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Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats 被引量:4
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作者 Teng Liu Ming-Wei Zhong +5 位作者 Yi Liu Xin Huang Yu-Gang Cheng Ke-Xin Wang Shao-Zhuang Liu San-Yuan Hu 《World Journal of Gastroenterology》 SCIE CAS 2017年第18期3269-3278,共10页
AIM To investigate the effects of sleeve gastrectomy plus trunk vagotomy(SGTV) compared with sleeve gastrectomy(SG) in a diabetic rat model.METHODS SGTV, SG, TV and Sham operations were performed on rats with diabetes... AIM To investigate the effects of sleeve gastrectomy plus trunk vagotomy(SGTV) compared with sleeve gastrectomy(SG) in a diabetic rat model.METHODS SGTV, SG, TV and Sham operations were performed on rats with diabetes induced by high-fat diet and streptozotocin. Body weight, food intake, oral glucose tolerance test, homeostasis model assessment of insulin resistance(HOMA-IR), hepatic insulin signaling(IR, IRS1, IRS2, PI3 K and AKT), oral glucose stimulatedinsulin secretion, GLP-1 and ghrelin were compared at various postoperative times.RESULTS Both SG and SGTV resulted in better glucose tolerance, lower HOMA-IR, up-regulated hepatic insulin signaling, higher levels of oral glucose-stimulated insulin secretion, higher postprandial GLP-1 and lower fasting ghrelin levels than the TV and Sham groups. No significant differences were observed between the SG and SGTV groups. In addition, no significant differences were found between the TV and Sham groups in terms of glucose tolerance, HOMA-IR, hepatic insulin signaling, oral glucose-stimulated insulin secretion, postprandial GLP-1 and fasting ghrelin levels. No differences in body weight and food intake were noted between the four groups.CONCLUSION SGTV is feasible for diabetes control and is independent of weight loss. However, SGTV did not result in a better improvement in diabetes than SG alone. 展开更多
关键词 Sleeve gastrectomy Trunk vagotomy Glucose metabolism GLP-1 GHRELIN
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Pseudoachalasia in a patient after truncal vagotomy surgery successfully treated by subsequent pneumatic dilations 被引量:2
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作者 Seng-Kee Chuah Chung-Mou Kuo +10 位作者 Keng-Liang Wu Chi-Sin Changchien Tsung-Hui Hu Chi-Chih Wang Yi-Chun Chiu Yeh-Pin Chou Pin-I Hsu King-Wah Chiu Chung-Huang Kuo Shue-Shian Chiou Chuan-Mo Lee 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第31期5087-5090,共4页
Pseudoachalasia is a difficult condition for the clinician to differentiate from idiopathic achalasia even by manometry, radiological studies or endoscopy. Its etiology is usually associated with tumors. In most cases... Pseudoachalasia is a difficult condition for the clinician to differentiate from idiopathic achalasia even by manometry, radiological studies or endoscopy. Its etiology is usually associated with tumors. In most cases, the diagnosis is made after surgical explorations. The proposed pathogenesis of the disease is considered as mechanical obstruction of the distal esophagus or infiltration of the malignancy that affects the inhibitory neurons of the meyenteric plexus in the majority of cases. Surgery has been reported as a cause of pseudoachalasia. We report a 70-year-old man who suffered from deglutination disorder caused by pseudo-achalasia after truncal vagotomy. The patient was symptom-free after a nine-year follow-up and complete recovery of esophageal motility status from pseudoachalasia after pneumatic dilations. We also reviewed the literature of pseudoachalasia. 展开更多
关键词 Truncal vagotomy Pseudo-achalasia Deglutination disorder Pneumatic dilations Sustain reversed esophageal motility
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Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy 被引量:6
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作者 Hyung Hun Kim Moo In Park +4 位作者 Sang Ho Lee Hyun Yong Hwang Sung Eun Kim Seun Ja Park Won Moon 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第30期4044-4050,共7页
AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy d... AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36. 展开更多
关键词 Peptide YY Ghrelin vagotomy Gastrectomy Body weight
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Subdiaphragmatic vagotomy reduces intake of sweet-tasting solutions in rats 被引量:1
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作者 Enshe Jiang Dongming Yu Zhifen Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第17期1560-1567,共8页
Studies have shown that there are strong interactions between gustatory and visceral sensations the central nervous system when rats ingest sweet foods or solutions. To investigate the role of th subdiaphragmatic vagi... Studies have shown that there are strong interactions between gustatory and visceral sensations the central nervous system when rats ingest sweet foods or solutions. To investigate the role of th subdiaphragmatic vagi in transmitting general visceral information during the process of drinking sweet-tasting solutions, we examined the effects of subdiaphragmatic vagotomy on the intake of 0.5 mol/L sucrose, 0.005 mol/L saccharin or distilled water over the course of 1 hour in rats depriv~ of water. Results showed no significant difference in consumption of these three solutions in vagotomized rats. However, rats in the sham-surgery group drank more saccharin solution than sucrose solution or distilled water. Moreover, the intake of distilled water was similar between vagotomized rats and sham-surgery group rats, but significantly less sucrose and saccharin were consumed by vagotomized rats compared with rats in the sham-surgery group. These findings indicate that subdiaphragmatic vagotomy reduces intake of sweet-tasting solution in rats, and suggest that vagal and extravagal inputs play a balanced role in the control of the intake of sweet-tasting solutions. They also suggest that subdiaphragmatic vagotomy eliminates the difference in hedonic perception induced by sweet-tasting solutions compared with distilled water II E 展开更多
关键词 neural regeneration peripheral nerve injury sweet taste visceral sensation vagotomy nucleus ofsolitary tract parabrachial nucleus INTAKE HEDONIC grants-supported paper NEUROREGENERATION
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Studies on histological features and motor functions of gastric antrum after high selective vagotomy associated with mucosal antrectomy in dogs 被引量:1
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作者 王代科 鄢俊 李维苏 《Journal of Medical Colleges of PLA(China)》 CAS 1996年第2期118-122,共5页
Studiesonhistologicalfeaturesandmotorfunctionsofgastricantrumafterhighselectivevagotomyassociatedwithmucosal... StudiesonhistologicalfeaturesandmotorfunctionsofgastricantrumafterhighselectivevagotomyassociatedwithmucosalantrectomyindogsW... 展开更多
关键词 highly SELECTIVE vagotomy MUCOSAL antrectomy HISTOLOGY MOTOR function DOGS
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Effects of highly selective vagotomy plus resection of antral mucosa or highly selective vagotomy alone on motility function of pyloric antrum
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作者 文亚渊 王代科 刘宝华 《Journal of Medical Colleges of PLA(China)》 CAS 2004年第4期238-240,共3页
Objective: To study the effects of highly selective vagotomy plus resection of antral mucosa (HSV+RAM) or highly selective vagotomy (HSV) alone on the motility function of the pyloric antrum. Methods: 48 patients with... Objective: To study the effects of highly selective vagotomy plus resection of antral mucosa (HSV+RAM) or highly selective vagotomy (HSV) alone on the motility function of the pyloric antrum. Methods: 48 patients with duodenal ulcer were studied. 18 dogs were employed as experimental animals. 20 patients were operated on with HSV and 28 with HSV+RAM. The frequency of gastric evacuation and the amplitude of electrogastrography were determined 4 to 6 months after operation. 18 dogs were divided into the control group, HSV group and HSV+RAM group. The time of gastric evacuation, antral myoelectric activity and antral pressure were determined in the dogs 4 to 6 months after operation. The preoperative findings of the patients and the control dogs served as the control. Results: After operation, barium meal revealed that the shape of the stomach and duodenum was normal and the gastric peristalsis was clearly visible in human patients and experimental dogs. In the HSV+RAM group of dogs, the initial evacuation time was (5.0+0.06) min and the time of complete evacuation was (4.0+0.4) h after food-taking, which were similar to those of the control and the HSV group of dogs (P>0.05). The frequency of the antral myoelectric action potential was (3.11+0.65) cycles/min in the dog HAS+RAM group and the frequency of electrogastrography was (3.25+0.75) cycles/min in the human HSV+RAM group, which were significantly lower than those of the control and the dog and human HSV groups (P<0.05). Injection of pentagastrin in dogs and food-taking in human beings significantly increased the antral pressure and the amplitude and frequency of electrogastrography. Conclusion: The findings of this study suggest that the motility function of the reconstructed pyloric antrum in the HSV+RAM group of both the experimental dogs and human patients approaches to the normal even though there is a decrease of antral myoelectric frequency. It is suggested that HSV+RAM should be the first choice for the surgical management of duodenal ulcer. 展开更多
关键词 highly selective vagotomy RESECTION antral mocusa motility function ELECTROGASTROGRAPHY dog
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Surgical Management of Perforated Peptic Ulcer;Closure with Omental Patch versus Definitive Repair with Vagotomy and Gastrojejunostomy: A Comparative Study
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作者 Walid A. Mawla Ibrahim A. Heggy +5 位作者 Gamal Osman Loay M. Gertallah Marwan N. Elgohary Ahmed S. Allam Ahmed M. Elsayed Heba F. Tantawy 《Surgical Science》 2019年第9期316-327,共12页
Background: The perforation of peptic ulcer is a common and serious life threatening surgical emergency. Up-till now no consensus was reached regarding the best practice in management of perforated peptic ulcer. The a... Background: The perforation of peptic ulcer is a common and serious life threatening surgical emergency. Up-till now no consensus was reached regarding the best practice in management of perforated peptic ulcer. The aim of this study is to evaluate and compare between both management strategies of perforated peptic ulcer;performing simple closure of the perforation with an omental patch then H. pylori eradication and inhibition of acid secretion using long time proton pump inhibitors versus performing definitive repair of perforated peptic ulcer (closure of the perforation with an omental patch, truncal vagotomy and gastrojejunostomy to discover a proper management strategy of perforated peptic ulcer. Patients and Methods: In the current study we included 30 patients which were divided into 2 groups: group 1 included 15 patients where we managed them by simple closure of the perforation with an omental patch then H. pylori eradication and inhibition of acid secretion using long time proton pump inhibitors and group 2 included 15 patients where we performed closure of the perforation with an omental patch, truncal vagotomy and gastrojejunostomy. Results: We found that younger patient underwent vagotomy and gastro-jejunostomy technique (p Conclusions: Peptic ulcer perforation could be safely managed by primary closure and covering by omentum in addition to medical treatment of H. pylori infection and inhibition of acid secretion especially in old patients with comorbid condition who presented late or with shock. 展开更多
关键词 Perforated PEPTIC ULCER OMENTAL PATCH vagotomy GASTROJEJUNOSTOMY
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Comparative study on highly selective vagotomy and its combination with mucosal antrectomy in treatment of duodenal ulcer
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作者 文亚渊 王代科 刘宝华 《Journal of Medical Colleges of PLA(China)》 CAS 2001年第3期203-205,共3页
Objective:To comparethe therapeuticeffectsof highly selectivevagotomyand mucosalantrectomy(HSV-MA)withthosesingleHSVon48casesof duodenalulcerinorderto confirmthatHSVcouldnotresultinhyper-gastrinemiaandulcerrecurrence.... Objective:To comparethe therapeuticeffectsof highly selectivevagotomyand mucosalantrectomy(HSV-MA)withthosesingleHSVon48casesof duodenalulcerinorderto confirmthatHSVcouldnotresultinhyper-gastrinemiaandulcerrecurrence.Methods:Forty-eightpatientswithduodenalulcerwerecarefullyexamined.Randomly,28of themwereoperatedon withHSV-MAand20withsimpleHSV.Postoperatively,thelevelof gastricacid,serumgas-trinandthepositiverateof helicobacter pylori(Hp)weredetermined.Results:It was foundthatthelevelof gastricacid was significantlylowerin thepostoperativeperiodsof theHSV-MAandsimpleHSVgroupsthanin thepreoperative stage;thelevelof serumgastrinwassignificantlylowerintheHSVgroupthanintheHSV-MAgrouppostoperativelyand thanin thepreoperativestage.Thepositiverateof Hpinfectionwas markedreducedin theHSV-MAgroupthanin the casesof preoperativestage.Conclusion:On thebasisof theabovementionedfindings,itis consideredthatHSV-MA wouldnotresulttheoccurrenceof ulcerrecurrenceandsuggestedthatHSV-MAis a betterapproachto treatchronicduo-denalulcer. 展开更多
关键词 vagotomy antrectomy DUODENAL ULCER
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Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22
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作者 Heng Zhou Ju-Ling Xu +4 位作者 San-Xiong Huang Ying He Xiao-Wei He Sheng Lu Bin Yao 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第12期2866-2878,共13页
BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regen... BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regeneration.It has been reported that vagus nerve signaling is beneficial to liver regeneration,but the potential mechanism at play here is not fully understood.AIM To explore the effect and mechanism of hepatic vagus nerve in liver regeneration after PHx.METHODS A PHx plus hepatic vagotomy(Hv)mouse model was established.The effect of Hv on liver regeneration after PHx was determined by comparing the liver regeneration levels of the PHx-Hv group and the PHx-sham group mice.In order to further investigate the role of interleukin(IL)-22 in liver regeneration inhibition mediated by Hv,the levels of IL-22 in the PHx-Hv group and the PHx-sham group was measured.The degree of liver injury in the PHx-Hv group and the PHx-sham group mice was detected to determine the role of the hepatic vagus nerve in liver injury after PHx.RESULTS Compared to control-group mice,Hv mice showed severe liver injury and weakened liver regeneration after PHx.Further research found that Hv downregulates the production of IL-22 induced by PHx and blocks activation of the signal transducer and activator of transcription 3(STAT3)pathway then reduces the expression of various mitogenic and anti-apoptotic proteins after PHx.Exogenous IL-22 reverses the inhibition of liver regeneration induced by Hv and alleviates liver injury,while treatment with IL-22 binding protein(an inhibitor of IL-22 signaling)reduce the concentration of IL-22 induced by PHx,inhibits the activation of the STAT3 signaling pathway in the liver after PHx,thereby hindering liver regeneration and aggravating liver injury in PHx-sham mice.CONCLUSION Hv attenuates liver regeneration after hepatectomy,and the mechanism may be related to the fact that Hv downregulates the production of IL-22,then blocks activation of the STAT3 pathway. 展开更多
关键词 INTERLEUKIN-22 Partial hepatectomy Hepatic vagotomy Liver regeneration Signal transducer and activator of transcription 3 Interleukin-22 binding protein
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Effect of Vagotomy on Acute Pancreatitis in Rats
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作者 李劲松 熊炯新 +1 位作者 陈道达 田源 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2000年第3期235-238,共4页
One hundred and eighty two SD rats were randomly divided into the normal control group, fast operating group and food intake operating group. The experimental model of acute pancreatitis (AP) in rats was established... One hundred and eighty two SD rats were randomly divided into the normal control group, fast operating group and food intake operating group. The experimental model of acute pancreatitis (AP) in rats was established by injecting 5 % sodium taurocholate into the pancreatic duct of rat according to Aho's method. The sandostatin was used for positive contrast. The concentrations of serum amylase, calcium, C reaction protein (CRP) and interleukin 6 (IL 6) were assayed respectively at different time points. The pathological sections were observed. Each operating group contained 10 rats. The mortality of the operating groups was observed during the 24 h. The serum amylase level in the AP rats was reduced after receiving vagotomy (VG, P <0.05). Although the serum calcium level in most groups was decreased, the reduction in the group with VG plus sandostatin was not obvious ( P >0.05). The increase of CRP and IL 6 was not obvious after VG ( P >0.05). The change of mortality was not significant ( P >0.05). The pathological sections showed that the AP pathological change was mild after VG. The disease condition of food intake operating group was more serious than that of fast operating group. It was suggested that VG had some influence on the prognosis of AP in rats. 展开更多
关键词 vagotomy acute pancreatitis
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Reduction of gastrointestinal motility by unilateral thyroparathyroidectomy plus subdiaphragmatic vagotomy in rats
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作者 Jun Ho Lee Oh Deog Kwon +5 位作者 Seon Ho Ahn Keun Han Choi Ji Hye Park Seoul Lee Bong Kyu Choi Kyu Yong Jung 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第33期4570-4577,共8页
AIM: To investigate whether the combined methods of unilateral thyroparathyroidectomy (TPX) and subdiaphragmatic vagotomy (VAX) can be adapted for rats and used as a reliable method to produce a rat model of long-term... AIM: To investigate whether the combined methods of unilateral thyroparathyroidectomy (TPX) and subdiaphragmatic vagotomy (VAX) can be adapted for rats and used as a reliable method to produce a rat model of long-term reduction of gastrointestinal (GI) motor function. METHODS: Male Sprague-Dawley rats were randomly divided into 3 groups, normal, sham-operated and unilateral TPX plus VAX. The TPX plus VAX rats received VAX 7 d after application of TPX, and dietary intake and fecal output were then measured daily for 1 wk.After completion of the experiments, gastric emptying and small bowel transit were measured in vivo, and the contractile responses of colonic strips to excitatory and inhibitory neurotransmitters were estimated using isometric force transducers in vitro. RESULTS: In comparison with normal and sham-operated rats, rats which received unilateral TPX plus VAX showed a significant decrease in body weight and in fecal pellet number and weight throughout the entire week. Application of TPX plus VAX to rats markedly delayed gastric emptying and small bowel transit. In TPX plus VAX rats, the longitudinal muscles of the proximal colon showed a significant reduction in contractile responses to acetylcholine (5 × 10-6 mol/L), and a dramatic attenuation of contractile responses was also observed in both the longitudinal and circular muscles of the distal colon. However, the spontaneous contractility of the colonic strips from TPX plus VAX rats was not significantly affected by treatment with N-nitro-Larginine-methyl ester (0.1 mol/L). CONCLUSION: The results indicate that unilateral TPX plus VAX reduced the motor function of the GI tract in rats, and the reduced gut motility is likely mediated, at least in part, by inhibition of the excitatory neurotransmitter system. 展开更多
关键词 Unilateral thyroparathyroidectomy Subdiaphragmatic vagotomy Gastric emptying Small bowel transit Rat
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Functional Roux-en-Y Gastric Bypass (F-RYGB), with Preservation of Duodenal Access: Report of Two Revisional Cases of Sleeve Gastrectomy
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作者 Victor Ramos Mussa Dib Carlos Augusto Scussel Madalosso +3 位作者 Paulo Reis Esselin de Melo Rui Ribeiro Paula Volpe Carlos Eduardo Domene 《Surgical Science》 2024年第3期135-158,共24页
Objective: This case report aimed to demonstrate a possible neuromuscular effect of Latarjet nerves transection or truncal vagotomy, in association with sleeve gastrectomy plus antrojejunostomy, in order to reproduce ... Objective: This case report aimed to demonstrate a possible neuromuscular effect of Latarjet nerves transection or truncal vagotomy, in association with sleeve gastrectomy plus antrojejunostomy, in order to reproduce a Roux-en-Y gastric bypass (RYGB) mechanistic principles, in patients with previous Sleeve Gastrectomy (SG) who had had weight regain, with or without concomitant gastroesophageal reflux disease (GERD). Background: Sleeve gastrectomy (SG) is one of the most frequently performed bariatric operations worldwide. Nevertheless, weight regain and gastroesophageal reflux disease (GERD) have been consistently demonstrated, in association with this technique, which may require a revisional procedure. RYGB is an option in such a situation but, implies in gastrointestinal exclusions, which represents a shortcoming of this revision. Surpassing this inconvenient would be of great value for the patients. Methods: We describe herein two cases of SG revision for weight regain and GERD, with a follow-up of one year. Gastroesophageal reflux disease was evaluated by validated questionnaire, upper endoscopy, seriography, high resolution manometry (HRM) and impedance pHmetry (I-pHmetry), in the pre and postoperative periods. A re-Sleeve Gastrectomy with antrojejunal anastomosis was done in both cases, after informed consents. The Latarjet nerves were transected in one case, due to a bleeding in the left gastric vessels and a truncal vagotomy was required in the other, to appropriately treat an associated hiatal hernia. Results: In the postoperative evaluation it was observed a pyloric spasm in both cases, during seriography and endoscopy, kept until the one-year follow-up. There was unidirectional contrast flow to the gastrointestinal anastomosis, filling the jejunal limb, in radiologic contrast study. No contrast passed through the pylorus. Nonetheless, the duodenum was kept endoscopically accessible. In the one-year evaluation, weight loss was adequate and GERD resolution was obtained in both cases, confirmed by endoscopic and functional esophageal assessment, together with symptoms questionnaire. Conclusion: The association of Latarjet nerves sectioning or truncal vagotomy with re-sleeve gastrectomy plus gastrointestinal anastomosis (antrojejunal), in a revision for a failed sleeve, can represent a technical approach, to reproduce RYGB results, without exclusions and with duodenum endoscopic accessibility maintenance. It maybe could be applied for primary surgeries. Additional studies are necessary to confirm this hypothesis. 展开更多
关键词 Roux-en-Y Gastric Bypass Sleeve Gastrectomy Jejuno Gastric Bypass Vagus Nerve vagotomy Bariatric Surgery
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Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer 被引量:5
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作者 Konstantinos Demertzis Dimitrios Polymeros +3 位作者 Theodoros Emmanuel Konstantinos Triantafyllou Pericles Tassios Spiros D Ladas 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第5期791-795,共5页
AIM: To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer. METHODS: We studied 15 consecutive patients with recurrent ulcer bleeding after surgery... AIM: To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer. METHODS: We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole (20 mg/d) maintenance therapy was given after ulcer healing. In addition to clinical follow-up, ambulatory 24-h gastric pH assay was performed before and during omeprazole therapy in those patients and controls with previous duodenal ulcer surgery but no ulcer recurrence. RESULTS: All the 15 ulcers were healed after being treated with omeprazole (40 mg/d) for 2 too. Eleven patients with two (1-9) episodes of recurrent ulcer bleeding completed the follow-up (43, 12-72 too). None of them had a bleeding episode while on omeprazole. One patient discontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH 〈4 in patients was 80, 46-95%, and was reduced to 32, 13-70% by omeprazole (P= 0.002). CONCLUSION: Long-term maintenance therapy with omeprazole (20 rag/day) is effective in preventing recurrent ulcer bleeding. 展开更多
关键词 Duodenal ulcer GASTRECTOMY vagotomy OMEPRAZOLE
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Hippocampal plasticity after a vagus nerve injury in the rat 被引量:1
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作者 Giulia Ronchi Vitaly Ryu +1 位作者 Michele Fornaro Krzysztof Czaja 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第14期1055-1063,共9页
Stimulation of the vagus nerve has been previously reported to promote neural plasticity and neurogenesis in the brain. Several studies also revealed plastic changes in the spinal cord after injuries to somatosensory ... Stimulation of the vagus nerve has been previously reported to promote neural plasticity and neurogenesis in the brain. Several studies also revealed plastic changes in the spinal cord after injuries to somatosensory nerves originating from both the brachial and lumbo-sacral plexuses. However, the neurogenic responses of the brain to the injury of the viscerosensory innervation are not as yet well understood. In the present study, we investigated whether cells in the dentate gyrus of the hippocampus respond to a chemical and physical damage to the vagus nerve in the adult rat. Intraperitoneal capsaicin administration was used to damage non-myelinated vagal afferents while subdiaphragmatic vagotomy was used to damage both the myelinated and non-myelinated vagal afferents. The 5-bromo-2-deoxyuridine (BrdU) incorporation together with cell-specific markers was used to study neural proliferation in subgranular zone, granule cell layer, molecular layer and hilus of the dentate gyrus. Microglia activation was determined by quantifying changes in the intensity of fluorescent staining with a primary antibody against ionizing calcium adapter-binding molecule 1. Results revealed that vagotomy decreased BrdU incorporation in the hilus 15 days after injury compared to the capsaicin group. Capsaicin administration decreased BrdU incorporation in the granular cell layer 60 days after the treatment. Capsaicin decreased the number of doublecortin-expressing cells in the dentate gyrus, whereas vagotomy did not alter the expression of doublecortin in the hippocampus. Both the capsaicin- and the vagotomy-induced damage to the vagus nerve decreased microglia activation in the hippocampus at 15 days after the injury. At 30 days post injury, capsaicin-treated and vagotomized rats revealed significantly more activated microglia. Our findings show that damage to the subdiaphragmatic vagus in adult rats is followed by microglia activation and long-lasting changes in the dentate gyrus, leading to alteration of neurogenesis. 展开更多
关键词 vagus injury hippocampus vagotomy CAPSAICIN vagal afferents MICROGLIA RAT
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DNA Content in Pancreatic ExocrinalCells after Vagotom yand Electron Microscopy in Rats 被引量:1
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作者 LI Jinsong, CHEN Daoda , TIAN Yuan Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan 430022 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第3期226-229,共4页
Fifty six SD rats were randomly divided into the normal control group and the operation group. The operating group was subdivided into six groups on the basis of killing time (the 12th h, the first day, 3rd day, firs... Fifty six SD rats were randomly divided into the normal control group and the operation group. The operating group was subdivided into six groups on the basis of killing time (the 12th h, the first day, 3rd day, first week, 2nd week and 4th week) after vagotomy (VG). The pancreatic tissues were taken for HE and Feulgen staining. The DNA content of pancreatic exocrine cells was determined by a domestically fabricated computer image analyzing system. In the control group, on the first day or in the first week after VG, the pancreatic samples were taken for transmission electron microscopic examination. The DNA content of pancreatic exocrinal cells was decreased from 1 to 3 days after VG. The secretion was found to be in inhibitory state and One week later, it gradually restored. The results indicated that the proliferation and the function of the SD rat's pancreatic exocrinal cells were prohibited at initial stage after VG, which might be concerned, at least in part, with dominance and nutrition of vagus. 展开更多
关键词 vagotomy pancreatic exocrinal cells DNA content
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The Long Magenstrasse with pyloroplasty as functional gastric bypass: 6-years experience, 308 operations 被引量:1
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作者 Carlo Vassallo Giovanni Berbiglia Matteo Carena 《Health》 2010年第8期935-940,共6页
Background: The Long Magenstrasse with py-loroplasty as functional Gastric Bypass (briefly LMGBP) procedure for morbid obesity may re- duce the incidence of side effects associated with gastric restrictive and malabso... Background: The Long Magenstrasse with py-loroplasty as functional Gastric Bypass (briefly LMGBP) procedure for morbid obesity may re- duce the incidence of side effects associated with gastric restrictive and malabsorptive sur- gery, particularly on quality of life and long-term nutritional insufficiency. In follow-up to pre- liminary findings in 34 patients, we report the results of an additional 274 LMGBPs performed over the past 3 years. Methods: Between October 2003 and 2009, 308 patients were treated with the LMGBP. 149 patients underwent open procedures;74, hand-assisted laparoscopic surgery (HALS);and 85 were operated laparo-scopically. 17% had ≥ 125 mg/dl glycemia, 43% sleep apnea, 38% hyperlipidemia, 12% hyperuricemia, and 58% arterial hypertension under treatment. Results: The mean BMI of 256 pre-operatively normoglycemic patients at 1 year was 29 (range 26-31);27 (25-30) in 45 patients at 3 years;and 27.5 (26-30) in 12 patients at 5 years. Mean BMI of 53 preoperatively hyperglycemic patients (≥ 125 mg/dl) at 1 year (21 patients) was 32 (29-34), and at 3 years (9 patients), 32.5 (30- 33). 15 patients with preoperative type 2 diabetes under oral treatment required no therapy 3-6 months after surgery. Patients reported considerable appetite reduction with rapid satiety but maintained good nutrition with no supplementation. There was no mortality. Conclusions: Safe and effective sustained weight loss, positive metabolic changes, and appetite diminution with rapid satiety were seen after LMGBP. 展开更多
关键词 MORBID Obesity BARIATRIC Surgery Partial vagotomy Pyloroplasty Magenstrasse and MILL GASTRIC BYPASS
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The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity:Disruption of microbial composition and short-chain fatty acid metabolism
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作者 Lijian Chen Kaikai Zhang +10 位作者 Jiali Liu Xiuwen Li Yi Liu Hongsheng M Jianzheng Yang Jiahao Li Long Chen Clare Hsu Jiahao Zeng Xiaoli Xie Qi Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第11期4832-4857,共26页
Methamphetamine(METH)abuse is associated with significant neurotoxicity,high addiction potential,and behavioral abnormalities.Recent studies have identified a connection between the gut microbiota and METH-induced neu... Methamphetamine(METH)abuse is associated with significant neurotoxicity,high addiction potential,and behavioral abnormalities.Recent studies have identified a connection between the gut microbiota and METH-induced neurotoxicity and behavioral disorders.However,the underlying causal mechanisms linking the gut microbiota to METH pathophysiology remain largely unexplored.In this study,we employed fecal microbiota transplantation(FMT)and antibiotic(Abx)intervention to manipulate the gut microbiota in mice administered METH.Furthermore,we supplemented METH-treated mice with short-chain fatty acids(SCFAs)and pioglitazone(Pio)to determine the protective effects on gut microbiota metabolism.Finally,we assessed the underlying mechanisms of the gut-brain neural circuit in vagotomized mice.Our data provide compelling evidence that modulation of the gut microbiome through FMT or microbiome knockdown by Abx plays a crucial role in METH-induced neurotoxicity,behavioral disorders,gut microbiota disturbances,and intestinal barrier impairment.Furthermore,our findings highlight a novel prevention strategy for mitigating the risks to both the nervous and intestinal systems caused by METH,which involves supplementation with SCFAs or Pio. 展开更多
关键词 METHAMPHETAMINE Gut dysbiosis Behavioral disorders Wnt/β-Catenin/GSK3βsignaling pathway Fecal microbiota transplantation Short-chainfatty acid vagotomy Microbiota-gut-brain axis
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Effects and mechanisms of L-glutamate microinjected into nucleus ambiguus on gastric motility in rats 被引量:4
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作者 SUN Hong-zhao ZHAO Shu-zhen +1 位作者 CUI Xi-yun AI Hong-bin 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第8期1052-1057,共6页
Background L-glutamate (L-GLU) is a major neurotransmitter in the nucleus ambiguus (NA), which can modulate respiration, arterial pressure, heart rate, etc. This study investigated the effects and mechanisms of L-... Background L-glutamate (L-GLU) is a major neurotransmitter in the nucleus ambiguus (NA), which can modulate respiration, arterial pressure, heart rate, etc. This study investigated the effects and mechanisms of L-GLU microinjected into NA on gastric motility in rats. Methods A latex balloon connected with a pressure transducer was inserted into the pylorus through the forestomach for continuous recording of the gastric motility. The total amplitude, total duration, and motility index of gastric contraction waves within 5 minutes before microinjection and after microinjection were measured. Results L-GLU (5 nmol, 10 nmol and 20 nmol in 50 nl normal saline (PS) respectively) microinjected into the right NA significantly inhibited gastric motility, while microinjection of physiological saline at the same position and the same volume did not change the gastric motility. The inhibitory effect was blocked by D-2-amino-5-phophonovalerate (D-AP5, 5 nmol, in 50 nl PS), the specific N-methyI-D-aspartic acid (NMDA) receptor antagonist, but was not influenced by 6-cyaon-7-nitroquinoxaline-2,3-(1H,4H)-dione (CNQX) (5 nmol, in 50 nl PS), the non-NMDA ionotropic receptor antagonist. Bilateral subdiaphragmatic vagotomy abolished the inhibitory effect by microinjection of L-GLU into NA. Conclusions Microinjection of L-GLU into NA inhibits the gastric motility through specific NMDA receptor activity, not non-NMDA receptor activity, and the efferent pathway is the vagal nerves. 展开更多
关键词 gastric motility L-GLUTAMATE nucleus ambiguus glutamate receptor vagotomy
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Effect of oxytocin on gastric ischemia-reperfusion injury in rats
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作者 ZHANG Wenwen ZHANG Jianfu +1 位作者 XU Ming ZHANG Yongmei 《Frontiers of Medicine》 SCIE CSCD 2007年第4期433-437,共5页
The effect of peripherally administered oxytocin(OT)on gastric ischemia-reperfusion injury(GI-RI)and its possible mechanism were investigated.The Sprague-Dawley(SD)rats were randomly divided into different treatment g... The effect of peripherally administered oxytocin(OT)on gastric ischemia-reperfusion injury(GI-RI)and its possible mechanism were investigated.The Sprague-Dawley(SD)rats were randomly divided into different treatment groups(n=6).The animal GI-RI model was established by clamping the celiac artery for 30 min to induce ischemia and then released to allow reperfusion for 1 h,and the degree of GI-RI was assessed by scoring the gastric mucosal damage index(GMDI),the gastric fluid output,gastric fluid output,gastric acidity were measured and the surgical preparations of vagotomy and sympathectomy were used to investigate the possible mechanism of OT on GI-RI.The results were as follows.Compared with the control group(NS plus GI-R only,GMDI 121.33P10.40,n=6),the intra peritoneal(ip)administration of oxytocin(20,100μg/0.5 mL)obviously attenuated GI-RI(P<0.05),GMDI were 82.33P14.26,53.5P5.58 respectively(n=6);the gastric fluid output and the gastric acidity(evaluated by pH)of the control group were(430.17P87.36)μL,1.55P0.25(n=6),and those of the OT group were(102.45P48.00)μL,2.65P0.40(n=6)res pectively;differences had statistical significance(P<0.01).The effect of oxytocin was reversed by atosiban,a selective oxytocin receptor antagonist.The GMDI of the group given atosiban 10 min before OT was 138.17P24.06(n=6),which had no significant difference with the control group.Oxytocin further attenuated GI-RI after vagotomy and sympathectomy(GMDI 6.83P8.89,29.67P5.54,n=6),compared with the GI-R group and the oxytocin group(P<0.01).These results indicated that the oxytocin could significantly protect gastric mucosal against injury induced by ischemia-reperfusion,and the oxytocin receptor was involved.This effect of oxytocin may be mediated through the vagus and sympathetic nerve,and then lead to the reduction of gastric juice output and the depression of gastric acidity. 展开更多
关键词 OXYTOCIN ISCHEMIA reperfusion injury gastric mucosal damage index vagotomy SYMPATHECTOMY
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