Objective： Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer re- mains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for...Objective： Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer re- mains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods： In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45~ angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontally inwardly inclined 45~. Results： A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8% （8/45）, and prostate intraepithelial neoplasm （PIN） was 6.7% （3/45）. The pa- tients receiving repeat transrectal prostate biopsies were pathologically diagnosed as lower Gleason grade prostate cancers. Conclusion： The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrecta~ prostate biopsies patients.展开更多
Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditiona...Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditional P300 (2t- P300) and three- tone paradigm auditory P300 (3t- P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9％ ) by 2t- P300, and in 26 of 30 patients who finished the 3t- P300 tests (86.7％ ). In 2t- P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t- P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t- P300 was found in 13 of 16 cases which showed normal 2t- P300. Besides prolonged and bad- shaped P300, no certain response of P300 to rare non- target stimulus (r- nT) was found in 10 mild cases by 3t- P300. Conclusion. Three- tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r- nT in 3t- P300 is an important index in early diagnosis of mild dementia.展开更多
基金Supported by grants from the Pudong New Area Medical Health System Outstanding Young Talent Training Plan(No.PWRq2013-17)Zhoupu Hospital of Pudong New District(No.ZP-XM-2012B-22)
文摘Objective： Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer re- mains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods： In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45~ angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontally inwardly inclined 45~. Results： A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8% （8/45）, and prostate intraepithelial neoplasm （PIN） was 6.7% （3/45）. The pa- tients receiving repeat transrectal prostate biopsies were pathologically diagnosed as lower Gleason grade prostate cancers. Conclusion： The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrecta~ prostate biopsies patients.
文摘Objective. To explore the changes of three- tone paradigm P300 and observe the improvement of the diagnostic sensitivity of P300 in aging dementia. Methods. Thirty- four patients of aging dementia underwent traditional P300 (2t- P300) and three- tone paradigm auditory P300 (3t- P300). The results of these two methods were compared. Results. Abnormal P300 was found in 18 of 34 dementia cases (52.9％ ) by 2t- P300, and in 26 of 30 patients who finished the 3t- P300 tests (86.7％ ). In 2t- P300, 9 of 24 mild cases, 7 of 8 moderate cases and 2 severe cases showed abnormal results. In 3t- P300, 20 of 24 mild cases and all 6 moderate cases showed abnormal results. Abnormal 3t- P300 was found in 13 of 16 cases which showed normal 2t- P300. Besides prolonged and bad- shaped P300, no certain response of P300 to rare non- target stimulus (r- nT) was found in 10 mild cases by 3t- P300. Conclusion. Three- tone paradigm auditory P300 had higher sensitivity in early diagnosis of aging dementia than traditional auditory P300. No P300 response to r- nT in 3t- P300 is an important index in early diagnosis of mild dementia.
