目的:使用中文版威斯康星结石生活质量问卷(Chinese version of Wisconsin stone quality of life questionnaire,C-WISQOL)评估肾结石患者的健康相关生活质量(health related quality of life,HRQOL),预测导致患者HRQOL降低的危险因素...目的:使用中文版威斯康星结石生活质量问卷(Chinese version of Wisconsin stone quality of life questionnaire,C-WISQOL)评估肾结石患者的健康相关生活质量(health related quality of life,HRQOL),预测导致患者HRQOL降低的危险因素。方法:自2020年7月至2021年6月前瞻性纳入就诊于北京大学人民医院的肾结石患者,入组标准为18~80岁有足够汉语基础的肾结石患者,排除标准包括体内留置输尿管支架管的患者以及患有恶性肿瘤、脓毒症等的患者。收集患者的人口统计学资料和肾结石相关的临床资料,记录患者填写的C-WISQOL问卷和健康调查简表(short form 36 health survey,SF-36)。C-WISQOL包括四个维度(domain,D):情感影响(D1)、社会影响(D2)、结石相关影响(D3)和活力影响(D4)。使用Cronbach’sα系数验证C-WISQOL的内部一致性,使用Spearman’s rho系数验证C-WISQOL和SF-36之间的校标关联效度,使用验证性因子分析验证C-WISQOL的结构效度、聚合效度和区分效度,使用单因素和多因素分析探讨导致肾结石患者HRQOL下降的危险因素。结果:共纳入307例肾结石患者,其中212例(69.1%)为男性,平均年龄(51.9±13.5)岁,平均体重指数(body mass index,BMI)(25.4±3.6)kg/m^(2),160例(52.1%)患者合并代谢综合征(metabolic syndrome,MS),202例(65.8%)有既往结石病史,217例(70.7%)有结石相关症状,53例(17.3%)为双侧肾结石,82例(26.7%)合并输尿管结石,199例(64.8%)伴有肾积水,78例(25.4%)伴有肾功能不全,168例(54.7%)合并泌尿系感染(urinary tract infection,UTI),肾结石的平均直径为(15.6±5.9)mm。所有患者C-WISQOL问卷的平均总分为(94.9±13.7)分,D1为(27.2±4.2)分,D2为(23.8±3.7)分,D3为(27.0±3.6)分,D4为(10.1±1.9)分。C-WISQOL问卷总分的Cronbach’sα系数为0.968,四个维度为0.860~0.898。C-WISQOL和SF-36问卷总分相关性的Spearman’s rho系数为0.564,维度间相关性为0.684~0.901,表明C-WISQOL有较好的内部一致性和校标关联效度。验证性因子分析显示,C-WISQOL具有较好的结构效度、聚合效度和区分效度。单因素分析显示,合并MS(OR=1.607,P<0.001)、有结石相关症状(OR=1.268,P<0.001)、双侧肾结石(OR=1.900,P<0.001)、合并输尿管结石(OR=1.018,P<0.001)、伴有肾积水(OR=1.685,P<0.001)、伴有UTI(OR=1.275,P<0.001)是肾结石患者HRQOL降低的危险因素;多因素分析表明,合并MS(OR=1.475,P<0.001)、合并输尿管结石(OR=1.546,P=0.043)、伴有UTI(OR=1.646,P=0.005)是肾结石患者HRQOL下降的独立危险因素。t检验结果显示,无MS、结石相关症状和UTI患者的C-WISQOL得分均显著高于合并相关危险因素组(P<0.001)。结论:C-WISQOL问卷可用于评估肾结石患者的HRQOL,具有较好的可靠性。合并MS、结石相关症状和UTI是肾结石患者HRQOL降低的独立危险因素。展开更多
Objective. Chronic constipation is characterized by difficult, infrequent, or seemingly incomplete bowel movements. The Patient Assessment of Constipation Quality of Life (PACQOL) questionnaire was developed to addres...Objective. Chronic constipation is characterized by difficult, infrequent, or seemingly incomplete bowel movements. The Patient Assessment of Constipation Quality of Life (PACQOL) questionnaire was developed to address the need for a standardized, patient-reported outcomes measure to evaluate constipation over time. Material and methods. Items for the PAC-QOL were generated from the literature, clinical experts, and patients. Following principal components and multitrait analyses, 28 items were retained forming four subscales (worries and concerns, physical discomfort, psychosocial discomfort, and satisfaction) and an overall scale. Validation studies were conducted in the United States, Europe, Canada, and Australia, to evaluate the internal consistency reliability (Cronbach’s alpha), reproducibility (Intraclass Correlation Coefficients (ICCs)), validity (analysis of variance models), and responsiveness (effect size) of the PAC-QOL scales. Results. The PAC-QOL scales were internally consistent (Cronbach’s alpha >0.80) and reproducible (ICCs > 0.70, except for the satisfaction subscale ICC = 0.66). PAC-QOL scale scores were significantly associated with abdominal pain (p < 0.001) and constipation severity (p < 0.05). Effect sizes in patients reporting improvements in constipation over a 6-week period were moderate to large, with subscale effect sizes ranging from 0.76 to 3.41 and the overall scale effect size = 1.77. Similar findings were observed in validation studies conducted in Europe, Canada, and Australia. Conclusions. The PAC-QOL is a brief but comprehensive assessment of the burden of constipation on patients’ everyday functioning and well-being. Multinational studies demonstrate that the PAC-QOL is internally consistent, reproducible, valid, and responsive to improvements over time.展开更多
Introduction-Being an easy-to-use (eight items) quality of life questionnaire specific to GERD, the Reflux- Qual Short form (RQS ) was developed for use in everyday practice. The purpose of this study was to assess ...Introduction-Being an easy-to-use (eight items) quality of life questionnaire specific to GERD, the Reflux- Qual Short form (RQS ) was developed for use in everyday practice. The purpose of this study was to assess the psychometric properties of the RQS . Methods and materials -The reliability of the RQS-was measured by the Cronbachs alpha coefficient and its clinical validity by comparing the RQS score for increasing clinical severity groups. The RQS discriminative power was compared with that of the SF- 12. Sensitivity to change over time was measured by calculating effect- sizes. Results-The reliability and validity of the questionnaire were assessed on a sample of 1195 patients. Its psychometric properties were very satisfactory: Cronbach alpha = 0.84;RQS score significantly reduced for the worst- affected patients; the discriminative power was up to 5 times higher when compared with the SF- 12. Sensitivity to change over time, evaluated with 362 patients, showed highly significant differences between groups with different levels of clinical progression (P = 0.0001). Conclusion- The RQS is a quality of life measurement instrument specific to GERD which is short, reliable, valid, and sensitive to within and between- subject differences.展开更多
Objective: Multiple sclerosis (MS) is a chronic progressive disease with multiple neurological impairments. The disease can also dramatically affect the health-related quality of life of patients. The objective of thi...Objective: Multiple sclerosis (MS) is a chronic progressive disease with multiple neurological impairments. The disease can also dramatically affect the health-related quality of life of patients. The objective of this study was to investigate the validation of the translated and cross-culturally adapted MSQOL- 54 in 183 Turkish MS patients. Methods: 183 adults classified as having definite MS patients were enrolled into the study. Patients were classified into four severity groups according to the expanded disability status scale (EDSS); group I(EDSS 0- 4), group II (EDSS 4.5- 5.5), group III (EDSS 6- 6.5) and group IV (EDSS 7- 8). MSQOL- 54 questionnaire were translated and culturally adapted into Turkish. Associations between age, gender, disease duration,EDSS score, marital status, education and health insurance and the MSQOL- 54 physical and mental health composite scores were determined. Results: The mean age of the 183 patients (138 female and 45 male) was 39 ± 10 years. The questionnaire was well accepted but small cultural adaptations were required. EDSS scores showed significant associations with the MSQOL- 54 physical and mental health composite scores. From the different EDSS groups only, the group I (EDSS 0- 4) score was significantly associated with the physical health composite as well as the disease duration showed significant correlation with the physical and mental composite scores. None of the other EDSS groups and the other parameters showed correlation with physical health composite or mental health composite. Conclusion: Assessment of quality of life of MS patients in addition to disease severity and disability level is important, because it provides unique information that is important to patients and to clinicians. A translation of an existing MS-targeted HRQOL measure from US English into Turkish was easily administered and well accepted in a Turkish MS sample.展开更多
文摘目的:使用中文版威斯康星结石生活质量问卷(Chinese version of Wisconsin stone quality of life questionnaire,C-WISQOL)评估肾结石患者的健康相关生活质量(health related quality of life,HRQOL),预测导致患者HRQOL降低的危险因素。方法:自2020年7月至2021年6月前瞻性纳入就诊于北京大学人民医院的肾结石患者,入组标准为18~80岁有足够汉语基础的肾结石患者,排除标准包括体内留置输尿管支架管的患者以及患有恶性肿瘤、脓毒症等的患者。收集患者的人口统计学资料和肾结石相关的临床资料,记录患者填写的C-WISQOL问卷和健康调查简表(short form 36 health survey,SF-36)。C-WISQOL包括四个维度(domain,D):情感影响(D1)、社会影响(D2)、结石相关影响(D3)和活力影响(D4)。使用Cronbach’sα系数验证C-WISQOL的内部一致性,使用Spearman’s rho系数验证C-WISQOL和SF-36之间的校标关联效度,使用验证性因子分析验证C-WISQOL的结构效度、聚合效度和区分效度,使用单因素和多因素分析探讨导致肾结石患者HRQOL下降的危险因素。结果:共纳入307例肾结石患者,其中212例(69.1%)为男性,平均年龄(51.9±13.5)岁,平均体重指数(body mass index,BMI)(25.4±3.6)kg/m^(2),160例(52.1%)患者合并代谢综合征(metabolic syndrome,MS),202例(65.8%)有既往结石病史,217例(70.7%)有结石相关症状,53例(17.3%)为双侧肾结石,82例(26.7%)合并输尿管结石,199例(64.8%)伴有肾积水,78例(25.4%)伴有肾功能不全,168例(54.7%)合并泌尿系感染(urinary tract infection,UTI),肾结石的平均直径为(15.6±5.9)mm。所有患者C-WISQOL问卷的平均总分为(94.9±13.7)分,D1为(27.2±4.2)分,D2为(23.8±3.7)分,D3为(27.0±3.6)分,D4为(10.1±1.9)分。C-WISQOL问卷总分的Cronbach’sα系数为0.968,四个维度为0.860~0.898。C-WISQOL和SF-36问卷总分相关性的Spearman’s rho系数为0.564,维度间相关性为0.684~0.901,表明C-WISQOL有较好的内部一致性和校标关联效度。验证性因子分析显示,C-WISQOL具有较好的结构效度、聚合效度和区分效度。单因素分析显示,合并MS(OR=1.607,P<0.001)、有结石相关症状(OR=1.268,P<0.001)、双侧肾结石(OR=1.900,P<0.001)、合并输尿管结石(OR=1.018,P<0.001)、伴有肾积水(OR=1.685,P<0.001)、伴有UTI(OR=1.275,P<0.001)是肾结石患者HRQOL降低的危险因素;多因素分析表明,合并MS(OR=1.475,P<0.001)、合并输尿管结石(OR=1.546,P=0.043)、伴有UTI(OR=1.646,P=0.005)是肾结石患者HRQOL下降的独立危险因素。t检验结果显示,无MS、结石相关症状和UTI患者的C-WISQOL得分均显著高于合并相关危险因素组(P<0.001)。结论:C-WISQOL问卷可用于评估肾结石患者的HRQOL,具有较好的可靠性。合并MS、结石相关症状和UTI是肾结石患者HRQOL降低的独立危险因素。
文摘Objective. Chronic constipation is characterized by difficult, infrequent, or seemingly incomplete bowel movements. The Patient Assessment of Constipation Quality of Life (PACQOL) questionnaire was developed to address the need for a standardized, patient-reported outcomes measure to evaluate constipation over time. Material and methods. Items for the PAC-QOL were generated from the literature, clinical experts, and patients. Following principal components and multitrait analyses, 28 items were retained forming four subscales (worries and concerns, physical discomfort, psychosocial discomfort, and satisfaction) and an overall scale. Validation studies were conducted in the United States, Europe, Canada, and Australia, to evaluate the internal consistency reliability (Cronbach’s alpha), reproducibility (Intraclass Correlation Coefficients (ICCs)), validity (analysis of variance models), and responsiveness (effect size) of the PAC-QOL scales. Results. The PAC-QOL scales were internally consistent (Cronbach’s alpha >0.80) and reproducible (ICCs > 0.70, except for the satisfaction subscale ICC = 0.66). PAC-QOL scale scores were significantly associated with abdominal pain (p < 0.001) and constipation severity (p < 0.05). Effect sizes in patients reporting improvements in constipation over a 6-week period were moderate to large, with subscale effect sizes ranging from 0.76 to 3.41 and the overall scale effect size = 1.77. Similar findings were observed in validation studies conducted in Europe, Canada, and Australia. Conclusions. The PAC-QOL is a brief but comprehensive assessment of the burden of constipation on patients’ everyday functioning and well-being. Multinational studies demonstrate that the PAC-QOL is internally consistent, reproducible, valid, and responsive to improvements over time.
文摘Introduction-Being an easy-to-use (eight items) quality of life questionnaire specific to GERD, the Reflux- Qual Short form (RQS ) was developed for use in everyday practice. The purpose of this study was to assess the psychometric properties of the RQS . Methods and materials -The reliability of the RQS-was measured by the Cronbachs alpha coefficient and its clinical validity by comparing the RQS score for increasing clinical severity groups. The RQS discriminative power was compared with that of the SF- 12. Sensitivity to change over time was measured by calculating effect- sizes. Results-The reliability and validity of the questionnaire were assessed on a sample of 1195 patients. Its psychometric properties were very satisfactory: Cronbach alpha = 0.84;RQS score significantly reduced for the worst- affected patients; the discriminative power was up to 5 times higher when compared with the SF- 12. Sensitivity to change over time, evaluated with 362 patients, showed highly significant differences between groups with different levels of clinical progression (P = 0.0001). Conclusion- The RQS is a quality of life measurement instrument specific to GERD which is short, reliable, valid, and sensitive to within and between- subject differences.
文摘Objective: Multiple sclerosis (MS) is a chronic progressive disease with multiple neurological impairments. The disease can also dramatically affect the health-related quality of life of patients. The objective of this study was to investigate the validation of the translated and cross-culturally adapted MSQOL- 54 in 183 Turkish MS patients. Methods: 183 adults classified as having definite MS patients were enrolled into the study. Patients were classified into four severity groups according to the expanded disability status scale (EDSS); group I(EDSS 0- 4), group II (EDSS 4.5- 5.5), group III (EDSS 6- 6.5) and group IV (EDSS 7- 8). MSQOL- 54 questionnaire were translated and culturally adapted into Turkish. Associations between age, gender, disease duration,EDSS score, marital status, education and health insurance and the MSQOL- 54 physical and mental health composite scores were determined. Results: The mean age of the 183 patients (138 female and 45 male) was 39 ± 10 years. The questionnaire was well accepted but small cultural adaptations were required. EDSS scores showed significant associations with the MSQOL- 54 physical and mental health composite scores. From the different EDSS groups only, the group I (EDSS 0- 4) score was significantly associated with the physical health composite as well as the disease duration showed significant correlation with the physical and mental composite scores. None of the other EDSS groups and the other parameters showed correlation with physical health composite or mental health composite. Conclusion: Assessment of quality of life of MS patients in addition to disease severity and disability level is important, because it provides unique information that is important to patients and to clinicians. A translation of an existing MS-targeted HRQOL measure from US English into Turkish was easily administered and well accepted in a Turkish MS sample.
