利用直流电弧等离子体法在甲烷气氛中制备碳包覆磁性镍纳米胶囊（Carbon-coated Ni nanocapsules,Ni（C）NCs）,将它作为电磁波吸收剂,按照质量比10%、20%、30%和40%与有机石蜡基体复合,在0.1～18GHz范围内测定其复介电常数和复磁导率,...利用直流电弧等离子体法在甲烷气氛中制备碳包覆磁性镍纳米胶囊（Carbon-coated Ni nanocapsules,Ni（C）NCs）,将它作为电磁波吸收剂,按照质量比10%、20%、30%和40%与有机石蜡基体复合,在0.1～18GHz范围内测定其复介电常数和复磁导率,并对其电磁波响应特性及吸收机制进行了研究。研究结果表明,Ni（C）纳米胶囊具有明显的极化损耗特征,其介电常数在低频范围内随频率提高而急剧衰减,而磁导率具有宽化的多重共振峰;随着Ni（C）纳米胶囊添加量的增加,其介电常数逐渐增加,其复磁导率实部和虚部分别在0.1～8GHz、0.1～10GHz出现增加,而在8～18GHz和10～18GHz范围内出现实部减小和虚部平缓变化的特征。根据极化、涡流以及反射损耗的理论分析,发现Ni（C）纳米胶囊以介电损耗为主,并对相关机制进行了探讨。展开更多
Objective: To test whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts of Dangfei Liganning capsules (...Objective: To test whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts of Dangfei Liganning capsules (当飞利肝宁胶囊) and their potential underlying mechanisms. Methods: Male Wistar rats were fed a high-fat diet to induce nonalcoholic fatty liver disease (NAFLD) or a normal diet (N). Eight weeks later, a nonlethal dose of CCl4 was applied intraperitoneally. From the start, HF-CCl4 rats were administered daily Dangyao extracts (D), Dangfei Liganning capsules (DF), or Diammonium Glycyrrhizinate (G) intragastrically. Rats were sacrificed 48 h after CCl4 administration. In addition to serum biochemistry, liver histopathology was observed using hematoxylin-eosin (HE) and oil red O staining, and hepatic levels of triglyceride (TG), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), caspase-3 activation and cytochrome P450 (CYP2E1) expression were assessed. Results: There was almost no response to the nonlethal dose of CCl4 in the N control group. However, the HF group demonstrated massive steatosis, and elevated levels of serum ALT and AST, liver MDA, CYP2E1, and caspase-3 activation, whereas the levels of GSH and SOD were significantly decreased. All indexes assessed were dramatically worse in the HF-CCl4 group compared to the HF group, in addition to the more severe steatosis, hepatocyte ballooning, and inflammatory infiltration apparent in the centrilobular area. The medicines we tested affected the pathological changes in HF-CCl4 rats to differing degrees: DF and G led to improvements in all of the above examined indexes, including an obvious improvement in histopathology, and DF improved serum ALT and MDA levels more markedly than G, whereas D extracts produced only mild liver injury attenuation. Conclusion: Liver with NAFLD is more sensitive to hepatotoxicity; furthermore, the disrupted balance of oxidative stress and anti-oxidant defense contributes to the underlying mechanisms. Dangfei Liganning capsules potentially decrease this toxic susceptibility and alleviate liver injury in non-alcoholic fatty liver.展开更多
The components and their concentration ratio of surfactant mixture in aqueous solution of gelatin and sodium carboxymethylcellulose (NaCMC) are very important during the preparation of stable microcapsules for electro...The components and their concentration ratio of surfactant mixture in aqueous solution of gelatin and sodium carboxymethylcellulose (NaCMC) are very important during the preparation of stable microcapsules for electrophoretic display.In this work,hydrocarbon/fluorocarbon composite surfactant was introduced for the first time into the capsule wall to improve the chemical resistance and barrier property of the microcapsules.By investigating surface tension and zeta potential of NaCMC with the mixture of sodium dodecyl sulfate (SDS)/perfluoro-nonene oxy benzene sulfonate (OBS),we found that both the presence of hydrophobic interaction and the hydrogen bonding between NaCMC and SDS/OBS enhanced the adsorption of NaCMC at the oil/water interface and thus facilitated the formation of capsule wall.The morphology,particle size,surface free energy and thermal stability of the obtained microcapsules were characterized.The results showed that optically transparent microcapsules with uniform size,smooth surface and compact wall can be obtained by adjusting the pH value of the reaction system and the concentration ratio of SDS/OBS.Based on the prepared microcapsules,a matrix display prototype operated at 9 V direct current in static driven mode was fabricated.展开更多
文摘利用直流电弧等离子体法在甲烷气氛中制备碳包覆磁性镍纳米胶囊（Carbon-coated Ni nanocapsules,Ni（C）NCs）,将它作为电磁波吸收剂,按照质量比10%、20%、30%和40%与有机石蜡基体复合,在0.1～18GHz范围内测定其复介电常数和复磁导率,并对其电磁波响应特性及吸收机制进行了研究。研究结果表明,Ni（C）纳米胶囊具有明显的极化损耗特征,其介电常数在低频范围内随频率提高而急剧衰减,而磁导率具有宽化的多重共振峰;随着Ni（C）纳米胶囊添加量的增加,其介电常数逐渐增加,其复磁导率实部和虚部分别在0.1～8GHz、0.1～10GHz出现增加,而在8～18GHz和10～18GHz范围内出现实部减小和虚部平缓变化的特征。根据极化、涡流以及反射损耗的理论分析,发现Ni（C）纳米胶囊以介电损耗为主,并对相关机制进行了探讨。
基金supported by the National Natural Science Foundation of China (30872360)Leading Academic Discipline Project and Innovative Research Team in Universities, Shanghai Municipal Education Commission (J50305)Natural Science Foundation of Shanghai (11ZR1436900)
文摘Objective: To test whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts of Dangfei Liganning capsules (当飞利肝宁胶囊) and their potential underlying mechanisms. Methods: Male Wistar rats were fed a high-fat diet to induce nonalcoholic fatty liver disease (NAFLD) or a normal diet (N). Eight weeks later, a nonlethal dose of CCl4 was applied intraperitoneally. From the start, HF-CCl4 rats were administered daily Dangyao extracts (D), Dangfei Liganning capsules (DF), or Diammonium Glycyrrhizinate (G) intragastrically. Rats were sacrificed 48 h after CCl4 administration. In addition to serum biochemistry, liver histopathology was observed using hematoxylin-eosin (HE) and oil red O staining, and hepatic levels of triglyceride (TG), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), caspase-3 activation and cytochrome P450 (CYP2E1) expression were assessed. Results: There was almost no response to the nonlethal dose of CCl4 in the N control group. However, the HF group demonstrated massive steatosis, and elevated levels of serum ALT and AST, liver MDA, CYP2E1, and caspase-3 activation, whereas the levels of GSH and SOD were significantly decreased. All indexes assessed were dramatically worse in the HF-CCl4 group compared to the HF group, in addition to the more severe steatosis, hepatocyte ballooning, and inflammatory infiltration apparent in the centrilobular area. The medicines we tested affected the pathological changes in HF-CCl4 rats to differing degrees: DF and G led to improvements in all of the above examined indexes, including an obvious improvement in histopathology, and DF improved serum ALT and MDA levels more markedly than G, whereas D extracts produced only mild liver injury attenuation. Conclusion: Liver with NAFLD is more sensitive to hepatotoxicity; furthermore, the disrupted balance of oxidative stress and anti-oxidant defense contributes to the underlying mechanisms. Dangfei Liganning capsules potentially decrease this toxic susceptibility and alleviate liver injury in non-alcoholic fatty liver.
基金supported by the National High-Tech Research & Development Program of China (863 Program,2008AA03A331)partly supported by the Science & Research Program of Zhejiang Province (2009C21024)
文摘The components and their concentration ratio of surfactant mixture in aqueous solution of gelatin and sodium carboxymethylcellulose (NaCMC) are very important during the preparation of stable microcapsules for electrophoretic display.In this work,hydrocarbon/fluorocarbon composite surfactant was introduced for the first time into the capsule wall to improve the chemical resistance and barrier property of the microcapsules.By investigating surface tension and zeta potential of NaCMC with the mixture of sodium dodecyl sulfate (SDS)/perfluoro-nonene oxy benzene sulfonate (OBS),we found that both the presence of hydrophobic interaction and the hydrogen bonding between NaCMC and SDS/OBS enhanced the adsorption of NaCMC at the oil/water interface and thus facilitated the formation of capsule wall.The morphology,particle size,surface free energy and thermal stability of the obtained microcapsules were characterized.The results showed that optically transparent microcapsules with uniform size,smooth surface and compact wall can be obtained by adjusting the pH value of the reaction system and the concentration ratio of SDS/OBS.Based on the prepared microcapsules,a matrix display prototype operated at 9 V direct current in static driven mode was fabricated.
