Objective To analyze and identify the differentially expressed proteins in human renal tubular epithelial ceils ( HK-2) after injury caused by oxalic acid and calcium oxalate monohydrate ( COM ) crystal,and to explore...Objective To analyze and identify the differentially expressed proteins in human renal tubular epithelial ceils ( HK-2) after injury caused by oxalic acid and calcium oxalate monohydrate ( COM ) crystal,and to explore the potential role of renal tubular cell injury in kidney stone formation. Methods Normal HK-2 cells展开更多
Objective To discuss the characters and management of renal lymphangiectasia. Methods The clinical data of two cases of renal lymphangiectasia were reviewed. The first patient was a 37-year-old woman with chief compla...Objective To discuss the characters and management of renal lymphangiectasia. Methods The clinical data of two cases of renal lymphangiectasia were reviewed. The first patient was a 37-year-old woman with chief complaint of lumbago in the right flank for 8 days. B-ultrasound showed mixed echo in perinephric space.展开更多
Objective To review the diagnosis and treatment of squamous cell carcinoma of renal pelvis. Methods The clinical data,from October 1991 to May 2009,of eight cases of squamous cell carcinoma of renal
Objective To discuss the diagnosis and surgical management of multilocular cystic renal cell carcinoma ( MCRCC) and to evaluate the gene function of the mutation of von Hippel-Lindau ( VHL) gene in MCRCC. Methods Seve...Objective To discuss the diagnosis and surgical management of multilocular cystic renal cell carcinoma ( MCRCC) and to evaluate the gene function of the mutation of von Hippel-Lindau ( VHL) gene in MCRCC. Methods Seventeen MCRCC cases ( 11 men and展开更多
Objective To evaluate the correlation between the pathologic findings of donor renal grafts and the post-transplantative diseases throuth the biopsies of donor grafts in 482 cases. Methods The renal structures of biop...Objective To evaluate the correlation between the pathologic findings of donor renal grafts and the post-transplantative diseases throuth the biopsies of donor grafts in 482 cases. Methods The renal structures of biopsies of the donor grafts in 482 cases were observed under microscope, and the pathologic findings combined with the post-transplantative conditions were analysed. Results After transplantation, acute rejection occurred in 71 cases,of when 16(22.5%) had adverse changes in donor grafts; chronic allograft nephropahty developed in 17 cases, of whom 7 (41.2% ) had adverse changes in donor grafts; elevated sera creatinine levels with unknown causes occurred in 39 cases, of whon 7(18.0% ) had adverse changes in donor grafts. The lesion of donor renal grafts had nothing to do with the acute rejection or other abnormalities after operation ( r≤ 0.3) but some kind of lesion had certain correlation with chronic allograft nephropathy(CAN, r 】0.3). Conclusion Routine biopsy of donor renal graft is展开更多
Objective To analysis the pathological demography in Chinese patients undergoing renal biopsy from our niphrology center.Methods Between January 1979 and October 2000 in Jinling Hospital, Nanjing, China, 10 002 attemp...Objective To analysis the pathological demography in Chinese patients undergoing renal biopsy from our niphrology center.Methods Between January 1979 and October 2000 in Jinling Hospital, Nanjing, China, 10 002 attempts of percutaneous renal were performed in patients with renal disease from 33 provinces of China. The pathological classifications were made according to the WHO criteria of 1982 for renal pathology or the modified WHO criteria of 1995 by a panel of pathologists and nephrologists during routine clinical-pathological rounds. The pathological demography between those specimens collected from 1979 -1989 and those from 1990 -1999 was compared.Results The mean age of the 10002 subjects undergoing renal biopsy was 31.4 ?3.0 years (ranging from 1 to 78 years), with a male to female ratio of 1. 3: 1; for the 592 renal transplant recipients, the mean age was 37. 5 ±9. 1 years (ranging from 16 to 66 years), with a male to female ratio of 2.36: 1. Primary glomerular diseases (PGD) accounted for 71% of the total patients undergoing renal biopsies, secondary glomerular nephritis (SGN) 23%, tubular-interstitial diseases 3. 2% , unclassified renal diseases 1. 3% , hereditary and congenital renal diseases 1. 0% , end stage renal diseases 0. 96% , and recently realized or rare renal diseases 0. 15%. IgA nephropathy (IgAN) was the most frequent pathological pattern (40%) of PGD, followed by mesangial proliferative lesion (MsPL) (30%), membranous nephropathy (MN) (10%), and focal segmental glomerulosclerosis ( FSGS) (6%). Lupus nephritis (LN) was the most pathology common seen (74%) in SGN. During the 22 years of the study period, there was a steady increase in patients with SGN discovered during pathological evaluation of renal disorders. A rise in prevalence was found in IgA nephropathy, MN (both P<0.001), crescentic glomerulonephritis (P<0. 0001), anti-GBM disease, and hemolytic-uremic syndrome/thrombotic thrombocytopenic purpura related renal damages ( both P < 0. 001 ). There was a decrease in endocapillary proliferative glomerulonephritis ( P < 0. 001 ) and IgM nephropathy (IgMN) ( P < 0. 01) from 1990 - 1999 as compared to 1979 - 1989. Infrequent renal pathological entities were also diagnosed in this group, including Niemann Pick disease, Fabry' s disease, POEMS syndrome, and lipoprotein glomerulonephropathy.Conclusions This is the largest series of renal biopsy data in China, and therefore may reflect the demographic picture of renal diseases in this country. Changes in prevalence of renal pathological entities were reflected in this group of patients over the last 22 years. In primary glomerular diseases, IgA nephropathy is still the most frequently observed pathological pattern. In SGN, LN appeared the most often. Increased prevalence was found in anti-GBM nephritis and HUS/TTP.展开更多
文摘Objective To analyze and identify the differentially expressed proteins in human renal tubular epithelial ceils ( HK-2) after injury caused by oxalic acid and calcium oxalate monohydrate ( COM ) crystal,and to explore the potential role of renal tubular cell injury in kidney stone formation. Methods Normal HK-2 cells
文摘Objective To discuss the characters and management of renal lymphangiectasia. Methods The clinical data of two cases of renal lymphangiectasia were reviewed. The first patient was a 37-year-old woman with chief complaint of lumbago in the right flank for 8 days. B-ultrasound showed mixed echo in perinephric space.
文摘Objective To review the diagnosis and treatment of squamous cell carcinoma of renal pelvis. Methods The clinical data,from October 1991 to May 2009,of eight cases of squamous cell carcinoma of renal
文摘Objective To discuss the diagnosis and surgical management of multilocular cystic renal cell carcinoma ( MCRCC) and to evaluate the gene function of the mutation of von Hippel-Lindau ( VHL) gene in MCRCC. Methods Seventeen MCRCC cases ( 11 men and
文摘Objective To evaluate the correlation between the pathologic findings of donor renal grafts and the post-transplantative diseases throuth the biopsies of donor grafts in 482 cases. Methods The renal structures of biopsies of the donor grafts in 482 cases were observed under microscope, and the pathologic findings combined with the post-transplantative conditions were analysed. Results After transplantation, acute rejection occurred in 71 cases,of when 16(22.5%) had adverse changes in donor grafts; chronic allograft nephropahty developed in 17 cases, of whom 7 (41.2% ) had adverse changes in donor grafts; elevated sera creatinine levels with unknown causes occurred in 39 cases, of whon 7(18.0% ) had adverse changes in donor grafts. The lesion of donor renal grafts had nothing to do with the acute rejection or other abnormalities after operation ( r≤ 0.3) but some kind of lesion had certain correlation with chronic allograft nephropathy(CAN, r 】0.3). Conclusion Routine biopsy of donor renal graft is
文摘Objective To analysis the pathological demography in Chinese patients undergoing renal biopsy from our niphrology center.Methods Between January 1979 and October 2000 in Jinling Hospital, Nanjing, China, 10 002 attempts of percutaneous renal were performed in patients with renal disease from 33 provinces of China. The pathological classifications were made according to the WHO criteria of 1982 for renal pathology or the modified WHO criteria of 1995 by a panel of pathologists and nephrologists during routine clinical-pathological rounds. The pathological demography between those specimens collected from 1979 -1989 and those from 1990 -1999 was compared.Results The mean age of the 10002 subjects undergoing renal biopsy was 31.4 ?3.0 years (ranging from 1 to 78 years), with a male to female ratio of 1. 3: 1; for the 592 renal transplant recipients, the mean age was 37. 5 ±9. 1 years (ranging from 16 to 66 years), with a male to female ratio of 2.36: 1. Primary glomerular diseases (PGD) accounted for 71% of the total patients undergoing renal biopsies, secondary glomerular nephritis (SGN) 23%, tubular-interstitial diseases 3. 2% , unclassified renal diseases 1. 3% , hereditary and congenital renal diseases 1. 0% , end stage renal diseases 0. 96% , and recently realized or rare renal diseases 0. 15%. IgA nephropathy (IgAN) was the most frequent pathological pattern (40%) of PGD, followed by mesangial proliferative lesion (MsPL) (30%), membranous nephropathy (MN) (10%), and focal segmental glomerulosclerosis ( FSGS) (6%). Lupus nephritis (LN) was the most pathology common seen (74%) in SGN. During the 22 years of the study period, there was a steady increase in patients with SGN discovered during pathological evaluation of renal disorders. A rise in prevalence was found in IgA nephropathy, MN (both P<0.001), crescentic glomerulonephritis (P<0. 0001), anti-GBM disease, and hemolytic-uremic syndrome/thrombotic thrombocytopenic purpura related renal damages ( both P < 0. 001 ). There was a decrease in endocapillary proliferative glomerulonephritis ( P < 0. 001 ) and IgM nephropathy (IgMN) ( P < 0. 01) from 1990 - 1999 as compared to 1979 - 1989. Infrequent renal pathological entities were also diagnosed in this group, including Niemann Pick disease, Fabry' s disease, POEMS syndrome, and lipoprotein glomerulonephropathy.Conclusions This is the largest series of renal biopsy data in China, and therefore may reflect the demographic picture of renal diseases in this country. Changes in prevalence of renal pathological entities were reflected in this group of patients over the last 22 years. In primary glomerular diseases, IgA nephropathy is still the most frequently observed pathological pattern. In SGN, LN appeared the most often. Increased prevalence was found in anti-GBM nephritis and HUS/TTP.
