Disturbances such as forest fires,intense winds,and insect damage exert strong impacts on forest ecosystems by shaping their structure and growth dynamics,with contributions from climate change.Consequently,there is a...Disturbances such as forest fires,intense winds,and insect damage exert strong impacts on forest ecosystems by shaping their structure and growth dynamics,with contributions from climate change.Consequently,there is a need for reliable and operational methods to monitor and map these disturbances for the development of suitable management strategies.While susceptibility assessment using machine learning methods has increased,most studies have focused on a single disturbance.Moreover,there has been limited exploration of the use of“Automated Machine Learning(AutoML)”in the literature.In this study,susceptibility assessment for multiple forest disturbances(fires,insect damage,and wind damage)was conducted using the PyCaret AutoML framework in the Izmir Regional Forest Directorate(RFD)in Turkey.The AutoML framework compared 14 machine learning algorithms and ranked the best models based on AUC(area under the curve)values.The extra tree classifier(ET)algorithm was selected for modeling the susceptibility of each disturbance due to its good performance(AUC values>0.98).The study evaluated susceptibilities for both individual and multiple disturbances,creating a total of four susceptibility maps using fifteen driving factors in the assessment.According to the results,82.5%of forested areas in the Izmir RFD are susceptible to multiple disturbances at high and very high levels.Additionally,a potential forest disturbances map was created,revealing that 15.6%of forested areas in the Izmir RFD may experience no damage from the disturbances considered,while 54.2%could face damage from all three disturbances.The SHAP(Shapley Additive exPlanations)methodology was applied to evaluate the importance of features on prediction and the nonlinear relationship between explanatory features and susceptibility to disturbance.展开更多
Objectives: To determine the susceptibilities of M.hominis and U. urealyticum to fluoroquinolones forthe instruction of reasonable clinical application ofantibiotics.Method: The susceptibilities of M. hominis and U.ur...Objectives: To determine the susceptibilities of M.hominis and U. urealyticum to fluoroquinolones forthe instruction of reasonable clinical application ofantibiotics.Method: The susceptibilities of M. hominis and U.urealyticum to six fluoroquinolones were determinedby the broth dilution method.Results: Sparfloxacin and gatifloxacin were veryactive with MIC50S of 0.03125 and 0.25 μg/ml againstM. hominis, 0.25 and 0.5 μg/ml against U. urealyticum,respectively. Levofloxacin and ofloxacin had MIC50S of1 μg/ml and 2 μg/ml, respectively against both species.Norfloxacin was less effective against both species at16 and 32 μg/ml. Ciprofloxacin was unusual in thatthe MIC50S varied fourfold between species, with 2 μg/ml against M. hominis and 8 μg/ml against U.urealyticum.Conclusions: The results can provide useful infor-mation for selecting fluoroquinolones for treatmentof urogenital mycoplasma infections.展开更多
Based on the parameterized fully dressed quark propagator proposed by us, the tensor susceptibilities of QCD vacuum and quark vacuum condensates are investigated. Our predicted values of the tensor susceptibilities ar...Based on the parameterized fully dressed quark propagator proposed by us, the tensor susceptibilities of QCD vacuum and quark vacuum condensates are investigated. Our predicted values of the tensor susceptibilities are in agreement with those predicted by many other theoretical models with QCD feature. The results also show that the tensor susceptibility of QCD vacuum strongly depends on flavor of quark but not sensitive to variation of quark vacuum condensates. However, the quark vacuum condensate is very sensitive to the change of cut-off-parameter μ^2 of the integration, that is, it depends on the separation point of perturbative and non-perturbative QCD region. The successful predictions clearly indicate the extensive validity of our parameterized fully dressed quark propagator used here.展开更多
It is commonly accepted that the system undergoes a crossover at high temperature and low chemical potential beyond the chiral limit case, and the properties of the crossover region are important for researchers to un...It is commonly accepted that the system undergoes a crossover at high temperature and low chemical potential beyond the chiral limit case, and the properties of the crossover region are important for researchers to understand the nature of strong interacting matters of quantum chromodynamics （QCD）. Since at present there is no exact order of parameters of the phase transitions beyond the chiral limit, QCD susceptibilities are widely used as indicators. In this work various susceptibilities are discussed in the framework of Dyson-Schwinger equations. The results show that different kinds of susceptibilities give the same critical end point, which is the bifurcation point of the crossover region and the first order phase transition line of QCD. Nevertheless, different pseudo- critical points are found in the temperature axis. We think that defining a critical band is more suitable in the crossover region.展开更多
Active metamaterials embedded with nonlinear elements are able to exhibit strong nonlinearity in microwave regime.However, existing S-parameter based parameter retrieval approaches developed for linear metamaterials d...Active metamaterials embedded with nonlinear elements are able to exhibit strong nonlinearity in microwave regime.However, existing S-parameter based parameter retrieval approaches developed for linear metamaterials do not apply in nonlinear cases. In this paper, a retrieval algorithm of high-order susceptibilities for nonlinear metamaterials is derived.Experimental demonstration shows that, by measuring the power level of each harmonic while sweeping the incident power,high-order susceptibilities of a thin-layer nonlinear metamaterial can be effectively retrieved. The proposed approach can be widely used in the research of active metamaterials.展开更多
A new multidisciplinary study is being carried out in several localities from Outer Carpathians of Central Europe. Outer Carpathians allow studying the Cretaceous-Paleogene (K-Pg) interval of the oceanic facies, inclu...A new multidisciplinary study is being carried out in several localities from Outer Carpathians of Central Europe. Outer Carpathians allow studying the Cretaceous-Paleogene (K-Pg) interval of the oceanic facies, including lower bathyal-abyssal sub-CCD turbidites. Preliminary results of field-measured magnetic susceptibilities from Uzgruň K-Pg section in the Czech Republic are presented.展开更多
Objective Mycobacterium avium （M. avium） and Mycobacterium intracellulare （M. intracellulare） are the major causative agents of nontuberculous mycobacteria （NTM）-related pulmonary infections. However, little is ...Objective Mycobacterium avium （M. avium） and Mycobacterium intracellulare （M. intracellulare） are the major causative agents of nontuberculous mycobacteria （NTM）-related pulmonary infections. However, little is known about the differences in drug susceptibility profiles between these two species. Methods A total of 393 NTM isolates were collected from Shanghai Pulmonary Disease Hospital. Sequencing of partial genes was performed to identify the strains at species level. The minimum inhibitory concentration （MIC） was used to evaluate the drug susceptibility against 20 antimicrobial agents. Variable number of tandem repeat （VNTR） typing was conducted to genotype these two species. Results A total of 173 （44.0%） M. avium complex （MAC） isolates were identified, including 41 （10.4%） M. avium isolates and 132 （33.6%） M. intracellulare isolates. Clarithromycin and amikacin were the two most effective agents against MAC isolates. The Hunter-Gaston Discriminatory Index （HGDI） values for VNTR typing of M. avium and M. intracellulare isolates were 0.993 and 0.995, respectively. Levofloxacin resistance was more common among the unclustered strains than among the clustered strains of M. intracellulare. Conclusion M. intrecellulare was the most common NTM species in China. Clarithromycin and amikacin had high antimicrobial activities against MAC. VNTR typing of MAC isolates revealed a high discriminatory power. Levofloxacin resistance was associated with unclustered strains of M. intracellulare.展开更多
The susceptibilities of Oxya chinensis to malathion were studied in three populations collected from outskirt of Tianjin, China, using bioassays and biochemical analysis. Populations were chosen to represent different...The susceptibilities of Oxya chinensis to malathion were studied in three populations collected from outskirt of Tianjin, China, using bioassays and biochemical analysis. Populations were chosen to represent different exposure to insecticides： BDG （Beidagang; low exposure）, BD （Baodi; high exposure previously but low exposure now）, and JN （Jinnan; high exposure）. The results showed that the LD50 values of BD and JN populations were 3.95- and 12.02-fold and 3.64- and 10.07- fold higher than that of BDG population in females and males, respectively. The LD50 values in females were higher than those in males. The results of biochemical analysis indicated that the esterase （EST） activities in JN population were higher than those in BD and BDG populations. They showed that when α-NA, α-NB, and α-NA were used as substrates, females＇ EST activities of JN population were 1.11-, 1.30-, and 1.14-fold and 1.39-, 1.59-, and 1.54-fold higher than those of BD and BDG populations, respectively. When α-NA, α-NB, and β-NA were used as substrates, males＇ EST activities of JN population were 1.13-, 1.12-, and 1,00-fold and 1.20-, 1.14-, and 1.07-fold higher than those of BD and BDG populations, respectively. The results also showed that the specific activities of the females were higher than those of the males in the BD and JN populations, whereas the specific activities of the males were higher than those of the females in the BDG population. The results of bioassay were consistent with those of biochemical analysis. Thus, it was inferred that the elevated ESTs activities might play an important role in conferring the differences of susceptibility of O. chinensis to malathion in the three collected populations. Enzyme kinetic studies indicated that the Km and Vmax values were different among the three collected populations and between the females and the males. The observed changes in the kinetic parameters might be explained by differential expression patterns of isozymes so that the insect esterases have different affinities and maximum velocities toward the same substrate.展开更多
Objective To determine the susceptibilities of M. tuberculosis H37Ra and M. chelonei subsp. absecessus to several frequently-used disinfectants and to evaluate the practicability of surrogating M. tuberculosis by the ...Objective To determine the susceptibilities of M. tuberculosis H37Ra and M. chelonei subsp. absecessus to several frequently-used disinfectants and to evaluate the practicability of surrogating M. tuberculosis by the latter. Methods A suspension quantitative bactericidal test was set up in accordance with Chinese Technique Standard for Disinfection to evaluate the susceptibility of each mycobacteria strain to each selected disinfectant. Killing log value was used as criterion in comparing the susceptibility to disinfectants between the two strains. Results M. chelonei subsp. abscessus was more resistant to chlorine disinfectant than M. tuberculosis while the two strains were similarly resistant to iodophor disinfectant, peracetic acid, alcohol and glutaraldehyde disinfectant. Conclusion M. chelonei subsp. abscessus has the potential to surrogate M. tuberculosis in evaluating mycobactericidal efficacies of disinfectants.展开更多
Based on a modified version of the global color symmetry model,the pion susceptibilities of vacuum needed in the QCD sum rule external-field method for the coupling of pseudoscalar current to hadron have bean calculat...Based on a modified version of the global color symmetry model,the pion susceptibilities of vacuum needed in the QCD sum rule external-field method for the coupling of pseudoscalar current to hadron have bean calculated beyond the vacuum saturation approximation.Comparison with the previous estimations has been given.展开更多
The pion and tensor vacuum susceptibilities are calculated in the framework of the renormalizable DysonSchwinger equations. A comparison with the results of other nonperturbative QCD approaches is given.
alculations of the nonlinear second-order optical susceptlbilities(β_(ijk))for sub- stituted tl1iophene derivative;with quinoidlike conformation are reported.These systetems possess small dipole moment;and large diff...alculations of the nonlinear second-order optical susceptlbilities(β_(ijk))for sub- stituted tl1iophene derivative;with quinoidlike conformation are reported.These systetems possess small dipole moment;and large differences between dipole mo- ments of ground and first-excited states.Geometry optimizations of the molecules investigated were carried out using AM 1 method.The calculations were performed using INDO/CI method comboned with a sum-over-states expression for β_(jik). The calculated results sbw that the second-order susceptibility is a function of the na- ture and location of substituents and is larger for disubstituted molecules than monosubstituted molecules. Bipolymeric thiophenemetmne with NH_2/NO_2 groups was calctilated to have a β_μof 79. 920 × 10￣(-30) esu. It was found that the NH_2 and NO_2 groups in above disubstituted molecules are pull-pull groups in ground states,but are usual push-pull groups in the first excited states.展开更多
The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For th...The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For this purpose, 127 chicken samples were collected from local markets. Investigation of Salmonella was done according to horizontal method, the guidelines of the method recommended by International Standards Organization （ISO）. Antimicrobial susceptibilities of Salmonella spp. was performed with microdilution method according to the guidelines of CLSI M100-SI8. Ampicillin, gentamicin sulphate, ofloxacin, levofloxacin, ciprofloxacin, enrofloxacin, tetracycline, ceftriaxon, amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole were used in the study. Salmonella spp. was isolated from 5 （3.94%） of the 127 chicken meat samples. Although our findings are not within Turkish Food Codex （TFC） values, lower number of samples that involve Salmonella spp. indicates an improvement in the hygienic conditions in Turkey. Among 5 isolates, one isolate was sensitive to all antimicrobial agents tested. 2 isolates exhibited multidrug resistance. Successfully, all the isolates were sensitive to quinolones as a good result in spite of the reported reduced susceptibility from different regions of the world. However, this study should be improved with more chicken samples and Salmonella spp. isolate numbers to support these results.展开更多
We study the sign distribution of generalized magnetic susceptibilities in the temperature-external magnetic field plane using the three-dimensional three-state Potts model. We find that the sign of odd-order suscepti...We study the sign distribution of generalized magnetic susceptibilities in the temperature-external magnetic field plane using the three-dimensional three-state Potts model. We find that the sign of odd-order susceptibility is opposite in the symmetric（disorder） and broken（order） phases, but that of the even-order one remains positive when it is far away from the phase boundary. When the critical point is approached from the crossover side, negative fourth-order magnetic susceptibility is observable. It is also demonstrated that non-monotonic behavior occurs in the temperature dependence of the generalized susceptibilities of the energy. The finite-size scaling behavior of the specific heat in this model is mainly controlled by the critical exponent of the magnetic susceptibility in the three-dimensional Ising universality class.展开更多
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.展开更多
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear...This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.展开更多
We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptib...We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptibilities along the freeze-out line can be used as a clean signature to locate the CEP in the QCD phase diagram.On the temperature and baryon chemical potential plane, the cumulant ratio of the baryon number susceptibilities（up to fourth order） forms a ridge along the phase boundary, and develops a sword-shaped ＂mountain＂ standing upright around the CEP in a narrow and oblate region. The measurement of baryon number susceptibilities from heavy-ion collision experiments is along the freeze-out line. If the freeze-out line crosses the foot of the CEP mountain, then one can observe the peaked baryon number susceptibilities along the freeze-out line, and the kurtosis of the baryon number distributions has the highest magnitude. The data from the first phase of the beam energy scan program at the Relativistic Heavy Ion Collider indicates that there should be a peak of the kurtosis of the baryon number distribution at a collision energy of around 5 Ge V, which suggests that the freeze-out line crosses the foot of the CEP mountain and the summit of the CEP should be located nearby, around a collision energy of 3–7 GeV.展开更多
BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial st...BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial stewardship.The coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these patterns.AIM To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these trends.METHODS A retrospective analysis of microbiological data was conducted,covering the period from 2018 to 2023.The study included key bacterial pathogens such as Escherichia coli(E.coli),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among others.The antibiotic susceptibility profiles of these isolates were assessed using standard laboratory methods.To contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United States.RESULTS The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 pandemic.For example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of E.coli showed a more variable pattern.Antibiotic resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and E.coli.Additionally,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and E.coli isolates.The impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key pathogens.CONCLUSION This study highlights the dynamic nature of bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex,particularly in the context of the COVID-19 pandemic.The findings underscore the need for continuous monitoring and effective anti-microbial stewardship programs to combat the evolving threat of antibiotic resistance.Further research and policy initiatives are required to address the identified challenges and improve patient outcomes in the face of these ongoing challenges.展开更多
Landslides are significant natural geological hazards.Landslide susceptibility evaluation involves the quantitative assessment and prediction of potential landslide locations and their probabilities.Research has explo...Landslides are significant natural geological hazards.Landslide susceptibility evaluation involves the quantitative assessment and prediction of potential landslide locations and their probabilities.Research has explored susceptibility assessment methods based on spatial-scale analysis.This evaluation integrates two models—global and local scale—using a CNN model and a PSO-CNN coupled model.Key aspects include selecting evaluation factors and optimizing model parameters for landslide susceptibility at different scales.A major focus of current landslide research is utilizing prediction results to enhance prevention and control measures.展开更多
文摘Disturbances such as forest fires,intense winds,and insect damage exert strong impacts on forest ecosystems by shaping their structure and growth dynamics,with contributions from climate change.Consequently,there is a need for reliable and operational methods to monitor and map these disturbances for the development of suitable management strategies.While susceptibility assessment using machine learning methods has increased,most studies have focused on a single disturbance.Moreover,there has been limited exploration of the use of“Automated Machine Learning(AutoML)”in the literature.In this study,susceptibility assessment for multiple forest disturbances(fires,insect damage,and wind damage)was conducted using the PyCaret AutoML framework in the Izmir Regional Forest Directorate(RFD)in Turkey.The AutoML framework compared 14 machine learning algorithms and ranked the best models based on AUC(area under the curve)values.The extra tree classifier(ET)algorithm was selected for modeling the susceptibility of each disturbance due to its good performance(AUC values>0.98).The study evaluated susceptibilities for both individual and multiple disturbances,creating a total of four susceptibility maps using fifteen driving factors in the assessment.According to the results,82.5%of forested areas in the Izmir RFD are susceptible to multiple disturbances at high and very high levels.Additionally,a potential forest disturbances map was created,revealing that 15.6%of forested areas in the Izmir RFD may experience no damage from the disturbances considered,while 54.2%could face damage from all three disturbances.The SHAP(Shapley Additive exPlanations)methodology was applied to evaluate the importance of features on prediction and the nonlinear relationship between explanatory features and susceptibility to disturbance.
基金Financially supported by a grant from the Education Com-mittee of Hunan Province (No.ooAoo9)
文摘Objectives: To determine the susceptibilities of M.hominis and U. urealyticum to fluoroquinolones forthe instruction of reasonable clinical application ofantibiotics.Method: The susceptibilities of M. hominis and U.urealyticum to six fluoroquinolones were determinedby the broth dilution method.Results: Sparfloxacin and gatifloxacin were veryactive with MIC50S of 0.03125 and 0.25 μg/ml againstM. hominis, 0.25 and 0.5 μg/ml against U. urealyticum,respectively. Levofloxacin and ofloxacin had MIC50S of1 μg/ml and 2 μg/ml, respectively against both species.Norfloxacin was less effective against both species at16 and 32 μg/ml. Ciprofloxacin was unusual in thatthe MIC50S varied fourfold between species, with 2 μg/ml against M. hominis and 8 μg/ml against U.urealyticum.Conclusions: The results can provide useful infor-mation for selecting fluoroquinolones for treatmentof urogenital mycoplasma infections.
基金supported by National Natural Science Foundation of China under Grant Nos.10647002 and 10565001the Natural Science Foundation of Guangxi under Grant Nos.0542042,0481030,and 0575020Guangxi University of Technology under Grant No.05006
文摘Based on the parameterized fully dressed quark propagator proposed by us, the tensor susceptibilities of QCD vacuum and quark vacuum condensates are investigated. Our predicted values of the tensor susceptibilities are in agreement with those predicted by many other theoretical models with QCD feature. The results also show that the tensor susceptibility of QCD vacuum strongly depends on flavor of quark but not sensitive to variation of quark vacuum condensates. However, the quark vacuum condensate is very sensitive to the change of cut-off-parameter μ^2 of the integration, that is, it depends on the separation point of perturbative and non-perturbative QCD region. The successful predictions clearly indicate the extensive validity of our parameterized fully dressed quark propagator used here.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11275097,11475085,11535005,and 11265017the Jiangsu Planned Projects for Postdoctoral Research Funds under Grant No 1402006C+2 种基金the China Postdoctoral Science Foundation under Grant No 2015M571728the Natural Science Foundation of Jiangsu Province under Grant No BK20130078the Guizhou-Provincial Outstanding Youth Science and Technology Talent Cultivation Object Special Funds under Grant No QKHRZ(2013)28
文摘It is commonly accepted that the system undergoes a crossover at high temperature and low chemical potential beyond the chiral limit case, and the properties of the crossover region are important for researchers to understand the nature of strong interacting matters of quantum chromodynamics （QCD）. Since at present there is no exact order of parameters of the phase transitions beyond the chiral limit, QCD susceptibilities are widely used as indicators. In this work various susceptibilities are discussed in the framework of Dyson-Schwinger equations. The results show that different kinds of susceptibilities give the same critical end point, which is the bifurcation point of the crossover region and the first order phase transition line of QCD. Nevertheless, different pseudo- critical points are found in the temperature axis. We think that defining a critical band is more suitable in the crossover region.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61401395 and 61604128)the Scientific Research Fund of Zhejiang Provincial Education Department,China(Grant No.Y201533913)the Fundamental Research Funds for the Central Universities,China(Grant Nos.2016QNA4025 and 2016QN81002)
文摘Active metamaterials embedded with nonlinear elements are able to exhibit strong nonlinearity in microwave regime.However, existing S-parameter based parameter retrieval approaches developed for linear metamaterials do not apply in nonlinear cases. In this paper, a retrieval algorithm of high-order susceptibilities for nonlinear metamaterials is derived.Experimental demonstration shows that, by measuring the power level of each harmonic while sweeping the incident power,high-order susceptibilities of a thin-layer nonlinear metamaterial can be effectively retrieved. The proposed approach can be widely used in the research of active metamaterials.
基金funded by Czech Science Foundation project no.19-07516S and is in accordance of research plan no.RVO67985831UNESCO/IUGS/IGCP 679 project.
文摘A new multidisciplinary study is being carried out in several localities from Outer Carpathians of Central Europe. Outer Carpathians allow studying the Cretaceous-Paleogene (K-Pg) interval of the oceanic facies, including lower bathyal-abyssal sub-CCD turbidites. Preliminary results of field-measured magnetic susceptibilities from Uzgruň K-Pg section in the Czech Republic are presented.
基金supported by a grant from the National Basic Research Program of China 2014CB744403the National Science and Technology Major Project 2014ZX100030002
文摘Objective Mycobacterium avium （M. avium） and Mycobacterium intracellulare （M. intracellulare） are the major causative agents of nontuberculous mycobacteria （NTM）-related pulmonary infections. However, little is known about the differences in drug susceptibility profiles between these two species. Methods A total of 393 NTM isolates were collected from Shanghai Pulmonary Disease Hospital. Sequencing of partial genes was performed to identify the strains at species level. The minimum inhibitory concentration （MIC） was used to evaluate the drug susceptibility against 20 antimicrobial agents. Variable number of tandem repeat （VNTR） typing was conducted to genotype these two species. Results A total of 173 （44.0%） M. avium complex （MAC） isolates were identified, including 41 （10.4%） M. avium isolates and 132 （33.6%） M. intracellulare isolates. Clarithromycin and amikacin were the two most effective agents against MAC isolates. The Hunter-Gaston Discriminatory Index （HGDI） values for VNTR typing of M. avium and M. intracellulare isolates were 0.993 and 0.995, respectively. Levofloxacin resistance was more common among the unclustered strains than among the clustered strains of M. intracellulare. Conclusion M. intrecellulare was the most common NTM species in China. Clarithromycin and amikacin had high antimicrobial activities against MAC. VNTR typing of MAC isolates revealed a high discriminatory power. Levofloxacin resistance was associated with unclustered strains of M. intracellulare.
基金supported by the National Natural Science Foundation of China (30570247)the Science and Technology Commission of Shanxi Province,China (2006011075)
文摘The susceptibilities of Oxya chinensis to malathion were studied in three populations collected from outskirt of Tianjin, China, using bioassays and biochemical analysis. Populations were chosen to represent different exposure to insecticides： BDG （Beidagang; low exposure）, BD （Baodi; high exposure previously but low exposure now）, and JN （Jinnan; high exposure）. The results showed that the LD50 values of BD and JN populations were 3.95- and 12.02-fold and 3.64- and 10.07- fold higher than that of BDG population in females and males, respectively. The LD50 values in females were higher than those in males. The results of biochemical analysis indicated that the esterase （EST） activities in JN population were higher than those in BD and BDG populations. They showed that when α-NA, α-NB, and α-NA were used as substrates, females＇ EST activities of JN population were 1.11-, 1.30-, and 1.14-fold and 1.39-, 1.59-, and 1.54-fold higher than those of BD and BDG populations, respectively. When α-NA, α-NB, and β-NA were used as substrates, males＇ EST activities of JN population were 1.13-, 1.12-, and 1,00-fold and 1.20-, 1.14-, and 1.07-fold higher than those of BD and BDG populations, respectively. The results also showed that the specific activities of the females were higher than those of the males in the BD and JN populations, whereas the specific activities of the males were higher than those of the females in the BDG population. The results of bioassay were consistent with those of biochemical analysis. Thus, it was inferred that the elevated ESTs activities might play an important role in conferring the differences of susceptibility of O. chinensis to malathion in the three collected populations. Enzyme kinetic studies indicated that the Km and Vmax values were different among the three collected populations and between the females and the males. The observed changes in the kinetic parameters might be explained by differential expression patterns of isozymes so that the insect esterases have different affinities and maximum velocities toward the same substrate.
文摘Objective To determine the susceptibilities of M. tuberculosis H37Ra and M. chelonei subsp. absecessus to several frequently-used disinfectants and to evaluate the practicability of surrogating M. tuberculosis by the latter. Methods A suspension quantitative bactericidal test was set up in accordance with Chinese Technique Standard for Disinfection to evaluate the susceptibility of each mycobacteria strain to each selected disinfectant. Killing log value was used as criterion in comparing the susceptibility to disinfectants between the two strains. Results M. chelonei subsp. abscessus was more resistant to chlorine disinfectant than M. tuberculosis while the two strains were similarly resistant to iodophor disinfectant, peracetic acid, alcohol and glutaraldehyde disinfectant. Conclusion M. chelonei subsp. abscessus has the potential to surrogate M. tuberculosis in evaluating mycobactericidal efficacies of disinfectants.
文摘Based on a modified version of the global color symmetry model,the pion susceptibilities of vacuum needed in the QCD sum rule external-field method for the coupling of pseudoscalar current to hadron have bean calculated beyond the vacuum saturation approximation.Comparison with the previous estimations has been given.
文摘The pion and tensor vacuum susceptibilities are calculated in the framework of the renormalizable DysonSchwinger equations. A comparison with the results of other nonperturbative QCD approaches is given.
文摘alculations of the nonlinear second-order optical susceptlbilities(β_(ijk))for sub- stituted tl1iophene derivative;with quinoidlike conformation are reported.These systetems possess small dipole moment;and large differences between dipole mo- ments of ground and first-excited states.Geometry optimizations of the molecules investigated were carried out using AM 1 method.The calculations were performed using INDO/CI method comboned with a sum-over-states expression for β_(jik). The calculated results sbw that the second-order susceptibility is a function of the na- ture and location of substituents and is larger for disubstituted molecules than monosubstituted molecules. Bipolymeric thiophenemetmne with NH_2/NO_2 groups was calctilated to have a β_μof 79. 920 × 10￣(-30) esu. It was found that the NH_2 and NO_2 groups in above disubstituted molecules are pull-pull groups in ground states,but are usual push-pull groups in the first excited states.
文摘The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For this purpose, 127 chicken samples were collected from local markets. Investigation of Salmonella was done according to horizontal method, the guidelines of the method recommended by International Standards Organization （ISO）. Antimicrobial susceptibilities of Salmonella spp. was performed with microdilution method according to the guidelines of CLSI M100-SI8. Ampicillin, gentamicin sulphate, ofloxacin, levofloxacin, ciprofloxacin, enrofloxacin, tetracycline, ceftriaxon, amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole were used in the study. Salmonella spp. was isolated from 5 （3.94%） of the 127 chicken meat samples. Although our findings are not within Turkish Food Codex （TFC） values, lower number of samples that involve Salmonella spp. indicates an improvement in the hygienic conditions in Turkey. Among 5 isolates, one isolate was sensitive to all antimicrobial agents tested. 2 isolates exhibited multidrug resistance. Successfully, all the isolates were sensitive to quinolones as a good result in spite of the reported reduced susceptibility from different regions of the world. However, this study should be improved with more chicken samples and Salmonella spp. isolate numbers to support these results.
基金Supported by Fund Project of National Natural Science Foundation of China(11647093,11405088,11521064)Fund Project of Sichuan Provincial Department of Education(16ZB0339)+1 种基金Fund Project of Chengdu Technological University(2016RC004)the Major State Basic Research Development Program of China(2014CB845402)
文摘We study the sign distribution of generalized magnetic susceptibilities in the temperature-external magnetic field plane using the three-dimensional three-state Potts model. We find that the sign of odd-order susceptibility is opposite in the symmetric（disorder） and broken（order） phases, but that of the even-order one remains positive when it is far away from the phase boundary. When the critical point is approached from the crossover side, negative fourth-order magnetic susceptibility is observable. It is also demonstrated that non-monotonic behavior occurs in the temperature dependence of the generalized susceptibilities of the energy. The finite-size scaling behavior of the specific heat in this model is mainly controlled by the critical exponent of the magnetic susceptibility in the three-dimensional Ising universality class.
基金supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ)the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
文摘Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.
基金the University of Transport Technology under the project entitled“Application of Machine Learning Algorithms in Landslide Susceptibility Mapping in Mountainous Areas”with grant number DTTD2022-16.
文摘This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.
基金Supported by NSFC(11275213,and 11261130311)(CRC 110 by DFG and NSFC)CAS key project KJCX2-EW-N01Youth Innovation Promotion Association of CAS
文摘We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptibilities along the freeze-out line can be used as a clean signature to locate the CEP in the QCD phase diagram.On the temperature and baryon chemical potential plane, the cumulant ratio of the baryon number susceptibilities（up to fourth order） forms a ridge along the phase boundary, and develops a sword-shaped ＂mountain＂ standing upright around the CEP in a narrow and oblate region. The measurement of baryon number susceptibilities from heavy-ion collision experiments is along the freeze-out line. If the freeze-out line crosses the foot of the CEP mountain, then one can observe the peaked baryon number susceptibilities along the freeze-out line, and the kurtosis of the baryon number distributions has the highest magnitude. The data from the first phase of the beam energy scan program at the Relativistic Heavy Ion Collider indicates that there should be a peak of the kurtosis of the baryon number distribution at a collision energy of around 5 Ge V, which suggests that the freeze-out line crosses the foot of the CEP mountain and the summit of the CEP should be located nearby, around a collision energy of 3–7 GeV.
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
文摘BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial stewardship.The coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these patterns.AIM To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these trends.METHODS A retrospective analysis of microbiological data was conducted,covering the period from 2018 to 2023.The study included key bacterial pathogens such as Escherichia coli(E.coli),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among others.The antibiotic susceptibility profiles of these isolates were assessed using standard laboratory methods.To contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United States.RESULTS The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 pandemic.For example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of E.coli showed a more variable pattern.Antibiotic resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and E.coli.Additionally,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and E.coli isolates.The impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key pathogens.CONCLUSION This study highlights the dynamic nature of bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex,particularly in the context of the COVID-19 pandemic.The findings underscore the need for continuous monitoring and effective anti-microbial stewardship programs to combat the evolving threat of antibiotic resistance.Further research and policy initiatives are required to address the identified challenges and improve patient outcomes in the face of these ongoing challenges.
基金Jiangxi Provincial Innovative Training Project“Post-earthquake Landslide Risk Evaluation Study under Spatial Scale Modelling”(Project No.:S202311318050)。
文摘Landslides are significant natural geological hazards.Landslide susceptibility evaluation involves the quantitative assessment and prediction of potential landslide locations and their probabilities.Research has explored susceptibility assessment methods based on spatial-scale analysis.This evaluation integrates two models—global and local scale—using a CNN model and a PSO-CNN coupled model.Key aspects include selecting evaluation factors and optimizing model parameters for landslide susceptibility at different scales.A major focus of current landslide research is utilizing prediction results to enhance prevention and control measures.
