Objective： To observe the effect of electroacupuncture （EA） and herbal cake-partitioned moxibustion on anxiety and depression in patients with Crohn＇s disease （CD） in remission. Methods： Sixty CD cases were ran...Objective： To observe the effect of electroacupuncture （EA） and herbal cake-partitioned moxibustion on anxiety and depression in patients with Crohn＇s disease （CD） in remission. Methods： Sixty CD cases were randomly allocated into an EA group （n=30） and an herbal cake-partitioned moxibustion group （n=30） using the random number table by the ratio of 1：1. In addition, 30 healthy subjects were included in a control group. Bilateral Tianshu （ST 25）, Qihai （CV 6） and Zhongwan （CV 12） were used in the EA and herbal cake- partitioned moxibustion groups. The treatment was done 3 times a week, for a total of 12 weeks. The efficacy was evaluated using self-rating anxiety scale （SAS）, self-rating depression scale （SDS） and traditional Chinese medicine （TCM） symptom scores. Results： Before treatment, the SAS and SDS scores in CD patients were remarkably higher than those in healthy subjects. After EA or herbal cake-partitioned moxibustion treatment, the SAS and SDS scores were significantly decreased in both groups, showing significant intra-group differences （P〈0.05）; the symptom scores of abdominal pain （severity, frequency and duration）, bowel sounds/flatus and general fatigue were significantly decreased, showing significant intra-group differences （P〈0.05）; however, there were no between-group statistical differences （P〉0.05）. Conclusion： Both EA and herbal cake-partitioned moxibustion can significantly decrease abnormally high SAS and SDS scores in CD patients as well as TCM symptom scores. The two therapies share similar effects in alleviating common symptoms and improving anxiety and depression.展开更多
Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two g...Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two groups according to their visiting sequence, 40 cases in each group. Cases in the observation group were treated with oral Tamsulosin Hydrochloride Sustained Release Capsules （Harnal） （0.2 mg for each dose, one dose a day） and ginger-partitioned moxibustion at Qihai （CV 6）, Guanyuan （CV 4）, Zhongji （CV 3） and bilateral Zusanli （ST 36）, Sanyinjiao （SP 6）, Pangguangshu （BL 28）, Shangliao （BL 31）, Ciliao （BL 32）, Zhongliao （BL 33） and Xialiao （BL 34） （once a day）. Cases in the control group were treated with the oral Western medication alone （same administration as those in the observation group）. Cases in both groups were treated for 28 d. Before and after treatment, the CD3＋, CD4＋, CDB＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, transforming growth factor （TGF）-β1, immunoglobulin （Ig） A, IgE, IgG and IgM were detected and scored using National Institutes of Health chronic prostatitis symptom index （NIH-CPSI）. Results： The total effective rate was 90.0% in the observation group, versus 72.5% in the control group, showing a statistical difference （P〈0.05）. After treatment, the CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG and IgM were significantly increased in both groups, showing statistical differences （P〈0.05）. There were between-group statistical differences in CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG, IgE, IgM, total NIH-CPSI score and pain and discomfort score （P〈0.05）. Conclusion： Ginger-partitioned moxibustion can improve clinical symptoms of CNP patients by improving their immune function.展开更多
Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an obser...Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an observation group and a control group according to their visiting sequence, 56 cases in each group. Patients in the observation group received ginger-partitioned moxibustion at Zigong（EX-CA 1）, while patients in the control group received oral intake of analgesic. For both groups, treatment started 1 week before menstruation and lasted for 3 menstrual cycles, continued by a 3-month follow-up visit, then the clinical efficacy was evaluated. Results： By the end of treatment, symptom score in the observation group was lower than that in the control group, showing a statistical significance（P〈0.05）. After 3 months of treatment, the value of prostaglandin F2 a（PGF2α）, systolic-to-diastolic peak velocity ratio（S/D）, resistance index（RI） and pulsatility index（PI） in the observation group were significantly higher than those in the control group, showing statistical significances（all P〈0.01）.The recovery rate in the observation group was higher than that in the control group, showing a statistical significance（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea is a combination of the merits of warming function of moxibustion, dissipating function of ginger and stimulation of acupoint, and is better than oral intake of analgesic.展开更多
Objective： To observe the changes of 5-hydroxytryptamine （5-HT） in colonic membrane of diarrhea-predominant irritable bowel syndrome （IBS-D） and the clinical efficacy of herbal cake-partitioned moxibustion in tre...Objective： To observe the changes of 5-hydroxytryptamine （5-HT） in colonic membrane of diarrhea-predominant irritable bowel syndrome （IBS-D） and the clinical efficacy of herbal cake-partitioned moxibustion in treating it, and to explore the action mechanisms. Methods： Seventy-three subjects were randomized into two groups： moxibustion group in which 37 cases were treated by herbal cake-partitioned moxibustion and needling group in which 36 cases were treated by needling. The clinical efficacy and 5-HT expression in colonic membrane were observed. Results： The cure rate was 43.2% in the moxibustion group and 36.1% in the needling group, with no significant difference between the two groups （P〉0.05）. Herbal cake-partitioned moxibustion could reduce 5-HT expression in colonic membrane. Conclusion： Herbal cake-partitioned moxibustion might improve the clinical symptoms of IBS-D by reducing 5-HT expression.展开更多
Objective： To observe the clinical effect of moxibustion on Governor Vessel for ankylosing spondylitis（AS） due to kidney yang deficiency.Methods： A total of 60 patients of AS due to kidney yang deficiency were ran...Objective： To observe the clinical effect of moxibustion on Governor Vessel for ankylosing spondylitis（AS） due to kidney yang deficiency.Methods： A total of 60 patients of AS due to kidney yang deficiency were randomly divided into a treatment group and a control group by random digital table, 30 cases in each group. Both of the two groups were treated by oral administration of Sulfasalazine tablets. Additionally, the treatment group was given moxibustion on Governor Vessel, and the control group was given sham moxibustion. The treatment was given once every other day, 4 weeks constituted one course, 2 courses in total. Before treatment, after 1-course and 2-course treatments, the quantified scores of traditional Chinese medicine（TCM） syndromes and the symptoms scores recommended by AS International Society [including Bath ankylosing spondylitis disease activity index（BASDAI）, visual analogue scale（VAS）, Bath ankylosing spondylitis functional index（BASFI） and Bath ankylosing spondylitis metrology index（BASMI）] were respectively observed and recorded, and the change of safety item was monitored. Results： After 1-course and 2-course treatments, the quantified scores of TCM syndromes were obviously improved than those before treatment in the two groups（P〈0.05）, and the score was improved better in the treatment group than that in the control group（P〈0.05）. In comparison within the group, there were no statistical differences between the scores after 1-course treatment and 2-course treatment in the two groups（P〈0.05）. After 1-course treatment, the items of the symptoms scores were improved than those before treatment in the two groups（P〉0.05）. After 2-course treatment, the therapeutic effect was more remarkable in the treatment group, with a statistical difference between the two groups（P〈0.05）. During treatment, no obvious abnormality in all safety items was noticed in the two groups. Conclusion： Moxibustion on Governor Vessel can effectively relieve the clinical symptoms of AS patients, without obvious adverse reaction.展开更多
Objective：To observe the clinical efficacy of herbal cone-partitioned moxibustion for irritable bowel syndrome（IBS） due to spleen deficiency. Methods：A total of 40 IBS cases due to spleen deficiency were randomly ...Objective：To observe the clinical efficacy of herbal cone-partitioned moxibustion for irritable bowel syndrome（IBS） due to spleen deficiency. Methods：A total of 40 IBS cases due to spleen deficiency were randomly assigned to two groups,20 in each group. Cases in the moxibustion group were treated with herbal cone-partitioned moxibustion on Shenque（CV 8）,while cases in the control group were treated with oral Pinaverium. Results：The spleen deficiency symptoms of patients in both groups were significantly improved during the treatment and follow-up investigation,showing a statistical difference（P〈0.05）; however,herbal cone-partitioned moxibustion showed better results. Conclusion：Oral Pinaverium and herbal cone-partitioned moxibustion could both improve the spleen deficiency symptoms of IBS patients; however,the moxibustion on Shenque（CV 8） showed better results than Pinaverium.展开更多
Objective： To investigate the clinical effect of ginger-partitioned moxibustion combined with manual repositioning for benign paroxysmal positional vertigo（BPPV）. Methods： A total of 76 BPPV cases were randomly al...Objective： To investigate the clinical effect of ginger-partitioned moxibustion combined with manual repositioning for benign paroxysmal positional vertigo（BPPV）. Methods： A total of 76 BPPV cases were randomly allocated into an observation group（n=38） and a control group（n=38）. Patients in the observation group received ginger-partitioned moxibustion at Tinggong（SI 19） plus manual repositioning, whereas patients in the control group received the same manual repositioning alone. Results： After 48 h of treatment, the total effective rate was 94.7% in the observation group, versus 86.8% in the control group; after 7 d of treatment, the total effective rate was 78.9% in the observation group, versus 73.7% in the control group, both showing between-group statistical differences（P〈0.05）. The follow-up after 3 months showed that 2 cases（6.7%） got relapse in the observation group, versus 8 cases（28.6%） in the control group, showing a statistical difference（P〈0.05）. The adverse reaction rate was 2.6% in the observation group, versus 21.1% in the control group, showing a statistical difference（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Tinggong（SI 19） plus manual repositioning can obtain better effect for BPPV than manual repositioning alone. In addition, this therapy has stable efficacy and causes less adverse reactions.展开更多
Objective：To observe the clinical effect and syndrome scores improvements of herbal cake-partitioned moxibustion（HPM） and ginger-partitioned moxibustion（GPM） in treating ulcerative colitis（UC）.Methods：A total ...Objective：To observe the clinical effect and syndrome scores improvements of herbal cake-partitioned moxibustion（HPM） and ginger-partitioned moxibustion（GPM） in treating ulcerative colitis（UC）.Methods：A total of 65 eligible cases were randomly divided into a HPM group（n=32） and a GPM group（n=33） according to their visiting order.Bilateral Tianshu（ST 25） and Dachangshu（BL 25） were selected for the HPM or the GPM treatment once daily,12 d as a treatment course with a 3-day interval,6 courses in all.The clinical effect,syndrome scale and Mayo scale were evaluated and compared between the two groups.Results：Of the 65 cases enrolled,2 cases dropped out in the HPM group and 3 cases dropped out in the GPM group,30 cases of each group finished the treatment courses.The total effective rate is 93.3% in HPM group and 86.7% in the GPM group,there was no statistically significant difference in the total effective rate between the two groups（P〉0.05）;there were statistically significant differences between the two groups in score evaluation of lasting time of abdominal pain and frequency of diarrhea,HPM is prior to GPM（P=0.032,P=0.044）.There are no statistical significant differences between the two groups in scores evaluation of general symptom,three main symptoms,quality of life（QOL）,frequency and severity of abdominal pain,times,and pattern of diarrhea（all P〉0.05）.There was a statistical significant difference in the improvement of Mayo score between the two groups,and HPM was superior to GPM（P=0.048）.Conclusion：HPM and GPM are both promising ways to treat UC,and the total effect is quite similar.HPM is superior to GPM in the improvement of lasting time of abdominal pain and frequency of diarrhea,and also the Mayo score.展开更多
Objective： To assess the clinical effects of acupuncture treatment for primary dysmenorrhea. Methods： 80 cases of the patients were randomly divided into two groups by single blind to 40 cases in the acupuncture gro...Objective： To assess the clinical effects of acupuncture treatment for primary dysmenorrhea. Methods： 80 cases of the patients were randomly divided into two groups by single blind to 40 cases in the acupuncture group were treated with acupuncture plus ginger-partitioned moxibustion. 40 cases in the medication group were treated with oral administration of Ibuprofen sustained release capsules. The therapeutic effects were observed after continuous treatment for 3 months. Results： The total effective rate was 85.0% in the acupuncture group and 70.0% in the medication group, with statistical significance in comparison of differences between the two groups （P〈0.05） Conclusion： Acupuncture plus ginger-partitioned moxibustion is better than Ibuprofen sustained release capsules in treating dysmenorrhea.展开更多
Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardizat...Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardization of moxibustion amount.Methods:The 42 big-ear white rabbits were divided into 6 groups according to the random number table method,a 2-cone direct moxibustion group,a 2-cone direct moxibustion group,a 3-cone direct moxibustion group,a 1-cone herbal cake-partitioned moxibustion group,a 2-cone herbal cake-partitioned moxibustion group,and a 3-cone herbal cake-partitioned moxibustion group,with 7 rabbits in each group.Shenque(CV 8);Shenshu(BL 23)and Zusanli(ST 36)were used in each group,but the moxibustion methods,cone numbers and durations of moxibustion were different・Rabbits in each group received moxibustion once every other day for 5 times in total.During the intervention,a thermoelectricity coupled probe and a temperature recorder were used to record the real-time-acupoint skin temperature and the temperature at different time points,so as to observe,analyze and process the real-time changes in the temperature difference between the surface and inside of acu point skin.Results:For herbal cake-partitioned moxibustion,the best temperature for cone changing was(46.38±0.51)℃when the highest surface temperature was(49.20±0.52)℃;the multi-factor comparison of acupoint×cone number×time and acupoint×moxibustion method×time showed that time×acupoint,time×moxibustion method and cone number×acupoint had interactive effects(all P<0.05).Comparing skin temperature differences between different cone numbers at the same acupoint,Shenque(CV 8)on the 1st and the 5th days,Shenshu(BL 23)on the 3rd and the 7th days,Zusanli(ST 36)on the 1st and the 9th days of experiment showed statistically significant differences(all P<0.05).The skin temperature comparison of different moxibustion methods at the same acupoint all had statistical differences(all Pv0.05),except for Shenque(CV 8)before moxibustion,Shenshu(BL 23)before moxibustion and on the 5th day;Zusanli(ST 36)only showed statistical differences on the 5th and 7th days(both P<0.05).The skin temperature differences of different acupoints after moxibustion in the 1-cone,2-cone and 3-cone groups were statistically different(all P<0.05);direct moxibustion and herbal cake-partitioned moxibustion at different acupoints were all statistically different(all P<0.05).Conclusion:Cone changing temperature under the same specifications of herbal cake-partitioned moxibustion was confirmed.Temperature differenee between surface and inside of different acupoint skin at the same maximum temperature was significantly different due to the cone numbers and moxibustion methods,which showed the highest at Shenshu(BL 23),the sec ond at Shenque(CV 8),and the lowest at Zusanli(ST 36).The in fluence of acupoint factor should be considered to determine the quantitative indicators of moxibustion.展开更多
Objective:To observe the clinical efficacy of ginger-partitioned moxibustion plus pediatric massage(tuina)in treating infantile diarrhea due to spleen deficiency.Methods:Ninety infants were randomly divided into a mas...Objective:To observe the clinical efficacy of ginger-partitioned moxibustion plus pediatric massage(tuina)in treating infantile diarrhea due to spleen deficiency.Methods:Ninety infants were randomly divided into a massage plus moxibustion group,a massage group and a drug group by the random number table method,with 30 cases in each group.The intervention was conducted for two consecutive courses.The infants in the massage plus moxibustion group were treated with pediatric massage and ginger-partitioned moxibustion at Shenque(CV 8).The infants in the massage group were treated with pediatric massage alone,while those in the drug group were treated with smecta.The primary and secondary symptom scales were assessed before and after treatment and at the follow-ups,and the total effective rate was evaluated after treatment.Results:The total effective rate in the massage plus moxibustion group was significantly different from that in the massage group and drug group(both P<0.05).After treatment,the scores of primary and secondary symptoms decreased in all three groups,with statistically significant intra-group differences(all P<0.05);the scores of primary symptoms were significantly different between the massage plus moxibustion group and the drug group(P<0.05);the scores of secondary symptoms in the massage plus moxibustion group and the massage group were significantly different from that in the drug group(both P<0.05).The differences in the time to recover normal bowel movement frequency among the three groups were not statistically significant(P>0.05).Conclusion:Ginger-partitioned moxibustion plus pediatric massage compared with pediatric massage or smecta monotherapy shows superior clinical efficacy in treating infantile diarrhea due to spleen deficiency,and has the advantages of appetite improvement,physique strengthening and short course.展开更多
Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized...Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized into a mild moxibustion group and a herbal cake-partitioned moxibustion group by the random number table,with 35 cases in each group.Shenque(CV 8),Zhongji(CV 3)and bilateral Zigong(EX-CA 1)were selected for both groups.The treatment continued for 3 menstrual cycles.The visual analog scale(VAS)and COX menstrual symptom scale(CMSS)were scored in both groups before treatment,after treatment and at the end of the 3rd menstrual cycle after treatment.The clinical efficacy was evaluated at the end of the 3rd menstrual cycle after treatment.Results:After treatment,the clinical efficacy of the herbal cake-partitioned moxibustion group had the tendency to be superior to that of the mild moxibustion group,while there was no statistically significant difference in the overall efficacy between the two groups(P>0.05).The VAS and CMSS scores after treatment and at the follow-up were significantly lower than those before treatment in both groups(all P<0.05).At the follow-up,the VAS scores in both groups had no significant intra-group differences from those after treatment(both P>0.05).The CMSS scores in both groups were significantly lower than those after treatment(both P<0.05).The VAS scores at the follow-up of both groups had no statistical differences from those after treatment(both P>0.05).After treatment,the CMSS score in the herbal cake-partitioned moxibustion group was significantly lower than that in the mild moxibustion group(P<0.05).At the follow-up,there were no statistical differences in the CMSS score between the two groups(P>0.05).Conclusion:The herbal cake-partitioned moxibustion has the same therapeutic efficacy for dysmenorrhea as the mild moxibustion;the two moxibustion methods can significantly improve the concomitant symptoms of dysmenorrhea,and the herbal cake-partitioned moxibustion is little better.展开更多
Objective: To observe the effect of herbal cake-partitioned moxibustion on liver X receptor alpha (LXRa) in rabbits with atherosclerosis. Methods: Thirty-six male New Zea la nd rabbits were ran domly divided into a no...Objective: To observe the effect of herbal cake-partitioned moxibustion on liver X receptor alpha (LXRa) in rabbits with atherosclerosis. Methods: Thirty-six male New Zea la nd rabbits were ran domly divided into a no rmal group, a model group, a herbal cake-partitioned moxibustion group and a simvastatin group according to the random number table method, with 9 rabbits in each group. Rabbits in the model group, the herbal cake-partitioned moxibustion group and the simvastatin group were modeled by high fat feeding method which took 12 weeks. After verification of the successful model, rabbits in the normal group were not treated, in the model group were bun died, in the herbal cake-partitioned moxibustio n group were treated with herbal cake-partitioned moxibustion, and those in the simvastatin group were treated with simvastatin, all for a total of 4 weeks. At the end of the experiment, the aorta and liver were observed for pathological changes;serum and liver were used to detect lipid levels;Western blot (WB) and real-time quantitative polymerase chain reaction (RT-qPCR) were used to detect LXRa protein and mRNA expression levels, respectively. Results: Compared with the normal group, the structure of aorta was disordered, the wall was rough and thick, the intima was unsmooth, and the vascular smooth muscle cells were arranged closely and disorderly in the model group, which was consistent with the characteristics of the rabbit model of aortic atherosclerosis. Compared with the model group, the aortic structure was clear;the degree of hepatocyte degeneration was reduced, the serum total cholesterol and low-density lipoprotein levels were significantly decreased (all P<0.01), the high-density lipoprotein level was elevated (P<0.01), and the total liver cholesterol was decreased significantly (P<0.01) in the rabbits of the herbal cake-partitioned moxibustion group and the simvastatin group;compared with the model group, the protein (PvO.Ol or P<0.05) and mRNA (P<0.01) expressions of rabbit LXRa in the herbal cake-partiti oned moxibusti on group and the simvastati n group were in creased. Conclusion: Herbal cake-partitioned moxibustion can improve the aortic and hepatic lesions, regulate blood lipid and liver lipid levels, in crease the expressi on of liver cholesterol reverse tran sport nu clear receptor LXRa, promote reverse cholesterol transport in the rabbits with aortic atherosclerosis, therefore produces an antiatherogenic effect.展开更多
Objective： To observe the clinical effect of combined moxibustion and medication for Hashimoto’s thyroiditis. Methods： A total of 85 cases with Hashimoto’s thyroiditis who met the inclusion criteria were randomly ...Objective： To observe the clinical effect of combined moxibustion and medication for Hashimoto’s thyroiditis. Methods： A total of 85 cases with Hashimoto’s thyroiditis who met the inclusion criteria were randomly allocated into an observation group and a control group. Forty-two cases in the observation group were treated with combined moxibustion with oral Levothyroxine Sodium tablets, whereas 43 cases in the control group were treated with oral Levothyroxine Sodium tablets alone. Then the scores of clinical symptoms and exophthalmos before and after treatment were compared. In addition, the time period for improvement of clinical symptoms in both groups were recorded and compared. Results： After one-month treatment, the scores of clinical symptoms and exophthalmos in the observation group were significantly improved than those in the control group （P0.05）; and it took less time for the cases in the observation group to get improvement compared with the control group. Conclusion： Combined moxibustion and oral Levothyroxine Sodium tablet is an efficient reliable therapy for Hashimoto’s thyroiditis.展开更多
Objective To observe the efficacy of herbal cake-partitioned moxibustion for lumbar disc herniation(LDH)due to kidney deficiency and blood stasis and observe the influence of this method on lumbar functions and inflam...Objective To observe the efficacy of herbal cake-partitioned moxibustion for lumbar disc herniation(LDH)due to kidney deficiency and blood stasis and observe the influence of this method on lumbar functions and inflammatory factors in patients with this condition.Methods A total of 120 LDH patients who met the inclusion criteria were randomly divided into three groups,including a herbal cake-partitioned moxibustion group,a flour cake-partitioned moxibustion group,and a Western medication group,with 40 patients in each group.The patients in the Western medication group were treated with diflunisal tablets,0.5 g per dose,2 doses a day.Those in the herbal cake-partitioned moxibustion group were treated with additional herbal cake-partitioned moxibustion group at Back-Shu Points and Jiaji(EX-B2)Points once a day.Those in the flour cake-partitioned moxibustion group were treated with the same methods as in the herbal cake-partitioned moxibustion group,except that the herbal cake was replaced by a flour cake.All the patients were treated for 10 d.After treatment,the scores of the visual analog scale(VAS)and Japanese Orthopaedic Association(JOA)and the changes of the interleukin(IL)-6,tumor necrosis factor(TNF)-α,and substance P(SP)levels were observed,and the efficacy was evaluated.Results After treatment,the VAS score and the levels of IL-6,TNF-α,and SP were lower than those before treatment,and the JOA score was higher than that before treatment in the three groups,indicating intra-group statistical significance(P<0.05).The VAS score and the levels of IL-6,TNF-α,and SP of the herbal cake-partitioned moxibustion group were lower than those of the flour cake-partitioned moxibustion group and the Western medication group,while the JOA score of the herbal cake-partitioned moxibustion group was higher than that of the other two groups,indicating inter-group statistical significance(P<0.05).The total effective rate of the herbal cake-partitioned moxibustion group was 92.5%,higher than that of the flour cake-partitioned moxibustion group(80.0%)and the Western medication group(72.5%),indicating inter-group statistical significance(P<0.05).Conclusion On the basis of Western oral medication,additional herbal cake-partitioned moxibustion can alleviate the pain and improve the lumbar functions in patients with LDH due to kidney deficiency and blood stasis.The efficacy of the integrated method is better than that of either flour cake-partitioned moxibustion or Western medication alone,which may be related to the reduction of serum inflammatory factors.展开更多
Objective To observe the effects of ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4)on the expression levels of endocrine-related molecules and their receptors in rats with primary dysmenorrhea(PD)due t...Objective To observe the effects of ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4)on the expression levels of endocrine-related molecules and their receptors in rats with primary dysmenorrhea(PD)due to cold-dampness stagnation,thus to explore their analgesic mechanisms.Methods Thirty-two female Wistar rats were divided into a normal group,a model group,a ginger-partitioned moxibustion group,and a Western medicine group according to the random number table method,with 8 rats in each group.Except for rats in the normal group,all other rats were treated with oxytocin combined with ice-water bath to establish the rat models of PD due to cold-dampness stagnation.After successful modeling,rats in the normal group and the model group did not receive treatment;rats in the ginger-partitioned moxibustion group received treatments with ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4);rats in the Western medicine group received ibuprofen by intragastric administration.The writhing response of rats was compared among groups,and the serum levels of prostaglandin F2α(PGF2α),estrogen(estradiol,E2),progesterone(P),and the mRNA expression of PGF2αand E2 receptors in the uterine tissues were detected.Results No writhing behavior was observed in the normal group;compared with the normal group,the serum PGF2αand E2 levels in the model group were increased(P<0.01),while the P level was decreased(P<0.01),and the mRNA expression levels of the uterine PGF2αand E2 receptors were increased(P<0.01,P<0.05).Compared with the model group,the writhing behavior latency was prolonged,and the writhing response score was decreased in the ginger-partitioned moxibustion group and the Western medicine group(P<0.01);the serum PGF2αand E2 levels in the ginger-partitioned moxibustion group and the Western medicine group were decreased,while the P level was increased(P<0.05 or P<0.01);the mRNA expression levels of the uterine PGF2αand E2 receptors in the ginger-partitioned moxibustion group and the Western medicine group were decreased(P<0.05).Compared with the Western medicine group,the ginger-partitioned moxibustion group showed a prolonged writhing behavior latency,reduced writhing response score(P<0.05),and decreased serum E2 level(P<0.05),while no statistical differences in the serum PGF2αand P levels,or the mRNA expression levels of uterine PGF2αand E2 receptors(P>0.05).Conclusion The analgesic effect of ginger-partitioned moxibustion on PD due to cold-dampness stagnation may be related to regulating the mRNA expression levels of PGF2αand E2 receptors in the uterine tissues.展开更多
Objective:To observe the lipid-lowering effect of different transdermal absorption enhancers applied to the herbal cake-partitioned moxibustion in hyperlipidemia model rabbits,and to explore the possible mechanism.Met...Objective:To observe the lipid-lowering effect of different transdermal absorption enhancers applied to the herbal cake-partitioned moxibustion in hyperlipidemia model rabbits,and to explore the possible mechanism.Methods:Forty New-Zea I a nd rabbits were ran domly divided into 5 groups using the ran dom nu mber table method,with 8 rats in each group.Rabbits in the blank group were fed routinely with normal diet;rabbits in the other groups were fed with high-fat diet for 12 weeks to establish the hyperlipidemia model.Rabbits in the blank and the model groups were not treated.After the model was prepared,rabbits in the non-transdermal absorption enhancer group received herbal cake-partitioned moxibustion without transdermal absorption enhancer;rabbits in the laurocapram group and the borneol group received herbal cake-partitioned moxibustion with laurocapram or borneol respectively.After 4 weeks of treatment,serum was collected for enzyme-linked immunosorbent assay(ELISA),and the liver tissues were isolated for imm uno histochemistry,qua ntitative polymerase chain reactio n(qPCR)and Western-blotting(WB)detecti on.Results:Serum ELISA results showed that leptin was significantly decreased in the model group compared with the blank group(P<0.05);compared with the model group,lepti n was significa ntly in creased in the non-tran sdermal absorpti on enhanee。the laurocapram and the borneol groups(all P<0.05);compared with the non-transdermal absorption enhancer group,leptin was significantly increased in the laurocapram group and the borneol group(both P<0.05);there was no significant differenee in leptin between the laurocapram and the borneol groups(P>0.05).The qPCR results of rabbit liver tissues showed that the mRNA expressions of leptin,Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STOT3)in the model group were significantly lower than those in the blank group(all P<0.05);compared with the model group,the mRNA expressions of leptin,leptin receptor(LR),JAK2 and S1AT3 in the non-transdermal absorptio n enhan cer,the laurocapram and the born eol groups were significantly in creased(all P<0.05);compared with the non-transdermal absorption enhancer group,the mRNA expressions of leptin,LR,JAK2 and S77VT3 in the laurocapram and the bor neol groups were sign ificantly in creased(all P<0.05);compared with the laurocapram group,the mRNA expressi ons of lepti n,LR,JAK2 and SW3 in the bor neol group were significa ntly in creased(P<0.05).The trend of immun ohistochemistry and WB detecti on results was basically con siste nt with the qPCR assay results.The immuno histochemistry and WB detection results of phosphorylated JAK2(phospho-JAK2)and phosphorylated S7AT3(phospho-STAT3)were basically consistent with those of JAK2 and S7AT3.Conclusion:The molecular expression of Leptin/JAK"S7AT3 pathway in the hyperlipidemia model rabbits was decreased.The molecular expression of Leptin/JAK0STCT3 pathway was significantly increased after the herbal cake-partitioned moxibustion.The application of laurocapram and borneol,as transdermal absorption enhancers,in the herbal cake-partitioned moxibustion could more obviously up-regulate the factors of the Leptin/JAK^SIAT3 lipid-regulating pathway than the herbal cake-partitioned moxibustion alone.展开更多
Objective： To observe the clinical effect of long snake moxibustion for ankylosing spondylitis （AS）. Methods： A total of 58 AS cases were randomized into a long snake moxibustion group and a Western medication gro...Objective： To observe the clinical effect of long snake moxibustion for ankylosing spondylitis （AS）. Methods： A total of 58 AS cases were randomized into a long snake moxibustion group and a Western medication group, 29 in each group. The cases in the former group received long snake moxibustion and Western medication, whereas cases in the latter group received Western medication alone. Results： The total effective rate in the long snake moxibustion group was 93.1%, versus 62.1% in the Western medication group, showing a statistical significance （P〈0.01）; after the treatment, the scores of Bath Ankylosing Spondylitis Disease Activity Index （BASDAI） and Bath Ankylosing Spondylitis Function Index （BASFI） were improved in both groups; however, the improvements of BASDAI and BASFI results in the long snake moxibustion group were more significant than those in the Western medication group （P〈0.05）. Conclusion： Long snake moxibustion and Western medication can significantly improve the clinical effect on AS, coupled with a remarkable effect in enhancing the patients＇ functions.展开更多
Objective： To observe the regulatory effects of herbal cake-partitioned moxibustion on Crohn＇s disease （CD） rat＇s colon inflammatory cytokine interleukin-17 （IL-17）, IL-23 and their mRNAs, and to investigate th...Objective： To observe the regulatory effects of herbal cake-partitioned moxibustion on Crohn＇s disease （CD） rat＇s colon inflammatory cytokine interleukin-17 （IL-17）, IL-23 and their mRNAs, and to investigate the action mechanism of moxibustion in treating CD. Methods： Forty SPF grade Sprague-Dauley （SD） male rats were randomly divided into a normal group, a model group, an herbal cake-partitioned moxibustion group and a Western medicine group, with 20 rats in each group. Except the normal group, rats in the other three groups were used to make CD model by giving an enema in colon with Trinitro-benzene-sulfonic acid （TNBS）. When the models were successful made, rats in the model group had no therapeutic intervention; rats in the herbal cake-partitioned moxibustion group were subjected to herbal cake-partitioned moxibustion treatment at bilateral Tianshu （ST 25） plus O.ihai （CV 6）; and rats in the Western medicine group were given oral Mesalazine. After treatment, the histopathological changes and inflammatory cytokines IL-17, IL-23 and their mRNAs expressions were observed in descending colon by hematoxylin-eosin （HE） staining, immunohistochemistry （IHC） and real-time polymerase chain reaction （RT-PCR） methods. Results： Colon tissues of TNBS enema rat models showed cracks-like ulcers accompanied by mucous layer inflammation, granulomas, and inflammatory cytokines IL-27, IL-23 and their mRNAs expressions were all higher than those in the normal group （P〈O.01）; after intervention, colon tissue cracks-like ulcers and inflammation degree reduced, inflammatory cytokines IL-17, IL-23 and their mRNAs expressions were all significantly decreased （P〈0.01） in the herbal cake-partitioned moxibustion group and the Western medicine group. Conclusion： Herbal cake-partitioned moxibustion may improve colon tissue ulcers and relieve intestinal inflammation by down-regulation of IL-17, IL-23 and their mRNAs expressions in CD model rats＇ colonic mucosa.展开更多
基金supported by National Basic Research Program of China 973 Program(No.2015CB554501,No.2009CB522900)Shanghai Rising-star Program(No.16QA1403400)the Program for New Century Excellent Talents in University of Ministry of Education(No.NCET-13-0907)~~
文摘Objective： To observe the effect of electroacupuncture （EA） and herbal cake-partitioned moxibustion on anxiety and depression in patients with Crohn＇s disease （CD） in remission. Methods： Sixty CD cases were randomly allocated into an EA group （n=30） and an herbal cake-partitioned moxibustion group （n=30） using the random number table by the ratio of 1：1. In addition, 30 healthy subjects were included in a control group. Bilateral Tianshu （ST 25）, Qihai （CV 6） and Zhongwan （CV 12） were used in the EA and herbal cake- partitioned moxibustion groups. The treatment was done 3 times a week, for a total of 12 weeks. The efficacy was evaluated using self-rating anxiety scale （SAS）, self-rating depression scale （SDS） and traditional Chinese medicine （TCM） symptom scores. Results： Before treatment, the SAS and SDS scores in CD patients were remarkably higher than those in healthy subjects. After EA or herbal cake-partitioned moxibustion treatment, the SAS and SDS scores were significantly decreased in both groups, showing significant intra-group differences （P〈0.05）; the symptom scores of abdominal pain （severity, frequency and duration）, bowel sounds/flatus and general fatigue were significantly decreased, showing significant intra-group differences （P〈0.05）; however, there were no between-group statistical differences （P〉0.05）. Conclusion： Both EA and herbal cake-partitioned moxibustion can significantly decrease abnormally high SAS and SDS scores in CD patients as well as TCM symptom scores. The two therapies share similar effects in alleviating common symptoms and improving anxiety and depression.
基金supported by Hebei Tangshan Science & Technology Program,No.121302118b~~
文摘Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two groups according to their visiting sequence, 40 cases in each group. Cases in the observation group were treated with oral Tamsulosin Hydrochloride Sustained Release Capsules （Harnal） （0.2 mg for each dose, one dose a day） and ginger-partitioned moxibustion at Qihai （CV 6）, Guanyuan （CV 4）, Zhongji （CV 3） and bilateral Zusanli （ST 36）, Sanyinjiao （SP 6）, Pangguangshu （BL 28）, Shangliao （BL 31）, Ciliao （BL 32）, Zhongliao （BL 33） and Xialiao （BL 34） （once a day）. Cases in the control group were treated with the oral Western medication alone （same administration as those in the observation group）. Cases in both groups were treated for 28 d. Before and after treatment, the CD3＋, CD4＋, CDB＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, transforming growth factor （TGF）-β1, immunoglobulin （Ig） A, IgE, IgG and IgM were detected and scored using National Institutes of Health chronic prostatitis symptom index （NIH-CPSI）. Results： The total effective rate was 90.0% in the observation group, versus 72.5% in the control group, showing a statistical difference （P〈0.05）. After treatment, the CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG and IgM were significantly increased in both groups, showing statistical differences （P〈0.05）. There were between-group statistical differences in CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG, IgE, IgM, total NIH-CPSI score and pain and discomfort score （P〈0.05）. Conclusion： Ginger-partitioned moxibustion can improve clinical symptoms of CNP patients by improving their immune function.
文摘Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an observation group and a control group according to their visiting sequence, 56 cases in each group. Patients in the observation group received ginger-partitioned moxibustion at Zigong（EX-CA 1）, while patients in the control group received oral intake of analgesic. For both groups, treatment started 1 week before menstruation and lasted for 3 menstrual cycles, continued by a 3-month follow-up visit, then the clinical efficacy was evaluated. Results： By the end of treatment, symptom score in the observation group was lower than that in the control group, showing a statistical significance（P〈0.05）. After 3 months of treatment, the value of prostaglandin F2 a（PGF2α）, systolic-to-diastolic peak velocity ratio（S/D）, resistance index（RI） and pulsatility index（PI） in the observation group were significantly higher than those in the control group, showing statistical significances（all P〈0.01）.The recovery rate in the observation group was higher than that in the control group, showing a statistical significance（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea is a combination of the merits of warming function of moxibustion, dissipating function of ginger and stimulation of acupoint, and is better than oral intake of analgesic.
基金State Administration of TCM of RR.China(2003ZL23)Shanghai Leading Academic Discipline Project
文摘Objective： To observe the changes of 5-hydroxytryptamine （5-HT） in colonic membrane of diarrhea-predominant irritable bowel syndrome （IBS-D） and the clinical efficacy of herbal cake-partitioned moxibustion in treating it, and to explore the action mechanisms. Methods： Seventy-three subjects were randomized into two groups： moxibustion group in which 37 cases were treated by herbal cake-partitioned moxibustion and needling group in which 36 cases were treated by needling. The clinical efficacy and 5-HT expression in colonic membrane were observed. Results： The cure rate was 43.2% in the moxibustion group and 36.1% in the needling group, with no significant difference between the two groups （P〉0.05）. Herbal cake-partitioned moxibustion could reduce 5-HT expression in colonic membrane. Conclusion： Herbal cake-partitioned moxibustion might improve the clinical symptoms of IBS-D by reducing 5-HT expression.
基金supported by Traditional Chinese Medicine Project of Shanghai Municipal Commission of Health and Family PlanningNo.2012QL045A+4 种基金Project of Health and Family Planning of Changning DistrictShanghaiNo.20124ZY03001Shanghai Cultivation Plan of New Stars in XinglinNo.ZYSNXD011-RC-XLXX-20130042~~
文摘Objective： To observe the clinical effect of moxibustion on Governor Vessel for ankylosing spondylitis（AS） due to kidney yang deficiency.Methods： A total of 60 patients of AS due to kidney yang deficiency were randomly divided into a treatment group and a control group by random digital table, 30 cases in each group. Both of the two groups were treated by oral administration of Sulfasalazine tablets. Additionally, the treatment group was given moxibustion on Governor Vessel, and the control group was given sham moxibustion. The treatment was given once every other day, 4 weeks constituted one course, 2 courses in total. Before treatment, after 1-course and 2-course treatments, the quantified scores of traditional Chinese medicine（TCM） syndromes and the symptoms scores recommended by AS International Society [including Bath ankylosing spondylitis disease activity index（BASDAI）, visual analogue scale（VAS）, Bath ankylosing spondylitis functional index（BASFI） and Bath ankylosing spondylitis metrology index（BASMI）] were respectively observed and recorded, and the change of safety item was monitored. Results： After 1-course and 2-course treatments, the quantified scores of TCM syndromes were obviously improved than those before treatment in the two groups（P〈0.05）, and the score was improved better in the treatment group than that in the control group（P〈0.05）. In comparison within the group, there were no statistical differences between the scores after 1-course treatment and 2-course treatment in the two groups（P〈0.05）. After 1-course treatment, the items of the symptoms scores were improved than those before treatment in the two groups（P〉0.05）. After 2-course treatment, the therapeutic effect was more remarkable in the treatment group, with a statistical difference between the two groups（P〈0.05）. During treatment, no obvious abnormality in all safety items was noticed in the two groups. Conclusion： Moxibustion on Governor Vessel can effectively relieve the clinical symptoms of AS patients, without obvious adverse reaction.
基金National Basic Research Program of China (973Program, 2007CB512703)
文摘Objective：To observe the clinical efficacy of herbal cone-partitioned moxibustion for irritable bowel syndrome（IBS） due to spleen deficiency. Methods：A total of 40 IBS cases due to spleen deficiency were randomly assigned to two groups,20 in each group. Cases in the moxibustion group were treated with herbal cone-partitioned moxibustion on Shenque（CV 8）,while cases in the control group were treated with oral Pinaverium. Results：The spleen deficiency symptoms of patients in both groups were significantly improved during the treatment and follow-up investigation,showing a statistical difference（P〈0.05）; however,herbal cone-partitioned moxibustion showed better results. Conclusion：Oral Pinaverium and herbal cone-partitioned moxibustion could both improve the spleen deficiency symptoms of IBS patients; however,the moxibustion on Shenque（CV 8） showed better results than Pinaverium.
基金supported by Fund Project of Zhejiang Province Administration of Traditional Chinese Medicine~~
文摘Objective： To investigate the clinical effect of ginger-partitioned moxibustion combined with manual repositioning for benign paroxysmal positional vertigo（BPPV）. Methods： A total of 76 BPPV cases were randomly allocated into an observation group（n=38） and a control group（n=38）. Patients in the observation group received ginger-partitioned moxibustion at Tinggong（SI 19） plus manual repositioning, whereas patients in the control group received the same manual repositioning alone. Results： After 48 h of treatment, the total effective rate was 94.7% in the observation group, versus 86.8% in the control group; after 7 d of treatment, the total effective rate was 78.9% in the observation group, versus 73.7% in the control group, both showing between-group statistical differences（P〈0.05）. The follow-up after 3 months showed that 2 cases（6.7%） got relapse in the observation group, versus 8 cases（28.6%） in the control group, showing a statistical difference（P〈0.05）. The adverse reaction rate was 2.6% in the observation group, versus 21.1% in the control group, showing a statistical difference（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Tinggong（SI 19） plus manual repositioning can obtain better effect for BPPV than manual repositioning alone. In addition, this therapy has stable efficacy and causes less adverse reactions.
基金supported by National Natural Science Foundation of China(No.81173331,No.81303033,No.81473758)the 3-year Action Plan for Traditional Chinese Medicine of Shanghai Municipal Health Bureau(No.ZYSNXD-CC-ZDYJ053)+1 种基金National Basic Research Program of China(973 Program,No.2015CB554500)Innovation Program of Shanghai Municipal Education Commission(No.2014YZ052)~~
文摘Objective：To observe the clinical effect and syndrome scores improvements of herbal cake-partitioned moxibustion（HPM） and ginger-partitioned moxibustion（GPM） in treating ulcerative colitis（UC）.Methods：A total of 65 eligible cases were randomly divided into a HPM group（n=32） and a GPM group（n=33） according to their visiting order.Bilateral Tianshu（ST 25） and Dachangshu（BL 25） were selected for the HPM or the GPM treatment once daily,12 d as a treatment course with a 3-day interval,6 courses in all.The clinical effect,syndrome scale and Mayo scale were evaluated and compared between the two groups.Results：Of the 65 cases enrolled,2 cases dropped out in the HPM group and 3 cases dropped out in the GPM group,30 cases of each group finished the treatment courses.The total effective rate is 93.3% in HPM group and 86.7% in the GPM group,there was no statistically significant difference in the total effective rate between the two groups（P〉0.05）;there were statistically significant differences between the two groups in score evaluation of lasting time of abdominal pain and frequency of diarrhea,HPM is prior to GPM（P=0.032,P=0.044）.There are no statistical significant differences between the two groups in scores evaluation of general symptom,three main symptoms,quality of life（QOL）,frequency and severity of abdominal pain,times,and pattern of diarrhea（all P〉0.05）.There was a statistical significant difference in the improvement of Mayo score between the two groups,and HPM was superior to GPM（P=0.048）.Conclusion：HPM and GPM are both promising ways to treat UC,and the total effect is quite similar.HPM is superior to GPM in the improvement of lasting time of abdominal pain and frequency of diarrhea,and also the Mayo score.
文摘Objective： To assess the clinical effects of acupuncture treatment for primary dysmenorrhea. Methods： 80 cases of the patients were randomly divided into two groups by single blind to 40 cases in the acupuncture group were treated with acupuncture plus ginger-partitioned moxibustion. 40 cases in the medication group were treated with oral administration of Ibuprofen sustained release capsules. The therapeutic effects were observed after continuous treatment for 3 months. Results： The total effective rate was 85.0% in the acupuncture group and 70.0% in the medication group, with statistical significance in comparison of differences between the two groups （P〈0.05） Conclusion： Acupuncture plus ginger-partitioned moxibustion is better than Ibuprofen sustained release capsules in treating dysmenorrhea.
文摘Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardization of moxibustion amount.Methods:The 42 big-ear white rabbits were divided into 6 groups according to the random number table method,a 2-cone direct moxibustion group,a 2-cone direct moxibustion group,a 3-cone direct moxibustion group,a 1-cone herbal cake-partitioned moxibustion group,a 2-cone herbal cake-partitioned moxibustion group,and a 3-cone herbal cake-partitioned moxibustion group,with 7 rabbits in each group.Shenque(CV 8);Shenshu(BL 23)and Zusanli(ST 36)were used in each group,but the moxibustion methods,cone numbers and durations of moxibustion were different・Rabbits in each group received moxibustion once every other day for 5 times in total.During the intervention,a thermoelectricity coupled probe and a temperature recorder were used to record the real-time-acupoint skin temperature and the temperature at different time points,so as to observe,analyze and process the real-time changes in the temperature difference between the surface and inside of acu point skin.Results:For herbal cake-partitioned moxibustion,the best temperature for cone changing was(46.38±0.51)℃when the highest surface temperature was(49.20±0.52)℃;the multi-factor comparison of acupoint×cone number×time and acupoint×moxibustion method×time showed that time×acupoint,time×moxibustion method and cone number×acupoint had interactive effects(all P<0.05).Comparing skin temperature differences between different cone numbers at the same acupoint,Shenque(CV 8)on the 1st and the 5th days,Shenshu(BL 23)on the 3rd and the 7th days,Zusanli(ST 36)on the 1st and the 9th days of experiment showed statistically significant differences(all P<0.05).The skin temperature comparison of different moxibustion methods at the same acupoint all had statistical differences(all Pv0.05),except for Shenque(CV 8)before moxibustion,Shenshu(BL 23)before moxibustion and on the 5th day;Zusanli(ST 36)only showed statistical differences on the 5th and 7th days(both P<0.05).The skin temperature differences of different acupoints after moxibustion in the 1-cone,2-cone and 3-cone groups were statistically different(all P<0.05);direct moxibustion and herbal cake-partitioned moxibustion at different acupoints were all statistically different(all P<0.05).Conclusion:Cone changing temperature under the same specifications of herbal cake-partitioned moxibustion was confirmed.Temperature differenee between surface and inside of different acupoint skin at the same maximum temperature was significantly different due to the cone numbers and moxibustion methods,which showed the highest at Shenshu(BL 23),the sec ond at Shenque(CV 8),and the lowest at Zusanli(ST 36).The in fluence of acupoint factor should be considered to determine the quantitative indicators of moxibustion.
文摘Objective:To observe the clinical efficacy of ginger-partitioned moxibustion plus pediatric massage(tuina)in treating infantile diarrhea due to spleen deficiency.Methods:Ninety infants were randomly divided into a massage plus moxibustion group,a massage group and a drug group by the random number table method,with 30 cases in each group.The intervention was conducted for two consecutive courses.The infants in the massage plus moxibustion group were treated with pediatric massage and ginger-partitioned moxibustion at Shenque(CV 8).The infants in the massage group were treated with pediatric massage alone,while those in the drug group were treated with smecta.The primary and secondary symptom scales were assessed before and after treatment and at the follow-ups,and the total effective rate was evaluated after treatment.Results:The total effective rate in the massage plus moxibustion group was significantly different from that in the massage group and drug group(both P<0.05).After treatment,the scores of primary and secondary symptoms decreased in all three groups,with statistically significant intra-group differences(all P<0.05);the scores of primary symptoms were significantly different between the massage plus moxibustion group and the drug group(P<0.05);the scores of secondary symptoms in the massage plus moxibustion group and the massage group were significantly different from that in the drug group(both P<0.05).The differences in the time to recover normal bowel movement frequency among the three groups were not statistically significant(P>0.05).Conclusion:Ginger-partitioned moxibustion plus pediatric massage compared with pediatric massage or smecta monotherapy shows superior clinical efficacy in treating infantile diarrhea due to spleen deficiency,and has the advantages of appetite improvement,physique strengthening and short course.
文摘Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized into a mild moxibustion group and a herbal cake-partitioned moxibustion group by the random number table,with 35 cases in each group.Shenque(CV 8),Zhongji(CV 3)and bilateral Zigong(EX-CA 1)were selected for both groups.The treatment continued for 3 menstrual cycles.The visual analog scale(VAS)and COX menstrual symptom scale(CMSS)were scored in both groups before treatment,after treatment and at the end of the 3rd menstrual cycle after treatment.The clinical efficacy was evaluated at the end of the 3rd menstrual cycle after treatment.Results:After treatment,the clinical efficacy of the herbal cake-partitioned moxibustion group had the tendency to be superior to that of the mild moxibustion group,while there was no statistically significant difference in the overall efficacy between the two groups(P>0.05).The VAS and CMSS scores after treatment and at the follow-up were significantly lower than those before treatment in both groups(all P<0.05).At the follow-up,the VAS scores in both groups had no significant intra-group differences from those after treatment(both P>0.05).The CMSS scores in both groups were significantly lower than those after treatment(both P<0.05).The VAS scores at the follow-up of both groups had no statistical differences from those after treatment(both P>0.05).After treatment,the CMSS score in the herbal cake-partitioned moxibustion group was significantly lower than that in the mild moxibustion group(P<0.05).At the follow-up,there were no statistical differences in the CMSS score between the two groups(P>0.05).Conclusion:The herbal cake-partitioned moxibustion has the same therapeutic efficacy for dysmenorrhea as the mild moxibustion;the two moxibustion methods can significantly improve the concomitant symptoms of dysmenorrhea,and the herbal cake-partitioned moxibustion is little better.
文摘Objective: To observe the effect of herbal cake-partitioned moxibustion on liver X receptor alpha (LXRa) in rabbits with atherosclerosis. Methods: Thirty-six male New Zea la nd rabbits were ran domly divided into a no rmal group, a model group, a herbal cake-partitioned moxibustion group and a simvastatin group according to the random number table method, with 9 rabbits in each group. Rabbits in the model group, the herbal cake-partitioned moxibustion group and the simvastatin group were modeled by high fat feeding method which took 12 weeks. After verification of the successful model, rabbits in the normal group were not treated, in the model group were bun died, in the herbal cake-partitioned moxibustio n group were treated with herbal cake-partitioned moxibustion, and those in the simvastatin group were treated with simvastatin, all for a total of 4 weeks. At the end of the experiment, the aorta and liver were observed for pathological changes;serum and liver were used to detect lipid levels;Western blot (WB) and real-time quantitative polymerase chain reaction (RT-qPCR) were used to detect LXRa protein and mRNA expression levels, respectively. Results: Compared with the normal group, the structure of aorta was disordered, the wall was rough and thick, the intima was unsmooth, and the vascular smooth muscle cells were arranged closely and disorderly in the model group, which was consistent with the characteristics of the rabbit model of aortic atherosclerosis. Compared with the model group, the aortic structure was clear;the degree of hepatocyte degeneration was reduced, the serum total cholesterol and low-density lipoprotein levels were significantly decreased (all P<0.01), the high-density lipoprotein level was elevated (P<0.01), and the total liver cholesterol was decreased significantly (P<0.01) in the rabbits of the herbal cake-partitioned moxibustion group and the simvastatin group;compared with the model group, the protein (PvO.Ol or P<0.05) and mRNA (P<0.01) expressions of rabbit LXRa in the herbal cake-partiti oned moxibusti on group and the simvastati n group were in creased. Conclusion: Herbal cake-partitioned moxibustion can improve the aortic and hepatic lesions, regulate blood lipid and liver lipid levels, in crease the expressi on of liver cholesterol reverse tran sport nu clear receptor LXRa, promote reverse cholesterol transport in the rabbits with aortic atherosclerosis, therefore produces an antiatherogenic effect.
基金supported by Project of Shanghai Science and Technology Committee (08DZ1972802)
文摘Objective： To observe the clinical effect of combined moxibustion and medication for Hashimoto’s thyroiditis. Methods： A total of 85 cases with Hashimoto’s thyroiditis who met the inclusion criteria were randomly allocated into an observation group and a control group. Forty-two cases in the observation group were treated with combined moxibustion with oral Levothyroxine Sodium tablets, whereas 43 cases in the control group were treated with oral Levothyroxine Sodium tablets alone. Then the scores of clinical symptoms and exophthalmos before and after treatment were compared. In addition, the time period for improvement of clinical symptoms in both groups were recorded and compared. Results： After one-month treatment, the scores of clinical symptoms and exophthalmos in the observation group were significantly improved than those in the control group （P0.05）; and it took less time for the cases in the observation group to get improvement compared with the control group. Conclusion： Combined moxibustion and oral Levothyroxine Sodium tablet is an efficient reliable therapy for Hashimoto’s thyroiditis.
文摘Objective To observe the efficacy of herbal cake-partitioned moxibustion for lumbar disc herniation(LDH)due to kidney deficiency and blood stasis and observe the influence of this method on lumbar functions and inflammatory factors in patients with this condition.Methods A total of 120 LDH patients who met the inclusion criteria were randomly divided into three groups,including a herbal cake-partitioned moxibustion group,a flour cake-partitioned moxibustion group,and a Western medication group,with 40 patients in each group.The patients in the Western medication group were treated with diflunisal tablets,0.5 g per dose,2 doses a day.Those in the herbal cake-partitioned moxibustion group were treated with additional herbal cake-partitioned moxibustion group at Back-Shu Points and Jiaji(EX-B2)Points once a day.Those in the flour cake-partitioned moxibustion group were treated with the same methods as in the herbal cake-partitioned moxibustion group,except that the herbal cake was replaced by a flour cake.All the patients were treated for 10 d.After treatment,the scores of the visual analog scale(VAS)and Japanese Orthopaedic Association(JOA)and the changes of the interleukin(IL)-6,tumor necrosis factor(TNF)-α,and substance P(SP)levels were observed,and the efficacy was evaluated.Results After treatment,the VAS score and the levels of IL-6,TNF-α,and SP were lower than those before treatment,and the JOA score was higher than that before treatment in the three groups,indicating intra-group statistical significance(P<0.05).The VAS score and the levels of IL-6,TNF-α,and SP of the herbal cake-partitioned moxibustion group were lower than those of the flour cake-partitioned moxibustion group and the Western medication group,while the JOA score of the herbal cake-partitioned moxibustion group was higher than that of the other two groups,indicating inter-group statistical significance(P<0.05).The total effective rate of the herbal cake-partitioned moxibustion group was 92.5%,higher than that of the flour cake-partitioned moxibustion group(80.0%)and the Western medication group(72.5%),indicating inter-group statistical significance(P<0.05).Conclusion On the basis of Western oral medication,additional herbal cake-partitioned moxibustion can alleviate the pain and improve the lumbar functions in patients with LDH due to kidney deficiency and blood stasis.The efficacy of the integrated method is better than that of either flour cake-partitioned moxibustion or Western medication alone,which may be related to the reduction of serum inflammatory factors.
文摘Objective To observe the effects of ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4)on the expression levels of endocrine-related molecules and their receptors in rats with primary dysmenorrhea(PD)due to cold-dampness stagnation,thus to explore their analgesic mechanisms.Methods Thirty-two female Wistar rats were divided into a normal group,a model group,a ginger-partitioned moxibustion group,and a Western medicine group according to the random number table method,with 8 rats in each group.Except for rats in the normal group,all other rats were treated with oxytocin combined with ice-water bath to establish the rat models of PD due to cold-dampness stagnation.After successful modeling,rats in the normal group and the model group did not receive treatment;rats in the ginger-partitioned moxibustion group received treatments with ginger-partitioned moxibustion at Shenque(CV8)and Guanyuan(CV4);rats in the Western medicine group received ibuprofen by intragastric administration.The writhing response of rats was compared among groups,and the serum levels of prostaglandin F2α(PGF2α),estrogen(estradiol,E2),progesterone(P),and the mRNA expression of PGF2αand E2 receptors in the uterine tissues were detected.Results No writhing behavior was observed in the normal group;compared with the normal group,the serum PGF2αand E2 levels in the model group were increased(P<0.01),while the P level was decreased(P<0.01),and the mRNA expression levels of the uterine PGF2αand E2 receptors were increased(P<0.01,P<0.05).Compared with the model group,the writhing behavior latency was prolonged,and the writhing response score was decreased in the ginger-partitioned moxibustion group and the Western medicine group(P<0.01);the serum PGF2αand E2 levels in the ginger-partitioned moxibustion group and the Western medicine group were decreased,while the P level was increased(P<0.05 or P<0.01);the mRNA expression levels of the uterine PGF2αand E2 receptors in the ginger-partitioned moxibustion group and the Western medicine group were decreased(P<0.05).Compared with the Western medicine group,the ginger-partitioned moxibustion group showed a prolonged writhing behavior latency,reduced writhing response score(P<0.05),and decreased serum E2 level(P<0.05),while no statistical differences in the serum PGF2αand P levels,or the mRNA expression levels of uterine PGF2αand E2 receptors(P>0.05).Conclusion The analgesic effect of ginger-partitioned moxibustion on PD due to cold-dampness stagnation may be related to regulating the mRNA expression levels of PGF2αand E2 receptors in the uterine tissues.
文摘Objective:To observe the lipid-lowering effect of different transdermal absorption enhancers applied to the herbal cake-partitioned moxibustion in hyperlipidemia model rabbits,and to explore the possible mechanism.Methods:Forty New-Zea I a nd rabbits were ran domly divided into 5 groups using the ran dom nu mber table method,with 8 rats in each group.Rabbits in the blank group were fed routinely with normal diet;rabbits in the other groups were fed with high-fat diet for 12 weeks to establish the hyperlipidemia model.Rabbits in the blank and the model groups were not treated.After the model was prepared,rabbits in the non-transdermal absorption enhancer group received herbal cake-partitioned moxibustion without transdermal absorption enhancer;rabbits in the laurocapram group and the borneol group received herbal cake-partitioned moxibustion with laurocapram or borneol respectively.After 4 weeks of treatment,serum was collected for enzyme-linked immunosorbent assay(ELISA),and the liver tissues were isolated for imm uno histochemistry,qua ntitative polymerase chain reactio n(qPCR)and Western-blotting(WB)detecti on.Results:Serum ELISA results showed that leptin was significantly decreased in the model group compared with the blank group(P<0.05);compared with the model group,lepti n was significa ntly in creased in the non-tran sdermal absorpti on enhanee。the laurocapram and the borneol groups(all P<0.05);compared with the non-transdermal absorption enhancer group,leptin was significantly increased in the laurocapram group and the borneol group(both P<0.05);there was no significant differenee in leptin between the laurocapram and the borneol groups(P>0.05).The qPCR results of rabbit liver tissues showed that the mRNA expressions of leptin,Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STOT3)in the model group were significantly lower than those in the blank group(all P<0.05);compared with the model group,the mRNA expressions of leptin,leptin receptor(LR),JAK2 and S1AT3 in the non-transdermal absorptio n enhan cer,the laurocapram and the born eol groups were significantly in creased(all P<0.05);compared with the non-transdermal absorption enhancer group,the mRNA expressions of leptin,LR,JAK2 and S77VT3 in the laurocapram and the bor neol groups were sign ificantly in creased(all P<0.05);compared with the laurocapram group,the mRNA expressi ons of lepti n,LR,JAK2 and SW3 in the bor neol group were significa ntly in creased(P<0.05).The trend of immun ohistochemistry and WB detecti on results was basically con siste nt with the qPCR assay results.The immuno histochemistry and WB detection results of phosphorylated JAK2(phospho-JAK2)and phosphorylated S7AT3(phospho-STAT3)were basically consistent with those of JAK2 and S7AT3.Conclusion:The molecular expression of Leptin/JAK"S7AT3 pathway in the hyperlipidemia model rabbits was decreased.The molecular expression of Leptin/JAK0STCT3 pathway was significantly increased after the herbal cake-partitioned moxibustion.The application of laurocapram and borneol,as transdermal absorption enhancers,in the herbal cake-partitioned moxibustion could more obviously up-regulate the factors of the Leptin/JAK^SIAT3 lipid-regulating pathway than the herbal cake-partitioned moxibustion alone.
基金supported by Maternal and Child Health Hospital,Xiacheng District of Hangzhou and Zhejiang Provincial Acupuncture & Tuina Hospital
文摘Objective： To observe the clinical effect of long snake moxibustion for ankylosing spondylitis （AS）. Methods： A total of 58 AS cases were randomized into a long snake moxibustion group and a Western medication group, 29 in each group. The cases in the former group received long snake moxibustion and Western medication, whereas cases in the latter group received Western medication alone. Results： The total effective rate in the long snake moxibustion group was 93.1%, versus 62.1% in the Western medication group, showing a statistical significance （P〈0.01）; after the treatment, the scores of Bath Ankylosing Spondylitis Disease Activity Index （BASDAI） and Bath Ankylosing Spondylitis Function Index （BASFI） were improved in both groups; however, the improvements of BASDAI and BASFI results in the long snake moxibustion group were more significant than those in the Western medication group （P〈0.05）. Conclusion： Long snake moxibustion and Western medication can significantly improve the clinical effect on AS, coupled with a remarkable effect in enhancing the patients＇ functions.
基金supported by National Basic Research Program of China(973 Program,No.2015CB554501)Natural Science Foundation of Shanghai(No.13ZR1439400)+1 种基金Program for New Century Excellent Talents in University(No.NCET-13-0907)Leading Academic Discipline Project of Shanghai(No.JZ2012019)~~
文摘Objective： To observe the regulatory effects of herbal cake-partitioned moxibustion on Crohn＇s disease （CD） rat＇s colon inflammatory cytokine interleukin-17 （IL-17）, IL-23 and their mRNAs, and to investigate the action mechanism of moxibustion in treating CD. Methods： Forty SPF grade Sprague-Dauley （SD） male rats were randomly divided into a normal group, a model group, an herbal cake-partitioned moxibustion group and a Western medicine group, with 20 rats in each group. Except the normal group, rats in the other three groups were used to make CD model by giving an enema in colon with Trinitro-benzene-sulfonic acid （TNBS）. When the models were successful made, rats in the model group had no therapeutic intervention; rats in the herbal cake-partitioned moxibustion group were subjected to herbal cake-partitioned moxibustion treatment at bilateral Tianshu （ST 25） plus O.ihai （CV 6）; and rats in the Western medicine group were given oral Mesalazine. After treatment, the histopathological changes and inflammatory cytokines IL-17, IL-23 and their mRNAs expressions were observed in descending colon by hematoxylin-eosin （HE） staining, immunohistochemistry （IHC） and real-time polymerase chain reaction （RT-PCR） methods. Results： Colon tissues of TNBS enema rat models showed cracks-like ulcers accompanied by mucous layer inflammation, granulomas, and inflammatory cytokines IL-27, IL-23 and their mRNAs expressions were all higher than those in the normal group （P〈O.01）; after intervention, colon tissue cracks-like ulcers and inflammation degree reduced, inflammatory cytokines IL-17, IL-23 and their mRNAs expressions were all significantly decreased （P〈0.01） in the herbal cake-partitioned moxibustion group and the Western medicine group. Conclusion： Herbal cake-partitioned moxibustion may improve colon tissue ulcers and relieve intestinal inflammation by down-regulation of IL-17, IL-23 and their mRNAs expressions in CD model rats＇ colonic mucosa.
