胰岛素抵抗是心血管病的独立危险因子。最近公布一项研究正常血糖的高血压病人，胰岛素抵抗发生率和胰岛素抵抗能否预警将来心血管发病率的研究结果（Am of Hypertension，2005，18：452）。该研究用HOMA-IR法测定高血压病人（m=106）...胰岛素抵抗是心血管病的独立危险因子。最近公布一项研究正常血糖的高血压病人，胰岛素抵抗发生率和胰岛素抵抗能否预警将来心血管发病率的研究结果（Am of Hypertension，2005，18：452）。该研究用HOMA-IR法测定高血压病人（m=106）及健康人（7＂／一18）的胰岛素抵抗。健康人年龄、体重（BMI）与病人相似，但空腹血糖、胰岛素、HOMA-IR较低。展开更多
Background: Since primary biliary cirrhosis (PBC) is usu- ally diagnosed in postmenopausal women with minor cholestasis, it has been que stioned whether PBC itself represents a further risk for osteoporosis. Aim: To a...Background: Since primary biliary cirrhosis (PBC) is usu- ally diagnosed in postmenopausal women with minor cholestasis, it has been que stioned whether PBC itself represents a further risk for osteoporosis. Aim: To a ssess the prevalence and risk factors for osteoporosis in an unselected series o f women with PBC. Patients and Methods: 142 women with PBC (age: 54.3±0.8 years ) and an age-matched control group. Osteoporosis was established by densitometr y (bone mineral density below -2.5 T-sc- ore). Age, duration and severity of PBC, body mass inde- x, menopausal status, histological stage and markers of bone turnover were ass essed. Results: Prevalence of osteoporosis was higher in PBC (32.4%) than in no rmal women (11. 1%)-(RR: 3.83, 95%CI: 2.59-5.67, P< 0.001). Osteoporosis was associated with older age, menopausal status, body mass index, longer PBC durat ion, advanced histological stage, high bilirubin and alkaline phosphatase, and l owalbumin and prothrombin index. Regression analysis identified older age, highe r Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis. Conclusions: Osteop orosis is more prevalent in women with PBC than in the general population. Age a nd severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.展开更多
We analyzed the genetic polymorphisms of vascular endothelial growth factor (VEGF) and its receptors [Fms-related tyrosine kinase-1, kinase insert domain receptor (KDR)] in Japanese patients with Kawasaki disease (KD)...We analyzed the genetic polymorphisms of vascular endothelial growth factor (VEGF) and its receptors [Fms-related tyrosine kinase-1, kinase insert domain receptor (KDR)] in Japanese patients with Kawasaki disease (KD) and normal control subjects to examine whether these genes would contribute to the KD occurrence and/or the development of coronary artery lesion (CAL) in KD.We found that the frequency of G allele of VEGF g.-634 G>C single-nucleotide polymorphism in the promoter region was significantly higher in KD patients with CAL than in those without CAL (p = 0.012) or control subjects (p = 0.021) because of a significantly higher frequency of the GG genotype in KD patients with CAL.In addition, the frequency of the A1 allele with 11 AC repeats of KDR g.+4422(AC)11-14 dinucleotide repeat polymorphism in intron 2 was significantly higher in KD patients with CAL than in those without CAL (p = 0.013) or control subjects (p = 0.040) as a result of a significantly higher frequency of the A1A1 genotype in KD with CAL patients.The multivariate analysis of clinical features and genotypes of the two polymorphisms showed that the A1A1 genotype of KDR g.+4422(AC)11-14 polymorphism was an independent risk factor for the development of CAL with the highest odds ratio among several clinical parameters (odds ratio 6.76; 95%confi-dence interval 1.05-43.48).Dual luciferase assay demonstrated that the A1 allele with KDR g.+4422(AC)11 repeats showed a weaker silencer function than the A2 allele with 12 AC repeats.These findings suggested that VEGF and its receptor, KDR, genes contributed to the development of CAL in KD patients.展开更多
文摘胰岛素抵抗是心血管病的独立危险因子。最近公布一项研究正常血糖的高血压病人，胰岛素抵抗发生率和胰岛素抵抗能否预警将来心血管发病率的研究结果（Am of Hypertension，2005，18：452）。该研究用HOMA-IR法测定高血压病人（m=106）及健康人（7＂／一18）的胰岛素抵抗。健康人年龄、体重（BMI）与病人相似，但空腹血糖、胰岛素、HOMA-IR较低。
文摘Background: Since primary biliary cirrhosis (PBC) is usu- ally diagnosed in postmenopausal women with minor cholestasis, it has been que stioned whether PBC itself represents a further risk for osteoporosis. Aim: To a ssess the prevalence and risk factors for osteoporosis in an unselected series o f women with PBC. Patients and Methods: 142 women with PBC (age: 54.3±0.8 years ) and an age-matched control group. Osteoporosis was established by densitometr y (bone mineral density below -2.5 T-sc- ore). Age, duration and severity of PBC, body mass inde- x, menopausal status, histological stage and markers of bone turnover were ass essed. Results: Prevalence of osteoporosis was higher in PBC (32.4%) than in no rmal women (11. 1%)-(RR: 3.83, 95%CI: 2.59-5.67, P< 0.001). Osteoporosis was associated with older age, menopausal status, body mass index, longer PBC durat ion, advanced histological stage, high bilirubin and alkaline phosphatase, and l owalbumin and prothrombin index. Regression analysis identified older age, highe r Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis. Conclusions: Osteop orosis is more prevalent in women with PBC than in the general population. Age a nd severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.
文摘We analyzed the genetic polymorphisms of vascular endothelial growth factor (VEGF) and its receptors [Fms-related tyrosine kinase-1, kinase insert domain receptor (KDR)] in Japanese patients with Kawasaki disease (KD) and normal control subjects to examine whether these genes would contribute to the KD occurrence and/or the development of coronary artery lesion (CAL) in KD.We found that the frequency of G allele of VEGF g.-634 G>C single-nucleotide polymorphism in the promoter region was significantly higher in KD patients with CAL than in those without CAL (p = 0.012) or control subjects (p = 0.021) because of a significantly higher frequency of the GG genotype in KD patients with CAL.In addition, the frequency of the A1 allele with 11 AC repeats of KDR g.+4422(AC)11-14 dinucleotide repeat polymorphism in intron 2 was significantly higher in KD patients with CAL than in those without CAL (p = 0.013) or control subjects (p = 0.040) as a result of a significantly higher frequency of the A1A1 genotype in KD with CAL patients.The multivariate analysis of clinical features and genotypes of the two polymorphisms showed that the A1A1 genotype of KDR g.+4422(AC)11-14 polymorphism was an independent risk factor for the development of CAL with the highest odds ratio among several clinical parameters (odds ratio 6.76; 95%confi-dence interval 1.05-43.48).Dual luciferase assay demonstrated that the A1 allele with KDR g.+4422(AC)11 repeats showed a weaker silencer function than the A2 allele with 12 AC repeats.These findings suggested that VEGF and its receptor, KDR, genes contributed to the development of CAL in KD patients.
