Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total...Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total of 52 ITP patients with SQFCB were enrolled and divided into bleeding group(38 cases) and non-bleeding group(14 cases).Bleeding group was further divided into mild qi deficiency group(25 cases) and moderate/severe qi deficiency group(13 cases) based on Chinese Medicine syndrome score.20 healthy volunteer were recruited as control group.The count of platelet(PLT) was taken as the blood related indicator.The expressions of cytokines including IL-1β, IL-17 A, TNF-α, CD40 L, and TGF-β, detected by Aim Plex Multiple Immunoassays for Flow, were taken as the qi related indicators.The expressions of VEGF-A, detected by Aim Plex Multiple Immunoassays for Flow and NO, NOS, and ET-1 detected by ELISA, were taken as the vessel related indicators.Results: As compared to the control group, the count of PLT, taken as the blood related indicator, was significantly lower in ITP group patients with SQFCB(P<0.05).The expression levels of IL-17 A and TNF-α, taken as the qi related indicators, were significantly higher, while those of CD40 L, IL-1β, and TGF-β, also taken as the qi related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The expression levels of NO and ET-1, taken as the vessel related indicators, were significantly higher, while the expression levels of NOS and VEGF-A also taken as the vessel related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The count of PLT, taken as the blood related indicator, was significantly lower in moderate/severe group than those in mild group(P<0.05).The expression levels of CD40 L and TGF-β, taken as the qi related indicators, were also significantly lower in moderate/severe group than those in mild group, respectively(P<0.05).Conclusion: The count of PLT might be the biological basis of blood.The expressions of NO, NOS, ET-1 and VEGF-A might be the biological basis of vessel.The expressions of IL-1β, IL-17 A, TNF-α, TGF-β, and CD40 L may be the biological basis of qi.The expressions of CD40 L and TGF-β could reflect the degree of qi deficiency in ITP patients based on the theory of qi and blood.展开更多
Thin endometrium has been proven to be a key contributing factor leading to infertility and poor pregnancy outcomes.Increasing the thickness and capacity of thin endometrium seems to be one of the challenging issues i...Thin endometrium has been proven to be a key contributing factor leading to infertility and poor pregnancy outcomes.Increasing the thickness and capacity of thin endometrium seems to be one of the challenging issues in reproductive medicine.The states of qi and blood are closely related to uterine blood circulation.Constitution is regarded as an important basis for determining the incidence as well as distinguishing,preventing,and treating diseases in traditional Chinese medicine.Based on the theory of qi and blood,this paper discusses the constitution factors of thin endometrium and puts forward the prospect of using big data tools to investigate the correlation between qi-blood imbalance constitution and the incidence of thin endometrium,so as to explore new approaches for the prevention and treatment of thin endometrium by regulating qi and blood as well as improving the constitution condition.展开更多
The revival of qi theory in the middle Ming dynasty is crucial in the development of Confucianism.In this stage,Luo Qinshun,Wang Yangming,Wang Tingxiang,and LüNan discussed issues such as the relationship between...The revival of qi theory in the middle Ming dynasty is crucial in the development of Confucianism.In this stage,Luo Qinshun,Wang Yangming,Wang Tingxiang,and LüNan discussed issues such as the relationship between li(principle)and qi(vital energy),the relationship between xing(human nature)and qi,and gongfu(e ort)for the theory of qi. e multifaceted debates between them are relevant to the development of Neo-Confucianism and the issues of Confucianism in the Ming and Qing dynasties,demonstrating the features of mid-Ming Confucian theories of qi.A general survey of the four Confucian scholars’theories of qi,especially the transition from li–qi monism to the xing–qi connection,reveals that how to establish the unity between the universe and human nature in the theories of qi became a central concern of mid-Ming Confucianism.In addition,the gongfu for the theory of qi represented a new level of the holistic development of Ming Confucianism,though it su ered setbacks in its development.展开更多
The deliberately ignorance of the subjective aspect in“sage’s intention”(圣人之意)and the omission of the interplay of differences are two major problems within the interpretation of“Chinese wisdom”which is suppo...The deliberately ignorance of the subjective aspect in“sage’s intention”(圣人之意)and the omission of the interplay of differences are two major problems within the interpretation of“Chinese wisdom”which is supposed to serve as the“other”perspective to western philosophy by Fran?ois Jullien.The two missing aspects indicate the tendency of sacrificing the particularity(differences)for“the unity”.Ultimately,with the“help”of the misunderstanding of the“Chinese wisdom”,the divisions inherently in western philosophy are merely replaced by the hollow homogenization.展开更多
Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which pro...Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.展开更多
基金the National Program on Key Basic Research Project(2015CB554403)
文摘Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total of 52 ITP patients with SQFCB were enrolled and divided into bleeding group(38 cases) and non-bleeding group(14 cases).Bleeding group was further divided into mild qi deficiency group(25 cases) and moderate/severe qi deficiency group(13 cases) based on Chinese Medicine syndrome score.20 healthy volunteer were recruited as control group.The count of platelet(PLT) was taken as the blood related indicator.The expressions of cytokines including IL-1β, IL-17 A, TNF-α, CD40 L, and TGF-β, detected by Aim Plex Multiple Immunoassays for Flow, were taken as the qi related indicators.The expressions of VEGF-A, detected by Aim Plex Multiple Immunoassays for Flow and NO, NOS, and ET-1 detected by ELISA, were taken as the vessel related indicators.Results: As compared to the control group, the count of PLT, taken as the blood related indicator, was significantly lower in ITP group patients with SQFCB(P<0.05).The expression levels of IL-17 A and TNF-α, taken as the qi related indicators, were significantly higher, while those of CD40 L, IL-1β, and TGF-β, also taken as the qi related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The expression levels of NO and ET-1, taken as the vessel related indicators, were significantly higher, while the expression levels of NOS and VEGF-A also taken as the vessel related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The count of PLT, taken as the blood related indicator, was significantly lower in moderate/severe group than those in mild group(P<0.05).The expression levels of CD40 L and TGF-β, taken as the qi related indicators, were also significantly lower in moderate/severe group than those in mild group, respectively(P<0.05).Conclusion: The count of PLT might be the biological basis of blood.The expressions of NO, NOS, ET-1 and VEGF-A might be the biological basis of vessel.The expressions of IL-1β, IL-17 A, TNF-α, TGF-β, and CD40 L may be the biological basis of qi.The expressions of CD40 L and TGF-β could reflect the degree of qi deficiency in ITP patients based on the theory of qi and blood.
基金National Natural Science Foundation of China(Grant Number:81603656)Infertility Innovation Team(Grant Number:132041929)+2 种基金National Pilot Project of Clinical Collaboration of Traditional ChineseWestern Medicine on InfertilityScientific Research Program of Shaanxi University of Traditional Chinese Medicine in 2017(Project Number:2017PY10)。
文摘Thin endometrium has been proven to be a key contributing factor leading to infertility and poor pregnancy outcomes.Increasing the thickness and capacity of thin endometrium seems to be one of the challenging issues in reproductive medicine.The states of qi and blood are closely related to uterine blood circulation.Constitution is regarded as an important basis for determining the incidence as well as distinguishing,preventing,and treating diseases in traditional Chinese medicine.Based on the theory of qi and blood,this paper discusses the constitution factors of thin endometrium and puts forward the prospect of using big data tools to investigate the correlation between qi-blood imbalance constitution and the incidence of thin endometrium,so as to explore new approaches for the prevention and treatment of thin endometrium by regulating qi and blood as well as improving the constitution condition.
基金This paper is a preliminary result of the research project Studies on Wang Tingxiang’s eory of Qi[王廷相气论思想研究],supported by National Social Science Fund of China in the later stage(Project No.19FZXB073)the project Studies on the eories of Qi in the Mid-and Late-Ming Dynasty and the Transition of Confucianism from the Ming to the Qing Dynasty[明代中后期气论思潮与明清儒学转型问题研究],supported by the 2018 Provincial Social Science Fund Youth Program of Hunan(Project No.18YBQ126).
文摘The revival of qi theory in the middle Ming dynasty is crucial in the development of Confucianism.In this stage,Luo Qinshun,Wang Yangming,Wang Tingxiang,and LüNan discussed issues such as the relationship between li(principle)and qi(vital energy),the relationship between xing(human nature)and qi,and gongfu(e ort)for the theory of qi. e multifaceted debates between them are relevant to the development of Neo-Confucianism and the issues of Confucianism in the Ming and Qing dynasties,demonstrating the features of mid-Ming Confucian theories of qi.A general survey of the four Confucian scholars’theories of qi,especially the transition from li–qi monism to the xing–qi connection,reveals that how to establish the unity between the universe and human nature in the theories of qi became a central concern of mid-Ming Confucianism.In addition,the gongfu for the theory of qi represented a new level of the holistic development of Ming Confucianism,though it su ered setbacks in its development.
文摘The deliberately ignorance of the subjective aspect in“sage’s intention”(圣人之意)and the omission of the interplay of differences are two major problems within the interpretation of“Chinese wisdom”which is supposed to serve as the“other”perspective to western philosophy by Fran?ois Jullien.The two missing aspects indicate the tendency of sacrificing the particularity(differences)for“the unity”.Ultimately,with the“help”of the misunderstanding of the“Chinese wisdom”,the divisions inherently in western philosophy are merely replaced by the hollow homogenization.
基金This study was supported by the Strategic Consulting Project of the Chinese Academy of Engineering-Strategic Research on Anti-aging Effects of Traditional Chinese Medicine(2022-XY-45)the Natural Science Foundation of Hebei Province of China(no.H2022106065)+1 种基金the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(no.2023172)the Scientific Research Project of Traditional Chinese Medicine Administration of Hebei Province(no.2023391).
文摘Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.
