This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights int...This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.展开更多
Hydrogel scaffolds have numerous potential applications in the tissue engineering field.However,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and hi...Hydrogel scaffolds have numerous potential applications in the tissue engineering field.However,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties.Inspired by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this gap.First,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent biocompatibility.Furthermore,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell growth.Interestingly,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT strategies.Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.展开更多
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.展开更多
The physiology of the central and enteric nervous systems and gastric muscle contributes to the complexities encountered in the research and clinical management of gastroparesis. A wide range of prescription drugs tar...The physiology of the central and enteric nervous systems and gastric muscle contributes to the complexities encountered in the research and clinical management of gastroparesis. A wide range of prescription drugs target the underlying neurotransmitter imbalances and adjust nucleotide levels in appropriate tissues, but treatment is unsatisfactory, as our understanding of the condition is far from complete. In this study, computational software is used to focus on the adenine nucleotide, ATP, as a comparative template for the structures of drugs used in gastroparesis treatment. The results demonstrate that muscarinic, dopamine, serotonin (5-HT) and histamine receptor ligand classes relate structurally and differentially to the molecular structure of ATP. In these neurotransmitter classes, compounds do not target cell membrane receptor G-protein signal transduction in a manner that provides a single mechanism for improving gastroparesis symptoms. The exploration of alternative nucleotide-based deficiencies of KATP channels, Na+/K+ATPases and guanine nucleotide directed nitrergic mechanisms should enhance our experimental approach to understanding this condition.展开更多
Sacred forests play a valuable role in the conservation of local biodiversity and provide numerous ecosystem services in Cameroon. The aim of this study was to estimate floristic diversity, stand structures and carbon...Sacred forests play a valuable role in the conservation of local biodiversity and provide numerous ecosystem services in Cameroon. The aim of this study was to estimate floristic diversity, stand structures and carbon stocks in the sacred forests of Bandrefam and Batoufam (western Cameroon). The floristic inventory and the stand structures were carried out in 25 m × 25 m plots for individuals with diameters greater than 10 cm;5 m × 5 m for individuals with diameters less than 10 cm. Carbon stocks were estimated using the non-destructive method and allometric equations. The floristic inventory identified 65 species divided into 57 genera and 30 families in the Bandrefam sacred forest and 45 species divided into 42 genera and 27 families in the Batoufam sacred forest. In the Bandrefam, the most important families are Phyllanthaceae (53.98%), Moraceae (21.69%), Lamiaceae (20.15%). At Batoufam, the most important families are Phyllanthaceae (39.73%), Fabaceae (28.47%), Araliaceae (23.77%). Malacantha alnifolia (55.14%), Vitex grandifolia (18.43%), Bosqueia angolensis (15.06%) were the most important species in Bandrefam. Otherwise, Malacantha alnifolia (28%), Polyscias fulva (22.73%), Psychotria sp. (21.28%) were the most important in Batoufam. The Bandrefam sacred forest has the highest tree density (2669 stems/ha). Total carbon stock is 484.88 ± 2.28 tC/ha at Batoufam and 313.95 ± 0.93 tC/ha at Bandrefam. The economic value varies between 5858.04 ± 27.62 USD/ha in Batoufam sacred forest and 3788.51 ± 11.26 USD/ha in Bandrefam sacred forest. The number of individuals and small-diameter trees has little influence on the carbon stocks in the trees. Medium-diameter trees store the most carbon, and very large-diameter trees, which are very poorly represented, store less carbon. In another way, wood density and the basal areas influence the carbon storage of the trees.展开更多
Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship betw...Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.展开更多
Port structures constitute the main link in the maritime transport chain of coastal countries and therefore contribute to their economic development. But it should be noted that the installation of said works is not w...Port structures constitute the main link in the maritime transport chain of coastal countries and therefore contribute to their economic development. But it should be noted that the installation of said works is not without consequences for the countries concerned. Benin, a country in the Gulf of Guinea, is no exception to this phenomenon because, due to its maritime history, it has a heritage of port structures. These structures, built on its coastline, cause a wide variety of environmental problems such as silting and erosion on either side of them. The general objective of this article is to contribute to the proper functionality of port facilities while minimizing environmental problems that may arise. It aims to provide managers with a tool allowing them to fully understand the state of their assets in order to rationalize maintenance actions. In order to achieve this objective, an assessment of the state of the structure, and then a structural diagnosis are necessary and recommendations can be established to restore the level of service of the latter. As a result, two examples were presented: the wharf of the Sèmè-Podji pipeline project and the maritime piles project of the Wasco de Gama bridge (control project), and recommendations adapted to this objective were established. The comparative analysis of the two examples, both maritime works, revealed an under-sizing at the level of the spans of the wharf bridge of the Sèmè-Podji pipeline project (spans of 7 m in length), while these spans vary on average by 45 m to 62 m for the Wasco da Gama bridge. Bringing the piles closer together at the Sèmè-Podji wharf reduces the energy of the current which promotes the accumulation of sediment. The structure no longer experiences a flow capable of setting in motion the sands accumulated since at least 2022. This element appears to be a fundamental characteristic explaining the erosion observed to the east of the structure.展开更多
In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4...In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4)alloy cast in a steel mold was carried out.The addition of Ca element plays an important role in the refinement of LPSO structure.The result reveals new poly-types including 20H F2F2F4,60R(F2F3F3)_(3),and 66H F2F3F3F2(F6)_(4)featuring a 6-Mg structure,alongside the prevalent 18R and 14H LPSO structures.The incoherent interface between 20H and the Mg matrix is split into two dislocation arrays,leading to the formation of a segment of 60R_(1).Moreover,the superstructure 116L,designated as(F2)_(18)F4,is formed through the ordered distribution of F4 stacking faults in 18R.展开更多
With the development of modern society,people put forward higher requirements for building safety,which makes the construction project face new challenges.Reinforced concrete frame structure as a common engineering ty...With the development of modern society,people put forward higher requirements for building safety,which makes the construction project face new challenges.Reinforced concrete frame structure as a common engineering type,although the construction technology has been relatively mature,but its earthquake collapse ability still needs to be strengthened.This paper analyzes the specific factors that affect the seismic collapse ability of reinforced concrete frame structure,summarizes the previous research results,and puts forward innovative application of fiber-reinforced polymer(FRP)composite materials,play the role of smart materials,improve the isolation and energy dissipation devices,etc.,to promote the continuous optimization of reinforced concrete frame structure design,and show better seismic performance.展开更多
Kinked rebar is a special type of steel material,which is installed in beam column nodes and frame beams.It effectively enhances the blast resilience,seismic collapse resistance,and progressive collapse resistance of ...Kinked rebar is a special type of steel material,which is installed in beam column nodes and frame beams.It effectively enhances the blast resilience,seismic collapse resistance,and progressive collapse resistance of reinforced concrete(RC)structures without imposing substantial cost burdens,thereby emerging as a focal point of recent research endeavors.On the basis of explaining the working principle of kinked rebars,this paper reviews the research status of kinked rebars at home and abroad from three core domains:the tensile mechanical properties of kinked rebars,beam column nodes with kinked rebars,and concrete frame structures with kinked rebars.The analysis underscores that the straightening process of kinked rebars does not compromise their ultimate strength but significantly bolsters structural ductility and enhances energy dissipation capabilities.In beam-column joints,the incorporation of kinked rebars facilitates the seamless transfer of plastic hinges,adhering to the design principle of“strong columns and weak beams.”In addition,kinked rebars can greatly improve the resistance of the beam;The seismic resistance,internal explosion resistance,and progressive collapse resistance of reinforced concrete frame structures with kinked rebar have significantly improved.Beyond its primary application,the principle of kinked rebar was extended to other applications of kinked materials such as corrugated steel plates and origami structures,and the stress characteristics of related components and structures were studied.Intriguingly,this paper also proposes the application of kinked rebars in bridge engineering,aiming to address the challenges of localized damage concentration and excessive residual displacement in RC bridge piers.The introduction of kinked rebars in piers is envisioned to mitigate these issues,with the paper outlining its advantages and feasibility,thereby offering valuable insights for future research on kinked reinforcement and seismic design strategies for bridges.展开更多
This paper explores the construction methods of“Same Course with Different Structures”curriculum resources based on knowledge graphs and their applications in the field of education.By reviewing the theoretical foun...This paper explores the construction methods of“Same Course with Different Structures”curriculum resources based on knowledge graphs and their applications in the field of education.By reviewing the theoretical foundations of knowledge graph technology,the“Same Course with Different Structures”teaching model,and curriculum resource construction,and integrating existing literature,the paper analyzes the methods for constructing curriculum resources using knowledge graphs.The research finds that knowledge graphs can effectively integrate multi-source data,support personalized teaching and precision education,and provide both a scientific foundation and technical support for the development of curriculum resources within the“Same Course with Different Structures”framework.展开更多
Rice seedling blight,caused by various fungi,including Fusarium oxysporum,poses a severe threat to rice production.As awareness grows regarding the environmental and safety hazards associated with the application of f...Rice seedling blight,caused by various fungi,including Fusarium oxysporum,poses a severe threat to rice production.As awareness grows regarding the environmental and safety hazards associated with the application of fungicides for managing rice seedling blight,there has been a shift in focus towards biological control agents.In this study,we isolated biocontrol bacteria from paddy fields that significantly inhibited the growth of F.oxysporum in vitro and identified the strains as Bacillus amyloliquefaciens T40 and Bacillus pumilus T208.Additionally,our findings indicated that the combined application of these Bacillus strains in soil was more effective in reducing the incidence of rice seedling blight than their individual use.Analysis of 16S and internal transcribed spacer rRNA gene sequencing data revealed that the mixture of the T40 and T208 strains exhibited the lowest average clustering coefficients,which were negatively correlated with the biomass of F.oxysporum-inoculated rice seedlings.Furthermore,this mixture led to higher stochastic assembly(average|βNTI|<2)and reduced selection pressures on rice rhizosphere bacteria compared with individual strain applications.The mixture of the T40 and T208 strains also significantly increased the expression of defense-related genes.In conclusion,the mixture of the T40 and T208 strains effectively modulates microbial community structures,enhances microbial network stability,and boosts the resistance against rice seedling blight.Our study supports the development and utilization of biological resources for crop protection.展开更多
Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design...Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.展开更多
Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than t...Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than the diffraction limit,making it a useful method for efficient nanomanufacturing.However,compared with the low-spatial-frequency LIPSS(LSFL),the structure size of the HSFL is smaller,and it is more easily submerged.Therefore,the formation mechanism of HSFL is complex and has always been a research hotspot in this field.In this study,regular LSFL with a period of 760 nm was fabricated in advance on a silicon surface with two-beam interference using an 800 nm,50 fs femtosecond laser.The ultrafast dynamics of HSFL formation on the silicon surface of prefabricated LSFL under single femtosecond laser pulse irradiation were observed and analyzed for the first time using collinear pump-probe imaging method.In general,the evolution of the surface structure undergoes five sequential stages:the LSFL begins to split,becomes uniform HSFL,degenerates into an irregular LSFL,undergoes secondary splitting into a weakly uniform HSFL,and evolves into an irregular LSFL or is submerged.The results indicate that the local enhancement of the submerged nanocavity,or the nanoplasma,in the prefabricated LSFL ridge led to the splitting of the LSFL,and the thermodynamic effect drove the homogenization of the splitting LSFL,which evolved into HSFL.展开更多
Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low re...Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low redox potential of zinc(Zn) metal. However,several issues such as dendrite formation, hydrogen evolution, corrosion, and passivation of Zn metal anodes cause irreversible loss of the active materials. To solve these issues, researchers often use large amounts of excess Zn to ensure a continuous supply of active materials for Zn anodes. This leads to the ultralow utilization of Zn anodes and squanders the high energy density of AZMBs. Herein, the design strategies for AZMBs with high Zn utilization are discussed in depth, from utilizing thinner Zn foils to constructing anode-free structures with theoretical Zn utilization of 100%, which provides comprehensive guidelines for further research. Representative methods for calculating the depth of discharge of Zn anodes with different structures are first summarized. The reasonable modification strategies of Zn foil anodes, current collectors with pre-deposited Zn, and anode-free aqueous Zn metal batteries(AF-AZMBs) to improve Zn utilization are then detailed. In particular, the working mechanism of AF-AZMBs is systematically introduced. Finally, the challenges and perspectives for constructing high-utilization Zn anodes are presented.展开更多
The laser powder bed fusion(LPBF) process can integrally form geometrically complex and high-performance metallic parts that have attracted much interest,especially in the molds industry.The appearance of the LPBF mak...The laser powder bed fusion(LPBF) process can integrally form geometrically complex and high-performance metallic parts that have attracted much interest,especially in the molds industry.The appearance of the LPBF makes it possible to design and produce complex conformal cooling channel systems in molds.Thus,LPBF-processed tool steels have attracted more and more attention.The complex thermal history in the LPBF process makes the microstructural characteristics and properties different from those of conventional manufactured tool steels.This paper provides an overview of LPBF-processed tool steels by describing the physical phenomena,the microstructural characteristics,and the mechanical/thermal properties,including tensile properties,wear resistance,and thermal properties.The microstructural characteristics are presented through a multiscale perspective,ranging from densification,meso-structure,microstructure,substructure in grains,to nanoprecipitates.Finally,a summary of tool steels and their challenges and outlooks are introduced.展开更多
The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and minerals.Various infrastructures such as floating structures,seabed structures,and foundations have been developed to...The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and minerals.Various infrastructures such as floating structures,seabed structures,and foundations have been developed to exploit these resources.The seabed structures and foundations can be mainly classified into three types:subsea production structures,offshore pipelines,and anchors.This study reviewed the development,installation,and operation of these infrastructures,including their structures,design,installation,marine environment loads,and applications.On this basis,the research gaps and further research directions were explored through this literature review.First,different floating structures were briefly analyzed and reviewed to introduce the design requirements of the seabed structures and foundations.Second,the subsea production structures,including subsea manifolds and their foundations,were reviewed and discussed.Third,the basic characteristics and design methods of deep‐sea pipelines,including subsea pipelines and risers,were analyzed and reviewed.Finally,the installation and bearing capacity of deep‐sea subsea anchors and seabed trench influence on the anchor were reviewed.Through the review,it was found that marine environment conditions are the key inputs for any offshore structure design.The fabrication,installation,and operation of infrastructures should carefully consider the marine loads and geological conditions.Different structures have their own mechanical problems.The fatigue and stability of pipelines mainly depend on the soil‐structure interaction.Anchor selection should consider soil types and possible trench formation.These focuses and research gaps can provide a helpful guide on further research,installation,and operation of deep‐sea structures and foundations.展开更多
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas...Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.展开更多
Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering structures.In this study,a constrained damping structure for underground tunnel lining,using ...Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering structures.In this study,a constrained damping structure for underground tunnel lining,using a rubber-sand-concrete(RSC)as the aseismic material,is proposed.The aseismic performances of constrained damping structure were investigated by a series of hammer impact tests.The damping layer thickness and shape effects on the aseismic performance such as effective duration and acceleration amplitude of time-domain analysis,composite loss factor and damping ratio of the transfer function analysis,and total vibration level of octave spectrum analysis were discussed.The hammer impact tests revealed that the relationship between the aseismic performance and damping layer thickness was not linear,and that the hollow damping layer had a better aseismic performance than the flat damping layer one.The aseismic performances of constrained damping structure under different seismicity magnitudes and geological conditions were investigated.The effects of the peak ground acceleration(PGA)and tunnel overburden depth on the aseismic performances such as the maximum principal stress and equivalent plastic strain(PEEQ)were discussed.The numerical results show the constrained damping structure proposed in this paper has a good aseismic performance,with PGA in the range(0.2-1.2)g and tunnel overburden depth in the range of 0-300 m.展开更多
基金support of Spea Ingegneria Europea SpA and Società Autostrade per l’Italia SpA
文摘This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.
基金supported by the Innovative Research Group Project of the National Natural Science Foundation of China(T2121004)Key Programme(52235007)National Outstanding Youth Foundation of China(52325504).
文摘Hydrogel scaffolds have numerous potential applications in the tissue engineering field.However,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties.Inspired by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this gap.First,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent biocompatibility.Furthermore,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell growth.Interestingly,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT strategies.Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.
基金supported in part by Award 2121063 from National Science Foundation(to YM)AG66986 from the National Institutes of Health(to MSW).
文摘γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.
文摘The physiology of the central and enteric nervous systems and gastric muscle contributes to the complexities encountered in the research and clinical management of gastroparesis. A wide range of prescription drugs target the underlying neurotransmitter imbalances and adjust nucleotide levels in appropriate tissues, but treatment is unsatisfactory, as our understanding of the condition is far from complete. In this study, computational software is used to focus on the adenine nucleotide, ATP, as a comparative template for the structures of drugs used in gastroparesis treatment. The results demonstrate that muscarinic, dopamine, serotonin (5-HT) and histamine receptor ligand classes relate structurally and differentially to the molecular structure of ATP. In these neurotransmitter classes, compounds do not target cell membrane receptor G-protein signal transduction in a manner that provides a single mechanism for improving gastroparesis symptoms. The exploration of alternative nucleotide-based deficiencies of KATP channels, Na+/K+ATPases and guanine nucleotide directed nitrergic mechanisms should enhance our experimental approach to understanding this condition.
文摘Sacred forests play a valuable role in the conservation of local biodiversity and provide numerous ecosystem services in Cameroon. The aim of this study was to estimate floristic diversity, stand structures and carbon stocks in the sacred forests of Bandrefam and Batoufam (western Cameroon). The floristic inventory and the stand structures were carried out in 25 m × 25 m plots for individuals with diameters greater than 10 cm;5 m × 5 m for individuals with diameters less than 10 cm. Carbon stocks were estimated using the non-destructive method and allometric equations. The floristic inventory identified 65 species divided into 57 genera and 30 families in the Bandrefam sacred forest and 45 species divided into 42 genera and 27 families in the Batoufam sacred forest. In the Bandrefam, the most important families are Phyllanthaceae (53.98%), Moraceae (21.69%), Lamiaceae (20.15%). At Batoufam, the most important families are Phyllanthaceae (39.73%), Fabaceae (28.47%), Araliaceae (23.77%). Malacantha alnifolia (55.14%), Vitex grandifolia (18.43%), Bosqueia angolensis (15.06%) were the most important species in Bandrefam. Otherwise, Malacantha alnifolia (28%), Polyscias fulva (22.73%), Psychotria sp. (21.28%) were the most important in Batoufam. The Bandrefam sacred forest has the highest tree density (2669 stems/ha). Total carbon stock is 484.88 ± 2.28 tC/ha at Batoufam and 313.95 ± 0.93 tC/ha at Bandrefam. The economic value varies between 5858.04 ± 27.62 USD/ha in Batoufam sacred forest and 3788.51 ± 11.26 USD/ha in Bandrefam sacred forest. The number of individuals and small-diameter trees has little influence on the carbon stocks in the trees. Medium-diameter trees store the most carbon, and very large-diameter trees, which are very poorly represented, store less carbon. In another way, wood density and the basal areas influence the carbon storage of the trees.
基金supported by the National Natural Science Foundation of China(22265021)the Aeronautical Science Foundation of China(2020Z056056003)Jiangxi Provincial Natural Science Foundation(20232BAB212004).
文摘Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.
文摘Port structures constitute the main link in the maritime transport chain of coastal countries and therefore contribute to their economic development. But it should be noted that the installation of said works is not without consequences for the countries concerned. Benin, a country in the Gulf of Guinea, is no exception to this phenomenon because, due to its maritime history, it has a heritage of port structures. These structures, built on its coastline, cause a wide variety of environmental problems such as silting and erosion on either side of them. The general objective of this article is to contribute to the proper functionality of port facilities while minimizing environmental problems that may arise. It aims to provide managers with a tool allowing them to fully understand the state of their assets in order to rationalize maintenance actions. In order to achieve this objective, an assessment of the state of the structure, and then a structural diagnosis are necessary and recommendations can be established to restore the level of service of the latter. As a result, two examples were presented: the wharf of the Sèmè-Podji pipeline project and the maritime piles project of the Wasco de Gama bridge (control project), and recommendations adapted to this objective were established. The comparative analysis of the two examples, both maritime works, revealed an under-sizing at the level of the spans of the wharf bridge of the Sèmè-Podji pipeline project (spans of 7 m in length), while these spans vary on average by 45 m to 62 m for the Wasco da Gama bridge. Bringing the piles closer together at the Sèmè-Podji wharf reduces the energy of the current which promotes the accumulation of sediment. The structure no longer experiences a flow capable of setting in motion the sands accumulated since at least 2022. This element appears to be a fundamental characteristic explaining the erosion observed to the east of the structure.
基金supported by the open research fund of Songshan Lake Materials Laboratory(No.2022SLABFN08)Guangxi Science and Technology Base and Talents Special Project(Nos.Guike AD20297034 and AD21220053)+2 种基金the National Natural Science Foundation of China(No.51801214 and 52171021)the Research Start-up Funding from Guangxi University of Science and Technology(No.03200150)the Middle-aged and Young Teachers’Basic Ability Promotion Project of Guangxi(No.2022KY0329)。
文摘In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4)alloy cast in a steel mold was carried out.The addition of Ca element plays an important role in the refinement of LPSO structure.The result reveals new poly-types including 20H F2F2F4,60R(F2F3F3)_(3),and 66H F2F3F3F2(F6)_(4)featuring a 6-Mg structure,alongside the prevalent 18R and 14H LPSO structures.The incoherent interface between 20H and the Mg matrix is split into two dislocation arrays,leading to the formation of a segment of 60R_(1).Moreover,the superstructure 116L,designated as(F2)_(18)F4,is formed through the ordered distribution of F4 stacking faults in 18R.
文摘With the development of modern society,people put forward higher requirements for building safety,which makes the construction project face new challenges.Reinforced concrete frame structure as a common engineering type,although the construction technology has been relatively mature,but its earthquake collapse ability still needs to be strengthened.This paper analyzes the specific factors that affect the seismic collapse ability of reinforced concrete frame structure,summarizes the previous research results,and puts forward innovative application of fiber-reinforced polymer(FRP)composite materials,play the role of smart materials,improve the isolation and energy dissipation devices,etc.,to promote the continuous optimization of reinforced concrete frame structure design,and show better seismic performance.
基金supported by the Zhejiang Provincial Natural Science Foundation of China under Grant No.LTGG23E080001Zhejiang Engineering Research Center of Intelligent Urban Infrastructure under Grant No.IUI2022-ZD-01.
文摘Kinked rebar is a special type of steel material,which is installed in beam column nodes and frame beams.It effectively enhances the blast resilience,seismic collapse resistance,and progressive collapse resistance of reinforced concrete(RC)structures without imposing substantial cost burdens,thereby emerging as a focal point of recent research endeavors.On the basis of explaining the working principle of kinked rebars,this paper reviews the research status of kinked rebars at home and abroad from three core domains:the tensile mechanical properties of kinked rebars,beam column nodes with kinked rebars,and concrete frame structures with kinked rebars.The analysis underscores that the straightening process of kinked rebars does not compromise their ultimate strength but significantly bolsters structural ductility and enhances energy dissipation capabilities.In beam-column joints,the incorporation of kinked rebars facilitates the seamless transfer of plastic hinges,adhering to the design principle of“strong columns and weak beams.”In addition,kinked rebars can greatly improve the resistance of the beam;The seismic resistance,internal explosion resistance,and progressive collapse resistance of reinforced concrete frame structures with kinked rebar have significantly improved.Beyond its primary application,the principle of kinked rebar was extended to other applications of kinked materials such as corrugated steel plates and origami structures,and the stress characteristics of related components and structures were studied.Intriguingly,this paper also proposes the application of kinked rebars in bridge engineering,aiming to address the challenges of localized damage concentration and excessive residual displacement in RC bridge piers.The introduction of kinked rebars in piers is envisioned to mitigate these issues,with the paper outlining its advantages and feasibility,thereby offering valuable insights for future research on kinked reinforcement and seismic design strategies for bridges.
基金Educational and Teaching Reform Project of Beihua University:Research on the Construction of“Same Course with Different Structures”Course Resources Based on Knowledge Graphs。
文摘This paper explores the construction methods of“Same Course with Different Structures”curriculum resources based on knowledge graphs and their applications in the field of education.By reviewing the theoretical foundations of knowledge graph technology,the“Same Course with Different Structures”teaching model,and curriculum resource construction,and integrating existing literature,the paper analyzes the methods for constructing curriculum resources using knowledge graphs.The research finds that knowledge graphs can effectively integrate multi-source data,support personalized teaching and precision education,and provide both a scientific foundation and technical support for the development of curriculum resources within the“Same Course with Different Structures”framework.
基金supported by the Zhejiang Provincial Natural Science Foundation,China(Grant No.LQ24C010007)Zhejiang Science and Technology Major Program on Rice New Variety Breeding,China(Grant No.2021C02063)+4 种基金the Agricultural Sciences and Technologies Innovation Program,China(Grant No.CAAS-CSCB-202301)the Key Projects of Zhejiang Provincial Natural Science Foundation,China(Grant No.LZ23C130002)the Youth Innovation Program of Chinese Academy of Agricultural Sciences(Grant No.Y2023QC22)the Joint Open Competitive Project of the Yazhou Bay Seed Laboratory and China National Seed Company Limited(Grant Nos.B23YQ1514 and B23CQ15EP)the External Cooperation Projects of Biotechnology Research Institute,Fujian Academy of Agricultural Sciences,China(Grant No.DWHZ2024-07).
文摘Rice seedling blight,caused by various fungi,including Fusarium oxysporum,poses a severe threat to rice production.As awareness grows regarding the environmental and safety hazards associated with the application of fungicides for managing rice seedling blight,there has been a shift in focus towards biological control agents.In this study,we isolated biocontrol bacteria from paddy fields that significantly inhibited the growth of F.oxysporum in vitro and identified the strains as Bacillus amyloliquefaciens T40 and Bacillus pumilus T208.Additionally,our findings indicated that the combined application of these Bacillus strains in soil was more effective in reducing the incidence of rice seedling blight than their individual use.Analysis of 16S and internal transcribed spacer rRNA gene sequencing data revealed that the mixture of the T40 and T208 strains exhibited the lowest average clustering coefficients,which were negatively correlated with the biomass of F.oxysporum-inoculated rice seedlings.Furthermore,this mixture led to higher stochastic assembly(average|βNTI|<2)and reduced selection pressures on rice rhizosphere bacteria compared with individual strain applications.The mixture of the T40 and T208 strains also significantly increased the expression of defense-related genes.In conclusion,the mixture of the T40 and T208 strains effectively modulates microbial community structures,enhances microbial network stability,and boosts the resistance against rice seedling blight.Our study supports the development and utilization of biological resources for crop protection.
基金the National Science Foundation(PFI-008513 and FET-2309403)for the support of this work.
文摘Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.
基金supports from the National Natural Science Foundation of China(12074123,12174108)the Foundation of‘Manufacturing beyond limits’of Shanghai‘Talent Program'of Henan Academy of Sciences.
文摘Femtosecond laser-induced periodic surface structures(LIPSS)have been extensively studied over the past few decades.In particular,the period and groove width of high-spatial-frequency LIPSS(HSFL)is much smaller than the diffraction limit,making it a useful method for efficient nanomanufacturing.However,compared with the low-spatial-frequency LIPSS(LSFL),the structure size of the HSFL is smaller,and it is more easily submerged.Therefore,the formation mechanism of HSFL is complex and has always been a research hotspot in this field.In this study,regular LSFL with a period of 760 nm was fabricated in advance on a silicon surface with two-beam interference using an 800 nm,50 fs femtosecond laser.The ultrafast dynamics of HSFL formation on the silicon surface of prefabricated LSFL under single femtosecond laser pulse irradiation were observed and analyzed for the first time using collinear pump-probe imaging method.In general,the evolution of the surface structure undergoes five sequential stages:the LSFL begins to split,becomes uniform HSFL,degenerates into an irregular LSFL,undergoes secondary splitting into a weakly uniform HSFL,and evolves into an irregular LSFL or is submerged.The results indicate that the local enhancement of the submerged nanocavity,or the nanoplasma,in the prefabricated LSFL ridge led to the splitting of the LSFL,and the thermodynamic effect drove the homogenization of the splitting LSFL,which evolved into HSFL.
基金the financial support from the National Natural Science Foundation of China (Grant Nos. 52201201, 52372171)the State Key Lab of Advanced Metals and Materials (Grant No. 2022Z-11)+1 种基金the Fundamental Research Funds for the Central Universities (Grant No. 00007747, 06500205)the Initiative Postdocs Supporting Program (Grant No. BX20190002)。
文摘Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low redox potential of zinc(Zn) metal. However,several issues such as dendrite formation, hydrogen evolution, corrosion, and passivation of Zn metal anodes cause irreversible loss of the active materials. To solve these issues, researchers often use large amounts of excess Zn to ensure a continuous supply of active materials for Zn anodes. This leads to the ultralow utilization of Zn anodes and squanders the high energy density of AZMBs. Herein, the design strategies for AZMBs with high Zn utilization are discussed in depth, from utilizing thinner Zn foils to constructing anode-free structures with theoretical Zn utilization of 100%, which provides comprehensive guidelines for further research. Representative methods for calculating the depth of discharge of Zn anodes with different structures are first summarized. The reasonable modification strategies of Zn foil anodes, current collectors with pre-deposited Zn, and anode-free aqueous Zn metal batteries(AF-AZMBs) to improve Zn utilization are then detailed. In particular, the working mechanism of AF-AZMBs is systematically introduced. Finally, the challenges and perspectives for constructing high-utilization Zn anodes are presented.
基金financial supports provided by the China Scholarship Council(Nos.202206 290061 and 202206290062)。
文摘The laser powder bed fusion(LPBF) process can integrally form geometrically complex and high-performance metallic parts that have attracted much interest,especially in the molds industry.The appearance of the LPBF makes it possible to design and produce complex conformal cooling channel systems in molds.Thus,LPBF-processed tool steels have attracted more and more attention.The complex thermal history in the LPBF process makes the microstructural characteristics and properties different from those of conventional manufactured tool steels.This paper provides an overview of LPBF-processed tool steels by describing the physical phenomena,the microstructural characteristics,and the mechanical/thermal properties,including tensile properties,wear resistance,and thermal properties.The microstructural characteristics are presented through a multiscale perspective,ranging from densification,meso-structure,microstructure,substructure in grains,to nanoprecipitates.Finally,a summary of tool steels and their challenges and outlooks are introduced.
基金Key Research and Development program of Zhejiang ProvinceGrant/Award Number:2018C03031+3 种基金The Open Foundation of Key Laboratory of Offshore Geotechnical and Material Engineering of Zhejiang Province,Grant/Award Number:OGME21003Natural Science Foundation of Zhejiang Province,Grant/Award Numbers:LHZ19E090003,LY15E090002Norges Forskningsr?d,Grant/Award Number:OGME21003National Natural Science Foundation of China,Grant/Award Numbers:51209183,51779220,52101334。
文摘The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and minerals.Various infrastructures such as floating structures,seabed structures,and foundations have been developed to exploit these resources.The seabed structures and foundations can be mainly classified into three types:subsea production structures,offshore pipelines,and anchors.This study reviewed the development,installation,and operation of these infrastructures,including their structures,design,installation,marine environment loads,and applications.On this basis,the research gaps and further research directions were explored through this literature review.First,different floating structures were briefly analyzed and reviewed to introduce the design requirements of the seabed structures and foundations.Second,the subsea production structures,including subsea manifolds and their foundations,were reviewed and discussed.Third,the basic characteristics and design methods of deep‐sea pipelines,including subsea pipelines and risers,were analyzed and reviewed.Finally,the installation and bearing capacity of deep‐sea subsea anchors and seabed trench influence on the anchor were reviewed.Through the review,it was found that marine environment conditions are the key inputs for any offshore structure design.The fabrication,installation,and operation of infrastructures should carefully consider the marine loads and geological conditions.Different structures have their own mechanical problems.The fatigue and stability of pipelines mainly depend on the soil‐structure interaction.Anchor selection should consider soil types and possible trench formation.These focuses and research gaps can provide a helpful guide on further research,installation,and operation of deep‐sea structures and foundations.
基金the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu Province.It was also supported in part by Young Elite Scientists Sponsorship Program by CAST.
文摘Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures.
基金supported by the National Natural Science Foundation of China(No.52079133)CRSRI Open Research Program(Program SN:CKWV2019746/KY)+1 种基金the project of Key Laboratory of Water Grid Project and Regulation of Ministry of Water Resources(QTKS0034W23291)the Youth Innovation Promotion Association CAS.
文摘Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering structures.In this study,a constrained damping structure for underground tunnel lining,using a rubber-sand-concrete(RSC)as the aseismic material,is proposed.The aseismic performances of constrained damping structure were investigated by a series of hammer impact tests.The damping layer thickness and shape effects on the aseismic performance such as effective duration and acceleration amplitude of time-domain analysis,composite loss factor and damping ratio of the transfer function analysis,and total vibration level of octave spectrum analysis were discussed.The hammer impact tests revealed that the relationship between the aseismic performance and damping layer thickness was not linear,and that the hollow damping layer had a better aseismic performance than the flat damping layer one.The aseismic performances of constrained damping structure under different seismicity magnitudes and geological conditions were investigated.The effects of the peak ground acceleration(PGA)and tunnel overburden depth on the aseismic performances such as the maximum principal stress and equivalent plastic strain(PEEQ)were discussed.The numerical results show the constrained damping structure proposed in this paper has a good aseismic performance,with PGA in the range(0.2-1.2)g and tunnel overburden depth in the range of 0-300 m.
