Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removi...Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant ( P <0.05, P <0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.展开更多
文摘Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant ( P <0.05, P <0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.
