Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypot...Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypothesis that the tumor is a retrogression of life evolution, in other word, a resurgence of some past fragments in human development history. Our inference was based on the fact that tumors are not foreign diseases, but use of human inherent developmental genes to achieve self-improvement. Characteristics and biological behavior of tumor cells are similar to human normal stem cell to some degree. Thus, studying the process of human evolution could speculate and analyze the occurrence and development of tumors. The latest research showed that many cancer treatment were also taking advantages of those features about retrogression. Continuous in-depth analysis about tumor environmental characteristics and internal law of human evolution may produce new approaches to promote cancer prevention and treatment. Our hypothesis, for the first time, proposed that taking advantage of the evolution laws to reverse the tumor progression as a path of life retrogression is better than exterminating them completely as outside enemies. Some new studies on tumor induced differentiation had also demonstrated the clinical significance of our hypothesis展开更多
Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is stil...Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography （LDCT） scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ame- liorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. Chemo- kines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer.展开更多
文摘Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypothesis that the tumor is a retrogression of life evolution, in other word, a resurgence of some past fragments in human development history. Our inference was based on the fact that tumors are not foreign diseases, but use of human inherent developmental genes to achieve self-improvement. Characteristics and biological behavior of tumor cells are similar to human normal stem cell to some degree. Thus, studying the process of human evolution could speculate and analyze the occurrence and development of tumors. The latest research showed that many cancer treatment were also taking advantages of those features about retrogression. Continuous in-depth analysis about tumor environmental characteristics and internal law of human evolution may produce new approaches to promote cancer prevention and treatment. Our hypothesis, for the first time, proposed that taking advantage of the evolution laws to reverse the tumor progression as a path of life retrogression is better than exterminating them completely as outside enemies. Some new studies on tumor induced differentiation had also demonstrated the clinical significance of our hypothesis
基金Project supported by the Science and Technology Commission of Shanghai Municipality(No.14140901400)the Natural Science Foundation of Shanghai(No.13ZR1435000)the National Natural Science Foundation of China(No.81372318)
文摘Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography （LDCT） scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ame- liorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. Chemo- kines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer.
