This review describes the recent developments in the pathobiology of endothelial dysfunction(ED) in the context of cirrhosis with portal hypertension and defines novel strategies and potential targets for therapy. ED ...This review describes the recent developments in the pathobiology of endothelial dysfunction(ED) in the context of cirrhosis with portal hypertension and defines novel strategies and potential targets for therapy. ED has prognostic implications by predicting unfavourable early hepatic events and mortality in patients with portal hypertension and advanced liver diseases. EDcharacterised by an impaired bioactivity of nitric oxide(NO) within the hepatic circulation and is mainly due to decreased bioavailability of NO and accelerated degradation of NO with reactive oxygen species. Furthermore, elevated inflammatory markers also inhibit NO synthesis and causes ED in cirrhotic liver. Therefore, improvement of NO availability in the hepatic circulation can be beneficial for the improvement of endothelial dysfunction and associated portal hypertension in patients with cirrhosis. Furthermore, therapeutic agents that are identified in increasing NO bioavailability through improvement of hepatic endothelial nitric oxide synthase(e NOS) activity and reduction in hepatic asymmetric dimethylarginine, an endogenous modulator of e NOS and a key mediator of elevated intrahepatic vascular tone in cirrhosis would be interesting therapeutic approaches in patients with endothelial dysfunction and portal hypertension in advanced liver diseases.展开更多
Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,...Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,liver and spleen is not consistent.Therefore,when the temporary syndrome from the Yin system Yang,to its outline;Adjust the air and blood to tamp the base;The liver and spleen should be dredged and the spleen should be regulated in accordance with its nature.Based on this objective,this paper discusses the clinical method of treating cirrhosis of liver by professor LV,so as to know its inverse,its shield and its life.展开更多
基金Supported by The Department of Biotechnology-Ramalingaswami Fellowship 5 years grant from the Government of India
文摘This review describes the recent developments in the pathobiology of endothelial dysfunction(ED) in the context of cirrhosis with portal hypertension and defines novel strategies and potential targets for therapy. ED has prognostic implications by predicting unfavourable early hepatic events and mortality in patients with portal hypertension and advanced liver diseases. EDcharacterised by an impaired bioactivity of nitric oxide(NO) within the hepatic circulation and is mainly due to decreased bioavailability of NO and accelerated degradation of NO with reactive oxygen species. Furthermore, elevated inflammatory markers also inhibit NO synthesis and causes ED in cirrhotic liver. Therefore, improvement of NO availability in the hepatic circulation can be beneficial for the improvement of endothelial dysfunction and associated portal hypertension in patients with cirrhosis. Furthermore, therapeutic agents that are identified in increasing NO bioavailability through improvement of hepatic endothelial nitric oxide synthase(e NOS) activity and reduction in hepatic asymmetric dimethylarginine, an endogenous modulator of e NOS and a key mediator of elevated intrahepatic vascular tone in cirrhosis would be interesting therapeutic approaches in patients with endothelial dysfunction and portal hypertension in advanced liver diseases.
基金Major national science and technology special project(No.2018ZX10303-502-003)national key R&D plan key research project of Chinese medicine modernization(No.2018YFC1705702)Beijing Tianjin Hebei national key clinical specialty liver disease collaborative ward project(No.GZY-GCS-2017-60)
文摘Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,liver and spleen is not consistent.Therefore,when the temporary syndrome from the Yin system Yang,to its outline;Adjust the air and blood to tamp the base;The liver and spleen should be dredged and the spleen should be regulated in accordance with its nature.Based on this objective,this paper discusses the clinical method of treating cirrhosis of liver by professor LV,so as to know its inverse,its shield and its life.
