BACKGROUND： Aspirin can decrease the incidence risk of high-risk crowdgroup of cerebral infarction, but there are still controversy if it might decrease the degree of disease in degree of patients with acute cerebral...BACKGROUND： Aspirin can decrease the incidence risk of high-risk crowdgroup of cerebral infarction, but there are still controversy if it might decrease the degree of disease in degree of patients with acute cerebral infarction. OBJECTIVE： To observe the effect of lower dose of aspirin during taking for a long time on disease degree of disease following onset of acute cerebral infarction. DESIGN： Grouping according to the admission time and 1：1 paired observation.SETTING ： Department of Neurology, Qilu Hospital of Shandong University.PARTICIPANTS ： The participants in present study were 321 patients with acute cerebral infarction who received treatments in the Department of Neurology, Qilu Hospital of Shandong University from January 1999 to June 2000. There were 190 male and 131 female ,with mean （65±11 ）years of age. Inclusive criteria： ① A focal neurological disturbance occurred suddenly and had lasted for more than 24 hours, patients were admitted within 3 days after onset of disease; ② A computed tomography of the brain was performed and excluded hemorrhage in all patients; ③ The patients were proved internal carotid occlusions by clinical features and image findings; ④ The functions of limbs were normal （before the first stroke） or almost normal （before the second stroke）. Exclusive criteria：①The patients who had have cardiogenic cerebral embolism; ②The patients who had taken warfarin orally and other platelet agglutination drugs. METHODS ：①All the patients were divided into 2 groups according to whether they had taken aspirin before： aspirin-treated group （n=110） and blank control group （n=211）. there were 70 male and 40 female in aspirin-treated group, with average（65±10） years of age.All patients had taken 50-100 mg/d aspirin for 6 months to 10 years before onset. There were 120 male and 91 female in blank control group, with average （65±13） years of age. Patients received a clinical scoring within 3 days and similar therapeutic measures （such as anti-platelet agglutination, improving cerebral circulation and metabolism-promoting reagent）. Two groups of patients had the same basic conditions except for taking aspirin or not before. ②The matched pairs were made between 50 cases selected from aspirin-treated group and 50 cases from non-aspirin-treated groups according to age, gender, and other stroke risk factors. ③ Evaluation： Degree of disease after onset was evaluated by means of Acute Cerebral Infarction Clinical Neurologic Impairment Degree Scoring Standard of Carotid Artery System. MAIN OUTCOME MEASURES： Acute Cerebral Infarction Clinical Neurologic Impairment Degree Scoring Standard of Carotid Artery System. RESULTS ： All 321 patients entered the stage of analysis with no loss in the midway. ① The symptom following onset of acute cerebral infarction was evaluated with clinical neurologic impairment scoring criteria, there were no significant differences between aspirin group and blank control group [（17.39±9.90） vs （16.22 ± 9.98） （t=1.025, P〉 0.05）]. ② No significant differences were found in 1：1 matched pairs of 100 cases from aspirin group and blank control group （t=1.74, P 〉 0.05）. CONCLUSION ： Taking a lower dose of aspirin during long time may not decrease the degree of disease following onset of acute cerebral infarction.展开更多
目的构建重型颅脑损伤患者术后继发急性脑梗死的预测模型,并进行验证。方法回顾性分析150例重型颅脑损伤患者临床资料,根据术后是否继发急性脑梗死,分为急性脑梗死组(n=52)和对照组(n=98),比较两组患者临床特征,同时分析重型颅脑损伤患...目的构建重型颅脑损伤患者术后继发急性脑梗死的预测模型,并进行验证。方法回顾性分析150例重型颅脑损伤患者临床资料,根据术后是否继发急性脑梗死,分为急性脑梗死组(n=52)和对照组(n=98),比较两组患者临床特征,同时分析重型颅脑损伤患者术后继发急性脑梗死的危险因素。根据相关危险因素,构建预测模型并进行内部验证。结果两组患者脑疝、低血压、糖尿病、血肌酐和弥散性血管内凝血(disseminated intravascular coagulation,DIC)评分等差异存在统计学意义(均P<0.05)。多因素Logistics回归分析显示:脑疝、低血压、糖尿病和DIC评分≥5是重型颅脑损伤患者术后继发急性脑梗死的危险因素(均P<0.05)。采用R4.0.3统计软件将数据集随机分为训练集和验证集,训练集样本量为105,验证集样本量为45。曲线下面积(area under the curve,AUC):训练集为0.790(95%CI:0.694~0.887),验证集为0.753(95%CI:0.599~0.907)。在验证集里对模型进行Hosmer-Lemeshow拟合优度检验,χ^(2)=13.322,P=0.101,表明本模型具有良好预测价值和可信度。结论本研究构建的预测模型对识别重型颅脑损伤患者术后继发急性脑梗死的高危人群,具有一定价值。展开更多
目的探究N端脑钠肽、同型半胱氨酸、纤维蛋白原、D-二聚体与急性脑梗死严重程度的相关性。方法选取2021年2月—2023年8月南通市瑞慈医院收治的118例急性脑梗死患者为研究对象,患者入院后使用美国国立卫生院卒中量表(National National H...目的探究N端脑钠肽、同型半胱氨酸、纤维蛋白原、D-二聚体与急性脑梗死严重程度的相关性。方法选取2021年2月—2023年8月南通市瑞慈医院收治的118例急性脑梗死患者为研究对象,患者入院后使用美国国立卫生院卒中量表(National National Health Stroke Scale,NIHSS)对患者疾病严重程度进行评估,根据NIHSS评分将患者分成轻度组(n=35)、中度组(n=46)和重度组(n=37),对比3组患者N端脑钠肽、血清同型半胱氨酸、纤维蛋白原、D-二聚体水平,分析上述指标与急性脑梗死疾病严重程度的相关性。结果3组同型半胱氨酸水平对比,差异无统计学意义(P>0.05);轻度组N端脑钠肽、纤维蛋白原、D-二聚体水平低于中度组和重度组,差异有统计学意义(P均<0.05)。N端脑钠肽、D-二聚体、纤维蛋白原水平与急性脑梗死严重程度呈正相关(r=0.95、0.30、0.78,P均<0.05)。结论N端脑钠肽、纤维蛋白原、D-二聚体与急性脑梗死的严重程度呈正相关,可以作为疾病严重程度的反馈指标。展开更多
目的探讨阿替普酶静脉溶栓辅助治疗急性重症脑梗死患者的临床价值。方法选取2019年1月至2021年1月于沈阳市第九人民医院接受治疗的78例急性重症脑梗死患者作为研究对象,采取随机数字表法分为对照组与观察组,每组39例。对照组行常规治疗...目的探讨阿替普酶静脉溶栓辅助治疗急性重症脑梗死患者的临床价值。方法选取2019年1月至2021年1月于沈阳市第九人民医院接受治疗的78例急性重症脑梗死患者作为研究对象,采取随机数字表法分为对照组与观察组,每组39例。对照组行常规治疗,观察组在对照组基础上给予阿替普酶静脉溶栓辅助治疗,比较两组美国国立卫生研究院卒中量表(National Institute of health stroke scale,NIHSS)评分、临床疗效及不良反应发生情况。结果治疗后12 h、1周、2周,观察组NIHSS评分均明显低于对照组(P<0.05);观察组治疗总有效率为84.62%,明显高于对照组61.54%,差异有统计学意义(P<0.05);观察组不良反应发生率为10.26%,对照组为2.56%,两组比较差异无统计学意义。结论阿替普酶静脉溶栓辅助治疗急性重症脑梗死患者疗效显著,能明显改善患者神经功能,且安全性较高,值得临床推广应用。展开更多
文摘BACKGROUND： Aspirin can decrease the incidence risk of high-risk crowdgroup of cerebral infarction, but there are still controversy if it might decrease the degree of disease in degree of patients with acute cerebral infarction. OBJECTIVE： To observe the effect of lower dose of aspirin during taking for a long time on disease degree of disease following onset of acute cerebral infarction. DESIGN： Grouping according to the admission time and 1：1 paired observation.SETTING ： Department of Neurology, Qilu Hospital of Shandong University.PARTICIPANTS ： The participants in present study were 321 patients with acute cerebral infarction who received treatments in the Department of Neurology, Qilu Hospital of Shandong University from January 1999 to June 2000. There were 190 male and 131 female ,with mean （65±11 ）years of age. Inclusive criteria： ① A focal neurological disturbance occurred suddenly and had lasted for more than 24 hours, patients were admitted within 3 days after onset of disease; ② A computed tomography of the brain was performed and excluded hemorrhage in all patients; ③ The patients were proved internal carotid occlusions by clinical features and image findings; ④ The functions of limbs were normal （before the first stroke） or almost normal （before the second stroke）. Exclusive criteria：①The patients who had have cardiogenic cerebral embolism; ②The patients who had taken warfarin orally and other platelet agglutination drugs. METHODS ：①All the patients were divided into 2 groups according to whether they had taken aspirin before： aspirin-treated group （n=110） and blank control group （n=211）. there were 70 male and 40 female in aspirin-treated group, with average（65±10） years of age.All patients had taken 50-100 mg/d aspirin for 6 months to 10 years before onset. There were 120 male and 91 female in blank control group, with average （65±13） years of age. Patients received a clinical scoring within 3 days and similar therapeutic measures （such as anti-platelet agglutination, improving cerebral circulation and metabolism-promoting reagent）. Two groups of patients had the same basic conditions except for taking aspirin or not before. ②The matched pairs were made between 50 cases selected from aspirin-treated group and 50 cases from non-aspirin-treated groups according to age, gender, and other stroke risk factors. ③ Evaluation： Degree of disease after onset was evaluated by means of Acute Cerebral Infarction Clinical Neurologic Impairment Degree Scoring Standard of Carotid Artery System. MAIN OUTCOME MEASURES： Acute Cerebral Infarction Clinical Neurologic Impairment Degree Scoring Standard of Carotid Artery System. RESULTS ： All 321 patients entered the stage of analysis with no loss in the midway. ① The symptom following onset of acute cerebral infarction was evaluated with clinical neurologic impairment scoring criteria, there were no significant differences between aspirin group and blank control group [（17.39±9.90） vs （16.22 ± 9.98） （t=1.025, P〉 0.05）]. ② No significant differences were found in 1：1 matched pairs of 100 cases from aspirin group and blank control group （t=1.74, P 〉 0.05）. CONCLUSION ： Taking a lower dose of aspirin during long time may not decrease the degree of disease following onset of acute cerebral infarction.
文摘目的构建重型颅脑损伤患者术后继发急性脑梗死的预测模型,并进行验证。方法回顾性分析150例重型颅脑损伤患者临床资料,根据术后是否继发急性脑梗死,分为急性脑梗死组(n=52)和对照组(n=98),比较两组患者临床特征,同时分析重型颅脑损伤患者术后继发急性脑梗死的危险因素。根据相关危险因素,构建预测模型并进行内部验证。结果两组患者脑疝、低血压、糖尿病、血肌酐和弥散性血管内凝血(disseminated intravascular coagulation,DIC)评分等差异存在统计学意义(均P<0.05)。多因素Logistics回归分析显示:脑疝、低血压、糖尿病和DIC评分≥5是重型颅脑损伤患者术后继发急性脑梗死的危险因素(均P<0.05)。采用R4.0.3统计软件将数据集随机分为训练集和验证集,训练集样本量为105,验证集样本量为45。曲线下面积(area under the curve,AUC):训练集为0.790(95%CI:0.694~0.887),验证集为0.753(95%CI:0.599~0.907)。在验证集里对模型进行Hosmer-Lemeshow拟合优度检验,χ^(2)=13.322,P=0.101,表明本模型具有良好预测价值和可信度。结论本研究构建的预测模型对识别重型颅脑损伤患者术后继发急性脑梗死的高危人群,具有一定价值。
文摘目的探究N端脑钠肽、同型半胱氨酸、纤维蛋白原、D-二聚体与急性脑梗死严重程度的相关性。方法选取2021年2月—2023年8月南通市瑞慈医院收治的118例急性脑梗死患者为研究对象,患者入院后使用美国国立卫生院卒中量表(National National Health Stroke Scale,NIHSS)对患者疾病严重程度进行评估,根据NIHSS评分将患者分成轻度组(n=35)、中度组(n=46)和重度组(n=37),对比3组患者N端脑钠肽、血清同型半胱氨酸、纤维蛋白原、D-二聚体水平,分析上述指标与急性脑梗死疾病严重程度的相关性。结果3组同型半胱氨酸水平对比,差异无统计学意义(P>0.05);轻度组N端脑钠肽、纤维蛋白原、D-二聚体水平低于中度组和重度组,差异有统计学意义(P均<0.05)。N端脑钠肽、D-二聚体、纤维蛋白原水平与急性脑梗死严重程度呈正相关(r=0.95、0.30、0.78,P均<0.05)。结论N端脑钠肽、纤维蛋白原、D-二聚体与急性脑梗死的严重程度呈正相关,可以作为疾病严重程度的反馈指标。
文摘目的探讨阿替普酶静脉溶栓辅助治疗急性重症脑梗死患者的临床价值。方法选取2019年1月至2021年1月于沈阳市第九人民医院接受治疗的78例急性重症脑梗死患者作为研究对象,采取随机数字表法分为对照组与观察组,每组39例。对照组行常规治疗,观察组在对照组基础上给予阿替普酶静脉溶栓辅助治疗,比较两组美国国立卫生研究院卒中量表(National Institute of health stroke scale,NIHSS)评分、临床疗效及不良反应发生情况。结果治疗后12 h、1周、2周,观察组NIHSS评分均明显低于对照组(P<0.05);观察组治疗总有效率为84.62%,明显高于对照组61.54%,差异有统计学意义(P<0.05);观察组不良反应发生率为10.26%,对照组为2.56%,两组比较差异无统计学意义。结论阿替普酶静脉溶栓辅助治疗急性重症脑梗死患者疗效显著,能明显改善患者神经功能,且安全性较高,值得临床推广应用。
