The title compound 1,4,7,10-tetrakis（2-（4-methoxyphenoxy）ethyl）-1,4,7,10-tetraazacyclododecane hydrobromide derivated from cyclen has been synthesized by 4-methoxyphenol via two steps and characterized by ^1H NMR ...The title compound 1,4,7,10-tetrakis（2-（4-methoxyphenoxy）ethyl）-1,4,7,10-tetraazacyclododecane hydrobromide derivated from cyclen has been synthesized by 4-methoxyphenol via two steps and characterized by ^1H NMR and X-ray single-crystal diffraction. The crystal belongs to the orthorhombic system, space group Pbcn with a = 17.3174（15）, b = 12.9891（11）, c = 19.3379（17） A, V = 4349.8（7） ？3, Z = 4, Dc = 1.304 g/cm3, Mr = 853.87, F（000） = 1808, μ = 1.001 mm^-1, Mo Ka radiation（λ = 0.71073 A）, R = 0.0467 and w R = 0.1045 for 2774 observed reflections with I 〉 2σ（I）. X-ray structural analysis reveals that the molecular structure of the title compound is stabilized by intramolecular C–H···O and C–H···Br hydrogen-bonding interactions, and a 3D 2-fold interpenetrated supramolecular framework is constructed by intermolecular C–H···O and C–H···Br hydrogen-bonding interactions.展开更多
A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity bindi...A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity binding between POGEC and DNA was demonstrated by agarose gel electrophoresis and scanning electron microscopy (SEM). Moreover,the formed POGEC/DNA complex (termed polyplex) could be disassociated to release the free DNA through addition of the physiological concentration of NaCl solution. Fluorescence spectrum was used to measure the high-affinity binding and DNA condensation capability of POGEC. Circular dichroism (CD) spectrum indicates that the DNA conformation did not change after binding to POEGC.展开更多
Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiologi...Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiological conditions.Fluorescence studies indicate that the binding ability of complex P1 to CT-DNA is as twice as that of P2.DNA melting experiments were also carried out and the results show that ΔTm caused by P1 is higher than that caused by P2.Agarose gel electrophoresis experiments demonstrate that P1 is an excellent chemical nuclease,which can cleavage plasmid DNA completely in 12 h.展开更多
A novel molecule tetra-N-alkylation of cyclen （1,4,7,10-tetraazacyclododecane）, 1,4,7,10-tetrakis（2-（（4-hydroxy）phenoxy）ethyl）-1,4,7,10-tetraazacyclododecane 2, was synthesized and structurally characterized b...A novel molecule tetra-N-alkylation of cyclen （1,4,7,10-tetraazacyclododecane）, 1,4,7,10-tetrakis（2-（（4-hydroxy）phenoxy）ethyl）-1,4,7,10-tetraazacyclododecane 2, was synthesized and structurally characterized by single-crystal X-ray diffraction. The molecule turned into chiral helical compound crystals grown from EtOH by slow diffusion at room temperature and three of the four hydroquinone groups of the benzene ring formed a g-electron-rich cavity by C-H…π stacking interaction. The crystal belongs to the monoclinic system, space group P21/C with a = 13.9192（9）, b = 13.2871（6）, c = 22.1894（15）A^°, β = 91.4600（10）°, V = 4102.5（4）A^°3, Z = 4, Dc = 1.219 g/cm^3, C40H52N4O8, Mr = 752.89, F（000） = 1616,μ = 0.088 mm^-1, MoKa radiation （λ = 0.71073）, R = 0.0578 and wR = 0.1389 for 5588 observed reflections with I 〉 2σ（I）. Moreover, compound 2 was characterized with ^1H NMR, ^13C NMR, IR spectra and MS.展开更多
The new compound 1,4,7,10-tetrakis-（2-（2,3-difluorophenyl） ethyl） -1,4,7,10-tetra-zacyclododecane 2 has been synthesized and structurally characterized by single-crystal X-ray diffraction. The molecule turned into...The new compound 1,4,7,10-tetrakis-（2-（2,3-difluorophenyl） ethyl） -1,4,7,10-tetra-zacyclododecane 2 has been synthesized and structurally characterized by single-crystal X-ray diffraction. The molecule turned into diamond crystals grown from CH3CN by slow diffusion at room temperature. It crystallizes in the triclinic system,space group P1^- with a = 9.543（2） ,b = 10.507（3） ,c = 10.734（3） A,α = 60.979（3） ,β = 81.870（4） ,γ = 84.279（4） o,V = 931.1（4） 3,Z = 1,Dc = 1.307 g/cm^3,C40H44F8N4,Mr = 732.79,F（000） = 384,μ = 0.105 mm^-1,T = 296（2） K,MoKa radiation（λ = 0.71073） ,R = 0.0494 and wR = 0.0989 for 1589 observed reflections with I 〉 2σ（I） . Hydrogen bonds and C-H···π stacking interactions in 2 contribute to a supramolecular structure. Moreover,compound 2 has been determined by ^1H NMR,^13C NMR,MS,IR spectra and elemental analysis.展开更多
A novel molecule tetra-N-alkylation of cyclen (1,4,7,10-tetraazacyclododecane), 1,4,7,10-tetrakis(2-((4-methoxy)phenoxy)ethyl)-1,4,7,10-tetraazacyclododecane 1, was synthesized and structurally characterized by the si...A novel molecule tetra-N-alkylation of cyclen (1,4,7,10-tetraazacyclododecane), 1,4,7,10-tetrakis(2-((4-methoxy)phenoxy)ethyl)-1,4,7,10-tetraazacyclododecane 1, was synthesized and structurally characterized by the single-crystal X-ray diffraction. The crystals were obtained from ethanol by slow evapora-tion at room temperature and the four hydroquinone groups of the benzene ring formed a π-electron-rich cavity by C-H···Br stacking interaction. The crystal belongs to the orthorhombic system, space group Pbcn with a = 17.3174(15), b = 12.9891(11), c = 19.3379(17) ?, α= β = γ = 90°, V = 4349.8(7) ?3, Z = 4, Dc = 1.304 g/cm3, C44H61 BrN4O8, Mr = 853.88, F(000) = 1808, μ = 1.001 mm?1, CuKa radiation (λ = 0.71073), R = 0.0434 and wR = 0.1091 for 5200 observed reflections with I > 2σ(I).展开更多
基金Supported by the National Natural Science Foundation of China(Nos.21572026 and 21002009)the Scientific and Technological Project of Changzhou(CE20135009)Changzhou University,Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
文摘The title compound 1,4,7,10-tetrakis（2-（4-methoxyphenoxy）ethyl）-1,4,7,10-tetraazacyclododecane hydrobromide derivated from cyclen has been synthesized by 4-methoxyphenol via two steps and characterized by ^1H NMR and X-ray single-crystal diffraction. The crystal belongs to the orthorhombic system, space group Pbcn with a = 17.3174（15）, b = 12.9891（11）, c = 19.3379（17） A, V = 4349.8（7） ？3, Z = 4, Dc = 1.304 g/cm3, Mr = 853.87, F（000） = 1808, μ = 1.001 mm^-1, Mo Ka radiation（λ = 0.71073 A）, R = 0.0467 and w R = 0.1045 for 2774 observed reflections with I 〉 2σ（I）. X-ray structural analysis reveals that the molecular structure of the title compound is stabilized by intramolecular C–H···O and C–H···Br hydrogen-bonding interactions, and a 3D 2-fold interpenetrated supramolecular framework is constructed by intermolecular C–H···O and C–H···Br hydrogen-bonding interactions.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 20725206 and 20732004)Specialized Research Fund for the Doctoral Program of Higher EducationScientific Fund of Sichuan Province for Outstanding Young Scientist
文摘A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity binding between POGEC and DNA was demonstrated by agarose gel electrophoresis and scanning electron microscopy (SEM). Moreover,the formed POGEC/DNA complex (termed polyplex) could be disassociated to release the free DNA through addition of the physiological concentration of NaCl solution. Fluorescence spectrum was used to measure the high-affinity binding and DNA condensation capability of POGEC. Circular dichroism (CD) spectrum indicates that the DNA conformation did not change after binding to POEGC.
基金financially supported by the National Natural Science Foundation of China (20725206, 20732004 & 20902062)Program for Changjiang Scholars and Innovative Research Team in University, the Key Project of Chinese Ministry of Education in China and Scientific Fund of Sichuan Province for Outstanding Young Scientists
文摘Two dinucleotide PNA-cyclen copper(II) complexes with α-PNA (P1) and classical PNA (P2) backbones were synthesized and characterized.The interactions between title complexes and DNA were investigated under physiological conditions.Fluorescence studies indicate that the binding ability of complex P1 to CT-DNA is as twice as that of P2.DNA melting experiments were also carried out and the results show that ΔTm caused by P1 is higher than that caused by P2.Agarose gel electrophoresis experiments demonstrate that P1 is an excellent chemical nuclease,which can cleavage plasmid DNA completely in 12 h.
基金supported by the National Natural Science Foundation of China (20872051)
文摘A novel molecule tetra-N-alkylation of cyclen （1,4,7,10-tetraazacyclododecane）, 1,4,7,10-tetrakis（2-（（4-hydroxy）phenoxy）ethyl）-1,4,7,10-tetraazacyclododecane 2, was synthesized and structurally characterized by single-crystal X-ray diffraction. The molecule turned into chiral helical compound crystals grown from EtOH by slow diffusion at room temperature and three of the four hydroquinone groups of the benzene ring formed a g-electron-rich cavity by C-H…π stacking interaction. The crystal belongs to the monoclinic system, space group P21/C with a = 13.9192（9）, b = 13.2871（6）, c = 22.1894（15）A^°, β = 91.4600（10）°, V = 4102.5（4）A^°3, Z = 4, Dc = 1.219 g/cm^3, C40H52N4O8, Mr = 752.89, F（000） = 1616,μ = 0.088 mm^-1, MoKa radiation （λ = 0.71073）, R = 0.0578 and wR = 0.1389 for 5588 observed reflections with I 〉 2σ（I）. Moreover, compound 2 was characterized with ^1H NMR, ^13C NMR, IR spectra and MS.
基金supported by the National Natural Science Foundation of China (20872051)
文摘The new compound 1,4,7,10-tetrakis-（2-（2,3-difluorophenyl） ethyl） -1,4,7,10-tetra-zacyclododecane 2 has been synthesized and structurally characterized by single-crystal X-ray diffraction. The molecule turned into diamond crystals grown from CH3CN by slow diffusion at room temperature. It crystallizes in the triclinic system,space group P1^- with a = 9.543（2） ,b = 10.507（3） ,c = 10.734（3） A,α = 60.979（3） ,β = 81.870（4） ,γ = 84.279（4） o,V = 931.1（4） 3,Z = 1,Dc = 1.307 g/cm^3,C40H44F8N4,Mr = 732.79,F（000） = 384,μ = 0.105 mm^-1,T = 296（2） K,MoKa radiation（λ = 0.71073） ,R = 0.0494 and wR = 0.0989 for 1589 observed reflections with I 〉 2σ（I） . Hydrogen bonds and C-H···π stacking interactions in 2 contribute to a supramolecular structure. Moreover,compound 2 has been determined by ^1H NMR,^13C NMR,MS,IR spectra and elemental analysis.
文摘A novel molecule tetra-N-alkylation of cyclen (1,4,7,10-tetraazacyclododecane), 1,4,7,10-tetrakis(2-((4-methoxy)phenoxy)ethyl)-1,4,7,10-tetraazacyclododecane 1, was synthesized and structurally characterized by the single-crystal X-ray diffraction. The crystals were obtained from ethanol by slow evapora-tion at room temperature and the four hydroquinone groups of the benzene ring formed a π-electron-rich cavity by C-H···Br stacking interaction. The crystal belongs to the orthorhombic system, space group Pbcn with a = 17.3174(15), b = 12.9891(11), c = 19.3379(17) ?, α= β = γ = 90°, V = 4349.8(7) ?3, Z = 4, Dc = 1.304 g/cm3, C44H61 BrN4O8, Mr = 853.88, F(000) = 1808, μ = 1.001 mm?1, CuKa radiation (λ = 0.71073), R = 0.0434 and wR = 0.1091 for 5200 observed reflections with I > 2σ(I).
