目的工业缺陷检测是现代工业质量控制中至关重要的一环,针对工业多模态缺陷检测场景下,捕捉不同形状大小、在RGB图像上感知度低的缺陷,以及减少单模态原始特征空间内存在的噪声对多模态信息交互的干扰的挑战,提出了一种基于归一化流的...目的工业缺陷检测是现代工业质量控制中至关重要的一环,针对工业多模态缺陷检测场景下,捕捉不同形状大小、在RGB图像上感知度低的缺陷,以及减少单模态原始特征空间内存在的噪声对多模态信息交互的干扰的挑战,提出了一种基于归一化流的多模态多尺度缺陷检测方法。方法首先,使用Vision Transformer和Point Transformer对RGB图像和3D点云两个模态的信息提取第1、3、11块的特征构建特征金字塔,保留低层次特征的空间信息助力缺陷定位任务,并提高模型对不同形状大小缺陷的鲁棒性;其次,为了简化多模态交互,使用过点特征对齐算法将3D点云特征对齐至RGB图像所在平面,通过构建对比学习矩阵的方式实现无监督多模态特征融合,促进不同模态之间信息的交互;此外,通过设计代理任务的方式将信息瓶颈机制扩展至无监督,并在尽可能保留原始信息的同时,减少噪声干扰得到更充分有力的多模态表示;最后,使用多尺度归一化流结构捕捉不同尺度的特征信息,实现不同尺度特征之间的交互。结果本文方法在MVTec-3D AD数据集上进行性能评估,实验结果显示Detection AUCROC(area under the curve of the receiveroperating characteristic)指标达到93.3%,SegmentationAUPRO(area under the precision-recall overlap)指标达到96.1%,Segmentation AUCROC指标达到98.8%,优于大多数现有的多模态缺陷检测方法。结论本文方法对于不同形状大小、在RGB图像上感知度低的缺陷有较好的检测效果,不但减少了原始特征空间内噪声对多模态表示的影响,并且对不同形状大小的缺陷具有一定的泛化能力,较好地满足了现代工业对于缺陷检测的要求。展开更多
We evaluated the antitumor effect of combined therapy with tegafur/uracil （UFT） plus leucovorin （LV） （UFT/LV） and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed ...We evaluated the antitumor effect of combined therapy with tegafur/uracil （UFT） plus leucovorin （LV） （UFT/LV） and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT/LV and PSK may be expected to augment the antitumor effect.展开更多
Platinum-based antitumour drug ZD0473 was designed to reduce the cisplatin resistance to the tumor cells. In this paper, the mixed method of molecular mechanics and quantum chemistry, HF/lanl2dz// MM/uff and B3LYP/lan...Platinum-based antitumour drug ZD0473 was designed to reduce the cisplatin resistance to the tumor cells. In this paper, the mixed method of molecular mechanics and quantum chemistry, HF/lanl2dz// MM/uff and B3LYP/lanl2dz//6-31G*, are used to investigate the differences between four types of GG, 3′AG5′, 3′GA5′, and AA complexes, which are formed from four discrete DNA fragments recognized by ZD0473 and cisplatin. The results show that the binding interaction of both ZD0473 and cisplatin drugs with the GG base pair is much stronger than with other base pairs, namely the recognition capability of such drugs to the GG base pair is more considerable. Moreover, the interaction of four complexes of ZD0473 with DNA fragments is stronger than that of cisplatin with corresponding DNA fragments, which indicates the stronger binding capability of ZD0473 with DNA fragments and high antitumour activity of ZD0473. The main reason for easier forming of 3′GA5′ complex than the 3′AG5′ one is that the drug molecule prefers to bind with a single G base to form a monoligand compound firstly; then the con- figuration transformation from such monoligand compound to the bi-ligand one is limited.展开更多
文摘目的工业缺陷检测是现代工业质量控制中至关重要的一环,针对工业多模态缺陷检测场景下,捕捉不同形状大小、在RGB图像上感知度低的缺陷,以及减少单模态原始特征空间内存在的噪声对多模态信息交互的干扰的挑战,提出了一种基于归一化流的多模态多尺度缺陷检测方法。方法首先,使用Vision Transformer和Point Transformer对RGB图像和3D点云两个模态的信息提取第1、3、11块的特征构建特征金字塔,保留低层次特征的空间信息助力缺陷定位任务,并提高模型对不同形状大小缺陷的鲁棒性;其次,为了简化多模态交互,使用过点特征对齐算法将3D点云特征对齐至RGB图像所在平面,通过构建对比学习矩阵的方式实现无监督多模态特征融合,促进不同模态之间信息的交互;此外,通过设计代理任务的方式将信息瓶颈机制扩展至无监督,并在尽可能保留原始信息的同时,减少噪声干扰得到更充分有力的多模态表示;最后,使用多尺度归一化流结构捕捉不同尺度的特征信息,实现不同尺度特征之间的交互。结果本文方法在MVTec-3D AD数据集上进行性能评估,实验结果显示Detection AUCROC(area under the curve of the receiveroperating characteristic)指标达到93.3%,SegmentationAUPRO(area under the precision-recall overlap)指标达到96.1%,Segmentation AUCROC指标达到98.8%,优于大多数现有的多模态缺陷检测方法。结论本文方法对于不同形状大小、在RGB图像上感知度低的缺陷有较好的检测效果,不但减少了原始特征空间内噪声对多模态表示的影响,并且对不同形状大小的缺陷具有一定的泛化能力,较好地满足了现代工业对于缺陷检测的要求。
文摘We evaluated the antitumor effect of combined therapy with tegafur/uracil （UFT） plus leucovorin （LV） （UFT/LV） and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT/LV and PSK may be expected to augment the antitumor effect.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 20673011, 20231010, 20631020)the Major State Basic Research Development Programs (Grant No. G2004CB719900)
文摘Platinum-based antitumour drug ZD0473 was designed to reduce the cisplatin resistance to the tumor cells. In this paper, the mixed method of molecular mechanics and quantum chemistry, HF/lanl2dz// MM/uff and B3LYP/lanl2dz//6-31G*, are used to investigate the differences between four types of GG, 3′AG5′, 3′GA5′, and AA complexes, which are formed from four discrete DNA fragments recognized by ZD0473 and cisplatin. The results show that the binding interaction of both ZD0473 and cisplatin drugs with the GG base pair is much stronger than with other base pairs, namely the recognition capability of such drugs to the GG base pair is more considerable. Moreover, the interaction of four complexes of ZD0473 with DNA fragments is stronger than that of cisplatin with corresponding DNA fragments, which indicates the stronger binding capability of ZD0473 with DNA fragments and high antitumour activity of ZD0473. The main reason for easier forming of 3′GA5′ complex than the 3′AG5′ one is that the drug molecule prefers to bind with a single G base to form a monoligand compound firstly; then the con- figuration transformation from such monoligand compound to the bi-ligand one is limited.
