24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenech...24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.展开更多
基金We are grateful to the National Natural Science Foundation of China (No. 29932030)the NationalHigh Technology Development Project (No. 2001AA624030)the Natural Science Foundationof Guangdong Province (No. 04300569) for financial support for this work.
文摘24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.
