目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、...目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、拉莫三嗪、左乙拉西坦及苯妥英钠。ADR以神经系统最为常见,主要表现为头晕、嗜睡、头痛等,其次为肝胆、胃肠及代谢系统疾病。结论:临床应关注抗癫痫药ADR,加强用药监测。展开更多
目的:通过meta分析来评估HLA-B*15:02等位基因与芳香族类抗癫痫药物(AEDs)诱发史蒂文斯–约翰逊综合征/中毒性表皮坏死松解症(SJS/TEN)的关联。方法:全面检索PubMed、Embase、The Cochrane Library、知网、万方、维普数据库,检索时间截...目的:通过meta分析来评估HLA-B*15:02等位基因与芳香族类抗癫痫药物(AEDs)诱发史蒂文斯–约翰逊综合征/中毒性表皮坏死松解症(SJS/TEN)的关联。方法:全面检索PubMed、Embase、The Cochrane Library、知网、万方、维普数据库,检索时间截止2024年7月1日,采用Revman5.3软件进行meta分析。结果:共纳入26篇文献,均为病例对照研究,共计芳香族类AEDs诱发SJS/TEN患者794例,对照2851例,分析结果合并为OR (95% CI)为26.32 (15.67~44.21) (Z = 12.36, P Objective: To assess the association of HLA-B*15:02 allele with aromatic antiepileptic drugs (AEDs) induced Stevens-Johnson syndrome/toxic epidermal necrolysis with laxity (SJS/TEN) by meta-analysis. Methods: A comprehensive search of PubMed, Embase, The Cochrane Library, Zhi.com, Wanfang, and Wipu databases was performed up to 1 July 2024, and meta-analysis was performed using Revman 5.3 software. Results: A total of 26 papers, all of which were case-control studies, were included, with a total of 794 patients with SJS/TEN induced by aromatic AEDs and 2851 controls, and the combined results of the analyses showed an OR (95% CI) of 26.32 (15.67~44.21) (Z = 12.36, P < 0.00001). Conclusion: There was a significant association of HLA-B*1502 allele eliciting AEDs of the Fragrant family class causing SJS/TEN.展开更多
文摘目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、拉莫三嗪、左乙拉西坦及苯妥英钠。ADR以神经系统最为常见,主要表现为头晕、嗜睡、头痛等,其次为肝胆、胃肠及代谢系统疾病。结论:临床应关注抗癫痫药ADR,加强用药监测。
文摘目的:通过meta分析来评估HLA-B*15:02等位基因与芳香族类抗癫痫药物(AEDs)诱发史蒂文斯–约翰逊综合征/中毒性表皮坏死松解症(SJS/TEN)的关联。方法:全面检索PubMed、Embase、The Cochrane Library、知网、万方、维普数据库,检索时间截止2024年7月1日,采用Revman5.3软件进行meta分析。结果:共纳入26篇文献,均为病例对照研究,共计芳香族类AEDs诱发SJS/TEN患者794例,对照2851例,分析结果合并为OR (95% CI)为26.32 (15.67~44.21) (Z = 12.36, P Objective: To assess the association of HLA-B*15:02 allele with aromatic antiepileptic drugs (AEDs) induced Stevens-Johnson syndrome/toxic epidermal necrolysis with laxity (SJS/TEN) by meta-analysis. Methods: A comprehensive search of PubMed, Embase, The Cochrane Library, Zhi.com, Wanfang, and Wipu databases was performed up to 1 July 2024, and meta-analysis was performed using Revman 5.3 software. Results: A total of 26 papers, all of which were case-control studies, were included, with a total of 794 patients with SJS/TEN induced by aromatic AEDs and 2851 controls, and the combined results of the analyses showed an OR (95% CI) of 26.32 (15.67~44.21) (Z = 12.36, P < 0.00001). Conclusion: There was a significant association of HLA-B*1502 allele eliciting AEDs of the Fragrant family class causing SJS/TEN.
