细胞自噬在肾缺血再灌注损伤中的作用是一个复杂且多面的过程。肾缺血再灌注损伤(IRI)是临床中较为常见的病理生理过程,它通常是由于肾脏血液供应中断后恢复血流所引起的。这种损伤与多种机制相关,包括氧化应激、钙超载、线粒体功能紊...细胞自噬在肾缺血再灌注损伤中的作用是一个复杂且多面的过程。肾缺血再灌注损伤(IRI)是临床中较为常见的病理生理过程,它通常是由于肾脏血液供应中断后恢复血流所引起的。这种损伤与多种机制相关,包括氧化应激、钙超载、线粒体功能紊乱、自噬和凋亡等。在这些机制中,自噬起着关键作用。The role of autophagy in renal ischemia-reperfusion injury is a complex and multifaceted process. Renal ischemia-reperfusion injury (IRI) is a common pathophysiological process in clinical practice. It is usually caused by the restoration of blood flow after the interruption of renal blood supply. This damage is associated with multiple mechanisms, including oxidative stress, calcium overload, mitochondrial dysfunction, autophagy and apoptosis. Among these mechanisms, autophagy plays a key role.展开更多
文摘细胞自噬在肾缺血再灌注损伤中的作用是一个复杂且多面的过程。肾缺血再灌注损伤(IRI)是临床中较为常见的病理生理过程,它通常是由于肾脏血液供应中断后恢复血流所引起的。这种损伤与多种机制相关,包括氧化应激、钙超载、线粒体功能紊乱、自噬和凋亡等。在这些机制中,自噬起着关键作用。The role of autophagy in renal ischemia-reperfusion injury is a complex and multifaceted process. Renal ischemia-reperfusion injury (IRI) is a common pathophysiological process in clinical practice. It is usually caused by the restoration of blood flow after the interruption of renal blood supply. This damage is associated with multiple mechanisms, including oxidative stress, calcium overload, mitochondrial dysfunction, autophagy and apoptosis. Among these mechanisms, autophagy plays a key role.
