Despite the breadth of knowledge about malaria, its transmission, preventive measures and available treatments and its difficulty in controlling the vector and the rapid spread of resistance to current drugs, there is...Despite the breadth of knowledge about malaria, its transmission, preventive measures and available treatments and its difficulty in controlling the vector and the rapid spread of resistance to current drugs, there is a stimulus to develop new research looking for active molecules. The phytochemical studies of the active extract confirmed the presence of alkaloids, flavonoids, coumarins, tannins, reducing compounds, anthocyanins, terpenes, triterpenes and steroids. In the present work, it was possible to isolate a mixture of isoquinolinic alkaloids from the tender leaves of Nectandra membranacea （Laureaceae） with antimalarial activity. The mixture composed of （-） - gliazovine and （＋） - aplogliazovine showed an IC50 value of 32.18 μg/mL against the P. berghei NK65 strain. It is important to continue with these studies and their chemical components isolated from N. membranacea that could be used as an alternative the treatment of malaria.展开更多
The increase in the population of neurodegenerative diseases has made it necessary to search for new drugs and phytopharmaceuticals for the prevention or treatment of these diseases,which is why the exploration of the...The increase in the population of neurodegenerative diseases has made it necessary to search for new drugs and phytopharmaceuticals for the prevention or treatment of these diseases,which is why the exploration of the potential of the plants present in the coffee zone is of great importance.The objective of this study was to determine the possible neuroprotective effect of the species Nectandra acutifolia.The methanolic extract of Nectandra acutifolia was obtained through maceration of the aerial part of the leaves.The phytochemical profile was detected by means of thin layer chromatography.The evaluation of the antioxidant capacity was carried out by means of the colorimetric techniques of DPPH and ABTS ^+.On the other hand,the total content of phenols and flavonoids was determined as well as the neuroprotective activity,by means of the negative geotaxis test and biochemical tests.Finally,the methanolic extract of N.acutifolia showed a high antioxidant capacity through the two colorimetric methods.The negative geotaxis test revealed that the concentration of 0.1%had a greater locomotor effect in D.melanogaster,which was used as a supplement in the feeding of the Drosophilas.The results showed that the methanolic extract of this species has neuroprotective activity using this in vivo model.展开更多
文摘Despite the breadth of knowledge about malaria, its transmission, preventive measures and available treatments and its difficulty in controlling the vector and the rapid spread of resistance to current drugs, there is a stimulus to develop new research looking for active molecules. The phytochemical studies of the active extract confirmed the presence of alkaloids, flavonoids, coumarins, tannins, reducing compounds, anthocyanins, terpenes, triterpenes and steroids. In the present work, it was possible to isolate a mixture of isoquinolinic alkaloids from the tender leaves of Nectandra membranacea （Laureaceae） with antimalarial activity. The mixture composed of （-） - gliazovine and （＋） - aplogliazovine showed an IC50 value of 32.18 μg/mL against the P. berghei NK65 strain. It is important to continue with these studies and their chemical components isolated from N. membranacea that could be used as an alternative the treatment of malaria.
文摘The increase in the population of neurodegenerative diseases has made it necessary to search for new drugs and phytopharmaceuticals for the prevention or treatment of these diseases,which is why the exploration of the potential of the plants present in the coffee zone is of great importance.The objective of this study was to determine the possible neuroprotective effect of the species Nectandra acutifolia.The methanolic extract of Nectandra acutifolia was obtained through maceration of the aerial part of the leaves.The phytochemical profile was detected by means of thin layer chromatography.The evaluation of the antioxidant capacity was carried out by means of the colorimetric techniques of DPPH and ABTS ^+.On the other hand,the total content of phenols and flavonoids was determined as well as the neuroprotective activity,by means of the negative geotaxis test and biochemical tests.Finally,the methanolic extract of N.acutifolia showed a high antioxidant capacity through the two colorimetric methods.The negative geotaxis test revealed that the concentration of 0.1%had a greater locomotor effect in D.melanogaster,which was used as a supplement in the feeding of the Drosophilas.The results showed that the methanolic extract of this species has neuroprotective activity using this in vivo model.
