Procathepsin D(pCD)is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas.pCD affects multiple features of tumor cells including proliferation,invasion,metastases and apopto...Procathepsin D(pCD)is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas.pCD affects multiple features of tumor cells including proliferation,invasion,metastases and apoptosis.Several laboratories have previously shown that the mitogenic effect of pCD on cancer cells is mediated via its propeptide part(APpCD).However,the exact mechanism of how pCD affects cancer cells has not been identified.Recent observations have also revealed the possible use of pCD/APpcD as a marker of cancer progression.The purpose of this review is to summarize the three major potentials of pCD-tumor marker,potential drug,and screening agent.展开更多
Current diagnostic assays for many cancers are antigen-based and rely on the detection of circulating proteins that are associated with a particular cancer.These assays depend on the expression,synthesis,and release o...Current diagnostic assays for many cancers are antigen-based and rely on the detection of circulating proteins that are associated with a particular cancer.These assays depend on the expression,synthesis,and release of specific proteins by cells(e.g.,tumor cells)through either active secretion or shedding,or as a consequence of cell death(either necrosis or apoptosis).As such,these antigenic proteins must“escape”the primary site of disease,saturate the antigen-processing capacity of the individual’s immune components,gain access to the circulation,and reach a sufficient steady-state concentration to be detected by enzyme-or radiolabel-based immunoassays.These events usually occur after the initial establishment of disease.Thus,and despite the fact that certain specific antigenic epitopes exhibit common recognition among patients with the same tumor types,the use of these antigen-based cancer assays has not been widely accepted in clinical practice,and many individual countries differ in the use of these potential diagnostic factors.Lately,an increasing number of studies demonstrated that procathepsin D secreted from cancer cells,acts as a mitogen on cancer cells and stimulates their pro-invasive and pro-metastatic properties.In this report,we focused on the possibility to use antiprocathepsin D autoantibodies as a diagnostic and/or predictive marker for cancers.展开更多
文摘Procathepsin D(pCD)is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas.pCD affects multiple features of tumor cells including proliferation,invasion,metastases and apoptosis.Several laboratories have previously shown that the mitogenic effect of pCD on cancer cells is mediated via its propeptide part(APpCD).However,the exact mechanism of how pCD affects cancer cells has not been identified.Recent observations have also revealed the possible use of pCD/APpcD as a marker of cancer progression.The purpose of this review is to summarize the three major potentials of pCD-tumor marker,potential drug,and screening agent.
文摘Current diagnostic assays for many cancers are antigen-based and rely on the detection of circulating proteins that are associated with a particular cancer.These assays depend on the expression,synthesis,and release of specific proteins by cells(e.g.,tumor cells)through either active secretion or shedding,or as a consequence of cell death(either necrosis or apoptosis).As such,these antigenic proteins must“escape”the primary site of disease,saturate the antigen-processing capacity of the individual’s immune components,gain access to the circulation,and reach a sufficient steady-state concentration to be detected by enzyme-or radiolabel-based immunoassays.These events usually occur after the initial establishment of disease.Thus,and despite the fact that certain specific antigenic epitopes exhibit common recognition among patients with the same tumor types,the use of these antigen-based cancer assays has not been widely accepted in clinical practice,and many individual countries differ in the use of these potential diagnostic factors.Lately,an increasing number of studies demonstrated that procathepsin D secreted from cancer cells,acts as a mitogen on cancer cells and stimulates their pro-invasive and pro-metastatic properties.In this report,we focused on the possibility to use antiprocathepsin D autoantibodies as a diagnostic and/or predictive marker for cancers.
