In order to improve the production of human-like collagen III(HLC III)by fed-batch culture of recombinant Escherichia coli BL21,the Plackett-Burman and Box-Behnken design were applied to optimize the fermentation proc...In order to improve the production of human-like collagen III(HLC III)by fed-batch culture of recombinant Escherichia coli BL21,the Plackett-Burman and Box-Behnken design were applied to optimize the fermentation process parameters.Three variables(induction time,inoculum age and pH),which have significant effects on HLC III production,were selected from eight variables by Plackett-Burman design.With the regression coefficient analysis in the Box-Behnken design,a relationship between HLC III production and three significant factors was obtained,and the optimum levels of the three variables were as follows:induction time 3.2h,inoculum age 12.6 h and pH 6.7.The 3D response surface plots and 2D contour plots created by the Box-Behnken design showed that the interaction between induction time and pH and that between innoculum age and pH were significant.An average 9.68 g·L1HLC III production was attained in the validation experiment under optimized condition,which was 80%higher than the yield of 5.36 g·L1before optimization.展开更多
Based on trajectory equations of gas bubble,an eddy-bubble interaction(EBI)model was developed. This model considered the effect of non-drag forces and took the eddy-bubble interaction time as the refreshing time scal...Based on trajectory equations of gas bubble,an eddy-bubble interaction(EBI)model was developed. This model considered the effect of non-drag forces and took the eddy-bubble interaction time as the refreshing time scale of turbulent fluctuations.The relationship between the crossing-eddy time and the eddy lifetime was discussed,and the predicted distributions of radial,axial velocities of bubbles and gas holdup were also given. Compared with eddy lifetime(EL)model,the EBI model gives somewhat smaller axial velocity in the upper circulation region and larger velocity in the lower circulation region,causing that fewer bubbles reach the lower circulation region and gas holdup becomes higher in the upper circulation region.The predicted gas holdup by the EBI model approaches closer to the experimental data in the discharge stream region.展开更多
This study investigated the relationship be- tween the asymmetry in the duration of El Nifio and La Nina and the length of their decaying phases. The results suggested that the duration asymmetry comes from the long d...This study investigated the relationship be- tween the asymmetry in the duration of El Nifio and La Nina and the length of their decaying phases. The results suggested that the duration asymmetry comes from the long decaying ENSO cases rather than the short decaying ones. The evolutions of short decaying El Nino and La Nina are approximately a mirror image with a rapid decline in the following summer for the warm and cold events. However, a robust asymmetry was found in long decaying cases, with a prolonged and re-intensified La Nina in the following winter. The asymmetry for long decaying cases starts from the westward extension of the zonal wind anomalies in a mature winter, and is further contributed to by the air-sea interaction over the tropical Pacific in the following seasons.展开更多
Background Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infa...Background Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infarction （STEMI）, are age dependent. The aim of this study is to examine the gender-age interaction with early and late mortality in patients with STEMI enrolled in the Korean nationwide regis-try. Methods This prospective study stratified outcomes according to gender and age from 17,021 STEMI patients. We compared in-hospital, early （30 days） and late （12 months） mortality between gender to examine the gender-age interaction in multivariable models. Results In younger women （〈 60 years）, in-hospital [5.8% vs. 2.5%, P 〈 0.001; unadjusted odds ratios （OR）： 2.41, 95% confidence inter-vals （CI）： 1.59-3.66], early （6.2% vs. 2.6%, P 〈 0.001; unadjusted OR： 2.4, 95% CI： 2.12-2.72） and late mortality （7.0% vs. 3.1%, P 〉 0.001; unadjusted OR： 2.33, 95% CI： 2.08-2.61） were significantly higher compared with men. However, after adjustment for patient characteristics, Killip class ≥ 3, symptom to balloon time and major bleeding, and in-hospital bleeding, overall early and late mortality were no longer re-lated to gender in any age groups. Conclusions Among a Korean population with STEMI, higher early and late mortality in younger women may be explained by poor patient characteristics, higher Killip class ≥3, longer symptom to balloon time and more frequent major bleeding. Therefore, based on gender-age differences, more precise and aggressive preventive strategies focused on risk factor reduction, education and more intensive management for yotmger women should be performed.展开更多
Background： Pacing, defined as percentage changes of speed between successive splits, has been extensively studied in running and cycling endurance sports; however, less information about the trends in change of spee...Background： Pacing, defined as percentage changes of speed between successive splits, has been extensively studied in running and cycling endurance sports; however, less information about the trends in change of speed during cross-country （XC） ski racing is available. Therefore, the aim of the present study was to examine the effect of performance （quartiles of race time （Q）, with Q1 the fastest and Q4 the slowest） level on pacing in the Vasaloppet ski race, the largest XC skiing race in the world. Methods： For this purpose, we analyzed female （n = 19,465） and male （n = 164,454） finishers in the Vasaloppet ski race from 2004 to 2017 using a one-way （2 sexes） analysis of variance with repeated measures to examine percentage changes of speed between 2 successive splits. Overall, the race consisted of 8 splits. Results： The race speeds of Q1, Q2, Q3, and Q4 were 13.6 ± 1.8, 10.6 ± 0.5, 9.2 ± 0.3, and 8.1 ±- 0.4 km/h, respectively, among females and 16.7 ± 1.7, 13.1 ± 0.7, 10.9 ± 0.6, and 8.9 ± 0.7 km/h, respectively, among males. The overall pacing strategy of finishers was variable. A small sex × split interaction on speed was observed （η^2= 0.016, p 〈 0.001）, with speed difference between sexes ranging from 14.9% （Split 7） to 27.0% （Split 1） and larger changes in speed between 2 successive splits being shown for females （p 〈 0.001, η^2=0.004）. A large performance × split interaction on speed, with Q1 presenting the smallest changes of speed between splits, was shown for females （η^2= 0.149, p 〈 0.001） and males （η^2 = 0.169,p 〈 0.001）. Conclusion： Male and fast XC skiers are more even pacers. Coaches and athletes should develop tailored sex- and performance-level pacing strategies; for instance, they should advise fast XC skiers to start fast and maintain their speed, rather than starting slowly and trying to make up time by going faster at times during the race.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. （http：//creativecommons.org/licenses/by-nc-nd/4.0/）.展开更多
Taking the intrinsic decoherence effect into account, the entanglement ofa two-qubit anisotropic Heisenberg XYZ chain in the presence of the Dzyaloshinski Moriya （DM） anisotropic antisymetric interaction is investig...Taking the intrinsic decoherence effect into account, the entanglement ofa two-qubit anisotropic Heisenberg XYZ chain in the presence of the Dzyaloshinski Moriya （DM） anisotropic antisymetric interaction is investigated in this paper. Concurrence, the measurement of entanglement, is calculated. Compared with the anisotropic in XY plane, the DM interaction is another kind of anisotropic antisymmetrie exchange interaction. It is shown that the intrinsic decoherence obviously suppresses the time evolution of the entanglement. The DM interaction only acts on the time evolution of the entanglement when the initial state is [ψ（0）〉 = cosα｜01〉 ＋ sinα｜10〉 and weakens the degree of entanglement. The anisotropic in XY plane merely impacts on the time evolution of the entanglement when the system ＆ initially in a state ｜ψ（0）〉 = cos α｜00〉 ＋ sin α｜11 〉. The sufficiently weak anisotropic in XY plane can effectively enhance the degree of entanglement.展开更多
By taking into account spatial degrees of freedom of atoms, we study the internal-state disentanglement dynamics of two atoms interacting with a vacuum multi-mode noise field. We show that the complete internal-state ...By taking into account spatial degrees of freedom of atoms, we study the internal-state disentanglement dynamics of two atoms interacting with a vacuum multi-mode noise field. We show that the complete internal-state disentanglement of the two atoms, caused due to the atomic spontaneous emission can be achieved in a finite time.展开更多
We investigate the quantum-classical transition of a kicked rotor （KR） under perturbation by a second one. The influence of such a chaotic KR makes decoherence of the first one, resulting in the emergence of classic...We investigate the quantum-classical transition of a kicked rotor （KR） under perturbation by a second one. The influence of such a chaotic KR makes decoherence of the first one, resulting in the emergence of classical diffusion from its quantum dynamics. Such quantum-classical transition persists by decreasing the effective Planck＇s constant h, and at the same time, decreasing the mass of the second KR and the interaction strength proportionally. In the limit of h → 0, due to vanishing small mass and interaction, the second KR has almost no effect on the classieal dynamics of the first one. We demonstrate this via two different coupling potentials.展开更多
N-lump solutions of the Kadomtsev-Petviashvili I equation in non-uniform media are derived through the inverse scattering transform. The obtained solutions describe lump waves with time-dependent amplitudes and veloci...N-lump solutions of the Kadomtsev-Petviashvili I equation in non-uniform media are derived through the inverse scattering transform. The obtained solutions describe lump waves with time-dependent amplitudes and velocities. Dynamics of l-lump wave and interactions of two lump wave are illustrated.展开更多
In this paper, an investigation into the propagation of far field explosion waves in water and their effects on nearby structures are carried out. For the far field structure, the motion of the fluid surrounding the s...In this paper, an investigation into the propagation of far field explosion waves in water and their effects on nearby structures are carried out. For the far field structure, the motion of the fluid surrounding the structure may be assumed small, allowing linearization of the governing fluid equations. A complete analysis of the problem must involve simultaneous solution of the dynamic response of the structure and the propagation of explosion wave in the surrounding fluid. In this study, a dynamic adaptive finite element procedure is proposed. Its application to the solution of a 2D fluid-structure interaction is investigated in the time domain. The research includes：a） calculation of the far-field scatter wave due to underwater explosion including solution of the time-depended acoustic wave equation, b） fluid-structure interaction analysis using coupled Euler-Lagrangian approach, and c） adaptive finite element procedures employing error estimates, and re-meshing. The temporal mesh adaptation is achieved by local regeneration of the grid using a time-dependent error indicator based on curvature of pressure function. As a result, the overall response is better predicted by a moving mesh than an equivalent uniform mesh. In addition, the cost of computation for large problems is reduced while the accuracy is improved.展开更多
Mixed lineage kinase 3 （MLK3） is a mitogen-activated protein kinase kinase kinase that is activated by tumor necrosis factor-α （TNF-α） and specifically activates c-Jun N-terminal kinase （JNK） on TNF-a stimulat...Mixed lineage kinase 3 （MLK3） is a mitogen-activated protein kinase kinase kinase that is activated by tumor necrosis factor-α （TNF-α） and specifically activates c-Jun N-terminal kinase （JNK） on TNF-a stimulation. The mecha- nism by which TNF-α activates MLK3 is still not known. TNF receptor-associated factors （TRAFs） are adapter molecules that are recruited to cytoplasmic end of TNF receptor and mediate the downstream signaling, including activation of JNK. Here, we report that MLK3 associates with TRAF2, TRAF5 and TRAF6; however only TRAF2 can significantly induce the kinase activity of MLK3. The interaction domain of TRAF2 maps to the TRAF domain and for MLK3 to its C-terminal half （amino acids 511-847）. Endogenous TRAF2 and MLK3 associate with each other in response to TNF-α treatment in a time-dependent manner. The association between MLK3 and TRAF2 mediates MLK3 activation and competition with the TRAF2 deletion mutant that binds to MLK3 attenuates MLK3 kinase activity in a dose-dependent manner, on TNF-α treatment. Furthermore the downstream target of MLK3, JNK was activated by TNF-α in a TRAF2-dependent manner. Hence, our data show that the direct interaction between TRAF2 and MLK3 is required for TNF-α-induced activation of MLK3 and its downstream target, JNK.展开更多
Glow discharge electrolysis provides an alternative method for the removal of arsenite from water. Glow discharge electrolysis of aqueous solution containing arsenite is studied under altemating current altemating cur...Glow discharge electrolysis provides an alternative method for the removal of arsenite from water. Glow discharge electrolysis of aqueous solution containing arsenite is studied under altemating current altemating current （50 Hz） discharge. It is found that arsenite [As（III）] get converted to arsenate [As（V）]. The yield is studied with various parameters such as discharge current, duration of discharge and pH （2-10）. The results are interpreted on the basis of interaction of the OH and eaq （produced consequent to the interaction of H2O＋ and e with water at the surface of the solution） with arsenite [As（III）] through the intermediate oxidation state, namely [As（IV）].展开更多
The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events：...The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events： high intensity and short duration Type A sediment disaster events, and low intensity and long duration Type B moderate non-disaster events. Two dimensionless parameters, sediment trapping rate and reduction rate of peak sediment transport, are defined to evaluate the sediment control function of river notches. Study results indicate that the contraction ratio of the notch has a significant influence on sediment control function, with high contraction ratios resulting in both high sediment-trapping and high reduction rates. River notches provide better sediment control during Type A events than Type B events. The sediment control mechanism of river notches is the result of multiple interactions among river flow, sediment transport, and riverbed variation. Analysis of these interactions supports the significant protection role of river notches on sediment control for disaster events.展开更多
We present three families of exact matter-wave soliton solutions for an effective one-dimension twocomponent Bose-Einstein condensates(BECs) with tunable interactions,harmonic potential and gain or loss term. We inves...We present three families of exact matter-wave soliton solutions for an effective one-dimension twocomponent Bose-Einstein condensates(BECs) with tunable interactions,harmonic potential and gain or loss term. We investigate the dynamics of bright-bright solitons,bright-dark solitons and dark-dark solitons for the time-dependent expulsive harmonic trap potential,periodically modulated harmonic trap potential,and kinklike modulated harmonic trap potential.Through the Feshbach resonance,these dynamics can be realized in experiments by suitable control of time-dependent trap parameters,atomic interactions,and interaction with thermal cloud.展开更多
Based on the field-theoretical bosonization we consider the spinful system consisting of two disconnected Luttinger liquids, which are coupled at time t = 0 through chiral density-density interactions. We show the wel...Based on the field-theoretical bosonization we consider the spinful system consisting of two disconnected Luttinger liquids, which are coupled at time t = 0 through chiral density-density interactions. We show the wellknown spin-charge separation in this 1D system by means of bosonization and Bogoliubov transformation. To evaluate analytically the one-particle equal-time correlation functions, Cazalilla＇s methods are extended to spin-charge sectors. It is found that in long time limit the behavior of correlations does not coincide with that of equilibrium equal-time correlations of two coupled spinful Luttinger liquids. In order to compare with experimental results, the improved exponent that governs the power-law behavior of equal-time correlations of the non-equilibrium system is obtained at the end of this work.展开更多
基金Supported by the National Natural Science Foundation of China（20776119） the National High Technology Research and Development Program of China（2007AA03Z456A） the Special Research Program of the Education Department of Shaanxi Province（07JK417）
文摘In order to improve the production of human-like collagen III(HLC III)by fed-batch culture of recombinant Escherichia coli BL21,the Plackett-Burman and Box-Behnken design were applied to optimize the fermentation process parameters.Three variables(induction time,inoculum age and pH),which have significant effects on HLC III production,were selected from eight variables by Plackett-Burman design.With the regression coefficient analysis in the Box-Behnken design,a relationship between HLC III production and three significant factors was obtained,and the optimum levels of the three variables were as follows:induction time 3.2h,inoculum age 12.6 h and pH 6.7.The 3D response surface plots and 2D contour plots created by the Box-Behnken design showed that the interaction between induction time and pH and that between innoculum age and pH were significant.An average 9.68 g·L1HLC III production was attained in the validation experiment under optimized condition,which was 80%higher than the yield of 5.36 g·L1before optimization.
基金Supported by the National Natural Science Foundation of China（20776121） the Scientific Fund of Hunan Provincial Education Department（07C765 07C744）
文摘Based on trajectory equations of gas bubble,an eddy-bubble interaction(EBI)model was developed. This model considered the effect of non-drag forces and took the eddy-bubble interaction time as the refreshing time scale of turbulent fluctuations.The relationship between the crossing-eddy time and the eddy lifetime was discussed,and the predicted distributions of radial,axial velocities of bubbles and gas holdup were also given. Compared with eddy lifetime(EL)model,the EBI model gives somewhat smaller axial velocity in the upper circulation region and larger velocity in the lower circulation region,causing that fewer bubbles reach the lower circulation region and gas holdup becomes higher in the upper circulation region.The predicted gas holdup by the EBI model approaches closer to the experimental data in the discharge stream region.
基金supported by the National Natural Science Foundation of China (Grant No. 41105046)
文摘This study investigated the relationship be- tween the asymmetry in the duration of El Nifio and La Nina and the length of their decaying phases. The results suggested that the duration asymmetry comes from the long decaying ENSO cases rather than the short decaying ones. The evolutions of short decaying El Nino and La Nina are approximately a mirror image with a rapid decline in the following summer for the warm and cold events. However, a robust asymmetry was found in long decaying cases, with a prolonged and re-intensified La Nina in the following winter. The asymmetry for long decaying cases starts from the westward extension of the zonal wind anomalies in a mature winter, and is further contributed to by the air-sea interaction over the tropical Pacific in the following seasons.
文摘Background Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infarction （STEMI）, are age dependent. The aim of this study is to examine the gender-age interaction with early and late mortality in patients with STEMI enrolled in the Korean nationwide regis-try. Methods This prospective study stratified outcomes according to gender and age from 17,021 STEMI patients. We compared in-hospital, early （30 days） and late （12 months） mortality between gender to examine the gender-age interaction in multivariable models. Results In younger women （〈 60 years）, in-hospital [5.8% vs. 2.5%, P 〈 0.001; unadjusted odds ratios （OR）： 2.41, 95% confidence inter-vals （CI）： 1.59-3.66], early （6.2% vs. 2.6%, P 〈 0.001; unadjusted OR： 2.4, 95% CI： 2.12-2.72） and late mortality （7.0% vs. 3.1%, P 〉 0.001; unadjusted OR： 2.33, 95% CI： 2.08-2.61） were significantly higher compared with men. However, after adjustment for patient characteristics, Killip class ≥ 3, symptom to balloon time and major bleeding, and in-hospital bleeding, overall early and late mortality were no longer re-lated to gender in any age groups. Conclusions Among a Korean population with STEMI, higher early and late mortality in younger women may be explained by poor patient characteristics, higher Killip class ≥3, longer symptom to balloon time and more frequent major bleeding. Therefore, based on gender-age differences, more precise and aggressive preventive strategies focused on risk factor reduction, education and more intensive management for yotmger women should be performed.
文摘Background： Pacing, defined as percentage changes of speed between successive splits, has been extensively studied in running and cycling endurance sports; however, less information about the trends in change of speed during cross-country （XC） ski racing is available. Therefore, the aim of the present study was to examine the effect of performance （quartiles of race time （Q）, with Q1 the fastest and Q4 the slowest） level on pacing in the Vasaloppet ski race, the largest XC skiing race in the world. Methods： For this purpose, we analyzed female （n = 19,465） and male （n = 164,454） finishers in the Vasaloppet ski race from 2004 to 2017 using a one-way （2 sexes） analysis of variance with repeated measures to examine percentage changes of speed between 2 successive splits. Overall, the race consisted of 8 splits. Results： The race speeds of Q1, Q2, Q3, and Q4 were 13.6 ± 1.8, 10.6 ± 0.5, 9.2 ± 0.3, and 8.1 ±- 0.4 km/h, respectively, among females and 16.7 ± 1.7, 13.1 ± 0.7, 10.9 ± 0.6, and 8.9 ± 0.7 km/h, respectively, among males. The overall pacing strategy of finishers was variable. A small sex × split interaction on speed was observed （η^2= 0.016, p 〈 0.001）, with speed difference between sexes ranging from 14.9% （Split 7） to 27.0% （Split 1） and larger changes in speed between 2 successive splits being shown for females （p 〈 0.001, η^2=0.004）. A large performance × split interaction on speed, with Q1 presenting the smallest changes of speed between splits, was shown for females （η^2= 0.149, p 〈 0.001） and males （η^2 = 0.169,p 〈 0.001）. Conclusion： Male and fast XC skiers are more even pacers. Coaches and athletes should develop tailored sex- and performance-level pacing strategies; for instance, they should advise fast XC skiers to start fast and maintain their speed, rather than starting slowly and trying to make up time by going faster at times during the race.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. （http：//creativecommons.org/licenses/by-nc-nd/4.0/）.
基金supported by the Natural Science Foundation of Hunan Province under Grant No. 06JJ50118
文摘Taking the intrinsic decoherence effect into account, the entanglement ofa two-qubit anisotropic Heisenberg XYZ chain in the presence of the Dzyaloshinski Moriya （DM） anisotropic antisymetric interaction is investigated in this paper. Concurrence, the measurement of entanglement, is calculated. Compared with the anisotropic in XY plane, the DM interaction is another kind of anisotropic antisymmetrie exchange interaction. It is shown that the intrinsic decoherence obviously suppresses the time evolution of the entanglement. The DM interaction only acts on the time evolution of the entanglement when the initial state is [ψ（0）〉 = cosα｜01〉 ＋ sinα｜10〉 and weakens the degree of entanglement. The anisotropic in XY plane merely impacts on the time evolution of the entanglement when the system ＆ initially in a state ｜ψ（0）〉 = cos α｜00〉 ＋ sin α｜11 〉. The sufficiently weak anisotropic in XY plane can effectively enhance the degree of entanglement.
基金Supported by Foundation of the Education Department of Liaoning Province under Grant No.20060160the Natural Science Foundation of Zhejiang Province under Grant No.Y6100098+1 种基金the National Natural Scinece Foundation of China under Grant No.11074062the funding support from Hangzhou Normal University
文摘By taking into account spatial degrees of freedom of atoms, we study the internal-state disentanglement dynamics of two atoms interacting with a vacuum multi-mode noise field. We show that the complete internal-state disentanglement of the two atoms, caused due to the atomic spontaneous emission can be achieved in a finite time.
基金Supported by National Science Foundation of China under Grant No.10875087
文摘We investigate the quantum-classical transition of a kicked rotor （KR） under perturbation by a second one. The influence of such a chaotic KR makes decoherence of the first one, resulting in the emergence of classical diffusion from its quantum dynamics. Such quantum-classical transition persists by decreasing the effective Planck＇s constant h, and at the same time, decreasing the mass of the second KR and the interaction strength proportionally. In the limit of h → 0, due to vanishing small mass and interaction, the second KR has almost no effect on the classieal dynamics of the first one. We demonstrate this via two different coupling potentials.
基金Supported by the National Natural Science Foundation of China under Grant No.11071157Shanghai Leading Academic Discipline Project under Grant No.J50101
文摘N-lump solutions of the Kadomtsev-Petviashvili I equation in non-uniform media are derived through the inverse scattering transform. The obtained solutions describe lump waves with time-dependent amplitudes and velocities. Dynamics of l-lump wave and interactions of two lump wave are illustrated.
文摘In this paper, an investigation into the propagation of far field explosion waves in water and their effects on nearby structures are carried out. For the far field structure, the motion of the fluid surrounding the structure may be assumed small, allowing linearization of the governing fluid equations. A complete analysis of the problem must involve simultaneous solution of the dynamic response of the structure and the propagation of explosion wave in the surrounding fluid. In this study, a dynamic adaptive finite element procedure is proposed. Its application to the solution of a 2D fluid-structure interaction is investigated in the time domain. The research includes：a） calculation of the far-field scatter wave due to underwater explosion including solution of the time-depended acoustic wave equation, b） fluid-structure interaction analysis using coupled Euler-Lagrangian approach, and c） adaptive finite element procedures employing error estimates, and re-meshing. The temporal mesh adaptation is achieved by local regeneration of the grid using a time-dependent error indicator based on curvature of pressure function. As a result, the overall response is better predicted by a moving mesh than an equivalent uniform mesh. In addition, the cost of computation for large problems is reduced while the accuracy is improved.
文摘Mixed lineage kinase 3 （MLK3） is a mitogen-activated protein kinase kinase kinase that is activated by tumor necrosis factor-α （TNF-α） and specifically activates c-Jun N-terminal kinase （JNK） on TNF-a stimulation. The mecha- nism by which TNF-α activates MLK3 is still not known. TNF receptor-associated factors （TRAFs） are adapter molecules that are recruited to cytoplasmic end of TNF receptor and mediate the downstream signaling, including activation of JNK. Here, we report that MLK3 associates with TRAF2, TRAF5 and TRAF6; however only TRAF2 can significantly induce the kinase activity of MLK3. The interaction domain of TRAF2 maps to the TRAF domain and for MLK3 to its C-terminal half （amino acids 511-847）. Endogenous TRAF2 and MLK3 associate with each other in response to TNF-α treatment in a time-dependent manner. The association between MLK3 and TRAF2 mediates MLK3 activation and competition with the TRAF2 deletion mutant that binds to MLK3 attenuates MLK3 kinase activity in a dose-dependent manner, on TNF-α treatment. Furthermore the downstream target of MLK3, JNK was activated by TNF-α in a TRAF2-dependent manner. Hence, our data show that the direct interaction between TRAF2 and MLK3 is required for TNF-α-induced activation of MLK3 and its downstream target, JNK.
文摘Glow discharge electrolysis provides an alternative method for the removal of arsenite from water. Glow discharge electrolysis of aqueous solution containing arsenite is studied under altemating current altemating current （50 Hz） discharge. It is found that arsenite [As（III）] get converted to arsenate [As（V）]. The yield is studied with various parameters such as discharge current, duration of discharge and pH （2-10）. The results are interpreted on the basis of interaction of the OH and eaq （produced consequent to the interaction of H2O＋ and e with water at the surface of the solution） with arsenite [As（III）] through the intermediate oxidation state, namely [As（IV）].
基金financial support were provided by the Disaster Prevention Research Center, National Cheng Kung University
文摘The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events： high intensity and short duration Type A sediment disaster events, and low intensity and long duration Type B moderate non-disaster events. Two dimensionless parameters, sediment trapping rate and reduction rate of peak sediment transport, are defined to evaluate the sediment control function of river notches. Study results indicate that the contraction ratio of the notch has a significant influence on sediment control function, with high contraction ratios resulting in both high sediment-trapping and high reduction rates. River notches provide better sediment control during Type A events than Type B events. The sediment control mechanism of river notches is the result of multiple interactions among river flow, sediment transport, and riverbed variation. Analysis of these interactions supports the significant protection role of river notches on sediment control for disaster events.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11041003 and 60802087the Natural Science Foundation of Jiangsu Province under Grant No.BK2004119
文摘We present three families of exact matter-wave soliton solutions for an effective one-dimension twocomponent Bose-Einstein condensates(BECs) with tunable interactions,harmonic potential and gain or loss term. We investigate the dynamics of bright-bright solitons,bright-dark solitons and dark-dark solitons for the time-dependent expulsive harmonic trap potential,periodically modulated harmonic trap potential,and kinklike modulated harmonic trap potential.Through the Feshbach resonance,these dynamics can be realized in experiments by suitable control of time-dependent trap parameters,atomic interactions,and interaction with thermal cloud.
文摘Based on the field-theoretical bosonization we consider the spinful system consisting of two disconnected Luttinger liquids, which are coupled at time t = 0 through chiral density-density interactions. We show the wellknown spin-charge separation in this 1D system by means of bosonization and Bogoliubov transformation. To evaluate analytically the one-particle equal-time correlation functions, Cazalilla＇s methods are extended to spin-charge sectors. It is found that in long time limit the behavior of correlations does not coincide with that of equilibrium equal-time correlations of two coupled spinful Luttinger liquids. In order to compare with experimental results, the improved exponent that governs the power-law behavior of equal-time correlations of the non-equilibrium system is obtained at the end of this work.
