Quinoline-based fibroblast activation protein(FAP)inhibitor(FAPI)-based positron emission tomography(PET)imaging and radioligand therapy(RLT)are being investigated for use in a wide variety of diseases,and recent resu...Quinoline-based fibroblast activation protein(FAP)inhibitor(FAPI)-based positron emission tomography(PET)imaging and radioligand therapy(RLT)are being investigated for use in a wide variety of diseases,and recent results have been promising.This review summarizes the current status of FAPI radiopharmaceuticals in PET imaging of malignant tumors and benign conditions and compares their diagnostic efficacy with ^(18)F-fluorodeoxyglucose.In addition,we summarize the previously published FAP-targeted RLT data and discuss its current clinical use and future potential.Our qualitative summary can inform future research directions,medical guidelines,and optimal clinical decision-making.展开更多
基金Key Scientific Research Program for Young Scholars in Fujian,Grant/Award Number:2021ZQNZD016Fujian Natural Science Foundation for Distinguished Young Scholars,Grant/Award Number:2022D005+3 种基金Medical and Health Guidance Projects of Xiamen,Grant/Award Numbers:3502Z20209269,3502Z20224ZD1001National Natural Science Foundation of China,Grant/Award Numbers:82071961,82102094Fujian Natural Science Foundation for Youth Innovation,Grant/Award Number:2022J05314Fujian Research and Training Grants for Young and Middle-Aged Leaders in Healthcare。
文摘Quinoline-based fibroblast activation protein(FAP)inhibitor(FAPI)-based positron emission tomography(PET)imaging and radioligand therapy(RLT)are being investigated for use in a wide variety of diseases,and recent results have been promising.This review summarizes the current status of FAPI radiopharmaceuticals in PET imaging of malignant tumors and benign conditions and compares their diagnostic efficacy with ^(18)F-fluorodeoxyglucose.In addition,we summarize the previously published FAP-targeted RLT data and discuss its current clinical use and future potential.Our qualitative summary can inform future research directions,medical guidelines,and optimal clinical decision-making.
