A high-accuracy,low-dropout （LDO） voltage regulator is presented. Using the slow-rolloff frequency compensation scheme, the LDO effectively overcomes the stability problem, facilitates the use of a ceramic capacitor...A high-accuracy,low-dropout （LDO） voltage regulator is presented. Using the slow-rolloff frequency compensation scheme, the LDO effectively overcomes the stability problem, facilitates the use of a ceramic capacitor, and improves the output voltage accuracy, which is critical for powering high-performance analog circuitry. The slow-rolloff compensation scheme is realized by introducing three pole-zero pairs, including the proposed polezero pair and sense zero. The post-layout simulation results demonstrate that this LDO has robust system stability, a high open-loop gain, and a high unit-gain frequency,which lead to excellent regulation and transient response performance. The line and load regulation are 27μV/V and 3.78μV/mA, and the overshoots of the output voltage are less than 30mV,while the dropout voltage is 120mV for a 150mA load current.展开更多
Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for...Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for the fidelity and robustness of these processes. Activation of receptor tyrosine kinases by their cognate growth factors not only leads to propagation of the signal through various biochemical cascades, but also sets in motion multiple attenuation mechanisms that ulti- mately terminate the active state. Early attenuators pre-exist prior to receptor activation and they act to limit signal propagation. Subsequently, late attenuators, such as Lrig and Sprouty, are transcriptionally induced and further act to dampen the signal. Central to the process of signaling attenuation is the role of the E3 ubiquitin ligase c-Cbl. While Cbl- mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated. Here we review some emerging interfaces between Cbl and the transcriptionally induced negative regulators Lrig and Sprouty.展开更多
The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to ...The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.展开更多
In order to control the locomotive wheel(axle) load distribution, a shimming process to adjust the locomotive secondary spring loads was heretofore developed. An immune dominance clonal selection multi-objective algor...In order to control the locomotive wheel(axle) load distribution, a shimming process to adjust the locomotive secondary spring loads was heretofore developed. An immune dominance clonal selection multi-objective algorithm based on the artificial immune system was presented to further improve the performance of the optimization algorithm for locomotive secondary spring load adjustment, especially to solve the lack of control on the output shim quantity. The algorithm was designed into a two-level optimization structure according to the preferences of the problem, and the priori knowledge of the problem was used as the immune dominance. Experiments on various types of locomotives show that owing to the novel algorithm, the shim quantity is cut down by 30% 60% and the calculation time is about 90% less while the secondary spring load distribution is controlled on the same level as before. The application of this optimization algorithm can significantly improve the availability and efficiency of the secondary spring adjustment process.展开更多
In order to achieve dynamical optimization of mobility load balancing,we analyze the conflict between mobility load balancing and mobility robustness optimization caused by the improper operation of handover parameter...In order to achieve dynamical optimization of mobility load balancing,we analyze the conflict between mobility load balancing and mobility robustness optimization caused by the improper operation of handover parameters.To this end,a method of Handover Parameters Adjustment for Conflict Avoidance(HPACA)is proposed.Considering the movement of users,HPCAC can dynamically adjust handover range to optimize the mobility load balancing.The movement of users is an important factor of handover,which has a dramatic impact on system performance.The numerical evaluation results show the proposed approach outperforms the existing method in terms of throughput,call blocking ratio,load balancing index,radio link failure ratio,ping-pong handover ratio and call dropping ratio.展开更多
文摘A high-accuracy,low-dropout （LDO） voltage regulator is presented. Using the slow-rolloff frequency compensation scheme, the LDO effectively overcomes the stability problem, facilitates the use of a ceramic capacitor, and improves the output voltage accuracy, which is critical for powering high-performance analog circuitry. The slow-rolloff compensation scheme is realized by introducing three pole-zero pairs, including the proposed polezero pair and sense zero. The post-layout simulation results demonstrate that this LDO has robust system stability, a high open-loop gain, and a high unit-gain frequency,which lead to excellent regulation and transient response performance. The line and load regulation are 27μV/V and 3.78μV/mA, and the overshoots of the output voltage are less than 30mV,while the dropout voltage is 120mV for a 150mA load current.
文摘Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for the fidelity and robustness of these processes. Activation of receptor tyrosine kinases by their cognate growth factors not only leads to propagation of the signal through various biochemical cascades, but also sets in motion multiple attenuation mechanisms that ulti- mately terminate the active state. Early attenuators pre-exist prior to receptor activation and they act to limit signal propagation. Subsequently, late attenuators, such as Lrig and Sprouty, are transcriptionally induced and further act to dampen the signal. Central to the process of signaling attenuation is the role of the E3 ubiquitin ligase c-Cbl. While Cbl- mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated. Here we review some emerging interfaces between Cbl and the transcriptionally induced negative regulators Lrig and Sprouty.
文摘The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.
基金Project(51305467)supported by the National Natural Science Foundation of ChinaProject(12JJ4050)supported by the Natural Science Foundation of Hunan Province,China
文摘In order to control the locomotive wheel(axle) load distribution, a shimming process to adjust the locomotive secondary spring loads was heretofore developed. An immune dominance clonal selection multi-objective algorithm based on the artificial immune system was presented to further improve the performance of the optimization algorithm for locomotive secondary spring load adjustment, especially to solve the lack of control on the output shim quantity. The algorithm was designed into a two-level optimization structure according to the preferences of the problem, and the priori knowledge of the problem was used as the immune dominance. Experiments on various types of locomotives show that owing to the novel algorithm, the shim quantity is cut down by 30% 60% and the calculation time is about 90% less while the secondary spring load distribution is controlled on the same level as before. The application of this optimization algorithm can significantly improve the availability and efficiency of the secondary spring adjustment process.
基金supported by the National Natural Science Foundation of China under Grant No.61071118the National Basic Research Program of China(973 Program)under Grant No.2012CB316004+1 种基金Special Fund of Chongqing Key Laboratory(CSTC)Chongqing Municipal Education Commission’s Science and Technology Research Project under Grant No.KJ111506
文摘In order to achieve dynamical optimization of mobility load balancing,we analyze the conflict between mobility load balancing and mobility robustness optimization caused by the improper operation of handover parameters.To this end,a method of Handover Parameters Adjustment for Conflict Avoidance(HPACA)is proposed.Considering the movement of users,HPCAC can dynamically adjust handover range to optimize the mobility load balancing.The movement of users is an important factor of handover,which has a dramatic impact on system performance.The numerical evaluation results show the proposed approach outperforms the existing method in terms of throughput,call blocking ratio,load balancing index,radio link failure ratio,ping-pong handover ratio and call dropping ratio.
