Scalp inflammation is a fundamental issue to many unhealthy scalp symptoms such as itching, redness, dandruff, and odor. Oxidized sebum, or specifically oxidization of the squalene component in sebum, is one of the ke...Scalp inflammation is a fundamental issue to many unhealthy scalp symptoms such as itching, redness, dandruff, and odor. Oxidized sebum, or specifically oxidization of the squalene component in sebum, is one of the key reasons causing scalp inflammation. Therefore, antioxidation of the sebum is an important way to maintain scalp health. In this study, we investigated the relationship between squalene peroxide formed and its exposure time under UVA light. Further, we found two oil-soluble antioxidants, ginger root extract and vitamin E, being effective on antioxidation of sebum, and can be potentially used as scalp care actives.展开更多
Background: Acne vulgaris is characterized by the enhancement of sebaceous lipogenesis and sebum secretion, and apart from retinoids and some natural products there are few effective antiacne agents that directly supp...Background: Acne vulgaris is characterized by the enhancement of sebaceous lipogenesis and sebum secretion, and apart from retinoids and some natural products there are few effective antiacne agents that directly suppress sebum production and accumulation in sebaceous glands. Objective: We examined the effects of β-cryptoxanthin (β-CRX), which is a carotenoid pigment most abundant in Citrus unshiu Marcovich (Satsuma mandarin orange) and plays a role as a vitamin A precursor on sebum production and accumulation in hamster sebaceous gland cells (sebocytes). Materials and methods: The regulation of sebum production was examined by the measurement of triacylglycerols (TGs), the major sebum component, and oil red O staining in insulindifferentiated hamster sebocytes. The expression of diacylglycerol acyltransferase-1 (DGAT-1), a rate-limiting enzyme of TG biosynthesis, and perilipin 1 (PLIN1), a lipid storage droplet protein, was analyzed using real-time PCR and Western blotting. Results: Hamster sebocytes constitutively produced TGs during cultivation and the production of TGs was enhanced by insulin treatment. Both constitutive and insulin-enhanced TG productions were dose- and time-dependently inhibited by β-CRX as well as 13-cis retinoic acid. In addition, the gene expression of DGAT-1 was suppressed by β-CRX in the sebocytes. Furthermore, the insulin-en- hanced sebum accumulation as lipid droplets was reduced in the β-CRX-treated cells. Moreover, β-CRX was found to suppress the gene expression and production of PLIN1 in insulin-differentiated hamster sebocytes. Conclusions: These results provide novel evidence that β-CRX is an effective candidate for acne therapy by its ability to exert dual inhibitory actions against DGAT-1-dependent TG production and PLIN1-mediated lipiddroplet formation in hamster sebocytes.展开更多
Perfect base makeup is the guarantee of exquisite makeup.However,the problem of base makeup darkening seriously affects the cosmetic effect,and also troubles many researchers and consumers.In this paper,a basic liquid...Perfect base makeup is the guarantee of exquisite makeup.However,the problem of base makeup darkening seriously affects the cosmetic effect,and also troubles many researchers and consumers.In this paper,a basic liquid foundation was chosen as model to explore the darkness reason from the aspects of foundation hue,volatility of emulsification system,and sebum secretion.DEcmc value determined by non-contact colorimeter was used to monitor the process of darkness.It’s widely accepted that foundation oxidation is key to darkness.We herein report a new insight into the essential reason of darkness due to the interaction between light and foundation.The red hue of the foundation darkened faster because the human eyes were more sensitive to the color difference of red.The volatility of foundation emulsion system and skin sebum secretion accelerated the foundation darkening process,which was caused by the change of foundation surface structure.Considering the above influencing factors,the formula was adjusted and an improved formula was proposed,which could significantly reduce the process of foundation darkening.展开更多
文摘Scalp inflammation is a fundamental issue to many unhealthy scalp symptoms such as itching, redness, dandruff, and odor. Oxidized sebum, or specifically oxidization of the squalene component in sebum, is one of the key reasons causing scalp inflammation. Therefore, antioxidation of the sebum is an important way to maintain scalp health. In this study, we investigated the relationship between squalene peroxide formed and its exposure time under UVA light. Further, we found two oil-soluble antioxidants, ginger root extract and vitamin E, being effective on antioxidation of sebum, and can be potentially used as scalp care actives.
文摘Background: Acne vulgaris is characterized by the enhancement of sebaceous lipogenesis and sebum secretion, and apart from retinoids and some natural products there are few effective antiacne agents that directly suppress sebum production and accumulation in sebaceous glands. Objective: We examined the effects of β-cryptoxanthin (β-CRX), which is a carotenoid pigment most abundant in Citrus unshiu Marcovich (Satsuma mandarin orange) and plays a role as a vitamin A precursor on sebum production and accumulation in hamster sebaceous gland cells (sebocytes). Materials and methods: The regulation of sebum production was examined by the measurement of triacylglycerols (TGs), the major sebum component, and oil red O staining in insulindifferentiated hamster sebocytes. The expression of diacylglycerol acyltransferase-1 (DGAT-1), a rate-limiting enzyme of TG biosynthesis, and perilipin 1 (PLIN1), a lipid storage droplet protein, was analyzed using real-time PCR and Western blotting. Results: Hamster sebocytes constitutively produced TGs during cultivation and the production of TGs was enhanced by insulin treatment. Both constitutive and insulin-enhanced TG productions were dose- and time-dependently inhibited by β-CRX as well as 13-cis retinoic acid. In addition, the gene expression of DGAT-1 was suppressed by β-CRX in the sebocytes. Furthermore, the insulin-en- hanced sebum accumulation as lipid droplets was reduced in the β-CRX-treated cells. Moreover, β-CRX was found to suppress the gene expression and production of PLIN1 in insulin-differentiated hamster sebocytes. Conclusions: These results provide novel evidence that β-CRX is an effective candidate for acne therapy by its ability to exert dual inhibitory actions against DGAT-1-dependent TG production and PLIN1-mediated lipiddroplet formation in hamster sebocytes.
文摘Perfect base makeup is the guarantee of exquisite makeup.However,the problem of base makeup darkening seriously affects the cosmetic effect,and also troubles many researchers and consumers.In this paper,a basic liquid foundation was chosen as model to explore the darkness reason from the aspects of foundation hue,volatility of emulsification system,and sebum secretion.DEcmc value determined by non-contact colorimeter was used to monitor the process of darkness.It’s widely accepted that foundation oxidation is key to darkness.We herein report a new insight into the essential reason of darkness due to the interaction between light and foundation.The red hue of the foundation darkened faster because the human eyes were more sensitive to the color difference of red.The volatility of foundation emulsion system and skin sebum secretion accelerated the foundation darkening process,which was caused by the change of foundation surface structure.Considering the above influencing factors,the formula was adjusted and an improved formula was proposed,which could significantly reduce the process of foundation darkening.
