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氯化两面针碱潜在靶标极光激酶A在结直肠癌组织中的临床病理价值
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作者 姚锦联 熊丹丹 +9 位作者 谢富香 梁子谦 唐宇星 温佳颖 何融泉 黄志广 韦京妤 方业颖 陈罡 刘丽敏 《医学理论与实践》 2024年第15期2533-2538,共6页
目的:探究极光激酶A(AURKA)在结直肠癌中的临床病理价值。方法:通过分子对接探究AURKA与氯化两面针碱(NC)结合强度。结合免疫组织化学数据和全球高通量数据集分析结直肠癌中AURKA蛋白和mRNA表达水平,计算标准平均偏差(SMD)和总结受试者... 目的:探究极光激酶A(AURKA)在结直肠癌中的临床病理价值。方法:通过分子对接探究AURKA与氯化两面针碱(NC)结合强度。结合免疫组织化学数据和全球高通量数据集分析结直肠癌中AURKA蛋白和mRNA表达水平,计算标准平均偏差(SMD)和总结受试者操作特征(sROC),以探讨AURKA在结直肠癌和放疗抵抗中综合表达水平,利用CRISPR敲除筛选以及体外敲低AURKA后的基因芯片数据,分析AURKA促癌潜在分子机制。结果:AURKA与NC结合能为-10kcal/mol, AURKA蛋白在结直肠癌中表达上调,mRNA在2 511个结直肠癌样本和41个放疗抵抗样本中表达上调,显示结直肠癌中SMD为2.07,放疗抵抗中SMD为0.73。敲低AURKA在结直肠癌LS123细胞系中生长抑制最显著。体外敲低AURKA mRNA后基因主要富集于肌动蛋白、线粒体膜、细胞周期检查点通路。结论:在结直肠癌中,AURKA是潜在的NC和放疗增敏靶点,下调AURKA有望用于临床治疗。 展开更多
关键词 结直肠癌 氯化两面针碱 极光激酶A 标准平均偏差 总结受试者操作特征 放疗
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Fluidization Characteristics of Silicon Particles with a Wide Size Distribution 被引量:2
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作者 罗务习 梁卫华 +1 位作者 张国良 王金福 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第6期851-856,共6页
Fluidization characteristics of silicon particle system are studied by the pressure fluctuation method.The existence of fine particles in the system can improve fluidization. Silicon particles with a wide size distrib... Fluidization characteristics of silicon particle system are studied by the pressure fluctuation method.The existence of fine particles in the system can improve fluidization. Silicon particles with a wide size distribution,preferably with some fines, behave as Group A particles according to Geldart classification, although the system belongs to Group B actually. The system is also approved to be suitable for organochlorosilane monomer production using a fluidized bed reactor. Experimental data obtained in this work are important for the design and operation of commercial fluidized bed reactors for the production of organochlorosilane monomers. 展开更多
关键词 silicon particle system wide size distribution pressure fluctuation average frequency standard deviation
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Experimental Analysis of Sediment Deposition Due to the Effect of an Upstream Reservoir Backwater
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作者 Issa E. Issa Nadhir Al-Ansari +1 位作者 Moayad Khaleel Sven Knutsson 《Journal of Civil Engineering and Architecture》 2014年第9期1185-1193,共9页
The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and ... The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and 0.70 m deep channel. A block was built at the end of the channel to work as a dam to impound water. The channel was supplied with drainage pipes on both sides to release water out in a manner similar to what happens in reservoirs. The bed of the channel was filled with sand of 0.80 mm median sieve diameter and 0.72 geometric standard deviation. The slope was 0.0093 for all experiments. Two sizes of sand were used representing the sediment. The median diameter and geometric standard deviation of the first were 0.365 mm and 0.46 mm, respectively. The second sample had 0.65 mm median diameter and 0.67 standard deviation. A total of 70 experiments were conducted in two groups to examine effects of sediment transport rate, particle size of sediment and flow velocity on aggradation characteristics. The results showed that there was a strong linear direct relationship between aggradation elements (length and depth) with the rate of sediment transport. Groups of dimensionless parameters affecting the aggradation characteristics were used to develop empirical equations to predict the length, maximum depth of aggradation and predict transient bed profile. The results of empirical approach were compared with the measurement data and previous numerical method. The results indicated that the percentage error was 19% to 31% for length of aggradation and -21% to 26% for maximum depth of aggradation. The results also showed that the sediment materials were deposited closer to the body of the dam when the released water from the dam is higher than the inflow. 展开更多
关键词 AGGRADATION alluvial channel reservoir sedimentation sediment deposition.
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Effect of Gender and Developmental Periods on Aggression Tendencies of Turkish Students: A Study of Meta-analysis
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作者 Mehmet Beyazsacli 《Sociology Study》 2016年第2期134-139,共6页
With this study, it is aimed at examining the effect of the gender and developmental phases on the aggression tendencies of the Turkish students. In this context, the meta-analysis of the studies existing in the liter... With this study, it is aimed at examining the effect of the gender and developmental phases on the aggression tendencies of the Turkish students. In this context, the meta-analysis of the studies existing in the literature and covering the Turkish students has been conducted. The examined researches to be included in the analysis have been identified in accordance with certain criteria. As criteria, the following conditions have been sought: inclusion of the studies published between 2004 and 2015, inclusion of child, adolescent, and young adult students in the sample, giving the validity and reliability studies of the measuring tools, the studies being obtained from sources of the published theses and articles; and in the data, the arithmetic mean, standard deviation, and sample size being given. In the research, gender has been found effective on the general aggression scores, at significant level (EDavg = .280, p 〈 .01), and against males at medium level. The general aggression scores from the moderator variables have been found to have a medium level of effect (EDavg = .402, p 〈 .01) on the childhood period, and to have the greatest effect against males. 展开更多
关键词 TURKISH META-ANALYSIS AGGRESSION CHILD ADOLESCENT young adult student
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