Grey system analysis method was used to study the correlation between water pollution in D Lake area and death rate of malignancy with death rate of malignancy as effect sequence and a variety of water pollution index...Grey system analysis method was used to study the correlation between water pollution in D Lake area and death rate of malignancy with death rate of malignancy as effect sequence and a variety of water pollution index as factor sequence. On the basis of grey correlation analysis, grey system predication model was established for death rate of malignancy in population in D Lake area including GM (1, N) model for death rate of malignancy [ MR (t+1) =(9.9987E 1+5.0001E 2 +10.8994E 3+1.1114E 4+165.1029) ·e -0.0070t -9.9987E 1-5.0001E 2-10.8994E 3-1.1114E 4 ] and GM (1, 1) model for related factors [ E 1(t+1) =52.1214-46.9468e -0.0058t , E 2(t+1) =4.6114-4.5664e 0.0015t, E 3(t+1) =1.1389-1.1212e 0.0065t , E 4(t+1) = 554.5867-549.8006e 0.0016t ], and the trend of death rate of malignancy from 2000 to 2010 was predicted.展开更多
Introduction: On March 11, 2020, the World Health Organization (WHO) declared that the entire World was overrun by a pandemic. Science has managed, in a short time, to characterize a new disease, sequence a new viral ...Introduction: On March 11, 2020, the World Health Organization (WHO) declared that the entire World was overrun by a pandemic. Science has managed, in a short time, to characterize a new disease, sequence a new viral genome, develop diagnostics, produce treatment protocols and establish the efficacy of drugs and vaccines in randomized controlled trials. In this paper we have dealt with different topics regarding the pandemic linked to COVID-19. Objectives: Aim of this paper is to compare the number of deaths attributable to COVID-19, that occurred in the different Italian macro-areas, in the different pandemic waves;we studied the trend of the curves relating to the proportion of deaths to the number of infected in the Italian macro-areas for the pandemic waves and analysed the mortality data, focusing on the Italian context and comparing it with other foreign countries. We examined the data regarding swabs, hospitalizations, home isolation, admissions to intensive care and deaths registered in pandemic period. Results: Geographically, Italy was differently affected by the pandemic. Northern Italy was the most affected area. In comparison with some foreign countries, Italy is one of the nations that paid the most in terms of deaths, due to: delays in understanding the seriousness of the emergency;the slow management in the tracking systems of contagions;the high number of hospitalizations;a corporate organizational system poorly planned. Conclusion: The years 2020 and 2021 have been dramatic and unprecedented. The year 2021 was the year of redemption, where, despite social, economic and health difficulties, thanks to mass vaccination, we were able to give a real strong response to the pandemic. Trust in science has led to a drastic decrease in mortality throughout the world.展开更多
In this paper, we propose an SIRS epidemic model with pulse vaccination, birth pulse and Logistic death rate. By using the stroboscopic map of a discrete dynamical system, the disease-free periodic solution (DFPS for ...In this paper, we propose an SIRS epidemic model with pulse vaccination, birth pulse and Logistic death rate. By using the stroboscopic map of a discrete dynamical system, the disease-free periodic solution (DFPS for short) of the model under pulse vaccination and birth pulse is obtained. Based on the Floquet theory and comparison theorem of impulsive differential equations, the global asymptotic stability of the DFPS is given, and sufficient conditions for the permanence of the model are obtained. In addition, numerical simulations are done to confirm our theoretical results.展开更多
本刊曾经多次刊登文章盛赞百年老药阿斯匹林。去年第10期就载文称阿斯匹林能抗前列腺癌,今又消息文称,阿斯匹林能减少心脏病人的死亡率。百年老药.青春犹在,至今仍能让人们不断发现其新的功效！本文除了传递了有关阿斯匹林的新信息之外...本刊曾经多次刊登文章盛赞百年老药阿斯匹林。去年第10期就载文称阿斯匹林能抗前列腺癌,今又消息文称,阿斯匹林能减少心脏病人的死亡率。百年老药.青春犹在,至今仍能让人们不断发现其新的功效！本文除了传递了有关阿斯匹林的新信息之外,以下观点,也让我们耳目一新: Even as we live and practice medicine in an era of high technology,we mustalways remember that widespread application of relatively low technology,efficacious(有效的;灵验的),and cost-effective(有成本效益的,值得花费的)therapies is often the way we help most of our patients and provide the greatestaggregate(集合的;聚合的)benefit for the broader population. 上句是否可以这样译: 即使我们生活、就医在一个高科技的时代,但是,我们仍必须一直牢记:科技含量相对较低却又广为应用的东西,其灵验而又具有成本效益的治疗常常是我们帮助大多数患者,为广大群众提供最大利益的途径。 上句的难点在于:如何理解provide the greatest aggregate benefit for thebroader population的主语。展开更多
Objectives: To determine the IMR in Al-Ramadi province, the center of Al-Anbar Governorate, Western Iraq, from 2000-2010 with rate comparison of the three different stages of that period. Methods: Data collected from ...Objectives: To determine the IMR in Al-Ramadi province, the center of Al-Anbar Governorate, Western Iraq, from 2000-2010 with rate comparison of the three different stages of that period. Methods: Data collected from the birth and death certificate center in Al-Ramadi province, Western Iraq, included;name, age, sex, residence, date of birth and death, in three different stages (the first stage 2000-2002, the second stage 2003-2007, and the third stage 2008-2010) in a study period from July to December, 2010. The IMRs were analyzed and compared with other studies. Results: The IMR of the last 3 years of sanction was 54.3/1000, 55.7/1000 and 50.6/1000 respectively, this rate had been increased in the war and violence period to reach its maximum rate 58.6/1000 in 2006, then decreased to reach its minimum rate 44.5/1000 in 2008. Approximately two-third of deaths occurred during the neonatal period and one third in the post neonatal period. Males had higher IMR than females, and rural residence higher than urban. Conclusion: Infant mortality rate is still high in Al-Ramadi province, since the American invasion (2003-2007), when compared with other developing countries. This study found increase of IMR in Al-Ramadi province during that period more than other studied years.展开更多
Early detection of sudden cardiac death may be used for surviving the life of cardiac patients. In this paper we have investigated an algorithm to detect and predict sudden cardiac death, by processing of heart rate v...Early detection of sudden cardiac death may be used for surviving the life of cardiac patients. In this paper we have investigated an algorithm to detect and predict sudden cardiac death, by processing of heart rate variability signal through the classical and time-frequency methods. At first, one minute of ECG signals, just before the cardiac death event are extracted and used to compute heart rate variability (HRV) signal. Five features in time domain and four features in frequency domain are extracted from the HRV signal and used as classical linear features. Then the Wigner Ville transform is applied to the HRV signal, and 11 extra features in the time-frequency (TF) domain are obtained. In order to improve the performance of classification, the principal component analysis (PCA) is applied to the obtained features vector. Finally a neural network classifier is applied to the reduced features. The obtained results show that the TF method can classify normal and SCD subjects, more efficiently than the classical methods. A MIT-BIH ECG database was used to evaluate the proposed method. The proposed method was implemented using MLP classifier and had 74.36% and 99.16% correct detection rate (accuracy) for classical features and TF method, respectively. Also, the accuracy of the KNN classifier were 73.87% and 96.04%.展开更多
An aggregation growth model of three species A, B and C with the competition between catalyzed birth and catalyzed death is proposed. Irreversible aggregation occurs between any two aggregates of the like species with...An aggregation growth model of three species A, B and C with the competition between catalyzed birth and catalyzed death is proposed. Irreversible aggregation occurs between any two aggregates of the like species with theconstant rate kernels In（n = 1,2, 3）. Meanwhile, a monomer birth of an A species aggregate of size k occurs under the catalysis of a B species aggregate of size j with the catalyzed birth rate kernel K（k, j） = Kkj^v, and a monomer death of an A species aggregate of size k occurs under the catalysis of a C species aggregate of size j with the catalyzed death rate kernel L（k, j） = Lkj^v, whcre v is a parameter reflecting the dependence of the catalysis reaction rates of birth and death on the size of catalyst aggregate. The kinetic evolution behaviours of the three species are investigated by the rate equation approach based on the mean-field theory. The form of the aggregate size distribution of A species ak （t） is found to be dependent crucially on the competition between the catalyzed birth and death of A species, as well as the irreversible aggregation processes of the three species： （i） In the v 〈 0 case, the irreversible aggregation dominates the process, and ak（t） satisfies the conventional scaling form; （2） In the v ≥ 0 casc, the competition between the catalyzed birth and death dominates the process. When the catalyzed birth controls the process, ak（t） takes the conventional or generalized scaling form. While the catalyzed death controls the process, the scaling description of the aggregate size distribution breaks down completely.展开更多
Objective: The aim of our study was to analyze the character of cause of death in Inner Mongolia of China from 2008 to 2014. Methods: We collected data from monitoring points of the Death Registry System (DRS) in Inne...Objective: The aim of our study was to analyze the character of cause of death in Inner Mongolia of China from 2008 to 2014. Methods: We collected data from monitoring points of the Death Registry System (DRS) in Inner Mongolia. We calculated the mortality rates by gender, year and age-specific. We calculated the proportion, the mortality rate and potential years of life lost (PYLL) of various system deaths. Results: During the period 2008-2014, the average crude mortality rate of all cause of death was 539.33/105. The mortality rate increased semilogarithm linearly with age. The top four system deaths were circulatory system, neoplasm, respiratory system and injury. In 2014, the mortality rates of circulatory system were increased and the mortality rates of certain infectious and parasitic diseases, neoplasms, respiratory system, genitourinary system and injury were decreased compared to those in 2008. Conclusion: Through analysis the indicators of proportion, the mortality rate and PYLL indicated that health status of a population in Inner Mongolia was at a better level.展开更多
Background:Tuberculosis(TB),caused by Mycobacterium tuberculosis,remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in...Background:Tuberculosis(TB),caused by Mycobacterium tuberculosis,remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in 2022.Of particular concern is the emergence of drug-resistant TB,accounting for 15%-20%of TB deaths.It is imperative to delve into the global trends of incidence and death rate for multidrug-resistant tuberculosis(MDRTB)and extensively drug-resistant tuberculosis(XDR-TB),drawing upon the comprehensive Global Burden of Disease(GBD)2021 drug-resistant tuberculosis dataset.Methods:From the GBD 2021,data on incidence,prevalence,disability-adjusted life years(DALYs),and death of MDR-TB and XDR-TB from 1990 to 2021 were collected.We calculated the estimated annual percentage changes in age standardized incidence rate(ASIR)and age-standardized death rate(ASDR),segmented by age,sex,and socio-demographic index(SDI).The impacts of various risk factors on MDR-TB and XDR-TB were also analyzed.Results:In 2021,there were an estimated 443,680(95%uncertainty interval[UI]:259,196-766,545)incident cases of MDR-TB,and an estimated 106,818(95%UI:41,612-211,854)death cases of MDR-TB,while there were an estimated 24,036(95%UI:17,144-34,587)incident cases of XDR-TB and 7,946(95%UI:3,326-14,859)death cases of XDR-TB.The incidence and death cases of MDR-TB were lowest in high SDI regions,whereas the incidence rates of XDR-TB in high-middle SDI regions were higher than those in middle SDI and high SDI regions.Conclusion:This study reported the disease burden of drug-resistant TB from 1990 to 2021.Until 2021,drugresistant TB is still a serious problem in low SDI countries,especially for high-risk age populations with highrisk factors.Controlling drug-resistant TB requires effective control strategies and healthcare systems.展开更多
目的通过Meta分析,综合分析运动后心率恢复(HRR)与心源性猝死(SCD)之间的关系。方法基于PubMed、Embase和Web of Science数据库,进行截至2024年1月2日的文献检索。队列研究关注于HRR和SCD间的风险关系,通过风险比(HR)及95%可信区间(CI)...目的通过Meta分析,综合分析运动后心率恢复(HRR)与心源性猝死(SCD)之间的关系。方法基于PubMed、Embase和Web of Science数据库,进行截至2024年1月2日的文献检索。队列研究关注于HRR和SCD间的风险关系,通过风险比(HR)及95%可信区间(CI)进行评估。统计学分析采用Stata 12.0软件。结果纳入6项研究。固定效应模型(I^(2)=41.8%,P=0.112)的汇总结果显示:与心率恢复慢相比,心率恢复快人群发生SCD风险更低(HR=0.74,95%CI:0.64~0.86,P<0.001)。大多数亚组分析中都观察到了持续结果。排除一项研究并不影响总体结果[HR(95%CI):0.66(0.55,0.79)~0.76(0.65,0.88)]。Egger检验未发现明显的发表偏倚(P=0.059)。结论心率恢复较慢会增加普通人群发生SCD的风险。因此,HRR可能是临床实践中预防SCD的一个潜在靶点。展开更多
This study explores the complex relationship between climate change and human development. The aim is to understand how climate change affects human development across countries, regions, and the global population. Vi...This study explores the complex relationship between climate change and human development. The aim is to understand how climate change affects human development across countries, regions, and the global population. Visual analytics were used to examine the impact of various climate change indicators on different aspects of human development. The study highlights the urgent need for climate change action and encourages policymakers to make decisive moves. Climate change adversely affects numerous aspects of daily life, leading to significant consequences that must be addressed through policy changes and global governance recommendations. Key findings include that regions with higher CO2 emissions experience a significantly higher incidence of life-threatening diseases compared to regions with lower emissions. Additionally, higher CO2 emissions correlate with consistent death rates. Increased pollution exposure is associated with a higher prevalence of life-threatening diseases and higher rates of malnutrition. Moreover, greater mineral depletion is linked to more frequent life-threatening diseases, suggesting that industrialization contributes to adverse health effects. These results provide valuable insights for policy and decision-making aimed at mitigating the impact of climate change on human development.展开更多
Objectives: To investigate the relationship between the use of angiotensin converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and hyperkalemia in patients diagnosed with sudden cardiac death. M...Objectives: To investigate the relationship between the use of angiotensin converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and hyperkalemia in patients diagnosed with sudden cardiac death. Methods: We examined oral ACE inhibitor or ARB use among cardiopulmonary arrest patients brought by ambulance to our emergency room during a 5-year period from January 2012 to December 2016. The cause of death was determined to be sudden cardiac death, despite temporary return of spontaneous circulation after starting cardiopulmonary resuscitation. Subjects were dichotomized into 2 groups, those taking and those not taking an ACE inhibitor or ARB. Variables determined retrospectively included serum potassium, estimated glomerular filtration rate as an index of kidney function and time from cardiopulmonary arrest to return of spontaneous circulation. The Mann-Whitney U-test was used to compare continuous data, and the chi-square test to compare categorical data between groups. The results are expressed as the median plus range. Statistical significance was assumed at p Results: Thirty-five patients met the inclusion criteria. The mean age was 77.1 years (range, 35 - 93 years), and there were 26 males and 9 females. Eleven subjects were ACE inhibitor or ARB users, and 24 were non-users. The serum potassium level was significantly higher in users than non-users (median, 6.2 mEq/L (range, 4.5 - 10.0) vs. 5.2 mEq/L (range, 3.6 - 8.3);p = 0.001). The estimated glomerular filtration rate was significantly lower in users than non-users (median, 25.1 mL/min/1.73 m2 (range, 4.6 - 60.3) vs. 46.9 mL/min/1.73 m2 (range, 19.8 - 97.1);p = 0.009). There was no significant difference in time from cardiopulmonary arrest to return of spontaneous circulation between the 2 groups (median, 24 minutes (range, 3 - 111) vs. 29 minutes (range, 10 - 54);p = 0.355). Conclusion: It is possible that hyperkalemia induced by ACE inhibitor or ARB use is a cause of sudden cardiac death, especially in patients with chronic kidney disease.展开更多
基金ThisprojectwassupportedbyagrantfromtheNational"TheNinthFive YearPlan"ScienceandTechnologyKeyProjectofChina (No .96 9110 70 2 0 4 )
文摘Grey system analysis method was used to study the correlation between water pollution in D Lake area and death rate of malignancy with death rate of malignancy as effect sequence and a variety of water pollution index as factor sequence. On the basis of grey correlation analysis, grey system predication model was established for death rate of malignancy in population in D Lake area including GM (1, N) model for death rate of malignancy [ MR (t+1) =(9.9987E 1+5.0001E 2 +10.8994E 3+1.1114E 4+165.1029) ·e -0.0070t -9.9987E 1-5.0001E 2-10.8994E 3-1.1114E 4 ] and GM (1, 1) model for related factors [ E 1(t+1) =52.1214-46.9468e -0.0058t , E 2(t+1) =4.6114-4.5664e 0.0015t, E 3(t+1) =1.1389-1.1212e 0.0065t , E 4(t+1) = 554.5867-549.8006e 0.0016t ], and the trend of death rate of malignancy from 2000 to 2010 was predicted.
文摘Introduction: On March 11, 2020, the World Health Organization (WHO) declared that the entire World was overrun by a pandemic. Science has managed, in a short time, to characterize a new disease, sequence a new viral genome, develop diagnostics, produce treatment protocols and establish the efficacy of drugs and vaccines in randomized controlled trials. In this paper we have dealt with different topics regarding the pandemic linked to COVID-19. Objectives: Aim of this paper is to compare the number of deaths attributable to COVID-19, that occurred in the different Italian macro-areas, in the different pandemic waves;we studied the trend of the curves relating to the proportion of deaths to the number of infected in the Italian macro-areas for the pandemic waves and analysed the mortality data, focusing on the Italian context and comparing it with other foreign countries. We examined the data regarding swabs, hospitalizations, home isolation, admissions to intensive care and deaths registered in pandemic period. Results: Geographically, Italy was differently affected by the pandemic. Northern Italy was the most affected area. In comparison with some foreign countries, Italy is one of the nations that paid the most in terms of deaths, due to: delays in understanding the seriousness of the emergency;the slow management in the tracking systems of contagions;the high number of hospitalizations;a corporate organizational system poorly planned. Conclusion: The years 2020 and 2021 have been dramatic and unprecedented. The year 2021 was the year of redemption, where, despite social, economic and health difficulties, thanks to mass vaccination, we were able to give a real strong response to the pandemic. Trust in science has led to a drastic decrease in mortality throughout the world.
基金The Fundamental Research Funds for the Central Universities,CHD (300102129202)the NSF (11701041) of China+1 种基金the Natural Science Basic Research Plan (2018JM1011) in Shaanxi Province of ChinaScientific Innovation Practice Project (300103002110) of Postgraduates of Chang’an University
文摘In this paper, we propose an SIRS epidemic model with pulse vaccination, birth pulse and Logistic death rate. By using the stroboscopic map of a discrete dynamical system, the disease-free periodic solution (DFPS for short) of the model under pulse vaccination and birth pulse is obtained. Based on the Floquet theory and comparison theorem of impulsive differential equations, the global asymptotic stability of the DFPS is given, and sufficient conditions for the permanence of the model are obtained. In addition, numerical simulations are done to confirm our theoretical results.
文摘本刊曾经多次刊登文章盛赞百年老药阿斯匹林。去年第10期就载文称阿斯匹林能抗前列腺癌,今又消息文称,阿斯匹林能减少心脏病人的死亡率。百年老药.青春犹在,至今仍能让人们不断发现其新的功效！本文除了传递了有关阿斯匹林的新信息之外,以下观点,也让我们耳目一新: Even as we live and practice medicine in an era of high technology,we mustalways remember that widespread application of relatively low technology,efficacious(有效的;灵验的),and cost-effective(有成本效益的,值得花费的)therapies is often the way we help most of our patients and provide the greatestaggregate(集合的;聚合的)benefit for the broader population. 上句是否可以这样译: 即使我们生活、就医在一个高科技的时代,但是,我们仍必须一直牢记:科技含量相对较低却又广为应用的东西,其灵验而又具有成本效益的治疗常常是我们帮助大多数患者,为广大群众提供最大利益的途径。 上句的难点在于:如何理解provide the greatest aggregate benefit for thebroader population的主语。
文摘Objectives: To determine the IMR in Al-Ramadi province, the center of Al-Anbar Governorate, Western Iraq, from 2000-2010 with rate comparison of the three different stages of that period. Methods: Data collected from the birth and death certificate center in Al-Ramadi province, Western Iraq, included;name, age, sex, residence, date of birth and death, in three different stages (the first stage 2000-2002, the second stage 2003-2007, and the third stage 2008-2010) in a study period from July to December, 2010. The IMRs were analyzed and compared with other studies. Results: The IMR of the last 3 years of sanction was 54.3/1000, 55.7/1000 and 50.6/1000 respectively, this rate had been increased in the war and violence period to reach its maximum rate 58.6/1000 in 2006, then decreased to reach its minimum rate 44.5/1000 in 2008. Approximately two-third of deaths occurred during the neonatal period and one third in the post neonatal period. Males had higher IMR than females, and rural residence higher than urban. Conclusion: Infant mortality rate is still high in Al-Ramadi province, since the American invasion (2003-2007), when compared with other developing countries. This study found increase of IMR in Al-Ramadi province during that period more than other studied years.
文摘Early detection of sudden cardiac death may be used for surviving the life of cardiac patients. In this paper we have investigated an algorithm to detect and predict sudden cardiac death, by processing of heart rate variability signal through the classical and time-frequency methods. At first, one minute of ECG signals, just before the cardiac death event are extracted and used to compute heart rate variability (HRV) signal. Five features in time domain and four features in frequency domain are extracted from the HRV signal and used as classical linear features. Then the Wigner Ville transform is applied to the HRV signal, and 11 extra features in the time-frequency (TF) domain are obtained. In order to improve the performance of classification, the principal component analysis (PCA) is applied to the obtained features vector. Finally a neural network classifier is applied to the reduced features. The obtained results show that the TF method can classify normal and SCD subjects, more efficiently than the classical methods. A MIT-BIH ECG database was used to evaluate the proposed method. The proposed method was implemented using MLP classifier and had 74.36% and 99.16% correct detection rate (accuracy) for classical features and TF method, respectively. Also, the accuracy of the KNN classifier were 73.87% and 96.04%.
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10275048 and 10305009)the Zhejiang Provincial Natural Science Foundation of China (Grant No 102067)
文摘An aggregation growth model of three species A, B and C with the competition between catalyzed birth and catalyzed death is proposed. Irreversible aggregation occurs between any two aggregates of the like species with theconstant rate kernels In（n = 1,2, 3）. Meanwhile, a monomer birth of an A species aggregate of size k occurs under the catalysis of a B species aggregate of size j with the catalyzed birth rate kernel K（k, j） = Kkj^v, and a monomer death of an A species aggregate of size k occurs under the catalysis of a C species aggregate of size j with the catalyzed death rate kernel L（k, j） = Lkj^v, whcre v is a parameter reflecting the dependence of the catalysis reaction rates of birth and death on the size of catalyst aggregate. The kinetic evolution behaviours of the three species are investigated by the rate equation approach based on the mean-field theory. The form of the aggregate size distribution of A species ak （t） is found to be dependent crucially on the competition between the catalyzed birth and death of A species, as well as the irreversible aggregation processes of the three species： （i） In the v 〈 0 case, the irreversible aggregation dominates the process, and ak（t） satisfies the conventional scaling form; （2） In the v ≥ 0 casc, the competition between the catalyzed birth and death dominates the process. When the catalyzed birth controls the process, ak（t） takes the conventional or generalized scaling form. While the catalyzed death controls the process, the scaling description of the aggregate size distribution breaks down completely.
文摘Objective: The aim of our study was to analyze the character of cause of death in Inner Mongolia of China from 2008 to 2014. Methods: We collected data from monitoring points of the Death Registry System (DRS) in Inner Mongolia. We calculated the mortality rates by gender, year and age-specific. We calculated the proportion, the mortality rate and potential years of life lost (PYLL) of various system deaths. Results: During the period 2008-2014, the average crude mortality rate of all cause of death was 539.33/105. The mortality rate increased semilogarithm linearly with age. The top four system deaths were circulatory system, neoplasm, respiratory system and injury. In 2014, the mortality rates of circulatory system were increased and the mortality rates of certain infectious and parasitic diseases, neoplasms, respiratory system, genitourinary system and injury were decreased compared to those in 2008. Conclusion: Through analysis the indicators of proportion, the mortality rate and PYLL indicated that health status of a population in Inner Mongolia was at a better level.
基金supported by International Joint Laboratory on Tropical Diseases Control in Greater Mekong Subregion(grant number 21410750200)from Shanghai Municipality Government.
文摘Background:Tuberculosis(TB),caused by Mycobacterium tuberculosis,remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in 2022.Of particular concern is the emergence of drug-resistant TB,accounting for 15%-20%of TB deaths.It is imperative to delve into the global trends of incidence and death rate for multidrug-resistant tuberculosis(MDRTB)and extensively drug-resistant tuberculosis(XDR-TB),drawing upon the comprehensive Global Burden of Disease(GBD)2021 drug-resistant tuberculosis dataset.Methods:From the GBD 2021,data on incidence,prevalence,disability-adjusted life years(DALYs),and death of MDR-TB and XDR-TB from 1990 to 2021 were collected.We calculated the estimated annual percentage changes in age standardized incidence rate(ASIR)and age-standardized death rate(ASDR),segmented by age,sex,and socio-demographic index(SDI).The impacts of various risk factors on MDR-TB and XDR-TB were also analyzed.Results:In 2021,there were an estimated 443,680(95%uncertainty interval[UI]:259,196-766,545)incident cases of MDR-TB,and an estimated 106,818(95%UI:41,612-211,854)death cases of MDR-TB,while there were an estimated 24,036(95%UI:17,144-34,587)incident cases of XDR-TB and 7,946(95%UI:3,326-14,859)death cases of XDR-TB.The incidence and death cases of MDR-TB were lowest in high SDI regions,whereas the incidence rates of XDR-TB in high-middle SDI regions were higher than those in middle SDI and high SDI regions.Conclusion:This study reported the disease burden of drug-resistant TB from 1990 to 2021.Until 2021,drugresistant TB is still a serious problem in low SDI countries,especially for high-risk age populations with highrisk factors.Controlling drug-resistant TB requires effective control strategies and healthcare systems.
文摘目的通过Meta分析,综合分析运动后心率恢复(HRR)与心源性猝死(SCD)之间的关系。方法基于PubMed、Embase和Web of Science数据库,进行截至2024年1月2日的文献检索。队列研究关注于HRR和SCD间的风险关系,通过风险比(HR)及95%可信区间(CI)进行评估。统计学分析采用Stata 12.0软件。结果纳入6项研究。固定效应模型(I^(2)=41.8%,P=0.112)的汇总结果显示:与心率恢复慢相比,心率恢复快人群发生SCD风险更低(HR=0.74,95%CI:0.64~0.86,P<0.001)。大多数亚组分析中都观察到了持续结果。排除一项研究并不影响总体结果[HR(95%CI):0.66(0.55,0.79)~0.76(0.65,0.88)]。Egger检验未发现明显的发表偏倚(P=0.059)。结论心率恢复较慢会增加普通人群发生SCD的风险。因此,HRR可能是临床实践中预防SCD的一个潜在靶点。
文摘This study explores the complex relationship between climate change and human development. The aim is to understand how climate change affects human development across countries, regions, and the global population. Visual analytics were used to examine the impact of various climate change indicators on different aspects of human development. The study highlights the urgent need for climate change action and encourages policymakers to make decisive moves. Climate change adversely affects numerous aspects of daily life, leading to significant consequences that must be addressed through policy changes and global governance recommendations. Key findings include that regions with higher CO2 emissions experience a significantly higher incidence of life-threatening diseases compared to regions with lower emissions. Additionally, higher CO2 emissions correlate with consistent death rates. Increased pollution exposure is associated with a higher prevalence of life-threatening diseases and higher rates of malnutrition. Moreover, greater mineral depletion is linked to more frequent life-threatening diseases, suggesting that industrialization contributes to adverse health effects. These results provide valuable insights for policy and decision-making aimed at mitigating the impact of climate change on human development.
文摘Objectives: To investigate the relationship between the use of angiotensin converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and hyperkalemia in patients diagnosed with sudden cardiac death. Methods: We examined oral ACE inhibitor or ARB use among cardiopulmonary arrest patients brought by ambulance to our emergency room during a 5-year period from January 2012 to December 2016. The cause of death was determined to be sudden cardiac death, despite temporary return of spontaneous circulation after starting cardiopulmonary resuscitation. Subjects were dichotomized into 2 groups, those taking and those not taking an ACE inhibitor or ARB. Variables determined retrospectively included serum potassium, estimated glomerular filtration rate as an index of kidney function and time from cardiopulmonary arrest to return of spontaneous circulation. The Mann-Whitney U-test was used to compare continuous data, and the chi-square test to compare categorical data between groups. The results are expressed as the median plus range. Statistical significance was assumed at p Results: Thirty-five patients met the inclusion criteria. The mean age was 77.1 years (range, 35 - 93 years), and there were 26 males and 9 females. Eleven subjects were ACE inhibitor or ARB users, and 24 were non-users. The serum potassium level was significantly higher in users than non-users (median, 6.2 mEq/L (range, 4.5 - 10.0) vs. 5.2 mEq/L (range, 3.6 - 8.3);p = 0.001). The estimated glomerular filtration rate was significantly lower in users than non-users (median, 25.1 mL/min/1.73 m2 (range, 4.6 - 60.3) vs. 46.9 mL/min/1.73 m2 (range, 19.8 - 97.1);p = 0.009). There was no significant difference in time from cardiopulmonary arrest to return of spontaneous circulation between the 2 groups (median, 24 minutes (range, 3 - 111) vs. 29 minutes (range, 10 - 54);p = 0.355). Conclusion: It is possible that hyperkalemia induced by ACE inhibitor or ARB use is a cause of sudden cardiac death, especially in patients with chronic kidney disease.
