Imidazo[1,2-b]pyridazine, an intermediate of cefozopran was synthesized from 3,6-dichloro- pyridazine by ammonolysis to give 3-amino-6-chloropyridazine, which was subjected to condensation and cyclization followed by ...Imidazo[1,2-b]pyridazine, an intermediate of cefozopran was synthesized from 3,6-dichloro- pyridazine by ammonolysis to give 3-amino-6-chloropyridazine, which was subjected to condensation and cyclization followed by catalytic hydrogenolysis with an overall yield of 85%.展开更多
文摘Imidazo[1,2-b]pyridazine, an intermediate of cefozopran was synthesized from 3,6-dichloro- pyridazine by ammonolysis to give 3-amino-6-chloropyridazine, which was subjected to condensation and cyclization followed by catalytic hydrogenolysis with an overall yield of 85%.
