本文于2022年6月发表于《Blood》杂志,发表后引起业内广泛关注,在Blood Podcast(Episode 22 Season 3,https://ashpublications.org/blood/pages/blood_podcast)和《JTH》杂志What The Neighbors Say栏目(J Thromb Haemost,2022,20:1036...本文于2022年6月发表于《Blood》杂志,发表后引起业内广泛关注,在Blood Podcast(Episode 22 Season 3,https://ashpublications.org/blood/pages/blood_podcast)和《JTH》杂志What The Neighbors Say栏目(J Thromb Haemost,2022,20:1036)重点介绍。本文文章题录为:Zeng JW,Shu ZM,Liang Q,Zhang J,Wu WM,Wang XF,Zhou AW.Structural basis of Von Willebrand Factor multimerization and tubular storage,Blood,2022 Jun 2;139(22):3314⁃3324.该研究首次通过单颗粒冷冻电镜技术获得了高分辨率的由VWF N端结构域(D1D2D’D3结构域)形成的管状多聚体结构,揭示了VWF多聚体组装和Weibel⁃Palade小体储存的结构机制。该理论不仅解开了VWF多聚体组装和储存机制的谜团,也为2A型血管性血友病(VWD)患者基因治疗新策略奠定了理论基础。经通信作者许可,再次通过佳文解读的方式来阐述这一发现。展开更多
意图识别和槽填充的联合模型将口语语言理解(Spoken Language Understanding,SLU)提升到了一个新的水平,但是现有模型通过话语上下文信息判断位置信息,缺少对槽信息标签之间位置信息的考虑,导致模型在槽位提取过程中容易发生边界错误,...意图识别和槽填充的联合模型将口语语言理解(Spoken Language Understanding,SLU)提升到了一个新的水平,但是现有模型通过话语上下文信息判断位置信息,缺少对槽信息标签之间位置信息的考虑,导致模型在槽位提取过程中容易发生边界错误,进而影响最终槽位提取表现。此外,在槽信息提取任务中,槽指称项(Slotmen-tions)可能与正常表述话语并没有区别,特别是电影名字、歌曲名字等,模型容易受到槽指称项话语的干扰,因而无法在槽位提取中正确识别槽位边界。该文提出了一种面向口语语言理解的结合边界预测和动态模板的槽填充(Boundary-prediction and Dynamic-template Slot Filling,BDSF)模型。该模型提供了一种联合预测边界信息的辅助任务,将位置信息引入到槽信息填充中,同时利用动态模板机制对话语句式建模,能够让模型聚焦于话语中的非槽指称项部分,避免了模型被槽指称项干扰,增强模型区分槽位边界的能力。在公共基准语料库SMP-ECDT和CAIS上的实验结果表明,该模型优于对比模型,特别是能够为槽标签预测模型提供准确的位置信息。展开更多
A theoretical method for selecting strip rolling mill type that considered shape control ability was established using the figure alteration range that was worked by the alteration track of vector expressing strip'...A theoretical method for selecting strip rolling mill type that considered shape control ability was established using the figure alteration range that was worked by the alteration track of vector expressing strip's cross section (crown) to express the shape control ability of rolling mill. With the mathematical models and simulation software that were developed by the authors' own models, four types of mills were aimed, including HCM (6-high middle rolls shift type HC (high crown) -mill), HCMW (6-high middle rolls and work rolls shift type HC-mill), UCM (6-high middle rolls shift type HC-mill with middle roll bender) and UCMW (6-high middle rolls and work rolls shift type HC-mill with middle roll bender), and the shape and crown control ability of every mill type was analyzed and compared. An appropriate arrangement mode of tandem mill was brought forward. The results show that UCMW mill is a perfect choice for controlling shape and crown, and the area of control characteristics curve of UCMW (or UCM) is twice than that of HCM, but UCM mill is also a good choice for its simple frame. In other word, the shape and crown controlling ability of UCMW mill is better than that of UCM mill, but the frame of UCM mill is simpler than that of UCMW mill. As for the final type of mill, should be synthetically decided by thinking over fund and equipment technology.展开更多
In order to study the water-inrush mechanism of concealed collapse pillars from the mechanical view, a mechanical model for water-inrush of collapse pillars has been established based on thick plate theory of elastic ...In order to study the water-inrush mechanism of concealed collapse pillars from the mechanical view, a mechanical model for water-inrush of collapse pillars has been established based on thick plate theory of elastic mechanics in this paper.By solving this model the deformation of water-resistant rock strata under the action of water pressure and the expression of critical water pressure for collapse pillar waterinrush have been obtained The research results indicate that：the boundary conditions and strength of water-resistant strata play important roles in influencing water-inrush of collapse pillars.The critical water-inrush pressure is determined by both relative thickness and absolute thickness of water-resistant strata.展开更多
Hoffa fracture is an uncommon injury. In the literature, lateral condylar Hoffa fracture is mentioned as a more common injury pattern than medial condylar Hoffa fracture. The mechanism of injury and method of treatmen...Hoffa fracture is an uncommon injury. In the literature, lateral condylar Hoffa fracture is mentioned as a more common injury pattern than medial condylar Hoffa fracture. The mechanism of injury and method of treatment is not very well described in the literature. We are present- ing a rare case of comrninuted medial condylar Hoffa frac- ture with ipsilateral patellar fracture. The mechanism of in-jury has not been described in the literature. Lag screw fixation, which is the most acceptable method of treatment, is not possible due to comminution. We explain the pos- sible mechanism of injury and fix the fracture with L-but- tress plate.展开更多
文摘本文于2022年6月发表于《Blood》杂志,发表后引起业内广泛关注,在Blood Podcast(Episode 22 Season 3,https://ashpublications.org/blood/pages/blood_podcast)和《JTH》杂志What The Neighbors Say栏目(J Thromb Haemost,2022,20:1036)重点介绍。本文文章题录为:Zeng JW,Shu ZM,Liang Q,Zhang J,Wu WM,Wang XF,Zhou AW.Structural basis of Von Willebrand Factor multimerization and tubular storage,Blood,2022 Jun 2;139(22):3314⁃3324.该研究首次通过单颗粒冷冻电镜技术获得了高分辨率的由VWF N端结构域(D1D2D’D3结构域)形成的管状多聚体结构,揭示了VWF多聚体组装和Weibel⁃Palade小体储存的结构机制。该理论不仅解开了VWF多聚体组装和储存机制的谜团,也为2A型血管性血友病(VWD)患者基因治疗新策略奠定了理论基础。经通信作者许可,再次通过佳文解读的方式来阐述这一发现。
文摘意图识别和槽填充的联合模型将口语语言理解(Spoken Language Understanding,SLU)提升到了一个新的水平,但是现有模型通过话语上下文信息判断位置信息,缺少对槽信息标签之间位置信息的考虑,导致模型在槽位提取过程中容易发生边界错误,进而影响最终槽位提取表现。此外,在槽信息提取任务中,槽指称项(Slotmen-tions)可能与正常表述话语并没有区别,特别是电影名字、歌曲名字等,模型容易受到槽指称项话语的干扰,因而无法在槽位提取中正确识别槽位边界。该文提出了一种面向口语语言理解的结合边界预测和动态模板的槽填充(Boundary-prediction and Dynamic-template Slot Filling,BDSF)模型。该模型提供了一种联合预测边界信息的辅助任务,将位置信息引入到槽信息填充中,同时利用动态模板机制对话语句式建模,能够让模型聚焦于话语中的非槽指称项部分,避免了模型被槽指称项干扰,增强模型区分槽位边界的能力。在公共基准语料库SMP-ECDT和CAIS上的实验结果表明,该模型优于对比模型,特别是能够为槽标签预测模型提供准确的位置信息。
基金Project (50374058) supported by the National Natural Science Foundation of China and Shanghai Baosteel Group Co.
文摘A theoretical method for selecting strip rolling mill type that considered shape control ability was established using the figure alteration range that was worked by the alteration track of vector expressing strip's cross section (crown) to express the shape control ability of rolling mill. With the mathematical models and simulation software that were developed by the authors' own models, four types of mills were aimed, including HCM (6-high middle rolls shift type HC (high crown) -mill), HCMW (6-high middle rolls and work rolls shift type HC-mill), UCM (6-high middle rolls shift type HC-mill with middle roll bender) and UCMW (6-high middle rolls and work rolls shift type HC-mill with middle roll bender), and the shape and crown control ability of every mill type was analyzed and compared. An appropriate arrangement mode of tandem mill was brought forward. The results show that UCMW mill is a perfect choice for controlling shape and crown, and the area of control characteristics curve of UCMW (or UCM) is twice than that of HCM, but UCM mill is also a good choice for its simple frame. In other word, the shape and crown controlling ability of UCMW mill is better than that of UCM mill, but the frame of UCM mill is simpler than that of UCMW mill. As for the final type of mill, should be synthetically decided by thinking over fund and equipment technology.
基金Projects are supported by the National Basic Research Program of China(No.2007CB209400)the National Natural Science Foundation of China(Nos.50974115,50904065 and 50974107)the 111 Project(No.B07028).
文摘In order to study the water-inrush mechanism of concealed collapse pillars from the mechanical view, a mechanical model for water-inrush of collapse pillars has been established based on thick plate theory of elastic mechanics in this paper.By solving this model the deformation of water-resistant rock strata under the action of water pressure and the expression of critical water pressure for collapse pillar waterinrush have been obtained The research results indicate that：the boundary conditions and strength of water-resistant strata play important roles in influencing water-inrush of collapse pillars.The critical water-inrush pressure is determined by both relative thickness and absolute thickness of water-resistant strata.
文摘Hoffa fracture is an uncommon injury. In the literature, lateral condylar Hoffa fracture is mentioned as a more common injury pattern than medial condylar Hoffa fracture. The mechanism of injury and method of treatment is not very well described in the literature. We are present- ing a rare case of comrninuted medial condylar Hoffa frac- ture with ipsilateral patellar fracture. The mechanism of in-jury has not been described in the literature. Lag screw fixation, which is the most acceptable method of treatment, is not possible due to comminution. We explain the pos- sible mechanism of injury and fix the fracture with L-but- tress plate.
