Objective: To investigate the age range, liver functiondamage and prognosis of patients with sporadic acutehepatitis A and E in Beijing.Methods: Enzyme immunoassay (EIA) was used todetect anti-HAV and anti-HEV immunog...Objective: To investigate the age range, liver functiondamage and prognosis of patients with sporadic acutehepatitis A and E in Beijing.Methods: Enzyme immunoassay (EIA) was used todetect anti-HAV and anti-HEV immunoglobulin M(IgM). Serum samples were collected from the pa-tients with sporadic acute viral hepatitis in Beijingfrom January 1995 to June 2000.Results: The total positive rate for anti-HAV and an-ti-HEV IgM was 55.2% (112)in 203 patients with a-cute hepatitis, of whom 22.2% (45 patients) and33.0% (67) were positive for anti-HAV and anti-HEV respectively. The duration of anti-HEV IgMwas 45-60 days and that of anti-HAV IgM was atleast 2-3 months. The patients with acute hepatitis Aand hepatitis E all experienced jaundice and a risingof liver enzyme, but did not develop chronic hepatitisor died.Conclusion: Acute hepatitis A as well as acute hepatitisE plays an important role in sporadic entericallytransmitted hepatitis in Beijing.展开更多
X连锁高IgM综合征(X-linked hyper-immunoglobulin M syndrome,XHIGM)是罕见的原发性免疫缺陷病,该病以反复感染为特征,易感染机会致病微生物。临床上以马尔尼菲篮状菌肺炎起病的XHIGM更为罕见。该文回顾性分析1例以马尔尼菲篮状菌肺炎...X连锁高IgM综合征(X-linked hyper-immunoglobulin M syndrome,XHIGM)是罕见的原发性免疫缺陷病,该病以反复感染为特征,易感染机会致病微生物。临床上以马尔尼菲篮状菌肺炎起病的XHIGM更为罕见。该文回顾性分析1例以马尔尼菲篮状菌肺炎起病的X连锁高IgM综合征婴儿的临床资料,实验室、影像学检查结果和诊疗经过并探讨其基因型,结合最新文献复习,以提高对该疾病的认识。展开更多
文摘目的探讨原发性IgA肾病(IgA nephropathy,IgAN)患者不同IgM沉积强度与肾小球超微结构病变及临床病理的关系。方法收集155例IgAN患者的临床病理资料。分为IgM阴性(51例)、轻度(89例)和中度及以上沉积(15例)3组。比较3组间肾小球超微特征性结构、临床指标、MEST-C评分差异并分析与IgM沉积强度的影响因素。结果与IgM阴性、IgM轻度沉积组相比,IgM中度及以上沉积组24 h尿蛋白水平、IgG沉积、肾小管萎缩/间质纤维化(T)评分、足突融合(foot process effacement,FPE)程度更高,血白蛋白水平、淋巴细胞计数更低(P<0.05)。logistic结果显示FPE程度、T评分是IgM沉积强度的独立影响因素。结论IgM沉积强度与原发性IgAN患者FPE程度相关。FPE程度可协同临床病理评分更精准评估肾组织损伤及制定治疗方案。
文摘Objective: To investigate the age range, liver functiondamage and prognosis of patients with sporadic acutehepatitis A and E in Beijing.Methods: Enzyme immunoassay (EIA) was used todetect anti-HAV and anti-HEV immunoglobulin M(IgM). Serum samples were collected from the pa-tients with sporadic acute viral hepatitis in Beijingfrom January 1995 to June 2000.Results: The total positive rate for anti-HAV and an-ti-HEV IgM was 55.2% (112)in 203 patients with a-cute hepatitis, of whom 22.2% (45 patients) and33.0% (67) were positive for anti-HAV and anti-HEV respectively. The duration of anti-HEV IgMwas 45-60 days and that of anti-HAV IgM was atleast 2-3 months. The patients with acute hepatitis Aand hepatitis E all experienced jaundice and a risingof liver enzyme, but did not develop chronic hepatitisor died.Conclusion: Acute hepatitis A as well as acute hepatitisE plays an important role in sporadic entericallytransmitted hepatitis in Beijing.
文摘X连锁高IgM综合征(X-linked hyper-immunoglobulin M syndrome,XHIGM)是罕见的原发性免疫缺陷病,该病以反复感染为特征,易感染机会致病微生物。临床上以马尔尼菲篮状菌肺炎起病的XHIGM更为罕见。该文回顾性分析1例以马尔尼菲篮状菌肺炎起病的X连锁高IgM综合征婴儿的临床资料,实验室、影像学检查结果和诊疗经过并探讨其基因型,结合最新文献复习,以提高对该疾病的认识。
