目的探讨基于冠状动脉CT血管成像(CCTA)的人工智能(AI)诊断系统及CT无创血流储备分数(CT-FFR)在评估高海拔地区冠状动脉临界病变结构及功能学中的应用价值。方法前瞻性收集2022年1月~2023年10月青海大学附属医院冠心病临界病变患者164例...目的探讨基于冠状动脉CT血管成像(CCTA)的人工智能(AI)诊断系统及CT无创血流储备分数(CT-FFR)在评估高海拔地区冠状动脉临界病变结构及功能学中的应用价值。方法前瞻性收集2022年1月~2023年10月青海大学附属医院冠心病临界病变患者164例,按居住地海拔进行分组,其中2000~3000m为A组(n=83),3000m以上为B组(n=81),再将两组患者按冠脉狭窄程度细分为50%~60%亚组(n=84)和61%~70%亚组(n=80)。将患者冠状动脉CT血管成像数据导入AI辅助诊断及CT-FFR测量系统,以冠脉造影及冠脉传统血流储备分数(FFR)为金标准,分别评价AI及CT-FFR在高海拔地区冠脉临界病变诊断中的应用。结果以FFR为金标准,CT-FFR与FFR的一致性为83.75%。B组钙化斑块、易损斑块高于A组(P=0.037、0.020);B组冠状动脉多支病变、61%~70%狭窄程度发生率均高于A组(P<0.05);A组、B组在61%~70%亚组钙化斑块、易损斑块发生率均高于50%~60%亚组(P<0.05)。B组CT-FFR值低于A组(0.76±0.04 vs 0.88±0.05,P<0.01);A、B两组在61%~70%亚组CT-FFR值≤0.80、<0.70的发生率高于50%~60%亚组(P<0.05)。结论AI诊断系统及CT-FFR对评估高海拔地区冠状动脉临界病变的结构特征及血流动力学改变的结果与冠脉造影、FFR一致性高,具有较高的诊断敏感度和特异度。展开更多
Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic ...Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic valve implantation (TAVI), based on references and data summaries. Methods: Seventy-eight patients with severe aortic stenosis diagnosed and treated in the Department of Cardiovascular Medicine of the Affiliated Hospital of Qingdao University from March 2019 to October 2022 were selected to detect the CT coronary flow reserve fraction of the anterior descending branches of the patients before and after transcatheter aortic replacement, and according to the pre- and post-surgery CT coronary flow reserve fractions, patients were divided into the variable group (Group I), the large group (Group II), and unchanged group (Group III), to explore the effects of left ventricular ejection fraction and age on each group. Results: Compared to Group III, in Group I, LVEF mainly influenced CT-FFR to become smaller after TAVI and played a positive role;compared to Group III, age mainly influenced CT-FFR to become larger after TAVI and played a negative role. Conclusion: LVEF and age predict changes in anterior descending CT coronary flow reserve fraction after transcatheter aortic implantation.展开更多
文摘目的探讨基于冠状动脉CT血管成像(CCTA)的人工智能(AI)诊断系统及CT无创血流储备分数(CT-FFR)在评估高海拔地区冠状动脉临界病变结构及功能学中的应用价值。方法前瞻性收集2022年1月~2023年10月青海大学附属医院冠心病临界病变患者164例,按居住地海拔进行分组,其中2000~3000m为A组(n=83),3000m以上为B组(n=81),再将两组患者按冠脉狭窄程度细分为50%~60%亚组(n=84)和61%~70%亚组(n=80)。将患者冠状动脉CT血管成像数据导入AI辅助诊断及CT-FFR测量系统,以冠脉造影及冠脉传统血流储备分数(FFR)为金标准,分别评价AI及CT-FFR在高海拔地区冠脉临界病变诊断中的应用。结果以FFR为金标准,CT-FFR与FFR的一致性为83.75%。B组钙化斑块、易损斑块高于A组(P=0.037、0.020);B组冠状动脉多支病变、61%~70%狭窄程度发生率均高于A组(P<0.05);A组、B组在61%~70%亚组钙化斑块、易损斑块发生率均高于50%~60%亚组(P<0.05)。B组CT-FFR值低于A组(0.76±0.04 vs 0.88±0.05,P<0.01);A、B两组在61%~70%亚组CT-FFR值≤0.80、<0.70的发生率高于50%~60%亚组(P<0.05)。结论AI诊断系统及CT-FFR对评估高海拔地区冠状动脉临界病变的结构特征及血流动力学改变的结果与冠脉造影、FFR一致性高,具有较高的诊断敏感度和特异度。
文摘Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic valve implantation (TAVI), based on references and data summaries. Methods: Seventy-eight patients with severe aortic stenosis diagnosed and treated in the Department of Cardiovascular Medicine of the Affiliated Hospital of Qingdao University from March 2019 to October 2022 were selected to detect the CT coronary flow reserve fraction of the anterior descending branches of the patients before and after transcatheter aortic replacement, and according to the pre- and post-surgery CT coronary flow reserve fractions, patients were divided into the variable group (Group I), the large group (Group II), and unchanged group (Group III), to explore the effects of left ventricular ejection fraction and age on each group. Results: Compared to Group III, in Group I, LVEF mainly influenced CT-FFR to become smaller after TAVI and played a positive role;compared to Group III, age mainly influenced CT-FFR to become larger after TAVI and played a negative role. Conclusion: LVEF and age predict changes in anterior descending CT coronary flow reserve fraction after transcatheter aortic implantation.
