目的基于多普勒超声监测妊娠高血压(HDCP)母体-胎盘循环相关指标并建立预测模型和进行验证。方法选择120例HDCP孕妇(研究组),年龄20~44岁,平均年龄30.17岁;孕周11~13^(+6)周,平均孕周12.14周;孕次1~5次,平均孕次2.32次;产次0~4次,平均产...目的基于多普勒超声监测妊娠高血压(HDCP)母体-胎盘循环相关指标并建立预测模型和进行验证。方法选择120例HDCP孕妇(研究组),年龄20~44岁,平均年龄30.17岁;孕周11~13^(+6)周,平均孕周12.14周;孕次1~5次,平均孕次2.32次;产次0~4次,平均产次1.75次。根据HDCP严重程度,研究组可细分为妊娠期高血压组46例、子痫前期组40例和重度子痫前期组34例。选择同期60例健康孕妇(对照组),年龄20~42岁,平均年龄29.52岁;孕周11~13+6周,平均孕周12.25周;孕次1~4次,平均孕次2.40次;产次0~3次,平均产次1.71次。所有研究对象在孕11~13^(+6)周进行超声检查,记录子宫动脉和子宫螺旋动脉的血流参数。采用Logitic回归分析探究HDCP的独立危险因素并建立预测模型,采用受试者工作特性(ROC)曲线判定预测模型的预测价值。再次纳入200例孕妇对模型的预测价值进行验证。结果研究组子宫动脉血流博动指数(PI)、阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D)值和双侧切迹阳性率均显著高于对照组(1.43±0.38 vs 0.94±0.22、0.69±0.15 vs 0.46±0.08、4.46±0.84 vs 3.96±0.91、40.00%vs 23.33%),差异均有统计学意义(P<0.05)。随着HDCP严重程度增加,PI、RI、S/D值和双侧切迹阳性率升高。研究组和对照组子宫螺旋动脉的PI、RI、S、D、S/D值差异均无统计学意义(P>0.05),仅重度子痫前期组PI和RI显著高于对照组(0.64±0.12 vs0.53±0.09、0.44±0.10 vs 0.35±0.07。P<0.05)。多元Logistic回归分析表明子宫动脉PI、RI和子宫动脉双侧切迹是HDCP的早期独立预测因素(P<0.05),获得预测模型为Logit(P)=1.214×子宫动脉PI+0.984×子宫动脉RI+0.82×子宫动脉双侧切迹。该模型的ROC曲线下面积为0.889[95%可信区间(CI)0.853~0.926],灵敏度和特异度分别为84.17%、80.00%。该模型对验证集孕妇预测的ROC曲线下面积为0.860(95%CI 0.809~0.911),灵敏度和特异度分别为83.33%、89.77%。结论孕早期超声对母体-胎盘血流循环监测可以为HDCP提供预测指标并建立预测模型,该模型对HDCP的早期筛查具有较高的预测价值。展开更多
The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated indiv...The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated individual cultures at 20℃,25℃ and 30℃, and with algae Scenedesmus obliquus for their food. There were highly significant effects of both temperature and female type, independently and interactively, on the duration of juvenile and post-reproduction periods, and the number of eggs produced by the rotifer per life cycle. Among all the temperature-female type combinations, all the juvenile periods of FMF, and the post-reproduction periods of UMF and FMF at 20℃, were the longest, and the number of eggs produced by an UMF at 30℃ was the highest. There were highly significant effects of both temperature and female type on the duration of the reproduction period, but no clear correlation was observed between temperature and female type. The reproduction period of AF was longer than that of UMF and FMF. Only temperature influenced significantly the mean life-span of the three types of females. The duration of juvenile, reproduction and post-reproduction periods as well as the life-span of the three types of females were all reduced very significantly with rise of temperature, but the rates of reduction varied with female type. Among the three types of females, the number of eggs produced per life cycle by an UMF was the highest, and that of a FMF was the lowest. A significant relationship between the number of eggs produced per life cycle and temperature was observed only in the UMF.展开更多
文摘目的基于多普勒超声监测妊娠高血压(HDCP)母体-胎盘循环相关指标并建立预测模型和进行验证。方法选择120例HDCP孕妇(研究组),年龄20~44岁,平均年龄30.17岁;孕周11~13^(+6)周,平均孕周12.14周;孕次1~5次,平均孕次2.32次;产次0~4次,平均产次1.75次。根据HDCP严重程度,研究组可细分为妊娠期高血压组46例、子痫前期组40例和重度子痫前期组34例。选择同期60例健康孕妇(对照组),年龄20~42岁,平均年龄29.52岁;孕周11~13+6周,平均孕周12.25周;孕次1~4次,平均孕次2.40次;产次0~3次,平均产次1.71次。所有研究对象在孕11~13^(+6)周进行超声检查,记录子宫动脉和子宫螺旋动脉的血流参数。采用Logitic回归分析探究HDCP的独立危险因素并建立预测模型,采用受试者工作特性(ROC)曲线判定预测模型的预测价值。再次纳入200例孕妇对模型的预测价值进行验证。结果研究组子宫动脉血流博动指数(PI)、阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D)值和双侧切迹阳性率均显著高于对照组(1.43±0.38 vs 0.94±0.22、0.69±0.15 vs 0.46±0.08、4.46±0.84 vs 3.96±0.91、40.00%vs 23.33%),差异均有统计学意义(P<0.05)。随着HDCP严重程度增加,PI、RI、S/D值和双侧切迹阳性率升高。研究组和对照组子宫螺旋动脉的PI、RI、S、D、S/D值差异均无统计学意义(P>0.05),仅重度子痫前期组PI和RI显著高于对照组(0.64±0.12 vs0.53±0.09、0.44±0.10 vs 0.35±0.07。P<0.05)。多元Logistic回归分析表明子宫动脉PI、RI和子宫动脉双侧切迹是HDCP的早期独立预测因素(P<0.05),获得预测模型为Logit(P)=1.214×子宫动脉PI+0.984×子宫动脉RI+0.82×子宫动脉双侧切迹。该模型的ROC曲线下面积为0.889[95%可信区间(CI)0.853~0.926],灵敏度和特异度分别为84.17%、80.00%。该模型对验证集孕妇预测的ROC曲线下面积为0.860(95%CI 0.809~0.911),灵敏度和特异度分别为83.33%、89.77%。结论孕早期超声对母体-胎盘血流循环监测可以为HDCP提供预测指标并建立预测模型,该模型对HDCP的早期筛查具有较高的预测价值。
基金NSFC (No .3 9870 15 8) ,NaturalScienceFoundationofAnhuiProvince (No .10 0 3 3 0 No .0 42 416)andtheExcellentYouthFoundation (No .0 40 43 0 5 0 )
文摘The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated individual cultures at 20℃,25℃ and 30℃, and with algae Scenedesmus obliquus for their food. There were highly significant effects of both temperature and female type, independently and interactively, on the duration of juvenile and post-reproduction periods, and the number of eggs produced by the rotifer per life cycle. Among all the temperature-female type combinations, all the juvenile periods of FMF, and the post-reproduction periods of UMF and FMF at 20℃, were the longest, and the number of eggs produced by an UMF at 30℃ was the highest. There were highly significant effects of both temperature and female type on the duration of the reproduction period, but no clear correlation was observed between temperature and female type. The reproduction period of AF was longer than that of UMF and FMF. Only temperature influenced significantly the mean life-span of the three types of females. The duration of juvenile, reproduction and post-reproduction periods as well as the life-span of the three types of females were all reduced very significantly with rise of temperature, but the rates of reduction varied with female type. Among the three types of females, the number of eggs produced per life cycle by an UMF was the highest, and that of a FMF was the lowest. A significant relationship between the number of eggs produced per life cycle and temperature was observed only in the UMF.
