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The Effect of Predictive Nursing Intervention on Cardiac Function and Clinical Outcomes in CCU Patients with Acute Myocardial Infarction After Interventional Therapy
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作者 Tingting Wang Cui Xia 《Journal of Clinical and Nursing Research》 2024年第8期237-242,共6页
Objective:To evaluate the impact of predictive nursing on the care of acute myocardial infarction(AMI)patients in the Coronary Care Unit(CCU)after interventional therapy.Methods:From September 2021 to September 2023,8... Objective:To evaluate the impact of predictive nursing on the care of acute myocardial infarction(AMI)patients in the Coronary Care Unit(CCU)after interventional therapy.Methods:From September 2021 to September 2023,84 AMI patients admitted to the CCU were randomly divided into two groups:the experimental group(42 patients)received predictive nursing,and the reference group(42 patients)received conventional nursing.Cardiac function and clinical outcomes were compared between the groups.Results:Before nursing,there was no difference in cardiac function between the two groups(P>0.05).After nursing,the cardiac function of the experimental group was better than that of the reference group(P<0.05).The clinical outcomes of the experimental group were better than those of the reference group(P<0.05).Before nursing,there was no difference in psychological scores between the two groups(P>0.05).After nursing,the psychological scores of the experimental group were lower than those of the reference group(P<0.05).Conclusion:Predictive nursing can improve the cardiac function and clinical outcomes of AMI patients after interventional therapy and can also regulate patients’negative psychological states. 展开更多
关键词 Predictive nursing CCU acute myocardial infarction Interventional therapy Cardiac function
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Application of a hospital–community–family trinity rehabilitation nursing model combined with motor imagery therapy in patients with cerebral infarction 被引量:7
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作者 Wen-Wen Li Min Li +1 位作者 Xiao-Juan Guo Fu-De Liu 《World Journal of Clinical Cases》 SCIE 2023年第3期621-628,共8页
BACKGROUND Rehabilitation nursing is considered an indispensable part of the cerebral infarction treatment system.The hospital–community–family trinity rehabilitation nursing model can provide continuous nursing ser... BACKGROUND Rehabilitation nursing is considered an indispensable part of the cerebral infarction treatment system.The hospital–community–family trinity rehabilitation nursing model can provide continuous nursing services across hospitals,communities,and families for patients.AIM To explore the application of a hospital–community–family rehabilitation nursing model combined with motor imagery therapy in patients with cerebral infarction.METHODS From January 2021 to December 2021,88 patients with cerebral infarction were divided into a study(n=44)and a control(n=44)group using a simple random number table.The control group received routine nursing and motor imagery therapy.The study group was given hospital–community–family trinity rehabilitation nursing based on the control group.Motor function(FMA),balance ability(BBS),activities of daily living(BI),quality of life(SS-QOL),activation status of the contralateral primary sensorimotor cortical area to the affected side,and nursing satisfaction were evaluated before and after intervention in both groups.RESULTS Before intervention,FMA and BBS were similar(P>0.05).After 6 months’intervention,FMA and BBS were significantly higher in the study than in the control group(both P<0.05).Before intervention,BI and SS-QOL scores were not different between the study and control group(P>0.05).However,after 6months’intervention,BI and SS-QOL were higher in the study than in the control group(P<0.05).Before intervention,activation frequency and volume were similar between the study and the control group(P>0.05).After 6 months’intervention,the activation frequency and volume were higher in the study than in the control group(P<0.05).The reliability,empathy,reactivity,assurance,and tangibles scores for quality of nursing service were higher in the study than in the control group(P<0.05).CONCLUSION Combining a hospital–community–family trinity rehabilitation nursing model and motor imagery therapy enhances the motor function and balance ability of patients with cerebral infarction,improving their quality of life. 展开更多
关键词 Activities of daily living cerebral infarction Hospital-community-family trinity rehabilitation nursing model Motor skills Motor imagery therapy Postural balance
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Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction
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作者 Zhi-Yong Lu 《Journal of Acute Disease》 2017年第2期66-69,共4页
Objective:To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction. Methods:A total of 74 patients with acute cere... Objective:To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction. Methods:A total of 74 patients with acute cerebral infarction treated in our hospital from March 2014 to December 2015 were retrospectively analyzed, and they were divided into ginkgo-damole group and conventional treatment group according to a therapeutic schedule that whether ginkgo-diyidamolum were included. At Week 2 and Week 4 after treatment, contents of apoptosis molecule, nerve injury molecule and index of platelet aggregation in serum were detected. Results:At Week 2 after treatment, contents of soluble Fas, soluble Fas ligand, soluble tumor necrosis factor related apoptosis inducing ligand, S100β, neuron specific enolase, glial fibrillary acidic protein, myelin basic protein, malonaldehyde, endothelin-1, fibrinogen and D-dimer in patients' sera of ginkgo-damole group were significantly lower than those of conventional treatment group. Contents of nitric oxide in sera were obviously higher than that of conventional treatment group. At Week 4 after treatment, contents of soluble Fas, soluble Fas ligand, soluble tumor necrosis factor related apoptosis inducing ligand, S100β, neuron specific enolase, glial fibrillary acidic protein, myelin basic protein, malonaldehyde, endothelin-1, fibrinogen and D-dimer in patients' sera of ginkgo-damole group were significantly lower than those of conventional treatment group. Contents of nitric oxide in sera were obviously higher than that of conventional treatment group. Conclusions:Adjuvant therapy with ginkgo-damole can inhibit the apoptosis of neuron cells and neurogliocyte and reduce the neural function injury and the situation of platelet aggregation. 展开更多
关键词 Ginkgo-damole ADJUVANT therapy PLATELET aggregation APOPTOSIS acute cerebral infarction
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Evolving of treatment options for cerebral infarction
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作者 Qiong-Yue Cao Zheng Li 《World Journal of Clinical Cases》 SCIE 2024年第32期6534-6537,共4页
In this editorial,we comment on a recent article which addressed the therapeutic effect of aspirin plus edaravone in patients with cerebral infarction(CI).Herein,we outline the progress in therapy of CI.Apart from thr... In this editorial,we comment on a recent article which addressed the therapeutic effect of aspirin plus edaravone in patients with cerebral infarction(CI).Herein,we outline the progress in therapy of CI.Apart from thrombolysis,aspirin is the most effective treatment for CI.Edaravone,a free radical scavenger,reduces endothelial cell damage and delays neuronal cell death.Aspirin plus edaravone mitigates damage to brain tissue by different mechanisms,thereby expediting the reinstation of neurological function.However,the nephrotoxic effect of edaravone,along with gastrointestinal bleeding associated with aspirin,may restrict this combination therapy.Although clinical studies have demonstrated the efficacy of thrombolytic therapy and mechanical thrombectomy,patients receiving these treatments experience modest efficacy and many adverse events.Moreover,interest in exploring natural medicines for CI is increasing,and they appear to have a high potential to protect against CI.The evolution of therapeutic strategies is expected to improve clinical outcomes of patients with CI. 展开更多
关键词 cerebral infarction Treatment thrombolytic therapy ASPIRIN EDARAVONE Natural medicine
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EFFECT OF ACUPUNCTURE ON PLASMA STRESS HORMONE LEVELS OF HYPOTHALAMUS-PITUITARY-ADRENAL AXIS IN TYPE II DIABETES WITH CONCURRENT ACUTE CEREBRAL INFARCTION PATIENTS 被引量:1
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作者 谌剑飞 梁浩荣 +1 位作者 关少侠 马雅玲 《World Journal of Acupuncture-Moxibustion》 2001年第1期9-12,共4页
Objective: To observe the effect of acupuncture on the contents of stress hormones of the hypothalamus pituitary adrenal axis (HPA) in treatment of type II diabetes with concurrent acute cerebral infarction patients. ... Objective: To observe the effect of acupuncture on the contents of stress hormones of the hypothalamus pituitary adrenal axis (HPA) in treatment of type II diabetes with concurrent acute cerebral infarction patients. Methods: 60 cases of inpatients were randomly and evenly divided into treatment group (conventional medication plus acupuncture) and control (conventional mediation) group. Plasma corticotropin releasing hormone (CRH), adrenocorticotropin hormone (ACTH) and corticosteroid (CS) contents before and after treatment were measured using radioimmunoassay (RIA) and compared with those of healthy subject group (n=30). Results: Plasma CRH, ACTH and CS levels in patients of both treatment group and control group at admission were significant higher than those of normal subject group (P<0.05). After treatment for 15~30 days, results showed that plasma CRH, ACTH and CS levels in both treatment and control groups lowered significantly in comparison with those of pre treatment (P<0.05 or 0.01); while those of treatment group were even more lower (being closer to the normal values) than those of control group (P<0.05 or 0.01). Conclusion: Acupuncture therapy can reduce the stress state of HPA in type II diabetes with concurrent acute cerebral infarction patients, i.e. regulate the neuroendocrine immunological net, which may be one of the mechanisms for acupuncture treatment of cerebral stroke. 展开更多
关键词 Acupuncture therapy Type II diabetes with concurrent acute cerebral infarction CRH ACTH CS
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CLINICAL OBSERVATION ON THE TREATMENT OF ACUTE CEREBRAL INFARCTION WITH SCALP-ACUPUNCTURE
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作者 吴绪平 杨毅红 +2 位作者 王亚文 王述菊 刘又香 《World Journal of Acupuncture-Moxibustion》 2001年第3期24-27,共4页
Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = ... Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = 50) and medication control group (n= 50). In the former group, penetration needling from Baihui (GV 20) to Qianding (GV 21) and from Shuaigu(GB 8) to Xuanli (GB 6) was performed, followed by conducting electroacupuncture (EA) stimulation; while in control group, intravenous drip of Ligustrazine injectio 120 mg plus 5% glucose solution 250 mL (once daily, with 14 days being a therapeutic course) was given in the first therapeutic course and then intravenous drip of Piracetum injectio (2 g plus 5% glucose or normal saline 250 mL, once daily, continuously for 14 days) conducted in the second therapeutic course. Results: After treatment, of the 50 cases in scalp acupuncture group, 26 (52%) were recovered basically, 15 (30%) had significant improvement, 7 (14%) had improvement and 2 (4%) failed in the treatment; while of the 50 cases in control group, 15 (30%) recovered basically, 17 (34%) had marked improvement, 16 (32%) had improvement and 2 (4%) failed in the treatment. The integral values of hemiplegia and aphasia of scalp acupuncture group were less than those of control group (P <0.01). It Indicates that the therapeutic effect of scalp acupuncture is superior to that of control group. 展开更多
关键词 acute cerebral infarction Scalp-acupuncture therapy Medication therapy
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Aortic Dissection Complicated with Fatal Cerebral Infarction: Case Report and Review of Literatures 被引量:3
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作者 Kentaro Hayashi Nobutaka Horie +1 位作者 Kazuhiko Suyama Izumi Nagata 《Open Journal of Modern Neurosurgery》 2012年第2期21-24,共4页
Acute aortic dissection is a life-threatening condition requiring immediate assessment and therapy. Rarely, aortic dis-section involves carotid arteries and manifest cerebral infarction. Here, we report a case of aort... Acute aortic dissection is a life-threatening condition requiring immediate assessment and therapy. Rarely, aortic dis-section involves carotid arteries and manifest cerebral infarction. Here, we report a case of aortic dissection complicated with fatal cerebral infarction. A 83-year-old man, who suddenly suffered consciousness disturbance and right hemiparesis, was transferred to our hospital for the treatment of stroke. Magnetic resonance image revealed massive cerebral infarction in the left cerebral hemisphere as well as occlusion of the left internal carotid artery. Duplex ultrasonography demonstrated arterial dissection in the bilateral carotid arteries and the blood flow was compromised especially in the left side. Aortic dissection was confirmed by the contrast enhanced computed tomography. He was treated conservatively and died of cerebral hernia three days after the onset. In conclusion, aortic dissection may involve carotid artery and results in cerebral infarction. Ultrasound screening can aid timely diagnosis of aortic dissection and further management. 展开更多
关键词 Aortic DISSECTION cerebral infarction thrombolytic therapy CAROTID Artery Occlusion
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阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果
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作者 王倩 彭晓 《中国药物应用与监测》 2025年第1期139-143,共5页
目的探究阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果。方法纳入2021年5月至2024年1月邯郸市第一医院接收的急性脑梗死患者,根据治疗方案不同分为溶栓组与替罗非班组,倾向性匹配排除基线资料,两组各105例。溶栓组给予阿替普酶... 目的探究阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果。方法纳入2021年5月至2024年1月邯郸市第一医院接收的急性脑梗死患者,根据治疗方案不同分为溶栓组与替罗非班组,倾向性匹配排除基线资料,两组各105例。溶栓组给予阿替普酶静脉溶栓治疗,替罗非班组在静脉溶栓基础上加用替罗非班治疗,治疗时间持续2周。对比溶栓组与替罗非班组临床疗效,治疗前后神经功能[卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数]、凝血指标[纤维蛋白原(fibrinogen,FIB)、凝血酶原时间(prothrombin time,PT)]、脑血流指标[脑动脉平均血流速度(mean flow velocity,Vm)、收缩期血流峰值(peak systolic velocity,Vs)、舒张期血流峰值(peak diastolic velocity,Vd)]、血清相关因子[胰岛素样生长因子1(iInsulin-like growth factor 1,IGF-1)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)]、氧化应激因子[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、丙二醛(malonaldehyde,MDA)、超氧化物歧化酶(superoxi dedismutase,SOD)]药物不良反应及出血转化情况。结果替罗非班组总疗效96.19%(101/105)高于溶栓组88.57%(93/105)(χ^(2)=4.330,P=0.037);治疗后,替罗非班组与溶栓组NIHSS下降[分别为(7.63±1.10)分、(8.71±1.20)分],Barthel指数上升[分别为(73.92±6.58)分、(68.54±6.01)分],差异均有统计学意义(均P<0.05),且替罗非班组NIHSS低于溶栓组,Barthel指数高于溶栓组,差异有统计学意义(均P<0.05);治疗后,替罗非班组与溶栓组FIB下降[分别为(2.79±0.52)g·L^(-1)、(3.45±0.62)g·L^(-1)],PT上升[分别为(15.59±3.01)s、(13.89±2.91)s],差异有统计学意义(均P<0.05),且替罗非班组FIB低于溶栓组,PT高于溶栓组,差异有统计学意义(均P<0.05);治疗后,替罗非班组与溶栓组Vm、Vs、Vd上升[分别为(55.65±7.52)cm·s^(-1)、(51.36±6.98)cm·s^(-1),(87.52±8.44)cm·s^(-1)、(82.65±8.14)cm·s^(-1),(29.65±5.87)cm·s^(-1)、(25.61±6.21)cm·s^(-1)],差异有统计学意义(均P<0.05),且替罗非班组高于溶栓组,差异有统计学意义(均P<0.05);治疗后,替罗非班组与溶栓组IGF-1、BDNF、VEGF上升[分别为(145.95±24.10)μg·L^(-1)、(134.37±22.21)μg·L^(-1),(9.21±1.51)μg·L^(-1)、(7.89±1.36)μg·L^(-1)、(74.52±6.30)μg·L^(-1)、(71.26±5.27)μg·L^(-1)],差异有统计学意义(均P<0.05),且替罗非班组高于溶栓组,差异有统计学意义(均P<0.05);治疗后,替罗非班组与溶栓组MDA下降[分别为(5.21±0.78)mmol·L^(-1)、(6.55±0.82)mmol·L^(-1),(125.52±20.11)U·mL^(-1)、(106.83±16.84)U·mL^(-1)],GSHPx、SOD上升[分别为(71.35±4.36)μmol·L^(-1),(64.93±5.04)μmol·L^(-1)],差异有统计学意义(均P<0.05),且替罗非班组MDA低于溶栓组(P<0.05),GSH-Px、SOD高于溶栓组,差异有统计学意义(均P<0.05);替罗非班组药物不良反应发生率为9.52%(10/105),溶栓组药物不良反应发生率为5.71%(6/105),差异无统计学意义(χ^(2)=1.082,P=0.398)。替罗非班组出血转化率为8.57%(9/105),溶栓组药物出血转化率为5.71%(6/105),差异无统计学意义(χ^(2)=0.646,P=0.421)。结论阿替普酶静脉溶栓后替罗非班可有效治疗急性脑梗死,提高神经功能,改善血清指标,安全性高,值得应用。 展开更多
关键词 急性脑梗死 替罗非班 阿替普酶 神经功能 溶栓治疗
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非急性期症状性颅内大动脉闭塞脑梗死预后的影响因素
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作者 张永梅 王亚婷 +3 位作者 胡甜甜 简溯 赵红领 何文龙 《临床神经病学杂志》 2025年第1期11-16,共6页
目的探讨非急性期症状性颅内大动脉闭塞(ILAO)脑梗死预后的影响因素。方法根据预后将86例非急性期症状性ILAO脑梗死患者分为预后良好组和预后不良组,比较两组的临床资料。采用多因素Logistic回归分析筛选出预后的影响因素,并将相关因素... 目的探讨非急性期症状性颅内大动脉闭塞(ILAO)脑梗死预后的影响因素。方法根据预后将86例非急性期症状性ILAO脑梗死患者分为预后良好组和预后不良组,比较两组的临床资料。采用多因素Logistic回归分析筛选出预后的影响因素,并将相关因素进行联合,构建预测非急性期ILAO脑梗死患者预后不良的列线图,通过校准曲线、决策曲线进行验证。结果与预后良好组比较,预后不良组患者的年龄、入院mRS、入院NIHSS评分、球蛋白水平及药物治疗比率显著升高,三酰甘油水平、白蛋白球蛋白比值显著降低(P<0.05~0.01)。多因素Logistic回归分析显示,入院mRS与非急性期ILAO脑梗死患者3个月预后不良呈正相关(OR=2.551,95%CI:1.134~5.738,P=0.024),血管内开通治疗与非急性期ILAO脑梗死患者3个月预后不良呈负相关(OR=0.132,95%CI:0.027~0.634,P=0.011)。纳入入院mRS及血管内开通治疗建立列线图模型,具有良好的预测效能。结论入院mRS和血管内开通治疗分别增加和降低非急性期ILAO脑梗死患者3个月预后不良的风险,两者结合建立的列线图对患者预后不良的预测具有良好的应用价值。 展开更多
关键词 非急性期症状性颅内大动脉闭塞性脑梗死 预后 血管内开通治疗 列线图
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多学科协作下无缝隙护理对急性脑梗死取栓治疗患者康复的促进效果
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作者 李艳荣 谢卫征 +2 位作者 周欣欣 赵娜娜 孟楠楠 《河南医学研究》 2025年第3期558-562,共5页
目的 分析多学科协作下无缝隙护理对急性脑梗死取栓治疗患者康复的促进效果。方法 选择2021年1月至2023年4月安阳市人民医院收治的308例急性脑梗死取栓治疗患者纳入研究。回顾性收集患者临床资料,根据护理方案分为对照组(165例,接受常... 目的 分析多学科协作下无缝隙护理对急性脑梗死取栓治疗患者康复的促进效果。方法 选择2021年1月至2023年4月安阳市人民医院收治的308例急性脑梗死取栓治疗患者纳入研究。回顾性收集患者临床资料,根据护理方案分为对照组(165例,接受常规干预),试验组(143例,接受多学科协作下无缝隙护理),两组均护理至出院后1个月。比较两组护理前后康复效果、生活自理能力、心理状态及睡眠,护理后护理满意度,护理期间并发症发生情况。结果 较护理前,护理后两组美国国立卫生研究院卒中量表(NIHSS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)评分降低,且试验组更低(P<0.05)。与护理前比较,护理后两组Fugl-Meyer运动功能量表(FMA)、Barthel指数(BI)、执行缺陷综合征行为评价量表(BADS)、自我护理能力测定量表(ESCA)得分均升高,且试验组更高(P<0.05)。护理后,相较对照组,试验组总满意率更高(93.71%比85.45%,P<0.05)。护理期间,试验组并发症发生率在两组中更低(P<0.05)。结论 多学科协作下无缝隙护理可改善急性脑梗死取栓治疗患者康复效果,提高生活自理能力,改善心理状态及睡眠,降低并发症发生风险,获得患者认可。 展开更多
关键词 多学科协作 无缝隙护理 急性脑梗死 取栓 生活自理能力 心理状态
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桥接治疗辅助血管内介入治疗对急性脑梗死的应用研究
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作者 张铁山 王冬梅 +1 位作者 邢汝月 陈骏 《中国医学工程》 2025年第2期44-48,共5页
目的 观察桥接治疗辅助血管内介入治疗(EVT)急性脑梗死的临床效果。方法 该研究为前瞻性研究,选择黄河科技学院附属医院2022年1月至2023年12月收治的105例急性脑梗死患者作为研究对象,分组方式为电脑随机分组法。将入组患者分别列为EVT... 目的 观察桥接治疗辅助血管内介入治疗(EVT)急性脑梗死的临床效果。方法 该研究为前瞻性研究,选择黄河科技学院附属医院2022年1月至2023年12月收治的105例急性脑梗死患者作为研究对象,分组方式为电脑随机分组法。将入组患者分别列为EVT组(52例)和联合组(53例),EVT组直接实施EVT治疗,联合组采用桥接治疗辅助EVT治疗,比较两组患者的血管再通情况,脑血流动力学改善情况,神经功能恢复情况及预后情况。结果 联合组的血管再通率为88.68%(47/53),高于EVT组[73.08%(38/52)](P<0.05);联合组的脑血流量(CBF)、脑血容量(CBV)分别为(50.23±10.31) mL/(100g·min)、(4.49±1.31) mL/100g,均高于EVT组[(45.25±10.44) mL/(100g·min)、(3.62±0.79) mL/100g],低灌注强度比值(HIR)为(0.36±0.11),低于EVT组(0.76±0.25)(P<0.05);联合组的神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白(S100β)分别为(8.61±1.46) ng/mL、(10.32±2.24) pg/mL,均低于EVT组[(10.66±2.39) ng/mL、(12.77±3.31) pg/mL](P<0.05);联合组的改良Rankin量表(mRS)评分为(3.44±0.45)分,低于EVT组[(4.25±1.72)分],改良Barthel指数(MBI)为(86.23±10.25)分,高于EVT组[(81.18±10.27)分](P<0.05);联合组的不良预后发生率为5.66%(3/53),低于EVT组[23.08%(12/52)](P<0.05)。结论 桥接治疗辅助EVT治疗能提高急性脑梗死的血管再通率,对促进患者脑血流动力、神经功能恢复并降低不良预后发生风险均有积极意义。 展开更多
关键词 急性脑梗死 血管内介入治疗 桥接治疗 血管再通率 预后情况
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基于海恩法则的预见性护理干预在急诊急性脑梗死静脉溶栓患者中的应用
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作者 刘南 《河南医学研究》 2025年第2期364-367,共4页
目的探讨基于海恩法则的预见性护理干预在急诊急性脑梗死静脉溶栓患者中的应用效果。方法回顾性收集2022年6月至2023年6月郑州大学第一附属医院收治的400例急诊急性脑梗死静脉溶栓患者的临床资料,根据护理方法分为对照组(190例,预见性... 目的探讨基于海恩法则的预见性护理干预在急诊急性脑梗死静脉溶栓患者中的应用效果。方法回顾性收集2022年6月至2023年6月郑州大学第一附属医院收治的400例急诊急性脑梗死静脉溶栓患者的临床资料,根据护理方法分为对照组(190例,预见性护理干预)和观察组(210例,基于海恩法则的预见性护理干预)。比较两组患者急救时间,入院时和转至专科病房时神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)评分],以及两组护理期间并发症发生情况。结果对照组采血送检时间、CT检查时间、入院至溶栓开始时间长于观察组(P<0.05);转至专科病房时,对照组NIHSS评分高于观察组(P<0.05);护理期间,对照组并发症总发生率高于观察组(P<0.05)。结论基于海恩法则的预见性护理干预可缩短急诊急性脑梗死静脉溶栓患者急救时间,降低患者神经功能缺损程度和并发症发生率。 展开更多
关键词 海恩法则 预见性护理 急诊 急性脑梗死 静脉溶栓
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替罗非班在急性脑梗死介入治疗中的应用效果
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作者 陈海 《中国医药指南》 2025年第1期138-140,共3页
目的分析急性脑梗死(CI)患者实施介入治疗期间应用替罗非班的效果。方法将2022年11月至2023年11月本院50例符合介入治疗指征的CI患者,采取随机数字表法分组的方式,将患者划分至对照组(25例,仅实施介入治疗)与试验组(25例,于对照组基础... 目的分析急性脑梗死(CI)患者实施介入治疗期间应用替罗非班的效果。方法将2022年11月至2023年11月本院50例符合介入治疗指征的CI患者,采取随机数字表法分组的方式,将患者划分至对照组(25例,仅实施介入治疗)与试验组(25例,于对照组基础上予以替罗非班治疗),对比两组治疗效果、神经功能、日常生活能力、炎症因子水平、血液流变学指标、血管内皮功能指标、并发症总发生率等研究数据。结果治疗后,试验组低切全血黏度与纤维蛋白原水平,美国国立卫生研究院卒中量表评分以及并发症总发生率均低于对照组(均P<0.05)。治疗后,生活能力评估表评分和治疗总有效率均高于对照组(均P<0.05)。治疗后,试验组肿瘤坏死因子α、白细胞介素6、白细胞介素8、内皮素1指标水平均低于对照组,一氧化氮水平高于对照组(均P<0.05)。结论罗非班治有助于改善CI患者的整体预后,避免因脑神经功能缺损等情况以降低生活能力,降低炎症因子水平,改善血液流变学及血管内皮指标,减少并发症发生。 展开更多
关键词 急性脑梗死 介入治疗 替罗非班 治疗总有效率
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CYP2C19基因多态性对氯吡格雷在急性脑梗死治疗中抗炎作用的影响
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作者 曹文达 姚利和 谷有全 《陕西医学杂志》 2025年第4期487-491,共5页
目的:探究CYP2C19基因多态性对氯吡格雷在急性脑梗死(ACI)治疗过程中抗炎作用的影响。方法:收集125例服用氯吡格雷进行抗凝治疗的ACI患者为研究对象。测定患者CYP2C19基因表型和治疗前后血清超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1... 目的:探究CYP2C19基因多态性对氯吡格雷在急性脑梗死(ACI)治疗过程中抗炎作用的影响。方法:收集125例服用氯吡格雷进行抗凝治疗的ACI患者为研究对象。测定患者CYP2C19基因表型和治疗前后血清超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNF-α)。比较患者治疗前后及携带不同CYP2C19基因型患者血清hs-CRP、IL-1β、IL-6、TNF-α水平。结果:纳入125例患者中共检出71例CYP2C19*1/*1基因型,32例CYP2C19*1/*2基因型,9例CYP2C19*1/*3基因型,5例CYP2C19*2/*2基因型,3例CYP2C19*3/*3基因型,5例CYP2C19*2/*3基因型。基因表型以快代谢型为主,占比56.80%,其余为中间代谢型(32.80%)和慢代谢型(10.40%)。患者治疗后血清hs-CRP、IL-1β、IL-6、TNF-α水平较治疗前明显下降(均P<0.05)。携带快代谢型CYP2C19基因的ACI患者治疗前和治疗后血清hs-CRP、IL-1β、IL-6、TNF-α水平均低于携带中间代谢型、慢代谢型CYP2C19基因患者(均P<0.05),治疗前后血清hs-CRP、IL-1β、IL-6、TNF-α水平下降差值高于携带中间代谢型、慢代谢型CYP2C19基因患者(均P<0.05)。携带中间代谢型与慢代谢型CYP2C19基因的ACI患者治疗前、治疗后和治疗前后血清hs-CRP、IL-1β、IL-6、TNF-α水平差值间比较差异无统计学意义(均P>0.05)。结论:CYP2C19基因型在ACI患者中以快代谢型为主,CYP2C19基因型与机体炎症水平有关,氯吡格雷对快代谢型CYP2C19基因ACI患者具有更好的抗炎作用。 展开更多
关键词 急性脑梗死 药物疗法 基因多态性 CYP2C19 氯吡格雷 抗炎
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老年急性脑梗死介入治疗患者家庭抗逆力现状调查及其影响因素分析
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作者 李慧 朱梦梦 胡礼婷 《临床医药实践》 2025年第3期185-189,共5页
目的:调查老年急性脑梗死介入治疗患者家庭抗逆力的现状,并分析可能影响抗逆力的因素。方法:回顾性分析2020年1月-2023年1月行介入治疗的156例急性脑梗死老年患者的临床资料,采用一般资料调查表、家庭抗逆力评定量表等进行评估。结果:15... 目的:调查老年急性脑梗死介入治疗患者家庭抗逆力的现状,并分析可能影响抗逆力的因素。方法:回顾性分析2020年1月-2023年1月行介入治疗的156例急性脑梗死老年患者的临床资料,采用一般资料调查表、家庭抗逆力评定量表等进行评估。结果:156例老年急性脑梗死介入治疗患者家庭抗逆力总分为(95.68±10.66)分。单因素结果显示,不同性别、居住地、与患者关系、是否存在慢性疾病、家属文化程度及宗教信仰的老年急性脑梗死介入治疗患者家庭抗逆力得分比较,差异无统计学意义(P>0.05);不同家庭亲密度、家庭收入、家庭成员健康状况、社会支持、家庭对患者治疗的态度及家庭支持度、神经缺损(NIHSS)评分和日常生活能力(ADL)评分的老年急性脑梗死介入治疗患者家庭抗逆力得分比较,差异有统计学意义(P<0.05)。多元线性回归分析结果显示,家庭亲密度差、家庭月收入<5000元、家庭成员健康状况差、社会支持低、家庭对患者治疗的态度差、家庭支持度低、NIHSS评分>4分及ADL评分≤50分均是老年急性脑梗死介入治疗患者家庭抗逆力的影响因素(P<0.05)。结论:老年急性脑梗死介入治疗患者家庭抗逆力较低,需要加强相关支持和干预措施,提高患者家庭的抗逆力水平,以促进患者康复和生活质量的提高。 展开更多
关键词 老年 急性脑梗死 介入治疗 家庭抗逆力 现状调查 影响因素
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基于FMEA模型的超早期个性化护理对急性脑梗死溶栓后出血患者的神经功能及并发症的影响
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作者 柏慧 高亚楠 +1 位作者 姬磊 汪宁 《海南医学》 2025年第4期585-589,共5页
目的探究基于失效模式和效应分析(FMEA)模型的超早期个性化护理对急性脑梗死溶栓后出血患者的神经功能及并发症的影响。方法选取2021年12月至2024年12月南阳市中心医院收治的102例急性脑梗死溶栓后出血患者作为研究对象,按随机数表法分... 目的探究基于失效模式和效应分析(FMEA)模型的超早期个性化护理对急性脑梗死溶栓后出血患者的神经功能及并发症的影响。方法选取2021年12月至2024年12月南阳市中心医院收治的102例急性脑梗死溶栓后出血患者作为研究对象,按随机数表法分为对照组和观察组各51例,对照组患者应用常规护理,观察组患者在对照组护理的基础上给予基于FMEA模型的超早期个性化护理,两组患者均护理至出院。出院前,比较两组患者护理前后的神经功能改善情况,包括神经功能缺损评分(NHISS),言语反应、睁眼反应、运动反应以及格拉斯哥昏迷评分法(GCS)评分的总分;出院前,比较两组患者并发症情况,并采用自制调查问卷调查患者对护理的满意度。结果护理前,两组患者的NHISS、GCS评分比较差异均无统计学意义(P>0.05),护理后,两组患者神经功能均优于护理前,且观察组患者的NHISS为(8.63±2.74)分,明显低于对照组的(14.53±2.26)分,差异有统计学意义(P<0.05);护理后,观察组患者的言语反应、睁眼反应、运动反应及GCS总分分别为(4.67±0.78)分、(3.68±0.76)分、(5.62±0.78)分、(12.27±1.38)分,明显高于对照组的(4.19±0.24)分、(3.19±0.24)分、(4.89±0.74)分、(10.29±1.34)分,差异均有统计学意义(P<0.05);观察组患者并发症总发生率为5.88%,明显低于对照组的19.61%,差异有统计学意义(P<0.05);观察组患者的护理满意度为96.08%,明显高于对照组的80.39%,差异有统计学意义(P<0.05)。结论基于FMEA模型超早期个性化护理应用于急性脑梗死溶栓后出血患者能显著改善神经功能,且并发症发生率低。 展开更多
关键词 急性脑梗死 溶栓后出血 失效模式和效应分析 个性化护理 并发症 神经功能
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