provinces,with the top five provinces and cities comprising 39.8%of the total registered institutions.Beijing had the highest number of major researchers(126),with their distribution positively correlated with the geographic spread of registered institutions.Furthermore,as of April 19,2024,there were 216 clinical drugs related to eye diseases,with the top three provinces conducting 77.8%of national clinical trial projects.The number of institutions was directly proportional to the volume of clinical trials conducted.Conclusion:The implementation of the registration system has facilitated the release of ophthalmic medical resources.However,regional disparities remain in the number of ophthalmology-specific institutions,the availability of major investigators,and the distribution of clinical trial projects.
文摘目的:探索全球关于外泌体在眼科中研究、热点及趋势,以期为今后该领域的相关研究提供理论依据和建设性的参考,促进该研究领域的深入发展。方法:检索中国知网(CNKI)数据库、Web of Science(WOS)核心合集数据库以及PubMed数据库自建库至2024-05-20已发表的关于外泌体在眼科中的研究相关文献,并通过CiteSpace 6.3.R1和VOSviewer等软件对发文国家、发文机构、研究作者、高频关键词、爆点关键词及时间线等内容进行可视化分析。结果:纳入中文文献37篇,英文文献548篇。全球发文量位于前5位的国家分别为美国(130)、中国(80)、韩国(24)、英国(20篇)和日本(19篇),国外前3位发文机构分别为University of California System、Duke University(杜克大学)、Harvard University,国内前3位发文机构分别为青岛大学、暨南大学附属第一医院眼科、北京师范大学体育与运动学院。中英文高频关键词和爆点关键词的分析结果显示,全球外泌体在眼科的研究热点中文高频词主要集中在干眼、细胞外囊泡、间充质干细胞、间充质干细胞来源外泌体、眼表疾病、眼表炎症、生物标志物、视网膜保护、免疫性眼病、葡萄膜炎、退行性眼病、黄斑变性、糖尿病视网膜病变、新生血管、甲状腺相关眼病、青光眼等方面;英文高频词主要集中在dry eye、dry eye disease、delivery、regenerative medicine、uveal melanoma、protein及transplantation等方面,外泌体在眼科的研究从最初的基础生物学研究,逐步向眼部疾病发病机制的探索以及作为新兴的诊断和治疗手段方向过渡。结论:近5 a来外泌体在眼科领域的研究迅速开展,外泌体作为新的生物标志物或潜在治疗靶点,在眼科疾病中的发病机制和临床应用前景成为主流研究热点,其在眼科疾病的诊断、治疗和预防将是外泌体未来新的研究方向。
文摘The rapid development of artificial intelligence (AI) technology is profoundly reshaping all walks of life, especially in the medical field. AI provides innovative tools for medical diagnosis, treatment, and management and lays a solid foundation for personalized medicine and precision medicine. This paper reviews the latest progress in the application of AI technologies such as machine learning (ML) and deep learning (DL) in ophthalmic diseases.
文摘BACKGROUND Luscan-Lumish syndrome(LLS)is a rare genetic congenital anomaly syndrome characterised by neurodevelopmental disorders,including delayed psychomotor development,behavioral difficulties,relative or true macrocephaly and,in individual cases,ocular abnormalities.This paper aims to present the case of a child with ocular abnormalities associated with LLS.CASE SUMMARY A 10-year-old girl born at 40 weeks gestation with features of dysmorphia,neurodevelopmental disorders,genetically confirmed LLS,convergent strabismus and suspected congenital glaucoma.Eye examination,ultrasound,optical coherence tomography(OCT),perimetry and electrophysiological study[pattern visually evoked potentials(VEP)]were performed.Best-corrected distance visual acuity was 0.5 in the right eye(correction-1.0 Dsph,-1.0 Dcyl,axis 180°)and 0.62 in the left eye(correction-2.0 Dsph).Near visual acuity(Snellen Chart)with the above correction was-0.5 D.A cycloplegic refraction test yielded-1.25 Dsph,-1.25 Dcyl,axis 165°in the right eye,and-2.0 Dsph,-0.25 Dcyl,axis 154°in the left eye.Intraocular pressure was 15 mmHg in both eyes.OCT of the maculae showed no abnormalities.In both eyes,the average ganglion cell layer and inner plexiform layer thickness was 73μm.OCT of the optic nerve disc showed an average retinal nerve fibre layer thickness of 89μm in the right eye and 81μm in the left eye,with symmetry of 90%.The rim area was 1.59 mm^(2) and 1.74 mm^(2) in the right and left eye,respectively.The disc area was 2.77 mm^(2) in the right eye and 2.89 mm^(2) in the left.The average cup-to-disc ratio was 0.64 in the right eye and 0.62 in the left eye.Ocular ultrasound depicted single extra echoes inside the vitreous chamber;otherwise,there were no abnormalities.Right and left eyeball lengths were 24.59 mm and 24.51 mm,respectively.Kinetic perimetry revealed no visual field defects,while static testing showed single relative scotomas.The mean defect was 4.7 dB in the right and 2.6 dB in the left eye.The loss variance values were 4.8 and 3.8 dB for the right and left eye,respectively.Pattern VEP test revealed normal values of P100 Latency.Wave amplitude in the right eye was 50%at a visual angle of 1.0°and 30%at 15’.Due to the rarity of LLS,it seems interesting to present the child ophthalmological examination with changes in the electrophysiological examination.CONCLUSION Although eye abnormalities are infrequently described in children with LLS,the patients should undergo eye examinations,especially as they may have central nervous system anomalies that may give rise to visual impairments.Generally,children with genetically determined congenital syndromes should receive regular ophthalmic check-ups for a thorough evaluation of the eyes and prognosis of the development of visual function.
