A series of alditol derivatives were designed and synthesized with relatively high yield. On the basis of reaction between sorbitol and a series of substituted benzaldehyde in the presence of an acid catalyst, a serie...A series of alditol derivatives were designed and synthesized with relatively high yield. On the basis of reaction between sorbitol and a series of substituted benzaldehyde in the presence of an acid catalyst, a series of acetal derivatives were synthesized through free hydroxyl esterification. D-sorbitol acetal amido derivatives were prepared by reduction of nitryl and acylation of amino. D-sorbitol acetal carboxyl esterification derivatives were prepared through esterification and hydrolysis. By high performance liquid chromatography-mass spectra (HPLC-MS) and 1H nuclear magnetic resonance spectra (1H-NMR), 36 compounds prepared were identified. Among these derivatives prepared, 26 compounds have not been reported in the previous literatures.展开更多
Catalytic activities of H3PWrMo6O40/PAn in synthesizing benzaldehyde glycol acetal were reported. It has been demonstrated that H3PW6MorO40/PAn is an excellent catalyst. Various factors concerned in the reaction have ...Catalytic activities of H3PWrMo6O40/PAn in synthesizing benzaldehyde glycol acetal were reported. It has been demonstrated that H3PW6MorO40/PAn is an excellent catalyst. Various factors concerned in the reaction have been investigated. The optimum conditions have been found, that is, the molar ratio of benzaldehyde to glycol is 1/1.4, the mass ratio of the catalyst used to the reactants is 0.8%, and the reaction time is 45min. Under these conditions, the yield of benzaldehyde glycol acetal is 79.0%.展开更多
Based on the principle of biomimetic catalysis, β-cyclodextrin was applied to the acetalation reaction as a facile and efficient catalyst, and the synthesis was environmentally friendly with atomic economy. The influ...Based on the principle of biomimetic catalysis, β-cyclodextrin was applied to the acetalation reaction as a facile and efficient catalyst, and the synthesis was environmentally friendly with atomic economy. The influencing factors of the acetalation reaction e.g. the reaction time, the volume of water-carrying agent,the molar ratio of catalyst to benzaldehyde and the molar ratio of glycol to benzaldehyde had been studied.The yield of benzaldehyde glycol acetal would reach a maximum of 81.3% under the conditions approached.Six of other acetals were also synthesized. Moreover, a plausible reaction mechanism for the formation of acetal had been proposed.展开更多
基金National Natural Science Foundation of China (No 20306022)
文摘A series of alditol derivatives were designed and synthesized with relatively high yield. On the basis of reaction between sorbitol and a series of substituted benzaldehyde in the presence of an acid catalyst, a series of acetal derivatives were synthesized through free hydroxyl esterification. D-sorbitol acetal amido derivatives were prepared by reduction of nitryl and acylation of amino. D-sorbitol acetal carboxyl esterification derivatives were prepared through esterification and hydrolysis. By high performance liquid chromatography-mass spectra (HPLC-MS) and 1H nuclear magnetic resonance spectra (1H-NMR), 36 compounds prepared were identified. Among these derivatives prepared, 26 compounds have not been reported in the previous literatures.
基金Acknowledgements： This work was financially supported by the Natural Science Foundation of Hubei Province, China （No. 2005ABA053） and Hubei Key Laboratory of Bioanalytical Technique.
文摘Catalytic activities of H3PWrMo6O40/PAn in synthesizing benzaldehyde glycol acetal were reported. It has been demonstrated that H3PW6MorO40/PAn is an excellent catalyst. Various factors concerned in the reaction have been investigated. The optimum conditions have been found, that is, the molar ratio of benzaldehyde to glycol is 1/1.4, the mass ratio of the catalyst used to the reactants is 0.8%, and the reaction time is 45min. Under these conditions, the yield of benzaldehyde glycol acetal is 79.0%.
基金Supported by the National Natural Science Foundation of China(21376265)
文摘Based on the principle of biomimetic catalysis, β-cyclodextrin was applied to the acetalation reaction as a facile and efficient catalyst, and the synthesis was environmentally friendly with atomic economy. The influencing factors of the acetalation reaction e.g. the reaction time, the volume of water-carrying agent,the molar ratio of catalyst to benzaldehyde and the molar ratio of glycol to benzaldehyde had been studied.The yield of benzaldehyde glycol acetal would reach a maximum of 81.3% under the conditions approached.Six of other acetals were also synthesized. Moreover, a plausible reaction mechanism for the formation of acetal had been proposed.
