探讨高血压与勃起功能障碍(ED)相关性的临床观察。方法:选取青岛市第三人民医院住院及门诊就诊病人120人,年龄40~70岁,其中高血压患者75人,无高血压45人,采用国际勃起功能问卷(IIE F -5)评价性功能,多因素Logistic回归分析ED与相关因素...探讨高血压与勃起功能障碍(ED)相关性的临床观察。方法:选取青岛市第三人民医院住院及门诊就诊病人120人,年龄40~70岁,其中高血压患者75人,无高血压45人,采用国际勃起功能问卷(IIE F -5)评价性功能,多因素Logistic回归分析ED与相关因素的关系。结果:高血压患者ED与年龄、靶器官损伤有显著的关联,具有统计学意义(P<0.05);在高血压患者的年龄分层中,中年组病人高血压患者ED与靶器官损伤、高血压病程、脉压有关,差异有统计学意义(P<0.05);而在老年组中,只有高血压病程、脉压与高血压患者ED有关系;高血压患者ED的独立危险因素为患者的年龄、高血压病史、脉压、体重指数、Hs-CRP;高血压患者中发生ED的概率为46.7%,显著高于无高血压患者的17.8%ED的发生率,差异显著,有统计学意义(P<0.05)。结论:男性ED与高血压患者有密切相关的联系,包括高血压患者的病程长短、年龄大小、脉压损伤、靶器官损伤等各方面。展开更多
Spiral waves have been observed in the biological experiments on rat cortex perfused with drugs which can block inhibitory synapse and switch neuron excitability from type II to type I. To simulate the spiral waves ob...Spiral waves have been observed in the biological experiments on rat cortex perfused with drugs which can block inhibitory synapse and switch neuron excitability from type II to type I. To simulate the spiral waves observed in the experiment, the spatiotemporal patterns are investigated in a network composed of neurons with type I and II excitabilities and excitatory coupling. Spiral waves emerge when the percentage(p) of neurons with type I excitability in the network is at middle levels, which is dependent on the coupling strength. Compared with other spatial patterns which appear at different p values, spiral waves exhibit optimal spatial correlation at a certain spatial frequency, implying the occurrence of spatial coherence resonance-like phenomenon. Some dynamical characteristics of the network such as mean firing frequency and synchronous degree can be well interpreted with distinct properties between type I excitability and type II excitability. The results not only identify dynamics of spiral waves in neuronal networks composed of neurons with different excitabilities, but also are helpful to understanding the emergence of spiral waves observed in the biological experiment.展开更多
文摘探讨高血压与勃起功能障碍(ED)相关性的临床观察。方法:选取青岛市第三人民医院住院及门诊就诊病人120人,年龄40~70岁,其中高血压患者75人,无高血压45人,采用国际勃起功能问卷(IIE F -5)评价性功能,多因素Logistic回归分析ED与相关因素的关系。结果:高血压患者ED与年龄、靶器官损伤有显著的关联,具有统计学意义(P<0.05);在高血压患者的年龄分层中,中年组病人高血压患者ED与靶器官损伤、高血压病程、脉压有关,差异有统计学意义(P<0.05);而在老年组中,只有高血压病程、脉压与高血压患者ED有关系;高血压患者ED的独立危险因素为患者的年龄、高血压病史、脉压、体重指数、Hs-CRP;高血压患者中发生ED的概率为46.7%,显著高于无高血压患者的17.8%ED的发生率,差异显著,有统计学意义(P<0.05)。结论:男性ED与高血压患者有密切相关的联系,包括高血压患者的病程长短、年龄大小、脉压损伤、靶器官损伤等各方面。
基金supported by the National Natural Science Foundation of China(Grant Nos.11372224&11572225)
文摘Spiral waves have been observed in the biological experiments on rat cortex perfused with drugs which can block inhibitory synapse and switch neuron excitability from type II to type I. To simulate the spiral waves observed in the experiment, the spatiotemporal patterns are investigated in a network composed of neurons with type I and II excitabilities and excitatory coupling. Spiral waves emerge when the percentage(p) of neurons with type I excitability in the network is at middle levels, which is dependent on the coupling strength. Compared with other spatial patterns which appear at different p values, spiral waves exhibit optimal spatial correlation at a certain spatial frequency, implying the occurrence of spatial coherence resonance-like phenomenon. Some dynamical characteristics of the network such as mean firing frequency and synchronous degree can be well interpreted with distinct properties between type I excitability and type II excitability. The results not only identify dynamics of spiral waves in neuronal networks composed of neurons with different excitabilities, but also are helpful to understanding the emergence of spiral waves observed in the biological experiment.
