We used a binomial regression model to determine the relationship between the percent of cerebrospinal fluid (CSF)-mononuclear white blood cells and symptom duration in children with proven enteroviral meningitis. The...We used a binomial regression model to determine the relationship between the percent of cerebrospinal fluid (CSF)-mononuclear white blood cells and symptom duration in children with proven enteroviral meningitis. The odds of a CSF white blood cell being mononuclear increased by 15.7%(95%confidence interval: -3.8%to 38.0%; P = .11) for each day of symptoms. Fifty percent of patients with symptoms of 1 day or less had predominance of mononuclear cells among CSF white blood cells. These findings suggest that factors other than symptom duration influence the composition and evolution of the CSF white blood cell response to enteroviral infection.展开更多
Background: It is widely believed that hydrostatic reduction of intussusception is less successful in children with prolonged symptoms prior to presentation. Aim: To prospectively evaluate success in relation to durat...Background: It is widely believed that hydrostatic reduction of intussusception is less successful in children with prolonged symptoms prior to presentation. Aim: To prospectively evaluate success in relation to duration of symptoms. Methods: Prospective study in which children, regardless of symptom duration, underwent an attempt at hydrostatic reduction. Results: Of 113 children presenting with intussusception, 16 had peritonitis and required immediate laparotomy. A hydrostatic reduction was attempted in 97 and was successful in 77 (79% ). There were 26 successful reductions with symptoms < 12 hours (81% ), 30 with symptoms for 12-24 hours (81% ), and 21 with symptoms >24 hours (75% ). Conclusion: The success rate with hydrostatic reduction was not significantly influenced by symptom duration.展开更多
Aims: To ascertain whether the severity of childhood asthma can be reliably assessed by simple clinical features, 94 newly diagnosed, school-aged asthmatic children were investigated. Methods: The study included paren...Aims: To ascertain whether the severity of childhood asthma can be reliably assessed by simple clinical features, 94 newly diagnosed, school-aged asthmatic children were investigated. Methods: The study included parental interviews, physical examination, skin prick tests, lung function studies, including a brief visual interpretation of the flow-volume curve, and a 6-min exercise challenge test on a treadmill, which was used as a reference. Results: Baseline lung function studies showed a concave-shaped flow-volume curve in 40 (43% ) patients, reduced maximal mid-expiratory flow (MMEF) in 25 (27% ) and a reduced ratio of forced expiratory volumein 1 s to forced vital capacity (FEV1/FVC) in 14 (15% ). The drop in peak expiratory flow (PEF) after exercise ranged from 0 to 79% of the baseline (mean 21.3% ) and exceeded 12.5% in 52 (55% ) patients. There was a small but significant correlation between the baseline FEV1/FVC and MMEF values and the response to exercise (r=-0.39 and -0.35; p=0.001, respectively), but when studied by linear regression analysis, the response to exercise was best predicted by the past symptom rate and a concave pattern in the pre-test maximal expiratory flow-volume curve. The values of traditional lung function tests or age, atopy, duration of symptoms or history of exercise-induced wheezing did not remain in the model. Conclusions: These results show that the severity of asthma in school-aged children can be predicted at the first visit based on the past rate of symptoms and a visual interpretation of the maximal expiratory flow-volume curve.展开更多
文摘We used a binomial regression model to determine the relationship between the percent of cerebrospinal fluid (CSF)-mononuclear white blood cells and symptom duration in children with proven enteroviral meningitis. The odds of a CSF white blood cell being mononuclear increased by 15.7%(95%confidence interval: -3.8%to 38.0%; P = .11) for each day of symptoms. Fifty percent of patients with symptoms of 1 day or less had predominance of mononuclear cells among CSF white blood cells. These findings suggest that factors other than symptom duration influence the composition and evolution of the CSF white blood cell response to enteroviral infection.
文摘Background: It is widely believed that hydrostatic reduction of intussusception is less successful in children with prolonged symptoms prior to presentation. Aim: To prospectively evaluate success in relation to duration of symptoms. Methods: Prospective study in which children, regardless of symptom duration, underwent an attempt at hydrostatic reduction. Results: Of 113 children presenting with intussusception, 16 had peritonitis and required immediate laparotomy. A hydrostatic reduction was attempted in 97 and was successful in 77 (79% ). There were 26 successful reductions with symptoms < 12 hours (81% ), 30 with symptoms for 12-24 hours (81% ), and 21 with symptoms >24 hours (75% ). Conclusion: The success rate with hydrostatic reduction was not significantly influenced by symptom duration.
文摘Aims: To ascertain whether the severity of childhood asthma can be reliably assessed by simple clinical features, 94 newly diagnosed, school-aged asthmatic children were investigated. Methods: The study included parental interviews, physical examination, skin prick tests, lung function studies, including a brief visual interpretation of the flow-volume curve, and a 6-min exercise challenge test on a treadmill, which was used as a reference. Results: Baseline lung function studies showed a concave-shaped flow-volume curve in 40 (43% ) patients, reduced maximal mid-expiratory flow (MMEF) in 25 (27% ) and a reduced ratio of forced expiratory volumein 1 s to forced vital capacity (FEV1/FVC) in 14 (15% ). The drop in peak expiratory flow (PEF) after exercise ranged from 0 to 79% of the baseline (mean 21.3% ) and exceeded 12.5% in 52 (55% ) patients. There was a small but significant correlation between the baseline FEV1/FVC and MMEF values and the response to exercise (r=-0.39 and -0.35; p=0.001, respectively), but when studied by linear regression analysis, the response to exercise was best predicted by the past symptom rate and a concave pattern in the pre-test maximal expiratory flow-volume curve. The values of traditional lung function tests or age, atopy, duration of symptoms or history of exercise-induced wheezing did not remain in the model. Conclusions: These results show that the severity of asthma in school-aged children can be predicted at the first visit based on the past rate of symptoms and a visual interpretation of the maximal expiratory flow-volume curve.
