目的本研究旨在探讨涎液化糖链抗原-6(krebs von den lungen-6,KL-6)在特发性肺含铁血黄素沉着症(idiopathic pulmonary hemosiderosis,IPH)患儿辅助诊断中的临床应用价值。方法收集2014年6月至2024年7月期间于广州医科大学附属第一医...目的本研究旨在探讨涎液化糖链抗原-6(krebs von den lungen-6,KL-6)在特发性肺含铁血黄素沉着症(idiopathic pulmonary hemosiderosis,IPH)患儿辅助诊断中的临床应用价值。方法收集2014年6月至2024年7月期间于广州医科大学附属第一医院就诊的140例患儿,分为病例组与对照组,其中病例组根据疾病类型细分为IPH组(32例)、间质性肺炎(interstitial lung disease,ILD)组(22例)、肺炎(pneumonia,PN)组(60例),对照组为非肺部疾病(non-pulmonary disease,NPD)组(26例)。以上患儿检测血清KL-6水平,分析KL-6在各组患儿中的表达差异。结果KL-6阳性率在各组患儿中从高到低分别为IPH(68.75%)、ILD(45.45%)、PN(1.69%)和NPD(0.00%),组间阳性率差异有统计学意义(χ^(2)=66.10,P<0.001)。IPH组患儿血清KL-6平均水平高于PN组患儿(Ζ=-6.92,P<0.001)。诊断试验结果显示ROC曲线下面积为0.940(95%CI:0.89~1.00,P<0.001),截断值为392.00 U/mL,灵敏度为81.30%,特异度为95.00%。结论KL-6在鉴别IPH患儿与PN和NPD患儿中具有较高的诊断价值,可作为IPH辅助诊断的血液生物标志物。展开更多
This paper,through mass spectrometric(MS)analysis for nitro compound explosives on a direct analysis in a real‑time time‑of‑flight MS,indicates that even on a high‑resolution MS with accurate mass measurement capabili...This paper,through mass spectrometric(MS)analysis for nitro compound explosives on a direct analysis in a real‑time time‑of‑flight MS,indicates that even on a high‑resolution MS with accurate mass measurement capabilities,there is no guarantee to obtain the unique molecular formula of a compound.By calculating spectra accuracy,highly accurate isotope pattern matching can be conducted to significantly improve performance of compound confirmation or identification.展开更多
文摘目的本研究旨在探讨涎液化糖链抗原-6(krebs von den lungen-6,KL-6)在特发性肺含铁血黄素沉着症(idiopathic pulmonary hemosiderosis,IPH)患儿辅助诊断中的临床应用价值。方法收集2014年6月至2024年7月期间于广州医科大学附属第一医院就诊的140例患儿,分为病例组与对照组,其中病例组根据疾病类型细分为IPH组(32例)、间质性肺炎(interstitial lung disease,ILD)组(22例)、肺炎(pneumonia,PN)组(60例),对照组为非肺部疾病(non-pulmonary disease,NPD)组(26例)。以上患儿检测血清KL-6水平,分析KL-6在各组患儿中的表达差异。结果KL-6阳性率在各组患儿中从高到低分别为IPH(68.75%)、ILD(45.45%)、PN(1.69%)和NPD(0.00%),组间阳性率差异有统计学意义(χ^(2)=66.10,P<0.001)。IPH组患儿血清KL-6平均水平高于PN组患儿(Ζ=-6.92,P<0.001)。诊断试验结果显示ROC曲线下面积为0.940(95%CI:0.89~1.00,P<0.001),截断值为392.00 U/mL,灵敏度为81.30%,特异度为95.00%。结论KL-6在鉴别IPH患儿与PN和NPD患儿中具有较高的诊断价值,可作为IPH辅助诊断的血液生物标志物。
文摘This paper,through mass spectrometric(MS)analysis for nitro compound explosives on a direct analysis in a real‑time time‑of‑flight MS,indicates that even on a high‑resolution MS with accurate mass measurement capabilities,there is no guarantee to obtain the unique molecular formula of a compound.By calculating spectra accuracy,highly accurate isotope pattern matching can be conducted to significantly improve performance of compound confirmation or identification.
