Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for th...Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for the first time a patient was given a retinal implant in order to treat dry agerelated macular degeneration. Retinal implants are suitable solutions for diseases that attack photoreceptors but spare most of the remaining retinal neurons. For eye diseases that result in loss of retinal output, implants that interface with more central structures in the visual system are needed. The standard site for central visual prostheses under development is the visual cortex. This perspective discusses the technical and socioeconomic challenges faced by visual prostheses.展开更多
In vivo implantation of microelectrodes opens the door to studying neural circuits and restoring damaged neural pathways through direct electrical stimulation and recording.Although some neuroprostheses have achieved ...In vivo implantation of microelectrodes opens the door to studying neural circuits and restoring damaged neural pathways through direct electrical stimulation and recording.Although some neuroprostheses have achieved clinical success,electrode material properties,inflammatory response,and glial scar formation at the electrode-tissue interfaces affect performance and sustainability.Those challenges can be addressed by improving some of the materials’mechanical,physical,chemical,and electrical properties.This paper reviews materials and designs of current microelectrodes and discusses perspectives to advance neuroprosthetics performance.展开更多
基金the National Priorities Research Program (NPRP) (NPRP 5-457-2-181) from the Qatar National Research Fund (a member of Qatar Foundation)
文摘Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for the first time a patient was given a retinal implant in order to treat dry agerelated macular degeneration. Retinal implants are suitable solutions for diseases that attack photoreceptors but spare most of the remaining retinal neurons. For eye diseases that result in loss of retinal output, implants that interface with more central structures in the visual system are needed. The standard site for central visual prostheses under development is the visual cortex. This perspective discusses the technical and socioeconomic challenges faced by visual prostheses.
基金funded through the NIH by grant R01DC018666 at Northwestern University.
文摘In vivo implantation of microelectrodes opens the door to studying neural circuits and restoring damaged neural pathways through direct electrical stimulation and recording.Although some neuroprostheses have achieved clinical success,electrode material properties,inflammatory response,and glial scar formation at the electrode-tissue interfaces affect performance and sustainability.Those challenges can be addressed by improving some of the materials’mechanical,physical,chemical,and electrical properties.This paper reviews materials and designs of current microelectrodes and discusses perspectives to advance neuroprosthetics performance.
