Calcium-release-activated calcium(CARC)channels are one of the major pathways of calcium entry in non-excitable cells.Despite a decade or two of research,its regulatory mechanism is not yet thoroughly understood.The s...Calcium-release-activated calcium(CARC)channels are one of the major pathways of calcium entry in non-excitable cells.Despite a decade or two of research,its regulatory mechanism is not yet thoroughly understood.The slow progress is due to the complexity of its pores(i.e.,Orai)on one hand and the difficulty in capturing its regulatory complex on the other hand.As a result,possible gating mechanisms have often been speculated by exploring the structure and properties of constitutive open mutants.However,there is much debate about how they can truly reflect the gating of CRAC channels under physiological conditions.In the present study,we combined molecular dynamics simulations with free energy calculations to study three dOrai mutants(G170P,H206A,and P288A),and further calculated their current-voltage curves.Results show that these constructs adopt different approaches to maintain their conductive state.Meanwhile they have unique pore structures and distinctive rectification properties and ion selectivity for cations compared to wild-type pores.We conclude that although the mutants may partially capture the gating motion characteristics of wild-type pores,the information obtained from these mutants is likely not a true reflection of CRAC channel gating under physiological conditions.展开更多
Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking ...Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, the PCC （Pearson＇s Correlation Coefficient） was proposed and applied as： discarding criteria methodology, dynamic power management solution, environment observer method which selects automatically only the regions-of-interest; and taking place in the obstacle avoidance context, as a method for collision risk estimation for vehicles in dynamic and unknown environments. Even if the PCC is a great tool to help the autonomous or semi-autonomous navigation, distortions in the imaging system, pixel noise, slight variations in the object＇s position relative to the camera, and other factors produce a false PCC threshold. Whereas there are homogeneous regions in the image, in order to obtain a more realistic Pearson＇s correlation, we propose to use some prior known environment information.展开更多
Objective:The main purpose of this work was to present a Z-phantom manufactured in home (at National Cancer Institute Cairo University) and it's use in a simple way to check the accuracy of the computed-tomography...Objective:The main purpose of this work was to present a Z-phantom manufactured in home (at National Cancer Institute Cairo University) and it's use in a simple way to check the accuracy of the computed-tomography (CT) table movement and CT gantry tilt, also the other general quality control (QC) tests of the CT simulator used at radiotherapy department. Methods:The laser phantom was used to check the external mobile laser position accuracy, for internal image indicator laser beam (light field) the coincidence between light field and radiation exposure at CT simulator was checked using X-Omat ready back film. The Z-phantom was used to check the slice thickness and the table movement and so the gantry tilts. The image quality testes were checked using the CT image quality phantom. TLDs were inserted to the Cicil phantom at the center of each scan volume to estimate the patient dose. Results:The results showed that the difference in the fixed distance between the external mobile laser and the internal image indicator laser beam was less than ± 1 mm; the orientation of the two mobile lateral lasers was coincident. The mechanical movement and the image quality of the CT simulator were within the tolerances and the results were 0.5 mm, 0.2% and 0.6% for the mechanical movement, noise and image uniformity respectively. Conclusion:A CT simulator with a good performance is important for the radiotherapy treatment planning specially with the extremely revolution in radiotherapy techniques, also a rotten quality assurance (QA) program is very important to be shore about the reproducibility of the CT performance. The use of Z-phantom to check the gantry tilt and the table movement is faster than the use of ready back films in these tests.展开更多
The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is t...The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is to improve the efficiency fuel of diesel engine using fuel filter. The method used for the research is testing the most efficient fuel filters made of coil wire coil winding 5,000, the three distinguished from the coil core diameter of 44.5, 28.5 and 17.5 mm in diesel engine. The performance test was conducted from 1,100 rpm to 1,700 rpm, the throttle opening of 30%-60%. The first testing was done by creating a constant speed 1,500 rpm and throttle opening varies from 30% to 60%, further testing is done by varying the rpm start from 1,100 rpm to 1,700 rpm to make constant valve 40% and 60%.展开更多
The layout features of unit shafting and their effects on vibration, as well as evaluation criteria, were introduced for a 1000-MW ultra-supercritical turbine-generator unit with Simens technology. Based on vibration ...The layout features of unit shafting and their effects on vibration, as well as evaluation criteria, were introduced for a 1000-MW ultra-supercritical turbine-generator unit with Simens technology. Based on vibration diagnosis and treatment for more than 10 units, some typical vibration faults were summarized, such as the vibration fluctuation of the high pressure (HP) rotor, abnormal vibration increases of the No.3 bearing pedestal and large vibration of the exciter rotor during its critical speed range. The vibration characteristics and the causes of faults and countermeasures were analyzed. Three applications for further illustration were given. The vibration fault identification method, control measures, and applications can provide a reference for vibration diagnoses and treatment of same type units.展开更多
This paper presents a new thermal computer, which is driven by heat current and not electricity current. The basic thermal logic gate, such as thermal logic AND gate. thermal logic NOT gate, thermal logic OR gate are ...This paper presents a new thermal computer, which is driven by heat current and not electricity current. The basic thermal logic gate, such as thermal logic AND gate. thermal logic NOT gate, thermal logic OR gate are discussed in this paper. Compared with electronic computer, it can work at some special environment, such as high temperature and high pressure Consequently, the heat computer is not only a new special computer, but also a lot of new heat computation cell or device could be invented in the future. The thermal computer and control device are a new thermal energy machines powered by heat energy, it is significant for the environmental protection, energy usage and developed and new discipline development.展开更多
This paper discusses the prospect of high efficiency motors based on usage in industrial sectors. In fact, energy consumption is globally classified into the industrial sector, transport system, residential and commer...This paper discusses the prospect of high efficiency motors based on usage in industrial sectors. In fact, energy consumption is globally classified into the industrial sector, transport system, residential and commercial building, agriculture and others sectors. In all the sectors, energy is eventually consumed by electrical appliances and equipments and the industrial sector accounts for the largest share of the overall energy consumption. The study concerns to identify the energy consumption using qualitative method. The main emphasis was given to comparison of the motor with high efficiency motors （HEMs） and traditional standard motors to investigate energy savings. According to the study, industrial sector has up to 25% of electrical energy conservation potential. Almost 70%-75% of the electrical energy consumption in industry is on account of use of electrical motors being used by pumps, fans, compressors and other motor driven system. Therefore, the potential for energy conservation through electric motors is quite high. Using high efficiency motors （HEMs） can thus reduce the losses and hence save vital energy costs. This paper will provide a contribution to electrical motors arena and will be a systematic knowledge base for researchers in this field.展开更多
In this study, an electro-mechanical valve （EMV） system for the intake valve ofa fottr stroke, single cylinder, overhead valve and spark ignition （SI） engine was designed and constructed. An engine with the EMV sy...In this study, an electro-mechanical valve （EMV） system for the intake valve ofa fottr stroke, single cylinder, overhead valve and spark ignition （SI） engine was designed and constructed. An engine with the EMV system and a standard engine were tested to observe the effects of the EMV on engine performance and emissions at different speeds under full load. The EMV engine showed improved engine power, engine torque and break specific fuel consumption （BSFC）. A 66% decrease in CO emissions was also obtained with the EMV system, but hydrocarbons （HC） and NOx emissions increased by 12% and 13% respectively.展开更多
We herein report the effective performance enhancement of the pentacene-based organic thin film transistors with silicon di- oxide dielectric by inserting a thin metal phthalocyanines interlayer between Au source/drai...We herein report the effective performance enhancement of the pentacene-based organic thin film transistors with silicon di- oxide dielectric by inserting a thin metal phthalocyanines interlayer between Au source/drain electrodes and the pentacene active layer. The threshold voltage decreased remarkably from ca. -20 V to a few volts （below -7.6 V） while the mobility in- creased 1.5-3 times after the insertion of the interlayer of only ca. 2 nm, which could be attributed to the reduction of the car- tier injection barrier. The results suggest a simple and effective way to achieve low-threshold-voltage pentacene-based organic thin film transistors with high mobility on silicon dioxide dielectric.展开更多
基金supported by the National Natural Science Foundation of China(No.21773115,No.21833002,No.11771435,and No.22073110)the Natural Science Foundation of Jiangsu Province(No.BK20190056)the Fundamental Research Funds for the Central Universities(021514380018)。
文摘Calcium-release-activated calcium(CARC)channels are one of the major pathways of calcium entry in non-excitable cells.Despite a decade or two of research,its regulatory mechanism is not yet thoroughly understood.The slow progress is due to the complexity of its pores(i.e.,Orai)on one hand and the difficulty in capturing its regulatory complex on the other hand.As a result,possible gating mechanisms have often been speculated by exploring the structure and properties of constitutive open mutants.However,there is much debate about how they can truly reflect the gating of CRAC channels under physiological conditions.In the present study,we combined molecular dynamics simulations with free energy calculations to study three dOrai mutants(G170P,H206A,and P288A),and further calculated their current-voltage curves.Results show that these constructs adopt different approaches to maintain their conductive state.Meanwhile they have unique pore structures and distinctive rectification properties and ion selectivity for cations compared to wild-type pores.We conclude that although the mutants may partially capture the gating motion characteristics of wild-type pores,the information obtained from these mutants is likely not a true reflection of CRAC channel gating under physiological conditions.
文摘Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, the PCC （Pearson＇s Correlation Coefficient） was proposed and applied as： discarding criteria methodology, dynamic power management solution, environment observer method which selects automatically only the regions-of-interest; and taking place in the obstacle avoidance context, as a method for collision risk estimation for vehicles in dynamic and unknown environments. Even if the PCC is a great tool to help the autonomous or semi-autonomous navigation, distortions in the imaging system, pixel noise, slight variations in the object＇s position relative to the camera, and other factors produce a false PCC threshold. Whereas there are homogeneous regions in the image, in order to obtain a more realistic Pearson＇s correlation, we propose to use some prior known environment information.
文摘Objective:The main purpose of this work was to present a Z-phantom manufactured in home (at National Cancer Institute Cairo University) and it's use in a simple way to check the accuracy of the computed-tomography (CT) table movement and CT gantry tilt, also the other general quality control (QC) tests of the CT simulator used at radiotherapy department. Methods:The laser phantom was used to check the external mobile laser position accuracy, for internal image indicator laser beam (light field) the coincidence between light field and radiation exposure at CT simulator was checked using X-Omat ready back film. The Z-phantom was used to check the slice thickness and the table movement and so the gantry tilts. The image quality testes were checked using the CT image quality phantom. TLDs were inserted to the Cicil phantom at the center of each scan volume to estimate the patient dose. Results:The results showed that the difference in the fixed distance between the external mobile laser and the internal image indicator laser beam was less than ± 1 mm; the orientation of the two mobile lateral lasers was coincident. The mechanical movement and the image quality of the CT simulator were within the tolerances and the results were 0.5 mm, 0.2% and 0.6% for the mechanical movement, noise and image uniformity respectively. Conclusion:A CT simulator with a good performance is important for the radiotherapy treatment planning specially with the extremely revolution in radiotherapy techniques, also a rotten quality assurance (QA) program is very important to be shore about the reproducibility of the CT performance. The use of Z-phantom to check the gantry tilt and the table movement is faster than the use of ready back films in these tests.
文摘The price of fuel oil continues to rise, decreased supplies oil at the other side, both factors increase the interest of researchers to conduct research related to fuel efficiency. Therefore the aim of this study is to improve the efficiency fuel of diesel engine using fuel filter. The method used for the research is testing the most efficient fuel filters made of coil wire coil winding 5,000, the three distinguished from the coil core diameter of 44.5, 28.5 and 17.5 mm in diesel engine. The performance test was conducted from 1,100 rpm to 1,700 rpm, the throttle opening of 30%-60%. The first testing was done by creating a constant speed 1,500 rpm and throttle opening varies from 30% to 60%, further testing is done by varying the rpm start from 1,100 rpm to 1,700 rpm to make constant valve 40% and 60%.
文摘The layout features of unit shafting and their effects on vibration, as well as evaluation criteria, were introduced for a 1000-MW ultra-supercritical turbine-generator unit with Simens technology. Based on vibration diagnosis and treatment for more than 10 units, some typical vibration faults were summarized, such as the vibration fluctuation of the high pressure (HP) rotor, abnormal vibration increases of the No.3 bearing pedestal and large vibration of the exciter rotor during its critical speed range. The vibration characteristics and the causes of faults and countermeasures were analyzed. Three applications for further illustration were given. The vibration fault identification method, control measures, and applications can provide a reference for vibration diagnoses and treatment of same type units.
基金Acknowledgment： The paper was supported by the Nature Science Foundation of China （No. 50876034）, Ph.D. Science Foundation of Ministry. of Education of China （No. 20040487039）： Key Discipline Construction Foundation of Shanghai Education Commission （No. J5180｜）： Science Foundation of Shanghai Education Commission （No. 08ZY79） SSPU Science Foundation （No. DZ207004）.
文摘This paper presents a new thermal computer, which is driven by heat current and not electricity current. The basic thermal logic gate, such as thermal logic AND gate. thermal logic NOT gate, thermal logic OR gate are discussed in this paper. Compared with electronic computer, it can work at some special environment, such as high temperature and high pressure Consequently, the heat computer is not only a new special computer, but also a lot of new heat computation cell or device could be invented in the future. The thermal computer and control device are a new thermal energy machines powered by heat energy, it is significant for the environmental protection, energy usage and developed and new discipline development.
文摘This paper discusses the prospect of high efficiency motors based on usage in industrial sectors. In fact, energy consumption is globally classified into the industrial sector, transport system, residential and commercial building, agriculture and others sectors. In all the sectors, energy is eventually consumed by electrical appliances and equipments and the industrial sector accounts for the largest share of the overall energy consumption. The study concerns to identify the energy consumption using qualitative method. The main emphasis was given to comparison of the motor with high efficiency motors （HEMs） and traditional standard motors to investigate energy savings. According to the study, industrial sector has up to 25% of electrical energy conservation potential. Almost 70%-75% of the electrical energy consumption in industry is on account of use of electrical motors being used by pumps, fans, compressors and other motor driven system. Therefore, the potential for energy conservation through electric motors is quite high. Using high efficiency motors （HEMs） can thus reduce the losses and hence save vital energy costs. This paper will provide a contribution to electrical motors arena and will be a systematic knowledge base for researchers in this field.
基金Project supported by T.R.Prime Ministry State Planning Organization,Turkey
文摘In this study, an electro-mechanical valve （EMV） system for the intake valve ofa fottr stroke, single cylinder, overhead valve and spark ignition （SI） engine was designed and constructed. An engine with the EMV system and a standard engine were tested to observe the effects of the EMV on engine performance and emissions at different speeds under full load. The EMV engine showed improved engine power, engine torque and break specific fuel consumption （BSFC）. A 66% decrease in CO emissions was also obtained with the EMV system, but hydrocarbons （HC） and NOx emissions increased by 12% and 13% respectively.
基金financially supported by the National Basic Research Program of China (973 Program) (Grant No. 2007CB936302)the National Natural Science Foundation of China (Grant No. 20833002)
文摘We herein report the effective performance enhancement of the pentacene-based organic thin film transistors with silicon di- oxide dielectric by inserting a thin metal phthalocyanines interlayer between Au source/drain electrodes and the pentacene active layer. The threshold voltage decreased remarkably from ca. -20 V to a few volts （below -7.6 V） while the mobility in- creased 1.5-3 times after the insertion of the interlayer of only ca. 2 nm, which could be attributed to the reduction of the car- tier injection barrier. The results suggest a simple and effective way to achieve low-threshold-voltage pentacene-based organic thin film transistors with high mobility on silicon dioxide dielectric.
