AIM:To compare the retinal nerve fiber layer (RNFL) thickness and macular thickness in the amblyopic eye with that in the sound eye of children with hyperopic anisometropic amblyopia using optical coherence tomography...AIM:To compare the retinal nerve fiber layer (RNFL) thickness and macular thickness in the amblyopic eye with that in the sound eye of children with hyperopic anisometropic amblyopia using optical coherence tomography (OCT). METHODS:A prospective, nonrandom, intraindividual comparative cohort study includes 72 children with hyperopic anisometropic amblyopia in a single center. Macular thickness, macular foveola thickness, and peripapillary RNFL thickness were compared between the amblyopia eyes and the contralateral sound eyes. ·RESULTS:There were 38 male and 34 female patients, with a mean age as 9.7 ±1.9 years (range, 5-16 years). Hyperopic was +3.62±1.16D (range +2.00D to +6.50D) in the amblyopic eyes, which was significantly higher in the control eyes with +0.76±0.90D (range 0D to +2.00D) (P 【 0.01). The mean peripapillary RNFL thickness was 113.9± 7.2μm and 109.2 ±6.9μm in the amblyopic eye and the normal eye, respectively, reaching statistical significance (P = 0.02). The mean macular foveola thickness was significantly thicker in the amblyopic eyes than the contralateral sound eyes (181.4±14.2μm vs 175.2±13.3μm, P 【0.01), but the 1mm, 3mm or 6mm macular thickness central macular thickness was not significantly different. Degree of anisometropia in the contralateral eyes was not significantly correlated with differences of peripapillary RNFL, macular foveola thickness or central macular thickness. CONCLUSION:Eyes with hyperopic anisometropic amblyopia are found thicker macular foveola and peripapillary RNFL than the contralateral eyes in children.展开更多
Background Conventional mechanical or alcohol-assisted photorefractive keratectomy(PRK)techniques for cor‑rection of hyperopia and hyperopic astigmatism were associated with inconsistent results.The aim of this study ...Background Conventional mechanical or alcohol-assisted photorefractive keratectomy(PRK)techniques for cor‑rection of hyperopia and hyperopic astigmatism were associated with inconsistent results.The aim of this study is to evaluate the 12-month visual and refractive outcomes of the relatively new single-step transepithelial photorefractive keratectomy(TE-PRK)for moderate hyperopia and hyperopic astigmatism.Methods This is a prospective interventional study.Forty-eight eyes of 30 patients with moderate hyperopia or hyperopic astigmatism with a cycloplegic spherical equivalent refraction(SEQ)between 2.0 and 4.5 diopters(D)underwent single-step StreamLight®TE-PRK using EX500 excimer laser(Alcon Laboratories,USA).The main outcome measures were recorded at 6 and 12 months postoperatively including assessment of logarithm of the minimum angle resolution(logMAR)uncorrected and corrected distance visual acuity(UDVA,CDVA),cycloplegic refraction,corneal topographic changes as well as post-PRK peripheral haze grading.Results The mean preoperative cycloplegic SEQ was signifcantly reduced from 3.21±0.61 D to 0.35±0.04 D and 0.41±0.04 D at 6 and 12 months,respectively(P<0.001).The mean preoperative UDVA signifcantly improved from 0.53±0.02 logMAR to 0.07±0.01 logMAR and 0.08±0.01 logMAR at 6 and 12 months,respectively(P<0.001)while the mean preoperative logMAR CDVA showed non-signifcant change over time throughout the study(P=0.135).At the end of the study,41 eyes(85.4%)achieved UDVA of 20/25 or better and no eye lost any lines of CDVA.Thirty-eight eyes(79.1%)had a postoperative cycloplegic cylinder of 0.5 D or less at 12 months.The mean preoperative mean keratometry showed signifcant increase at 6 and 12 months postoperatively(P<0.001)while there was no signifcant change between the two postoperative visits denoting topographic stability(P=0.058).The mean postoperative Q value at 6 and 12 months showed a signifcant prolate shift(P<0.001).No haze was observed in 62.5%and 85.4%of the enrolled eyes at 6 and 12 months,respectively.Conclusions Single-step StreamLight®TE-PRK for moderate hyperopia and hyperopic astigmatism achieved acceptable visual and refractive outcomes.展开更多
BACKGROUND Myopia,as one of the common ocular diseases,often occurs in adolescence.In addition to the harm from itself,it may also lead to serious complications.Thus,prevention and control of myopia are attracting mor...BACKGROUND Myopia,as one of the common ocular diseases,often occurs in adolescence.In addition to the harm from itself,it may also lead to serious complications.Thus,prevention and control of myopia are attracting more and more attention.Previous research revealed that single-focal glasses and orthokeratology lenses(OK lenses)played an important part in slowing down myopia and preventing high myopia.AIM To compare the clinical effects of OK lenses and frame glasses against the increase of diopter in adolescent myopia and further explore the mechanism of the OK lens.METHODS Changes in diopter and axial length were collected among 70 adolescent myopia patients(124 eyes)wearing OK lenses for 1 year(group A)and 59 adolescent myopia patients(113 eyes)wearing frame glasses(group B).Refractive states of their retina were inspected through multispectral refraction topography.The obtained hyperopic defocus was analyzed for the mechanism of OK lenses on slowing down the increase of myopic diopter by delaying the increase of ocular axis length and reducing the near hyperopia defocus.RESULTS Teenagers in groups A and B were divided into low myopia(0 D--3.00 D)and moderate myopia(-3.25 D--6.00 D),without statistical differences among gender and age.After 1-year treatment,the increase of diopter and axis length and changes of retinal hyperopic defocus amount of group A were significantly less than those of group B.According to the multiple linear analysis,the retinal defocus in the upper,lower,nasal,and temporal directions had almost the same effect on the total defocus.The amount of peripheral retinal defocus(15°-53°)in group A was significantly lower than that in group B.CONCLUSION Multispectral refraction topography is progressive and instructive in clinical prevention and control of myopia.展开更多
文摘AIM:To compare the retinal nerve fiber layer (RNFL) thickness and macular thickness in the amblyopic eye with that in the sound eye of children with hyperopic anisometropic amblyopia using optical coherence tomography (OCT). METHODS:A prospective, nonrandom, intraindividual comparative cohort study includes 72 children with hyperopic anisometropic amblyopia in a single center. Macular thickness, macular foveola thickness, and peripapillary RNFL thickness were compared between the amblyopia eyes and the contralateral sound eyes. ·RESULTS:There were 38 male and 34 female patients, with a mean age as 9.7 ±1.9 years (range, 5-16 years). Hyperopic was +3.62±1.16D (range +2.00D to +6.50D) in the amblyopic eyes, which was significantly higher in the control eyes with +0.76±0.90D (range 0D to +2.00D) (P 【 0.01). The mean peripapillary RNFL thickness was 113.9± 7.2μm and 109.2 ±6.9μm in the amblyopic eye and the normal eye, respectively, reaching statistical significance (P = 0.02). The mean macular foveola thickness was significantly thicker in the amblyopic eyes than the contralateral sound eyes (181.4±14.2μm vs 175.2±13.3μm, P 【0.01), but the 1mm, 3mm or 6mm macular thickness central macular thickness was not significantly different. Degree of anisometropia in the contralateral eyes was not significantly correlated with differences of peripapillary RNFL, macular foveola thickness or central macular thickness. CONCLUSION:Eyes with hyperopic anisometropic amblyopia are found thicker macular foveola and peripapillary RNFL than the contralateral eyes in children.
基金Open access funding provided by The Science,Technology&Innovation Funding Authority(STDF)in cooperation with The Egyptian Knowledge Bank(EKB).
文摘Background Conventional mechanical or alcohol-assisted photorefractive keratectomy(PRK)techniques for cor‑rection of hyperopia and hyperopic astigmatism were associated with inconsistent results.The aim of this study is to evaluate the 12-month visual and refractive outcomes of the relatively new single-step transepithelial photorefractive keratectomy(TE-PRK)for moderate hyperopia and hyperopic astigmatism.Methods This is a prospective interventional study.Forty-eight eyes of 30 patients with moderate hyperopia or hyperopic astigmatism with a cycloplegic spherical equivalent refraction(SEQ)between 2.0 and 4.5 diopters(D)underwent single-step StreamLight®TE-PRK using EX500 excimer laser(Alcon Laboratories,USA).The main outcome measures were recorded at 6 and 12 months postoperatively including assessment of logarithm of the minimum angle resolution(logMAR)uncorrected and corrected distance visual acuity(UDVA,CDVA),cycloplegic refraction,corneal topographic changes as well as post-PRK peripheral haze grading.Results The mean preoperative cycloplegic SEQ was signifcantly reduced from 3.21±0.61 D to 0.35±0.04 D and 0.41±0.04 D at 6 and 12 months,respectively(P<0.001).The mean preoperative UDVA signifcantly improved from 0.53±0.02 logMAR to 0.07±0.01 logMAR and 0.08±0.01 logMAR at 6 and 12 months,respectively(P<0.001)while the mean preoperative logMAR CDVA showed non-signifcant change over time throughout the study(P=0.135).At the end of the study,41 eyes(85.4%)achieved UDVA of 20/25 or better and no eye lost any lines of CDVA.Thirty-eight eyes(79.1%)had a postoperative cycloplegic cylinder of 0.5 D or less at 12 months.The mean preoperative mean keratometry showed signifcant increase at 6 and 12 months postoperatively(P<0.001)while there was no signifcant change between the two postoperative visits denoting topographic stability(P=0.058).The mean postoperative Q value at 6 and 12 months showed a signifcant prolate shift(P<0.001).No haze was observed in 62.5%and 85.4%of the enrolled eyes at 6 and 12 months,respectively.Conclusions Single-step StreamLight®TE-PRK for moderate hyperopia and hyperopic astigmatism achieved acceptable visual and refractive outcomes.
文摘BACKGROUND Myopia,as one of the common ocular diseases,often occurs in adolescence.In addition to the harm from itself,it may also lead to serious complications.Thus,prevention and control of myopia are attracting more and more attention.Previous research revealed that single-focal glasses and orthokeratology lenses(OK lenses)played an important part in slowing down myopia and preventing high myopia.AIM To compare the clinical effects of OK lenses and frame glasses against the increase of diopter in adolescent myopia and further explore the mechanism of the OK lens.METHODS Changes in diopter and axial length were collected among 70 adolescent myopia patients(124 eyes)wearing OK lenses for 1 year(group A)and 59 adolescent myopia patients(113 eyes)wearing frame glasses(group B).Refractive states of their retina were inspected through multispectral refraction topography.The obtained hyperopic defocus was analyzed for the mechanism of OK lenses on slowing down the increase of myopic diopter by delaying the increase of ocular axis length and reducing the near hyperopia defocus.RESULTS Teenagers in groups A and B were divided into low myopia(0 D--3.00 D)and moderate myopia(-3.25 D--6.00 D),without statistical differences among gender and age.After 1-year treatment,the increase of diopter and axis length and changes of retinal hyperopic defocus amount of group A were significantly less than those of group B.According to the multiple linear analysis,the retinal defocus in the upper,lower,nasal,and temporal directions had almost the same effect on the total defocus.The amount of peripheral retinal defocus(15°-53°)in group A was significantly lower than that in group B.CONCLUSION Multispectral refraction topography is progressive and instructive in clinical prevention and control of myopia.
