目的:研究益气健脾汤治疗脾气亏虚型糖耐量减低(IGT)患者的疗效以及对血糖波动指数的影响。方法:纳入2023年12月—2024年2月在黑龙江中医药大学附属第三医院内分泌(老年病)科门诊、住院部的60例IGT(脾气亏虚型)患者,按照随机数字表法分...目的:研究益气健脾汤治疗脾气亏虚型糖耐量减低(IGT)患者的疗效以及对血糖波动指数的影响。方法:纳入2023年12月—2024年2月在黑龙江中医药大学附属第三医院内分泌(老年病)科门诊、住院部的60例IGT(脾气亏虚型)患者,按照随机数字表法分为对照组和治疗组,每组30例。两组患者均给予饮食、宣教、运动等一般基础治疗。对照组在基础治疗的基础上给予阿卡波糖胶囊;治疗组在对照组基础上加用益气健脾汤联合治疗。两组患者均治疗6周。观察两组在治疗前后的空腹血糖(FPG)、2 h血糖(2 h PG)、糖化血红蛋白(HbA1c);甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL);血糖变异系数(GLUCV)、血糖标准差(GLUsd)、平均血糖值(GLUmean)、日内平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)及中医证候评分,并观察其疗程结束时的随访转归情况。结果:治疗6周后,两组患者的糖代谢指标、GLUsd、GLUmean、GLUCV、MAGE、中医证候评分均显著降低(P<0.05),治疗组的糖代谢指标、GLUsd、GLUCV、MAGE、中医证候评分显著低于对照组,差异有统计学意义(P<0.05)。结论:益气健脾汤能有效改善IGT患者症状,调节糖代谢,并能缩小血糖波动,延缓2型糖尿病发生发展,比单纯生活方式干预和阿卡波糖治疗持久有效。展开更多
目的:观察益气健脾汤治疗2型糖尿病胰岛素抵抗的临床疗效,阐述TyG指数对胰岛素抵抗指数的补充作用。方法:选取就诊于本院内分泌老年病科符合2型糖尿病胰岛素抵抗患者60例,随机分组,分为对照组30例和治疗组30例,对照组给予盐酸二甲双胍片...目的:观察益气健脾汤治疗2型糖尿病胰岛素抵抗的临床疗效,阐述TyG指数对胰岛素抵抗指数的补充作用。方法:选取就诊于本院内分泌老年病科符合2型糖尿病胰岛素抵抗患者60例,随机分组,分为对照组30例和治疗组30例,对照组给予盐酸二甲双胍片,治疗组在对照组治疗的基础上加用益气健脾汤,观察经过8周的治疗后,患者脾气亏虚证候的评分变化,以及与之相关的血糖指标、空腹胰岛素指标、血脂指标和胰岛素抵抗指标(TyG指数、HOMA-IR、TG/HDL-C)的具体改善情况。结果:脾气亏虚证候的评分方面,治疗后的脾气亏虚证候均低于治疗前(p p p p p p p p Objective: To observe the clinical efficacy of replenishing Qi to invigorate the spleen decoction in the treatment of insulin resistance in type 2 diabetes mellitus (spleen qi deficiency type) Methods: 60 patients with type 2 diabetes mellitus insulin resistance were selected from the Department of Endocrinology and Geriatrics of the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, randomly divided into the control group (n = 30 cases) and the treatment group (n = 30 cases), and the control group was given metformin hydrochloride tablets, and the treatment group was given replenishing Qi to invigorate the spleen decoction on the basis of the control group’s treatment, and the spleen Qi deficiency syndrome scores, blood glucose-related indexes, lipid-related indexes, and insulin resistance-related indexes (including TyG indexes) were observed after 8 weeks of treatment, etc. Results: In terms of spleen Qi deficiency symptoms scores, the scores post-treatment were lower than pre-treatment (p p p p p p p p < 0.05). Conclusion: Replenishing Qi to invigorate the spleen decoction could significantly improve glycolipid metabolism, insulin resistance and improve related TCM symptoms.展开更多
文摘目的:研究益气健脾汤治疗脾气亏虚型糖耐量减低(IGT)患者的疗效以及对血糖波动指数的影响。方法:纳入2023年12月—2024年2月在黑龙江中医药大学附属第三医院内分泌(老年病)科门诊、住院部的60例IGT(脾气亏虚型)患者,按照随机数字表法分为对照组和治疗组,每组30例。两组患者均给予饮食、宣教、运动等一般基础治疗。对照组在基础治疗的基础上给予阿卡波糖胶囊;治疗组在对照组基础上加用益气健脾汤联合治疗。两组患者均治疗6周。观察两组在治疗前后的空腹血糖(FPG)、2 h血糖(2 h PG)、糖化血红蛋白(HbA1c);甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL);血糖变异系数(GLUCV)、血糖标准差(GLUsd)、平均血糖值(GLUmean)、日内平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)及中医证候评分,并观察其疗程结束时的随访转归情况。结果:治疗6周后,两组患者的糖代谢指标、GLUsd、GLUmean、GLUCV、MAGE、中医证候评分均显著降低(P<0.05),治疗组的糖代谢指标、GLUsd、GLUCV、MAGE、中医证候评分显著低于对照组,差异有统计学意义(P<0.05)。结论:益气健脾汤能有效改善IGT患者症状,调节糖代谢,并能缩小血糖波动,延缓2型糖尿病发生发展,比单纯生活方式干预和阿卡波糖治疗持久有效。
文摘目的:观察益气健脾汤治疗2型糖尿病胰岛素抵抗的临床疗效,阐述TyG指数对胰岛素抵抗指数的补充作用。方法:选取就诊于本院内分泌老年病科符合2型糖尿病胰岛素抵抗患者60例,随机分组,分为对照组30例和治疗组30例,对照组给予盐酸二甲双胍片,治疗组在对照组治疗的基础上加用益气健脾汤,观察经过8周的治疗后,患者脾气亏虚证候的评分变化,以及与之相关的血糖指标、空腹胰岛素指标、血脂指标和胰岛素抵抗指标(TyG指数、HOMA-IR、TG/HDL-C)的具体改善情况。结果:脾气亏虚证候的评分方面,治疗后的脾气亏虚证候均低于治疗前(p p p p p p p p Objective: To observe the clinical efficacy of replenishing Qi to invigorate the spleen decoction in the treatment of insulin resistance in type 2 diabetes mellitus (spleen qi deficiency type) Methods: 60 patients with type 2 diabetes mellitus insulin resistance were selected from the Department of Endocrinology and Geriatrics of the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, randomly divided into the control group (n = 30 cases) and the treatment group (n = 30 cases), and the control group was given metformin hydrochloride tablets, and the treatment group was given replenishing Qi to invigorate the spleen decoction on the basis of the control group’s treatment, and the spleen Qi deficiency syndrome scores, blood glucose-related indexes, lipid-related indexes, and insulin resistance-related indexes (including TyG indexes) were observed after 8 weeks of treatment, etc. Results: In terms of spleen Qi deficiency symptoms scores, the scores post-treatment were lower than pre-treatment (p p p p p p p p < 0.05). Conclusion: Replenishing Qi to invigorate the spleen decoction could significantly improve glycolipid metabolism, insulin resistance and improve related TCM symptoms.
