Objective: To investigate microvessel density (MVD) and expression of Survivin in non-small cell lung cancer (NSCLC), and to explore their correlations to clinicopathologic features of NSCLC. Methods: 66 specimens of ...Objective: To investigate microvessel density (MVD) and expression of Survivin in non-small cell lung cancer (NSCLC), and to explore their correlations to clinicopathologic features of NSCLC. Methods: 66 specimens of tumor adjacent tissues, and 20 specimens of benign lesions were detected by SP immunohistochemistry; their interrelations and correlations to clinicopathologic features of NSCLC were analyzed. Results: Positive rate of Survivin in NSCLC was significantly higher than that in adjacent tissues and benign lesions (54.5% vs. 30 %, P < 0.05), its positive rate was 63.6% in lung adenocarcinoma tissues, and its positive rate was 54.5% in lung SCC, there was no significant difference between them. Its expressions were respectively 41.2%, 87.5% in well-differentiated and poorly differentiated lung SCC; its expressions were respectively 47.1%, 81.2% in well-differentiated and poorly differentiated lung adenocarcinoma; the discrepancy had statistical significance. Its expression was 74.1% in lymphatic metastasis group, which was obviously higher than that in no lymphatic metastasis group, which was 48.7%. The rate of MVD in Survivin positive group was obviously higher than that of Survivin negative group. Conclusion: The expression of Survivin is connected with the degree of differentiation on lung cancer and lymphatic metastasis, which indicates Survivin can be as an index for the judgment of condition and the evaluation of prognosis, the expression of Survivin is direct correlation with that of MVD. It is evident that Survivin functions the promotion of tumor angiogenesis.展开更多
基金a grant from the Liaoning Provincial Department of Science & Technology (No. 2007225005-13).
文摘Objective: To investigate microvessel density (MVD) and expression of Survivin in non-small cell lung cancer (NSCLC), and to explore their correlations to clinicopathologic features of NSCLC. Methods: 66 specimens of tumor adjacent tissues, and 20 specimens of benign lesions were detected by SP immunohistochemistry; their interrelations and correlations to clinicopathologic features of NSCLC were analyzed. Results: Positive rate of Survivin in NSCLC was significantly higher than that in adjacent tissues and benign lesions (54.5% vs. 30 %, P < 0.05), its positive rate was 63.6% in lung adenocarcinoma tissues, and its positive rate was 54.5% in lung SCC, there was no significant difference between them. Its expressions were respectively 41.2%, 87.5% in well-differentiated and poorly differentiated lung SCC; its expressions were respectively 47.1%, 81.2% in well-differentiated and poorly differentiated lung adenocarcinoma; the discrepancy had statistical significance. Its expression was 74.1% in lymphatic metastasis group, which was obviously higher than that in no lymphatic metastasis group, which was 48.7%. The rate of MVD in Survivin positive group was obviously higher than that of Survivin negative group. Conclusion: The expression of Survivin is connected with the degree of differentiation on lung cancer and lymphatic metastasis, which indicates Survivin can be as an index for the judgment of condition and the evaluation of prognosis, the expression of Survivin is direct correlation with that of MVD. It is evident that Survivin functions the promotion of tumor angiogenesis.
